Input Cluster (n=200) YBL043W ECM13 YBL063W KIP1 YBL086C YBL101C ECM21 YBR009C HHF1 YBR010W HHT1 YBR014C YBR044C TCM62 YBR046C ZTA1 YBR054W YRO2 YBR062C YBR067C TIP1 YBR073W RDH54 YBR077C YBR105C VID24 YBR106W PHO88 YBR240C THI2 YBR260C RGD1 YCR021C HSP30 YCR027C RHB1 YCR061W YDL056W MBP1 YDL114W YDL128W VCX1 YDL134C PPH21 YDL138W RGT2 YDL182W LYS20 YDR004W RAD57 YDR036C YDR051C YDR072C IPT1 YDR085C AFR1 YDR123C INO2 YDR139C RUB1 YDR151C CTH1 YDR152W YDR223W YDR242W AMD2 YDR275W YDR297W SUR2 YDR298C ATP5 YDR299W BFR2 YDR331W GPI8 YDR345C HXT3 YDR380W ARO10 YDR391C YDR500C RPL37B YDR501W PLM2 YDR508C GNP1 YDR510W SMT3 YDR525W-A SNA2 YDR536W STL1 YEL017C-A PMP2 YEL017W YEL046C GLY1 YEL060C PRB1 YEL067C YER055C HIS1 YER064C YER068W MOT2 YER130C YER137C YER162C RAD4 YFL010W-A AUA1 YFL021W GAT1 YFL053W DAK2 YFR015C GSY1 YFR017C YGL009C LEU1 YGL037C PNC1 YGL055W OLE1 YGL056C SDS23 YGL124C MON1 YGL158W RCK1 YGL162W SUT1 YGL202W ARO8 YGL209W MIG2 YGL252C RTG2 YGL253W HXK2 YGR023W MTL1 YGR030C POP6 YGR067C YGR143W SKN1 YGR250C YHL025W SNF6 YHL026C YHL028W WSC4 YHL029C YHR031C RRM3 YHR094C HXT1 YHR136C SPL2 YHR137W ARO9 YHR178W STB5 YHR199C YHR200W RPN10 YIL065C FIS1 YIL068C SEC6 YIL101C XBP1 YIL133C RPL16A YIL166C YJL033W HCA4 YJL078C PRY3 YJL210W PEX2 YJL213W YJL214W HXT8 YJL216C YJR001W YJR058C APS2 YJR059W PTK2 YJR127C ZMS1 YJR147W HMS2 YJR153W PGU1 YJR155W AAD10 YKL052C ASK1 YKL163W PIR3 YKL166C TPK3 YKL187C YKL216W URA1 YKR006C MRPL13 YKR042W UTH1 YKR074W YKR075C YKR079C YLL028W TPO1 YLR055C SPT8 YLR056W ERG3 YLR152C YLR153C ACS2 YLR174W IDP2 YLR295C ATP14 YLR344W RPL26A YLR378C SEC61 YLR380W CSR1 YML007W YAP1 YML008C ERG6 YML051W GAL80 YML087C YML088W UFO1 YML120C NDI1 YMR002W YMR011W HXT2 YMR015C ERG5 YMR085W YMR135C DCR1 YMR136W GAT2 YMR142C RPL13B YMR145C NDE1 YMR149W SWP1 YMR244C-A YMR246W FAA4 YMR280C CAT8 YMR290C HAS1 YNL030W HHF2 YNL031C HHT2 YNL065W AQR1 YNL093W YPT53 YNL107W YAF9 YNL117W MLS1 YNL118C DCP2 YNL124W NAF1 YNL125C ESBP6 YNL134C YNL186W UBP10 YNL194C YNR018W YNR019W ARE2 YOL004W SIN3 YOL039W RPP2A YOL053W YOL059W GPD2 YOL060C MAM3 YOL126C MDH2 YOR028C CIN5 YOR100C CRC1 YOR107W RGS2 YOR136W IDH2 YOR179C YOR213C SAS5 YOR273C TPO4 YOR312C RPL20B YOR320C GNT1 YOR321W PMT3 YOR340C RPA43 YOR349W CIN1 YOR370C MRS6 YPL026C SKS1 YPL058C PDR12 YPL070W YPL071C YPL082C MOT1 YPL152W RRD2 YPL221W BOP1 YPL262W FUM1 YPL265W DIP5 YPR065W ROX1 YPR074C TKL1 YPR128C ANT1 YPR151C YPR157W YPR192W AQY1 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f METABOLISM 1.26203e-06 YBL086C YBR014C TIP1 PHO88 PPH21 RGT2 LYS20 IPT1 INO2 AMD2 SUR2 GPI8 HXT3 ARO10 GNP1 STL1 GLY1 HIS1 AUA1 GAT1 DAK2 GSY1 LEU1 OLE1 SUT1 ARO8 MIG2 RTG2 HXK2 SKN1 SNF6 HXT1 ARO9 HXT8 YJL216C PGU1 AAD10 URA1 ERG3 ACS2 IDP2 CSR1 ERG6 GAL80 HXT2 ERG5 SWP1 FAA4 CAT8 MLS1 ARE2 SIN3 GPD2 MDH2 IDH2 PMT3 MRS6 SKS1 DIP5 ROX1 TKL1 61 1066 C-compound and carbohydrate metabolism 2.1645e-06 YBL086C PPH21 RGT2 LYS20 HXT3 ARO10 STL1 DAK2 GSY1 MIG2 RTG2 HXK2 SKN1 SNF6 HXT1 HXT8 YJL216C PGU1 AAD10 ACS2 IDP2 GAL80 HXT2 SWP1 CAT8 MLS1 GPD2 MDH2 IDH2 PMT3 SKS1 TKL1 32 415 transcriptional control 6.20421e-06 HHF1 HHT1 THI2 MBP1 INO2 MOT2 YER130C GAT1 MIG2 SNF6 STB5 XBP1 HMS2 TPK3 SPT8 YAP1 GAL80 CAT8 HHF2 HHT2 YAF9 UBP10 SIN3 CIN5 SAS5 MOT1 ROX1 27 334 mRNA synthesis 0.000194486 HHF1 HHT1 THI2 MBP1 INO2 MOT2 YER130C GAT1 MIG2 SNF6 STB5 XBP1 HMS2 TPK3 SPT8 YAP1 GAL80 CAT8 HHF2 HHT2 YAF9 UBP10 SIN3 CIN5 SAS5 MOT1 ROX1 27 406 ENERGY 0.000397093 ATP5 ARO10 GSY1 HXK2 YJL216C AAD10 ACS2 IDP2 ATP14 YML087C NDI1 NDE1 CAT8 MLS1 DCP2 MDH2 IDH2 FUM1 TKL1 19 252 TRANSPORT FACILITATION 0.000893355 VCX1 RGT2 ATP5 HXT3 GNP1 STL1 PMP2 HXT1 YIL166C HXT8 YJR001W TPO1 ATP14 SEC61 HXT2 AQR1 ESBP6 TPO4 PDR12 DIP5 AQY1 21 312 C-compound and carbohydrate utilization 0.00159254 LYS20 ARO10 DAK2 GSY1 HXK2 SKN1 YJL216C PGU1 AAD10 ACS2 IDP2 SWP1 MLS1 GPD2 MDH2 IDH2 PMT3 TKL1 18 261 C-compound, carbohydrate transport 0.00196986 RGT2 HXT3 STL1 HXT1 HXT8 HXT2 6 42 C-compound and carbohydrate transporters 0.00316469 RGT2 HXT3 STL1 HXT1 HXT8 HXT2 6 46 lipid, fatty-acid and isoprenoid metabolism 0.00318088 TIP1 IPT1 INO2 SUR2 GPI8 OLE1 SUT1 ERG3 CSR1 ERG6 ERG5 FAA4 ARE2 SIN3 MRS6 15 213 homeostasis of protons 0.0046866 HSP30 VCX1 ATP5 PMP2 ATP14 5 35 MIPS Phenotypes Category p-value In Category from Cluster k f Silencing mutants 0.000132237 HHF1 HHT1 HHF2 HHT2 UBP10 SIN3 6 26 Transcriptional mutants 0.000133037 HHF1 HHT1 SPT8 YAP1 CAT8 HHF2 HHT2 UBP10 SIN3 MOT1 10 76 other transcriptional mutants 0.00106656 SPT8 YAP1 CAT8 HHF2 HHT2 SIN3 MOT1 7 51 Carbohydrate and lipid biosynthesis defects 0.00353338 INO2 SUR2 GPI8 OLE1 ERG6 ERG5 6 47 MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f Nucleosomal protein complex 6.37246e-05 HHF1 HHT1 HHF2 HHT2 4 8 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.000158001 HXT3 GNP1 STL1 HXT1 YIL166C HXT8 YJR001W TPO1 SEC61 HXT2 AQR1 ESBP6 TPO4 DIP5 14 142 Histones 0.000278515 HHF1 HHT1 HHF2 HHT2 4 11 H4 0.00101352 HHF1 HHF2 2 2 H3 0.0029765 HHT1 HHT2 2 3 GO Molecular Function Category p-value In Category from Cluster k f glucose transporter [GO:0005355] 0.000142455 RGT2 HXT3 HXT1 HXT8 HXT2 5 17 hexose transporter [GO:0015149] 0.000254088 RGT2 HXT3 HXT1 HXT8 HXT2 5 19 monosaccharide transporter [GO:0015145] 0.000254088 RGT2 HXT3 HXT1 HXT8 HXT2 5 19 aromatic amino acid transferase [GO:0008793] 0.00101352 ARO8 ARO9 2 2 mannose transporter [GO:0015578] 0.0010418 HXT3 HXT1 HXT8 HXT2 4 15 transporter [GO:0005215] 0.00161185 PHO88 VCX1 RGT2 ATP5 HXT3 GNP1 STL1 HXT1 HXT8 ATP14 SEC61 CSR1 NDI1 HXT2 NDE1 NAF1 ESBP6 MAM3 CRC1 PDR12 DIP5 ANT1 AQY1 23 372 carbohydrate transporter [GO:0015144] 0.0016999 RGT2 HXT3 HXT1 HXT8 HXT2 5 28 DNA binding [GO:0003677] 0.00278128 HHF1 HHT1 RDH54 THI2 MBP1 INO2 MOT2 RAD4 GAT1 SUT1 MIG2 SNF6 RRM3 STB5 XBP1 HMS2 YAP1 GAT2 CAT8 HHF2 HHT2 CIN5 ROX1 23 388 transcription regulator [GO:0030528] 0.00430895 THI2 MBP1 INO2 MOT2 GAT1 SUT1 MIG2 SNF6 STB5 XBP1 HMS2 SPT8 YAP1 GAL80 GAT2 CAT8 CIN5 ROX1 18 286 GO Biological Process Category p-value In Category from Cluster k f monosaccharide transport [GO:0015749] 4.76857e-05 RGT2 HXT3 HXT1 HXT8 HXT2 SKS1 6 22 hexose transport [GO:0008645] 4.76857e-05 RGT2 HXT3 HXT1 HXT8 HXT2 SKS1 6 22 organic acid metabolism [GO:0006082] 0.000184758 OLE1 ACS2 IDP2 MLS1 MDH2 CRC1 IDH2 PDR12 FUM1 ANT1 10 79 carboxylic acid metabolism [GO:0019752] 0.000184758 OLE1 ACS2 IDP2 MLS1 MDH2 CRC1 IDH2 PDR12 FUM1 ANT1 10 79 carbohydrate transport [GO:0008643] 0.000306566 RGT2 HXT3 HXT1 HXT8 HXT2 SKS1 6 30 lipid metabolism [GO:0006629] 0.000890576 IPT1 INO2 SUR2 GPI8 DAK2 OLE1 ERG3 ERG6 ERG5 FAA4 ARE2 GPD2 CRC1 ANT1 14 168 main pathways of carbohydrate metabolism [GO:0006092] 0.00134561 IDP2 CAT8 MLS1 MDH2 IDH2 FUM1 TKL1 7 53 alcohol metabolism [GO:0006066] 0.00184928 DAK2 MIG2 HXK2 GAL80 NDE1 CAT8 GPD2 MDH2 TKL1 9 88 carbohydrate metabolism [GO:0005975] 0.0022495 GSY1 MIG2 HXK2 SKN1 PGU1 IDP2 GAL80 CAT8 MLS1 MDH2 IDH2 FUM1 TKL1 13 165 cell growth and/or maintenance [GO:0008151] 0.00277865 ECM13 KIP1 ECM21 HHF1 HHT1 TCM62 TIP1 RDH54 VID24 PHO88 THI2 HSP30 RHB1 MBP1 VCX1 PPH21 RGT2 LYS20 RAD57 YDR036C IPT1 AFR1 INO2 RUB1 CTH1 SUR2 ATP5 BFR2 GPI8 HXT3 ARO10 RPL37B GNP1 SMT3 STL1 PMP2 GLY1 PRB1 HIS1 MOT2 RAD4 AUA1 GAT1 DAK2 GSY1 LEU1 PNC1 OLE1 MON1 RCK1 SUT1 ARO8 MIG2 HXK2 MTL1 POP6 SKN1 SNF6 WSC4 RRM3 HXT1 SPL2 ARO9 RPN10 FIS1 SEC6 XBP1 RPL16A HCA4 PEX2 HXT8 APS2 PTK2 HMS2 PGU1 AAD10 ASK1 PIR3 TPK3 URA1 MRPL13 UTH1 SPT8 ERG3 ACS2 IDP2 ATP14 RPL26A SEC61 CSR1 YAP1 ERG6 GAL80 UFO1 NDI1 HXT2 ERG5 GAT2 RPL13B NDE1 SWP1 FAA4 CAT8 HHF2 HHT2 YPT53 MLS1 DCP2 NAF1 ESBP6 UBP10 ARE2 SIN3 RPP2A GPD2 MAM3 MDH2 CIN5 CRC1 IDH2 SAS5 RPL20B PMT3 RPA43 CIN1 MRS6 SKS1 PDR12 MOT1 RRD2 FUM1 DIP5 ROX1 TKL1 ANT1 AQY1 136 3657 TCA intermediate metabolism [GO:0006100] 0.00393128 IDP2 MDH2 IDH2 FUM1 4 21 GO Cellular Component Category p-value In Category from Cluster k f nucleosome [GO:0005718] 0.000407383 HHF1 HHT1 HHF2 HHT2 4 12 chromatin [GO:0005717] 0.00115248 HHF1 HHT1 RRM3 HHF2 HHT2 SAS5 6 38 SMART Domains Category p-value In Category from Cluster k f H4 0.00101352 HHF1 HHF2 2 2 H3 0.0029765 HHT1 HHT2 2 3 PFam-A Domains Category p-value In Category from Cluster k f PF00125 (histone) 0.000181761 HHF1 HHT1 HHF2 HHT2 4 10 PF00083 (sugar_tr) 0.00024113 RGT2 HXT3 STL1 HXT1 HXT8 TPO1 HXT2 AQR1 8 53 PF01598 (Sterol_desat) 0.0029765 SUR2 ERG3 2 3 PF03366 (YEATS) 0.0029765 YAF9 SAS5 2 3 PF01036 (Bac_rhodopsin) 0.0029765 YRO2 HSP30 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YNL088W (TOP2) 0.0029765 SMT3 FAA4 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f cell periphery 0.00403694 TIP1 HSP30 YCR061W YDR036C STL1 YER064C YNR018W 7 64 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 1.66448e-05 ECM13 KIP1 YBL086C ECM21 HHF1 HHT1 YBR014C TCM62 ZTA1 YRO2 YBR062C TIP1 RDH54 YBR077C THI2 RGD1 HSP30 YCR061W MBP1 YDL114W VCX1 PPH21 RGT2 LYS20 YDR036C YDR051C IPT1 AFR1 RUB1 CTH1 YDR152W YDR223W AMD2 YDR275W SUR2 HXT3 ARO10 YDR391C SNA2 STL1 PMP2 YEL017W GLY1 PRB1 YEL067C HIS1 YER064C AUA1 GAT1 DAK2 GSY1 YFR017C LEU1 PNC1 SDS23 ARO8 MIG2 RTG2 HXK2 MTL1 SKN1 YGR250C YHL026C WSC4 YHL029C HXT1 SPL2 ARO9 STB5 YHR199C FIS1 RPL16A YIL166C PRY3 PEX2 YJL213W HXT8 YJL216C APS2 PTK2 ZMS1 HMS2 PGU1 PIR3 TPK3 YKL187C URA1 UTH1 YKR074W YKR075C TPO1 YLR152C IDP2 ATP14 RPL26A CSR1 YAP1 GAL80 YML087C UFO1 NDI1 YMR002W HXT2 ERG5 YMR085W DCR1 GAT2 NDE1 YMR244C-A FAA4 CAT8 HHT2 AQR1 YPT53 MLS1 ESBP6 YNL134C YNL194C YNR018W ARE2 RPP2A YOL053W GPD2 MAM3 MDH2 CIN5 CRC1 IDH2 SAS5 TPO4 RPL20B GNT1 PMT3 SKS1 PDR12 YPL070W YPL071C RRD2 BOP1 FUM1 ROX1 TKL1 ANT1 YPR151C YPR157W AQY1 146 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f