Input Cluster (n=200) YAL007C ERP2 YAL018C YAL034C FUN19 YBL061C SKT5 YBL112C YBR014C YBR089C-A NHP6B YBR118W TEF2 YBR145W ADH5 YBR239C YCL048W YCL049C YCR010C ADY2 YCR017C CWH43 YCR065W HCM1 YDL028C MPS1 YDL118W YDL132W CDC53 YDL133W YDL184C RPL41A YDL246C YDR006C SOK1 YDR007W TRP1 YDR080W VPS41 YDR186C YDR224C HTB1 YDR270W CCC2 YDR281C PHM6 YDR299W BFR2 YDR335W MSN5 YDR384C ATO3 YDR399W HPT1 YDR410C STE14 YDR441C APT2 YDR462W MRPL28 YDR516C EMI2 YDR517W GRH1 YEL013W VAC8 YEL044W IES6 YEL052W AFG1 YEL053C MAK10 YEL060C PRB1 YEL065W SIT1 YER028C YER039C-A YER040W GLN3 YER077C YER136W GDI1 YER145C FTR1 YER146W LSM5 YER168C CCA1 YER175C TMT1 YER176W ECM32 YFL020C PAU5 YFL021W GAT1 YFL037W TUB2 YFL038C YPT1 YFL041W FET5 YFR022W YFR030W MET10 YFR044C YGL039W YGL093W SPC105 YGL094C PAN2 YGL124C MON1 YGL163C RAD54 YGL207W SPT16 YGL209W MIG2 YGL255W ZRT1 YGR227W DIE2 YGR245C SDA1 YGR260W TNA1 YGR287C YHL004W MRP4 YHL006C SHU1 YHL028W WSC4 YHL035C YHL040C ARN1 YHR051W COX6 YHR131C YHR139C SPS100 YIL057C YIL068C SEC6 YIL074C SER33 YIL118W RHO3 YIL144W TID3 YIL146C ECM37 YIL164C NIT1 YJL090C DPB11 YJL096W MRPL49 YJL143W TIM17 YJL149W YJL151C SNA3 YJR012C YJR039W YJR094W-A RPL43B YJR102C VPS25 YJR152W DAL5 YJR159W SOR1 YKL006W RPL14A YKL039W PTM1 YKL040C NFU1 YKL045W PRI2 YKL046C DCW1 YKL112W ABF1 YKL128C PMU1 YKL175W ZRT3 YKL176C LST4 YKL187C YKL201C MNN4 YKL203C TOR2 YKL220C FRE2 YKR015C YKR069W MET1 YKR075C YKR103W YLL048C YBT1 YLR004C YLR005W SSL1 YLR030W YLR034C SMF3 YLR048W RPS0B YLR055C SPT8 YLR092W SUL2 YLR126C YLR136C TIS11 YLR137W YLR178C TFS1 YLR187W YLR193C YLR205C HMX1 YLR214W FRE1 YLR256W HAP1 YLR267W BOP2 YLR321C SFH1 YLR378C SEC61 YLR399C BDF1 YLR421C RPN13 YML083C YML088W UFO1 YML115C VAN1 YMR003W YMR006C PLB2 YMR018W YMR026C PEX12 YMR056C AAC1 YMR058W FET3 YMR068W AVO2 YMR097C MTG1 YMR105C PGM2 YMR156C TPP1 YMR179W SPT21 YMR234W RNH1 YMR243C ZRC1 YMR253C YMR319C FET4 YNL015W PBI2 YNL018C YNL034W YNL035C YNL163C RIA1 YNL195C YNL221C POP1 YNL237W YTP1 YNL241C ZWF1 YNL259C ATX1 YNL278W CAF120 YNR039C ZRG17 YNR060W FRE4 YOL012C HTZ1 YOL081W IRA2 YOL132W GAS4 YOL158C ENB1 YOR020C HSP10 YOR056C NOB1 YOR057W SGT1 YOR140W SFL1 YOR155C YOR206W NOC2 YOR207C RET1 YOR208W PTP2 YOR242C SSP2 YOR326W MYO2 YOR328W PDR10 YOR381W FRE3 YOR382W FIT2 YOR383C FIT3 YOR384W FRE5 YPL015C HST2 YPL054W LEE1 YPL111W CAR1 YPL145C KES1 YPL200W CSM4 YPL201C YPL216W YPL220W RPL1A YPL278C YPR079W MRL1 YPR103W PRE2 YPR124W CTR1 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f heavy metal ion transporters (Cu, Fe, etc.) 2.57381e-11 CCC2 SIT1 FTR1 FET5 ZRT1 FET3 ZRC1 FET4 ATX1 ZRG17 CTR1 11 23 homeostasis of metal ions (Na, K, Ca etc.) 5.33522e-10 CCC2 FTR1 FET5 ZRT1 NFU1 FRE2 SMF3 FET3 ZRC1 FET4 ATX1 FRE4 FRE3 FRE5 CTR1 15 62 ionic homeostasis 4.03996e-07 CCC2 FTR1 FET5 ZRT1 NFU1 FRE2 SMF3 SUL2 FRE1 FET3 ZRC1 FET4 ATX1 FRE4 FRE3 FRE5 CTR1 17 126 homeostasis of cations 6.63192e-07 CCC2 FTR1 FET5 ZRT1 NFU1 FRE2 SMF3 FRE1 FET3 ZRC1 FET4 ATX1 FRE4 FRE3 FRE5 CTR1 16 116 ion transporters 8.56643e-07 CCC2 SIT1 FTR1 FET5 ZRT1 ZRT3 SUL2 FET3 ZRC1 FET4 ATX1 ZRG17 CTR1 13 78 cation transporters 2.74381e-06 CCC2 SIT1 FTR1 FET5 ZRT1 FET3 ZRC1 FET4 ATX1 ZRG17 CTR1 11 61 TRANSPORT FACILITATION 5.39348e-06 CWH43 CCC2 SIT1 FTR1 FET5 ZRT1 TNA1 YHL035C ARN1 TIM17 DAL5 ZRT3 YKR103W YBT1 YLR004C SUL2 SEC61 AAC1 FET3 ZRC1 FET4 ATX1 ZRG17 ENB1 PDR10 CTR1 26 312 REGULATION OF / INTERACTION WITH CELLULAR ENVIRONMENT 1.53307e-05 CCC2 FTR1 FET5 ZRT1 NFU1 FRE2 SMF3 SUL2 TFS1 FRE1 FET3 ZRC1 FET4 ATX1 FRE4 PTP2 FRE3 FRE5 CTR1 19 198 plasma membrane 0.00218848 FTR1 FET5 SEC6 DAL5 FRE2 FRE1 FET3 ZRC1 FET4 IRA2 PDR10 CTR1 12 145 allantoin and allantoate transporters 0.00233288 TNA1 DAL5 YLR004C 3 9 MIPS Phenotypes Category p-value In Category from Cluster k f Stress response defects 0.00245583 CWH43 YPT1 ZRT1 COX6 SUL2 BDF1 VAN1 ZRC1 ZWF1 ATX1 IRA2 CTR1 12 147 MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 0.00161284 SIT1 FET5 SEC6 DAL5 FRE2 FRE1 PLB2 FET3 ZRC1 FET4 IRA2 PDR10 CTR1 13 159 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.000158001 SIT1 FET5 TNA1 ARN1 DAL5 PTM1 YLR004C SUL2 SEC61 FET3 ZRC1 FET4 ENB1 CTR1 14 142 GO Molecular Function Category p-value In Category from Cluster k f heavy metal ion porter [GO:0005373] 1.9762e-14 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 ZRT3 SMF3 FET3 ZRC1 FET4 ENB1 CTR1 13 23 heavy metal ion transporter [GO:0015076] 4.40759e-14 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 ZRT3 SMF3 FET3 ZRC1 FET4 ENB1 CTR1 13 24 iron transporter [GO:0005381] 2.79776e-13 SIT1 FTR1 FET5 ZRT1 ARN1 SMF3 FET3 FET4 ENB1 9 10 di-, tri-valent inorganic cation transporter [GO:0015082] 4.92506e-12 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 ZRT3 SMF3 FET3 ZRC1 FET4 ENB1 CTR1 13 32 electrochemical potential-driven transporter [GO:0015290] 9.93189e-10 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 ZRT3 SMF3 AAC1 FET3 ZRC1 FET4 ENB1 CTR1 14 55 porter [GO:0015291] 9.93189e-10 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 ZRT3 SMF3 AAC1 FET3 ZRC1 FET4 ENB1 CTR1 14 55 ion transporter [GO:0015075] 6.34666e-09 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 COX6 DAL5 ZRT3 YBT1 SMF3 SUL2 FET3 ZRC1 FET4 ENB1 CTR1 17 96 cation transporter [GO:0008324] 1.03115e-07 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 COX6 ZRT3 SMF3 FET3 ZRC1 FET4 ENB1 CTR1 14 77 ferric-chelate reductase [GO:0000293] 6.28137e-07 FRE2 FRE1 FRE4 FRE3 FRE5 5 7 carrier [GO:0005386] 2.77484e-06 CCC2 SIT1 FTR1 FET5 ZRT1 ARN1 COX6 ZRT3 YKR103W YBT1 SMF3 AAC1 FET3 ZRC1 FET4 ENB1 PDR10 CTR1 18 160 oxidoreductase, acting on NADH or NADPH, other acceptor [GO:0016659] 1.24424e-05 FRE2 FRE1 FRE4 FRE3 FRE5 5 11 siderochrome-iron transporter [GO:0015343] 0.000125104 SIT1 ARN1 ENB1 3 4 transporter [GO:0005215] 0.00029115 CCC2 SIT1 FTR1 FET5 MET10 ZRT1 TNA1 ARN1 COX6 TIM17 DAL5 ZRT3 LST4 YKR103W YBT1 SMF3 SUL2 SEC61 AAC1 FET3 ZRC1 FET4 ENB1 PDR10 CTR1 25 372 zinc ion transporter [GO:0005385] 0.000305393 ZRT1 ZRT3 ZRC1 3 5 oxidoreductase, acting on NADH or NADPH [GO:0016651] 0.000330073 FRE2 FRE1 FRE4 FRE3 FRE5 5 20 oxidoreductase, oxidizing metal ions, oxygen as acceptor [GO:0016724] 0.00101352 FET5 FET3 2 2 oxidoreductase, oxidizing metal ions [GO:0016722] 0.00101352 FET5 FET3 2 2 ferroxidase [GO:0004322] 0.00101352 FET5 FET3 2 2 iron ion transporter [GO:0016033] 0.00101352 FET5 FET3 2 2 multicopper ferroxidase iron transport mediator [GO:0004323] 0.00101352 FET5 FET3 2 2 protease inhibitor [GO:0030414] 0.0029765 TFS1 PBI2 2 3 GO Biological Process Category p-value In Category from Cluster k f heavy metal ion transport [GO:0006823] 1.04738e-12 CCC2 FET5 ZRT1 ZRT3 FRE2 FRE1 FET3 ZRC1 FET4 ATX1 ZRG17 ENB1 CTR1 13 29 di-, tri-valent inorganic cation transport [GO:0015674] 1.92367e-11 CCC2 FET5 ZRT1 ZRT3 FRE2 FRE1 FET3 ZRC1 FET4 ATX1 ZRG17 ENB1 CTR1 13 35 metal ion transport [GO:0030001] 4.38762e-11 CCC2 FET5 ZRT1 ZRT3 FRE2 FRE1 FET3 ZRC1 FET4 ATX1 ZRG17 ENB1 CTR1 13 37 transition metal transport [GO:0000041] 6.98258e-10 CCC2 FET5 FRE2 FRE1 FET3 ZRC1 FET4 ATX1 ENB1 CTR1 10 23 ion transport [GO:0006811] 4.44123e-08 CCC2 FET5 ZRT1 DAL5 ZRT3 FRE2 YBT1 SUL2 FRE1 FET3 ZRC1 FET4 ATX1 ZRG17 ENB1 CTR1 16 96 iron transport [GO:0006826] 7.60695e-08 FET5 FRE2 FRE1 FET3 FET4 ENB1 6 9 siderochrome transport [GO:0015891] 1.84246e-07 SIT1 ARN1 FRE4 ENB1 FRE3 5 6 iron-siderochrome transport [GO:0015892] 1.84246e-07 SIT1 ARN1 FRE4 ENB1 FRE3 5 6 cation transport [GO:0006812] 2.7487e-07 CCC2 FET5 ZRT1 ZRT3 FRE2 FRE1 FET3 ZRC1 FET4 ATX1 ZRG17 ENB1 CTR1 13 71 copper ion transport [GO:0006825] 7.71958e-07 CCC2 FRE2 FRE1 FET4 ATX1 CTR1 6 12 zinc ion transport [GO:0006829] 1.43638e-05 ZRT1 ZRT3 ZRC1 ZRG17 4 6 heavy metal ion homeostasis [GO:0030006] 7.8446e-05 SIT1 NFU1 ZRT3 SMF3 HMX1 ZRC1 FRE3 7 34 transport [GO:0006810] 0.000139898 ERP2 CCC2 BFR2 MSN5 VAC8 SIT1 GDI1 FTR1 YPT1 FET5 MON1 ZRT1 TNA1 ARN1 SEC6 RHO3 TIM17 VPS25 DAL5 ZRT3 LST4 FRE2 YKR103W YBT1 SUL2 FRE1 SEC61 AAC1 FET3 ZRC1 FET4 ATX1 ZRG17 FRE4 ENB1 MYO2 PDR10 FRE3 KES1 CTR1 40 698 di-, tri-valent inorganic cation homeostasis [GO:0030005] 0.000195885 SIT1 NFU1 ZRT3 SMF3 HMX1 ZRC1 FRE3 7 39 copper uptake transport [GO:0015677] 0.000305393 FRE2 FRE1 CTR1 3 5 iron homeostasis [GO:0006879] 0.00042209 SIT1 NFU1 SMF3 HMX1 FRE3 5 21 metal ion homeostasis [GO:0006875] 0.000426347 SIT1 NFU1 ZRT3 SMF3 HMX1 ZRC1 FRE3 7 44 iron ion transport [GO:0015681] 0.0029765 FET3 FET4 2 3 GO Cellular Component Category p-value In Category from Cluster k f lytic vacuole [GO:0000323] 0.000368332 VPS41 VAC8 PRB1 YBT1 SMF3 ZRC1 PBI2 7 43 vacuole (sensu Fungi) [GO:0000324] 0.000368332 VPS41 VAC8 PRB1 YBT1 SMF3 ZRC1 PBI2 7 43 storage vacuole [GO:0000322] 0.000368332 VPS41 VAC8 PRB1 YBT1 SMF3 ZRC1 PBI2 7 43 vacuole [GO:0005773] 0.000474384 VPS41 VAC8 PRB1 ZRT3 TOR2 YBT1 SMF3 ZRC1 PBI2 9 73 plasma membrane [GO:0005886] 0.00156099 CWH43 FTR1 ZRT1 TNA1 DAL5 FRE2 SUL2 FRE1 FET3 FET4 FRE4 PDR10 FRE3 CTR1 14 178 endosome [GO:0005768] 0.0046866 SIT1 ARN1 VPS25 ENB1 MRL1 5 35 SMART Domains Category p-value In Category from Cluster k f TRANS 0.00418916 ERP2 YAL018C FUN19 YBR014C YCL048W ADY2 CWH43 YDL118W YDL133W CCC2 PHM6 ATO3 STE14 SIT1 YER039C-A FTR1 ZRT1 DIE2 TNA1 WSC4 YHL035C ARN1 ECM37 TIM17 SNA3 YJR012C DAL5 PTM1 DCW1 ZRT3 YKL187C MNN4 FRE2 YKR103W YBT1 YLR004C SMF3 SUL2 HMX1 FRE1 SEC61 VAN1 PEX12 AAC1 FET3 ZRC1 YMR253C FET4 YTP1 ZRG17 FRE4 GAS4 ENB1 PDR10 FRE3 FRE5 CSM4 MRL1 CTR1 59 1346 PFam-A Domains Category p-value In Category from Cluster k f PF01794 (Ferric_reduct) 3.57605e-06 FRE2 FRE1 FRE4 FRE3 FRE5 5 9 PF00394 (Cu-oxidase) 0.0029765 FET5 FET3 2 3 PF01184 (Grp1_Fun34_YaaH) 0.0029765 ADY2 ATO3 2 3 PF00318 (Ribosomal_S2) 0.0029765 MRP4 RPS0B 2 3 PF00664 (ABC_membrane) 0.00325479 YHL035C YKR103W YBT1 3 10 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YDL246C 0.00101352 YDL246C SOR1 2 2 YMR308C (PSE1) 0.00437089 YDL246C SOR1 HSP10 3 11 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YIL053W (RHR2) 0.00101352 PTP2 YPL201C 2 2 YCR041W 0.0029765 HCM1 RHO3 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YDR328C (SKP1) 6.28137e-07 CDC53 PRB1 BOP2 UFO1 SGT1 5 7 YLR248W (RCK2) 0.0029765 VPS41 FET4 2 3 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f en2 0.000502713 ERP2 YCL048W CWH43 VPS41 CCC2 STE14 VAC8 PRB1 FTR1 PAU5 FET5 WSC4 YHL035C SPS100 SNA3 YJR012C PTM1 DCW1 ZRT3 YKL187C FRE2 YKR103W YBT1 SMF3 TIS11 FRE1 SEC61 VAN1 PLB2 FET3 ZRC1 YTP1 FRE4 GAS4 FRE3 FIT3 FRE5 MRL1 38 692 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f