Input Cluster (n=198) YAL047C SPC72 YAL054C ACS1 YAR035W YAT1 YBL043W ECM13 YBL102W SFT2 YBL103C RTG3 YBR050C REG2 YBR105C VID24 YBR106W PHO88 YBR112C CYC8 YBR183W YPC1 YBR240C THI2 YBR297W MAL33 YCR010C ADY2 YCR027C RHB1 YCR061W YDL022W GPD1 YDL031W DBP10 YDL075W RPL31A YDL076C RXT3 YDL085W NDE2 YDL124W YDL125C HNT1 YDR034C-A YDR034W-B YDR036C YDR037W KRS1 YDR046C BAP3 YDR098C GRX3 YDR148C KGD2 YDR150W NUM1 YDR153C ENT5 YDR170C SEC7 YDR186C YDR275W YDR276C PMP3 YDR277C MTH1 YDR297W SUR2 YDR298C ATP5 YDR299W BFR2 YDR309C GIC2 YDR322W MRPL35 YDR345C HXT3 YDR384C ATO3 YDR391C YDR392W SPT3 YDR406W PDR15 YDR441C APT2 YDR525W-A SNA2 YEL017C-A PMP2 YEL017W YEL034W HYP2 YEL060C PRB1 YEL066W HPA3 YER035W EDC2 YER048C CAJ1 YER048W-A YER065C ICL1 YER088C DOT6 YER091C MET6 YER092W IES5 YER137C YER150W SPI1 YER167W BCK2 YER177W BMH1 YFL016C MDJ1 YFL021W GAT1 YFL053W DAK2 YFL054C YGL009C LEU1 YGL054C ERV14 YGL055W OLE1 YGL056C SDS23 YGL181W GTS1 YGL183C MND1 YGR023W MTL1 YGR035C YGR067C YGR161C YGR209C TRX2 YGR243W YGR281W YOR1 YGR289C MAL11 YGR292W MAL12 YHL028W WSC4 YHL029C YHL047C ARN2 YHR015W MIP6 YHR031C RRM3 YHR048W YHR081W LRP1 YHR096C HXT5 YHR199C YHR200W RPN10 YIL065C FIS1 YIR035C YJL026W RNR2 YJL043W YJL161W YJL210W PEX2 YJL216C YJR016C ILV3 YJR077C MIR1 YJR078W BNA2 YJR126C VPS70 YKL007W CAP1 YKL008C LAC1 YKL052C ASK1 YKL062W MSN4 YKL171W YKR016W YKR075C YKR097W PCK1 YLL018C-A COX19 YLL028W TPO1 YLL039C UBI4 YLR108C YLR109W AHP1 YLR121C YPS3 YLR152C YLR154C YLR174W IDP2 YLR178C TFS1 YLR183C TOS4 YLR185W RPL37A YLR304C ACO1 YLR312C YLR312W-A MRPL15 YLR323C CWC24 YLR324W YLR377C FBP1 YLR406C RPL31B YML007W YAP1 YML091C RPM2 YML100W TSL1 YML101C CUE4 YML126C ERG13 YMR002W YMR008C PLB1 YMR015C ERG5 YMR070W MOT3 YMR135C DCR1 YMR205C PFK2 YMR251W-A HOR7 YMR303C ADH2 YMR304W UBP15 YNL065W AQR1 YNL078W NIS1 YNL079C TPM1 YNL093W YPT53 YNL103W MET4 YNL117W MLS1 YNL118C DCP2 YNL144C YNL193W YNL231C PDR16 YNL241C ZWF1 YNL304W YPT11 YNR018W YNR019W ARE2 YOL012C HTZ1 YOL039W RPP2A YOL040C RPS15 YOL052C SPE2 YOL052C-A DDR2 YOL053W YOL060C MAM3 YOL125W YOL126C MDH2 YOR065W CYT1 YOR138C YOR140W SFL1 YOR226C ISU2 YOR227W YOR250C CLP1 YOR274W MOD5 YOR316C COT1 YOR335C ALA1 YOR348C PUT4 YOR349W CIN1 YOR382W FIT2 YPL024W NCE4 YPL026C SKS1 YPL070W YPL075W GCR1 YPL107W YPL135W ISU1 YPL144W YPL200W CSM4 YPL201C YPL221W BOP1 YPL222W YPL262W FUM1 YPL263C KEL3 YPR030W CSR2 YPR046W MCM16 YPR151C YPR157W Genes Not Found: YDR170W-A YML100W-A MIPS Functional Classification Category p-value In Category from Cluster k f glyoxylate cycle 1.38008e-05 ICL1 ACO1 MLS1 MDH2 4 6 C-compound and carbohydrate metabolism 1.39129e-05 ACS1 RTG3 REG2 MAL33 ADY2 GPD1 YDL124W KGD2 MTH1 HXT3 ATO3 ICL1 DAK2 MAL11 MAL12 HXT5 YJL216C MSN4 PCK1 IDP2 ACO1 FBP1 TSL1 PFK2 ADH2 MLS1 ZWF1 MDH2 SKS1 GCR1 30 415 METABOLISM 1.97286e-05 ACS1 YAT1 RTG3 REG2 PHO88 YPC1 MAL33 ADY2 GPD1 YDL124W HNT1 BAP3 KGD2 MTH1 SUR2 HXT3 ATO3 APT2 HYP2 ICL1 MET6 GAT1 DAK2 LEU1 OLE1 MAL11 MAL12 HXT5 YIR035C RNR2 YJL216C ILV3 MIR1 BNA2 MSN4 PCK1 IDP2 ACO1 FBP1 TSL1 ERG13 PLB1 ERG5 PFK2 ADH2 MET4 MLS1 PDR16 ZWF1 ARE2 SPE2 MDH2 ISU2 PUT4 SKS1 GCR1 ISU1 57 1066 ENERGY 3.98492e-05 ACS1 NDE2 KGD2 ATP5 ATO3 ICL1 YJL216C YKR016W PCK1 IDP2 ACO1 FBP1 TSL1 PFK2 ADH2 MLS1 DCP2 ZWF1 MDH2 CYT1 FUM1 21 252 CELL RESCUE, DEFENSE AND VIRULENCE 0.000450627 GPD1 GRX3 MDJ1 DAK2 GTS1 TRX2 WSC4 ARN2 YHR048W MSN4 TPO1 UBI4 AHP1 YAP1 ERG5 HOR7 AQR1 ZWF1 SPE2 DDR2 20 278 C-compound and carbohydrate utilization 0.000542619 ACS1 GPD1 YDL124W KGD2 ATO3 ICL1 DAK2 MAL12 YJL216C PCK1 IDP2 ACO1 FBP1 TSL1 PFK2 ADH2 MLS1 ZWF1 MDH2 19 261 stress response 0.00345079 GPD1 GRX3 MDJ1 DAK2 GTS1 WSC4 MSN4 UBI4 AHP1 YAP1 HOR7 ZWF1 DDR2 13 175 cytoplasm 0.00435651 GPD1 RPL31A KRS1 SEC7 HYP2 ICL1 MET6 LEU1 MAL12 RNR2 MSN4 PCK1 UBI4 IDP2 RPL37A ACO1 FBP1 RPL31B YAP1 TSL1 PFK2 ADH2 ZWF1 RPP2A RPS15 MDH2 MOD5 ALA1 FUM1 29 554 drug transporters 0.00449046 YOR1 ARN2 YHR048W TPO1 AQR1 5 35 MIPS Phenotypes Category p-value In Category from Cluster k f Methionine auxotrophy (Met) 0.00226655 MET6 MET4 ZWF1 3 9 MIPS Subcellular Localization Category p-value In Category from Cluster k f cytoplasm 0.00325132 GPD1 RPL31A KRS1 SEC7 HYP2 ICL1 MET6 BCK2 LEU1 MAL12 RNR2 MSN4 PCK1 UBI4 AHP1 IDP2 RPL37A ACO1 FBP1 RPL31B YAP1 TSL1 PFK2 ADH2 ZWF1 RPP2A RPS15 MDH2 MOD5 ALA1 FUM1 31 593 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Transcription factors 0.00482271 RTG3 THI2 MAL33 DOT6 GAT1 GTS1 YGR067C MSN4 YAP1 MOT3 MET4 SFL1 GCR1 13 182 GO Molecular Function Category p-value In Category from Cluster k f lyase [GO:0016829] 0.00159133 ICL1 LEU1 ILV3 PCK1 ACO1 ERG13 MLS1 SPE2 FUM1 9 87 transcriptional repressor [GO:0016564] 0.00424866 CYC8 MOT3 SFL1 3 11 GO Biological Process Category p-value In Category from Cluster k f main pathways of carbohydrate metabolism [GO:0006092] 5.65741e-07 KGD2 ICL1 PCK1 IDP2 ACO1 FBP1 PFK2 MLS1 ZWF1 MDH2 FUM1 11 53 energy pathways [GO:0006091] 3.66799e-05 ACS1 NDE2 KGD2 ICL1 BMH1 PCK1 IDP2 ACO1 FBP1 TSL1 PFK2 ADH2 MLS1 ZWF1 MDH2 FUM1 16 159 energy derivation by oxidation of organic compounds [GO:0015980] 3.66799e-05 ACS1 NDE2 KGD2 ICL1 BMH1 PCK1 IDP2 ACO1 FBP1 TSL1 PFK2 ADH2 MLS1 ZWF1 MDH2 FUM1 16 159 carbohydrate metabolism [GO:0005975] 0.000204712 MAL33 KGD2 ICL1 BMH1 MAL12 PCK1 IDP2 ACO1 FBP1 TSL1 PFK2 MLS1 ZWF1 MDH2 FUM1 15 165 glyoxylate metabolism [GO:0046487] 0.000296423 ICL1 MLS1 MDH2 3 5 glyoxylate cycle [GO:0006097] 0.000296423 ICL1 MLS1 MDH2 3 5 TCA intermediate metabolism [GO:0006100] 0.000402935 KGD2 IDP2 ACO1 MDH2 FUM1 5 21 hexose transport [GO:0008645] 0.000508192 MTH1 HXT3 MAL11 HXT5 SKS1 5 22 monosaccharide transport [GO:0015749] 0.000508192 MTH1 HXT3 MAL11 HXT5 SKS1 5 22 glucose transport [GO:0015758] 0.000579045 MTH1 MAL11 SKS1 3 6 organic acid metabolism [GO:0006082] 0.000793498 ACS1 KGD2 ICL1 OLE1 IDP2 ACO1 MLS1 MDH2 FUM1 9 79 carboxylic acid metabolism [GO:0019752] 0.000793498 ACS1 KGD2 ICL1 OLE1 IDP2 ACO1 MLS1 MDH2 FUM1 9 79 alcohol metabolism [GO:0006066] 0.00172518 YAT1 NDE2 DAK2 PCK1 FBP1 PFK2 ADH2 ZWF1 MDH2 9 88 carbohydrate transport [GO:0008643] 0.00223968 MTH1 HXT3 MAL11 HXT5 SKS1 5 30 maltose metabolism [GO:0000023] 0.00291776 MAL33 MAL12 2 3 disaccharide metabolism [GO:0005984] 0.00424866 MAL33 MAL12 TSL1 3 11 GO Cellular Component Category p-value In Category from Cluster k f cytoplasm [GO:0005737] 0.00133045 SPC72 ACS1 YAT1 SFT2 RTG3 VID24 YPC1 GPD1 RPL31A NDE2 HNT1 KRS1 KGD2 ENT5 SEC7 SUR2 ATP5 GIC2 MRPL35 HYP2 PRB1 MET6 MDJ1 ERV14 OLE1 SDS23 GTS1 TRX2 ARN2 RPN10 FIS1 YIR035C RNR2 YJL043W MIR1 BNA2 CAP1 LAC1 ASK1 YKL171W YKR075C PCK1 COX19 UBI4 AHP1 IDP2 RPL37A ACO1 MRPL15 FBP1 RPL31B YAP1 RPM2 CUE4 ERG13 ERG5 PFK2 ADH2 TPM1 YPT53 MLS1 DCP2 PDR16 ZWF1 ARE2 RPP2A RPS15 MDH2 CYT1 YOR138C ISU2 MOD5 COT1 ALA1 CIN1 ISU1 FUM1 77 1810 cytosol [GO:0005829] 0.00175398 ACS1 RPL31A SEC7 MET6 TRX2 RPN10 RNR2 PCK1 COX19 IDP2 RPL37A ACO1 FBP1 RPL31B PFK2 RPP2A RPS15 MDH2 MOD5 FUM1 20 310 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF01592 (NifU_N) 0.000993302 ISU2 ISU1 2 2 PF01198 (Ribosomal_L31e) 0.000993302 RPL31A RPL31B 2 2 PF00083 (sugar_tr) 0.00126917 HXT3 MAL11 ARN2 YHR048W HXT5 TPO1 AQR1 7 53 PF01184 (Grp1_Fun34_YaaH) 0.00291776 ADY2 ATO3 2 3 PF01161 (PBP) 0.00291776 MRPL35 TFS1 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YOR043W (WHI2) 0.000993302 HYP2 CSR2 2 2 YAR003W (SWD1) 0.000993302 RNR2 UBI4 2 2 YDR477W (SNF1) 0.00226655 SEC7 PRB1 UBI4 3 9 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.00242093 ACS1 ECM13 REG2 CYC8 YPC1 THI2 MAL33 ADY2 YCR061W YDL124W HNT1 YDR036C BAP3 GRX3 KGD2 ENT5 YDR186C YDR275W MTH1 SUR2 GIC2 HXT3 ATO3 YDR391C PDR15 SNA2 PMP2 YEL017W PRB1 HPA3 ICL1 DOT6 MET6 IES5 GAT1 DAK2 YFL054C LEU1 ERV14 SDS23 MTL1 YGR035C YGR161C TRX2 YGR243W YOR1 MAL12 WSC4 YHL029C ARN2 MIP6 YHR048W LRP1 HXT5 YHR199C FIS1 YIR035C YJL043W YJL161W PEX2 YJL216C MIR1 BNA2 VPS70 LAC1 MSN4 YKL171W YKR016W YKR075C PCK1 COX19 TPO1 UBI4 YLR108C AHP1 YPS3 YLR152C YLR154C IDP2 TFS1 TOS4 RPL37A ACO1 YLR312C MRPL15 YLR324W FBP1 RPL31B YAP1 TSL1 CUE4 YMR002W PLB1 ERG5 DCR1 PFK2 HOR7 ADH2 AQR1 NIS1 TPM1 YPT53 MLS1 YNL193W PDR16 YPT11 YNR018W ARE2 HTZ1 RPP2A SPE2 YOL053W MAM3 YOL125W MDH2 YOR138C ISU2 YOR227W COT1 PUT4 FIT2 SKS1 YPL070W YPL107W ISU1 YPL144W CSM4 YPL201C BOP1 YPL222W FUM1 KEL3 CSR2 MCM16 YPR151C YPR157W 136 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f