Input Cluster (n=200) YAL044C GCV3 YAL060W BDH1 YAR071W PHO11 YBL045C COR1 YBL087C RPL23A YBL093C ROX3 YBL101C ECM21 YBL102W SFT2 YBL103C RTG3 YBR010W HHT1 YBR076W ECM8 YBR086C IST2 YBR111C YSA1 YBR117C TKL2 YBR139W YBR147W YBR185C MBA1 YBR186W PCH2 YBR220C YBR240C THI2 YBR248C HIS7 YBR270C YBR291C CTP1 YBR296C PHO89 YCL030C HIS4 YCR009C RVS161 YDL054C MCH1 YDL058W USO1 YDL130W-A STF1 YDL146W YDL178W DLD2 YDL241W YDR068W DOS2 YDR074W TPS2 YDR089W YDR092W UBC13 YDR127W ARO1 YDR186C YDR239C YDR240C SNU56 YDR246W TRS23 YDR261C EXG2 YDR305C HNT2 YDR372C VPS74 YDR408C ADE8 YDR409W SIZ1 YDR435C PPM1 YDR495C VPS3 YDR524C AGE1 YDR530C APA2 YEL029C BUD16 YEL067C YEL069C HXT13 YER023W PRO3 YER039C HVG1 YER044C-A MEI4 YER048C CAJ1 YER061C CEM1 YER065C ICL1 YER091C MET6 YER092W IES5 YER111C SWI4 YER116C SLX8 YER117W RPL23B YER125W RSP5 YFL023W BUD27 YFL024C EPL1 YFL052W YFR011C YFR021W AUT10 YFR026C YFR040W SAP155 YGL009C LEU1 YGL011C SCL1 YGL077C HNM1 YGL080W YGL150C INO80 YGL186C YGL187C COX4 YGL207W SPT16 YGL236C MTO1 YGL255W ZRT1 YGR191W HIP1 YGR240C PFK1 YHL019C APM2 YHL036W MUP3 YHL038C CBP2 YHR002W LEU5 YHR010W RPL27A YHR075C PPE1 YHR098C SFB3 YHR162W YHR215W PHO12 YIL019W YIL093C RSM25 YIL101C XBP1 YIL116W HIS5 YIL128W MET18 YIL129C TAO3 YIL136W OM45 YIL156W UBP7 YIL157C YIL165C YIR034C LYS1 YJL011C RPC17 YJL063C MRPL8 YJL089W SIP4 YJL130C URA2 YJL134W LCB3 YJL143W TIM17 YJL160C YJR060W CBF1 YJR077C MIR1 YJR078W BNA2 YJR110W YKL046C DCW1 YKL060C FBA1 YKL061W YKL080W VMA5 YKL124W SSH4 YKL164C PIR1 YKL179C COY1 YKL210W UBA1 YKR046C YKR058W GLG1 YKR066C CCP1 YKR080W MTD1 YKR097W PCK1 YLL029W YLR031W YLR045C STU2 YLR053C YLR058C SHM2 YLR125W YLR134W PDC5 YLR271W YLR351C NIT3 YLR355C ILV5 YLR359W ADE13 YLR363C NMD4 YLR420W URA4 YML036W YML052W SUR7 YML110C COQ5 YMR039C SUB1 YMR042W ARG80 YMR060C TOM37 YMR061W RNA14 YMR095C SNO1 YMR096W SNZ1 YMR120C ADE17 YMR135C DCR1 YMR145C NDE1 YMR188C YMR189W GCV2 YMR195W ICY1 YMR216C SKY1 YMR217W GUA1 YMR300C ADE4 YNL010W YNL130C CPT1 YNL163C RIA1 YNL186W UBP10 YNL192W CHS1 YNL220W ADE12 YNL223W AUT2 YNL224C YNL231C PDR16 YNL247W YNL248C RPA49 YNL300W YNR010W CSE2 YNR020C YNR059W MNT4 YOL058W ARG1 YOL112W MSB4 YOL132W GAS4 YOL140W ARG8 YOL158C ENB1 YOR098C NUP1 YOR130C ORT1 YOR182C RPS30B YOR184W SER1 YOR226C ISU2 YOR227W YOR250C CLP1 YOR355W GDS1 YPL003W ULA1 YPL004C YPL137C YPL144W YPL184C YPL234C TFP3 YPL279C YPR004C YPR026W ATH1 YPR128C ANT1 YPR145W ASN1 YPR167C MET16 YPR168W NUT2 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f METABOLISM 6.19679e-09 GCV3 BDH1 PHO11 RTG3 YSA1 TKL2 HIS7 CTP1 PHO89 HIS4 TPS2 ARO1 EXG2 HNT2 ADE8 APA2 HXT13 PRO3 CEM1 ICL1 MET6 YFL052W LEU1 YGL186C HIP1 PFK1 MUP3 LEU5 PHO12 HIS5 LYS1 URA2 LCB3 CBF1 MIR1 BNA2 FBA1 SSH4 MTD1 PCK1 SHM2 PDC5 NIT3 ILV5 ADE13 NMD4 URA4 COQ5 ARG80 TOM37 ADE17 GCV2 GUA1 ADE4 CPT1 CHS1 ADE12 PDR16 MNT4 ARG1 ARG8 ORT1 SER1 ISU2 ATH1 ASN1 MET16 67 1066 amino acid metabolism 2.24968e-08 GCV3 TKL2 HIS7 HIS4 ARO1 PRO3 MET6 LEU1 HIP1 MUP3 HIS5 LYS1 CBF1 BNA2 SSH4 ILV5 ARG80 GCV2 ARG1 ARG8 ORT1 SER1 ASN1 MET16 24 204 amino acid biosynthesis 8.40041e-07 TKL2 HIS7 HIS4 ARO1 PRO3 MET6 LEU1 MUP3 HIS5 LYS1 ILV5 ARG1 ARG8 SER1 ASN1 MET16 16 118 nucleotide metabolism 1.6917e-05 YSA1 HNT2 ADE8 APA2 YGL186C LEU5 URA2 MTD1 SHM2 ADE13 NMD4 URA4 ADE17 GUA1 ADE4 ADE12 16 148 purine ribonucleotide metabolism 7.29958e-05 ADE8 MTD1 SHM2 ADE13 ADE17 GUA1 ADE4 ADE12 8 45 mitochondrion 0.000555045 GCV3 COR1 MBA1 CTP1 STF1 TPS2 CEM1 COX4 MTO1 CBP2 PPE1 OM45 MRPL8 TIM17 MIR1 CCP1 ILV5 COQ5 TOM37 NDE1 GCV2 ARG8 ORT1 YPR004C 24 366 SUBCELLULAR LOCALISATION 0.00198137 GCV3 PHO11 COR1 RPL23A ROX3 SFT2 RTG3 HHT1 TKL2 MBA1 PCH2 THI2 CTP1 RVS161 USO1 STF1 DLD2 TPS2 ARO1 SNU56 TRS23 EXG2 VPS74 ADE8 VPS3 HXT13 PRO3 CEM1 ICL1 MET6 SWI4 RPL23B RSP5 LEU1 SCL1 HNM1 COX4 SPT16 MTO1 HIP1 PFK1 APM2 MUP3 CBP2 RPL27A PPE1 PHO12 MET18 TAO3 OM45 LYS1 MRPL8 SIP4 URA2 TIM17 CBF1 MIR1 FBA1 VMA5 PIR1 UBA1 CCP1 MTD1 PCK1 STU2 SHM2 PDC5 ILV5 COQ5 SUB1 ARG80 TOM37 RNA14 NDE1 GCV2 CPT1 CHS1 ADE12 AUT2 RPA49 CSE2 ARG1 ARG8 NUP1 ORT1 RPS30B CLP1 TFP3 YPR004C ATH1 ASN1 NUT2 92 2256 ENERGY 0.00270516 COR1 TKL2 MBA1 STF1 TPS2 CEM1 ICL1 COX4 PFK1 FBA1 YKR046C GLG1 PCK1 PDC5 NDE1 YPR004C ATH1 17 252 MIPS Phenotypes Category p-value In Category from Cluster k f Auxotrophies, carbon and 0.0018881 HHT1 MBA1 RVS161 ICL1 MET6 CBP2 MET18 MRPL8 CBF1 ILV5 ADE13 COQ5 SUB1 TOM37 NDE1 SER1 GDS1 ATH1 18 265 Methionine auxotrophy (Met) 0.00233288 MET6 MET18 CBF1 3 9 MIPS Subcellular Localization Category p-value In Category from Cluster k f mitochondria 0.00278128 GCV3 COR1 MBA1 CTP1 STF1 TPS2 CEM1 COX4 CBP2 PPE1 OM45 MRPL8 TIM17 MIR1 CCP1 ILV5 COQ5 TOM37 NDE1 GCV2 ARG8 ORT1 ISU2 23 388 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Ubiquitin-system proteins 0.00483174 UBC13 RSP5 UBP7 UBA1 UBP10 ULA1 6 50 GO Molecular Function Category p-value In Category from Cluster k f enzyme [GO:0003824] 0.000107019 GCV3 BDH1 PHO11 COR1 YSA1 TKL2 HIS7 HIS4 DLD2 TPS2 UBC13 ARO1 EXG2 HNT2 ADE8 SIZ1 PPM1 APA2 PRO3 CEM1 ICL1 MET6 RSP5 EPL1 SAP155 LEU1 SCL1 INO80 COX4 PFK1 PPE1 PHO12 HIS5 UBP7 LYS1 RPC17 URA2 LCB3 BNA2 YJR110W FBA1 VMA5 UBA1 GLG1 CCP1 MTD1 PCK1 SHM2 PDC5 ILV5 ADE13 URA4 COQ5 SNO1 ADE17 NDE1 GCV2 SKY1 GUA1 ADE4 CPT1 UBP10 CHS1 ADE12 YNL247W RPA49 MNT4 ARG1 ARG8 SER1 ULA1 TFP3 ATH1 ASN1 MET16 75 1604 L-amino acid transporter [GO:0015179] 0.000596423 HIP1 MUP3 ORT1 3 6 phosphoribosyl-ATP pyrophosphatase [GO:0004636] 0.00101352 YSA1 HIS4 2 2 glycine hydroxymethyltransferase [GO:0004372] 0.00101923 ADE8 SHM2 ADE17 3 7 oxidoreductase, acting on the CH-NH group of donors, NAD or NADP as acceptor [GO:0016646] 0.00233288 PRO3 LYS1 MTD1 3 9 transferase, transferring one-carbon groups [GO:0016741] 0.00253479 ADE8 PPM1 MET6 URA2 SHM2 COQ5 ADE17 7 59 glycine dehydrogenase (decarboxylating) [GO:0004375] 0.0029765 GCV3 GCV2 2 3 oxidoreductase, acting on the CH-NH2 group of donors, disulfide as acceptor [GO:0016642] 0.0029765 GCV3 GCV2 2 3 oxidoreductase [GO:0016491] 0.0034766 GCV3 BDH1 COR1 HIS4 DLD2 PRO3 COX4 LYS1 BNA2 CCP1 MTD1 ILV5 NDE1 GCV2 MET16 15 215 transporter [GO:0005215] 0.00353451 COR1 CTP1 PHO89 MCH1 HXT13 HNM1 COX4 ZRT1 HIP1 MUP3 LEU5 TIM17 MIR1 VMA5 TOM37 NDE1 PDR16 ENB1 ORT1 TFP3 YPR004C ANT1 22 372 oxidoreductase, acting on the CH-NH group of donors [GO:0016645] 0.00437089 PRO3 LYS1 MTD1 3 11 GO Biological Process Category p-value In Category from Cluster k f amino acid metabolism [GO:0006520] 7.35936e-08 HIS7 HIS4 ARO1 PRO3 MET6 LEU1 HIS5 MET18 LYS1 CBF1 ILV5 ARG80 YNL247W ARG1 ARG8 ORT1 SER1 ASN1 MET16 19 140 amino acid and derivative metabolism [GO:0006519] 2.02309e-07 HIS7 HIS4 ARO1 PRO3 MET6 LEU1 HIS5 MET18 LYS1 CBF1 ILV5 ARG80 YNL247W ARG1 ARG8 ORT1 SER1 ASN1 MET16 19 149 amine metabolism [GO:0009308] 2.50488e-07 HIS7 HIS4 ARO1 PRO3 MET6 LEU1 HIS5 MET18 LYS1 CBF1 ILV5 ARG80 YNL247W ARG1 ARG8 ORT1 SER1 ASN1 MET16 19 151 amino acid biosynthesis [GO:0008652] 6.68259e-07 HIS7 HIS4 ARO1 PRO3 LEU1 HIS5 LYS1 CBF1 ILV5 ARG1 ARG8 ORT1 SER1 ASN1 14 89 amine biosynthesis [GO:0009309] 1.51137e-06 HIS7 HIS4 ARO1 PRO3 LEU1 HIS5 LYS1 CBF1 ILV5 ARG1 ARG8 ORT1 SER1 ASN1 14 95 energy pathways [GO:0006091] 1.06021e-05 BDH1 COR1 TKL2 MBA1 ICL1 COX4 PFK1 SIP4 FBA1 GLG1 PCK1 PDC5 COQ5 NDE1 YMR188C GDS1 ATH1 17 159 energy derivation by oxidation of organic compounds [GO:0015980] 1.06021e-05 BDH1 COR1 TKL2 MBA1 ICL1 COX4 PFK1 SIP4 FBA1 GLG1 PCK1 PDC5 COQ5 NDE1 YMR188C GDS1 ATH1 17 159 purine base metabolism [GO:0006144] 3.28926e-05 ADE8 MTD1 ADE13 ADE4 SER1 5 13 cell growth and/or maintenance [GO:0008151] 3.34138e-05 GCV3 BDH1 PHO11 COR1 RPL23A ROX3 ECM21 SFT2 RTG3 HHT1 ECM8 IST2 TKL2 MBA1 PCH2 THI2 HIS7 CTP1 PHO89 HIS4 RVS161 MCH1 USO1 STF1 TPS2 UBC13 ARO1 SNU56 TRS23 HNT2 VPS74 ADE8 SIZ1 PPM1 VPS3 AGE1 APA2 BUD16 HXT13 PRO3 MEI4 CEM1 ICL1 MET6 SWI4 SLX8 RPL23B RSP5 BUD27 EPL1 AUT10 SAP155 LEU1 SCL1 HNM1 INO80 COX4 SPT16 MTO1 ZRT1 HIP1 PFK1 APM2 MUP3 CBP2 LEU5 RPL27A PPE1 SFB3 RSM25 XBP1 HIS5 MET18 TAO3 UBP7 LYS1 RPC17 MRPL8 SIP4 URA2 LCB3 TIM17 CBF1 MIR1 BNA2 FBA1 VMA5 PIR1 UBA1 GLG1 CCP1 MTD1 PCK1 STU2 SHM2 PDC5 ILV5 ADE13 NMD4 URA4 SUR7 COQ5 SUB1 ARG80 TOM37 RNA14 SNO1 SNZ1 ADE17 NDE1 YMR188C GCV2 SKY1 GUA1 ADE4 CPT1 RIA1 UBP10 CHS1 ADE12 AUT2 PDR16 YNL247W RPA49 CSE2 MNT4 ARG1 MSB4 ARG8 ENB1 NUP1 ORT1 RPS30B SER1 ISU2 CLP1 GDS1 ULA1 TFP3 ATH1 ANT1 ASN1 MET16 NUT2 144 3657 one-carbon compound metabolism [GO:0006730] 0.000111843 GCV3 MTD1 SHM2 GCV2 4 9 metabolism [GO:0008152] 0.000196701 GCV3 BDH1 PHO11 COR1 RPL23A ROX3 SFT2 RTG3 HHT1 TKL2 MBA1 THI2 HIS7 HIS4 USO1 TPS2 UBC13 ARO1 SNU56 TRS23 HNT2 VPS74 ADE8 SIZ1 PPM1 VPS3 AGE1 APA2 PRO3 MEI4 CEM1 ICL1 MET6 SLX8 RPL23B RSP5 EPL1 AUT10 LEU1 SCL1 INO80 COX4 SPT16 MTO1 PFK1 CBP2 RPL27A PPE1 SFB3 RSM25 HIS5 MET18 UBP7 LYS1 RPC17 MRPL8 SIP4 URA2 LCB3 TIM17 CBF1 BNA2 FBA1 UBA1 GLG1 CCP1 MTD1 PCK1 SHM2 PDC5 ILV5 ADE13 NMD4 URA4 COQ5 SUB1 ARG80 TOM37 RNA14 SNO1 SNZ1 ADE17 NDE1 YMR188C GCV2 SKY1 GUA1 ADE4 CPT1 UBP10 ADE12 AUT2 PDR16 YNL247W RPA49 CSE2 MNT4 ARG1 ARG8 NUP1 ORT1 RPS30B SER1 CLP1 GDS1 ULA1 ATH1 ANT1 ASN1 MET16 NUT2 111 2693 nucleobase metabolism [GO:0009112] 0.000205152 ADE8 URA2 MTD1 ADE13 ADE4 SER1 6 28 glycolytic fermentation [GO:0019660] 0.000596423 BDH1 PDC5 NDE1 3 6 purine base biosynthesis [GO:0009113] 0.000596423 ADE8 MTD1 SER1 3 6 aromatic compound metabolism [GO:0006725] 0.000735386 ARO1 ADE8 URA2 MTD1 ADE13 ADE4 SER1 7 48 urea cycle intermediate metabolism [GO:0000051] 0.0010418 ARG80 ARG1 ARG8 ORT1 4 15 biosynthesis [GO:0009058] 0.00143385 RPL23A THI2 HIS7 HIS4 ARO1 ADE8 PRO3 CEM1 RPL23B LEU1 MTO1 RPL27A RSM25 HIS5 LYS1 MRPL8 SIP4 URA2 LCB3 CBF1 BNA2 FBA1 GLG1 MTD1 PCK1 ILV5 URA4 ADE17 CPT1 ADE12 PDR16 MNT4 ARG1 ARG8 ORT1 RPS30B SER1 ASN1 38 731 aspartate family amino acid metabolism [GO:0009066] 0.00173371 MET6 MET18 LYS1 CBF1 ASN1 MET16 6 41 sulfur amino acid metabolism [GO:0000096] 0.00200157 MET6 MET18 CBF1 YNL247W MET16 5 29 nucleobase biosynthesis [GO:0046112] 0.00267631 ADE8 URA2 MTD1 SER1 4 19 methionine metabolism [GO:0006555] 0.00326287 MET6 MET18 CBF1 MET16 4 20 arginine metabolism [GO:0006525] 0.00437089 ARG80 ARG1 ORT1 3 11 GO Cellular Component Category p-value In Category from Cluster k f mitochondrion [GO:0005739] 0.00198676 GCV3 COR1 MBA1 CTP1 STF1 DLD2 CEM1 COX4 MTO1 CBP2 LEU5 RSM25 OM45 MRPL8 TIM17 MIR1 CCP1 ILV5 COQ5 TOM37 NDE1 YMR188C GCV2 ARG8 ORT1 ISU2 26 448 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00117 (GATase) 0.00233288 HIS7 URA2 GUA1 3 9 PF00238 (Ribosomal_L14) 0.0029765 RPL23A RPL23B 2 3 PF03650 (UPF0041) 0.0029765 YGL080W YHR162W 2 3 PF00153 (mito_carr) 0.0041219 CTP1 LEU5 MIR1 ORT1 ANT1 5 34 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YDR388W (RVS167) 1.19185e-05 COR1 RVS161 RSP5 MET18 UBP7 ILV5 ARG1 7 26 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f cyto 0.00464306 BDH1 ECM21 YBR270C HIS4 MCH1 USO1 DLD2 TPS2 YDR186C HNT2 VPS74 PPM1 AGE1 BUD16 PRO3 MET6 RPL23B RSP5 BUD27 SAP155 LEU1 PFK1 LEU5 XBP1 HIS5 MET18 UBP7 YIL165C LYS1 BNA2 FBA1 YKL061W SSH4 YKR046C GLG1 MTD1 PCK1 YLL029W YLR031W SHM2 YML036W SNZ1 ADE17 DCR1 GUA1 YNL010W RIA1 AUT2 PDR16 MSB4 SER1 YOR227W YPL004C YPL137C YPL184C ANT1 ASN1 MET16 58 1324 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f