Input Cluster (n=196) YBL015W ACH1 YBL024W NCL1 YBL063W KIP1 YBL082C RHK1 YBL085W BOI1 YBR019C GAL10 YBR145W ADH5 YBR154C RPB5 YBR208C "DUR1,2" YBR211C AME1 YBR240C THI2 YCR005C CIT2 YCR024C-A PMP1 YCR065W HCM1 YCR087C-A YCR088W ABP1 YDL003W MCD1 YDL013W HEX3 YDL039C PRM7 YDL085W NDE2 YDL177C YDL182W LYS20 YDL232W OST4 YDL236W PHO13 YDR042C YDR058C TGL2 YDR063W YDR073W SNF11 YDR117C YDR118W APC4 YDR211W GCD6 YDR233C RTN1 YDR234W LYS4 YDR281C PHM6 YDR310C SUM1 YDR311W TFB1 YDR402C DIT2 YDR403W DIT1 YDR441C APT2 YDR507C GIN4 YDR517W GRH1 YEL046C GLY1 YEL058W PCM1 YEL059C-A SOM1 YEL069C HXT13 YEL071W DLD3 YER019C-A SBH2 YER020W GPA2 YER033C ZRG8 YER034W YER070W RNR1 YER078C YER109C FLO8 YER111C SWI4 YER120W SCS2 YER138W-A YER157W COG3 YER167W BCK2 YFL017W-A SMX2 YFL018C LPD1 YFL056C AAD6 YFR017C YFR019W FAB1 YFR047C BNA6 YGL057C YGL062W PYC1 YGL103W RPL28 YGL123W RPS2 YGL124C MON1 YGL148W ARO2 YGL163C RAD54 YGR021W YGR068C YGR078C PAC10 YGR086C YGR109C CLB6 YGR211W ZPR1 YGR229C SMI1 YGR241C YAP1802 YGR243W YGR267C FOL2 YHL002W HSE1 YHL033C RPL8A YHR019C DED81 YHR020W YHR041C SRB2 YHR042W NCP1 YHR098C SFB3 YHR099W TRA1 YHR155W YHR195W NVJ1 YIL026C IRR1 YIL046W MET30 YIL047C SYG1 YIL060W YIL066C RNR3 YIL084C SDS3 YIL111W COX5B YIL115C NUP159 YIL122W POG1 YIL140W AXL2 YIR027C DAL1 YJL012C VTC4 YJL026W RNR2 YJL036W SNX4 YJL043W YJL044C GYP6 YJL147C YJL181W YJL187C SWE1 YJL189W RPL39 YJL190C RPS22A YJL213W YJR014W YJR017C ESS1 YJR055W HIT1 YJR058C APS2 YJR059W PTK2 YJR113C RSM7 YJR147W HMS2 YJR154W YKL029C MAE1 YKL101W HSL1 YKL121W YKL166C TPK3 YKR072C SIS2 YKR076W ECM4 YLL057C YLR049C YLR055C SPT8 YLR103C CDC45 YLR104W YLR110C CCW12 YLR120C YPS1 YLR125W YLR136C TIS11 YLR162W YLR308W CDA2 YLR342W FKS1 YLR348C DIC1 YLR354C TAL1 YLR355C ILV5 YLR380W CSR1 YLR437C YLR438W CAR2 YML022W APT1 YML023C YML070W DAK1 YML102W CAC2 YMR018W YMR076C PDS5 YMR083W ADH3 YMR135C DCR1 YMR240C CUS1 YMR241W YHM2 YMR261C TPS3 YMR305C SCW10 YNL030W HHF2 YNL031C HHT2 YNL032W SIW14 YNL045W YNL055C POR1 YNL104C LEU4 YNL183C NPR1 YNL243W SLA2 YNL244C SUI1 YNL273W TOF1 YNL274C YNL284C MRPL10 YNL289W PCL1 YNR002C FUN34 YNR009W YNR015W SMM1 YNR017W MAS6 YNR070W PDR18 YOL011W PLB3 YOR063W RPL3 YOR096W RPS7A YOR288C MPD1 YOR349W CIN1 YOR357C GRD19 YOR358W HAP5 YPL018W CTF19 YPL057C SUR1 YPL079W RPL21B YPL082C MOT1 YPL170W YPL171C OYE3 YPL233W NSL1 YPL234C TFP3 YPL240C HSP82 YPL250C ICY2 YPL256C CLN2 YPR011C YPR120C CLB5 YPR175W DPB2 Genes Not Found: YAR010C YBL005W-A YBL005W-B YER138C MIPS Functional Classification Category p-value In Category from Cluster k f METABOLISM 0.000119518 ACH1 RHK1 GAL10 ADH5 "DUR1,2" CIT2 HEX3 LYS20 OST4 PHO13 TGL2 SNF11 LYS4 APT2 GLY1 PCM1 HXT13 RNR1 SCS2 LPD1 AAD6 FAB1 BNA6 PYC1 ARO2 SMI1 FOL2 NCP1 YHR155W MET30 RNR3 DAL1 RNR2 MAE1 CDA2 FKS1 DIC1 TAL1 ILV5 CSR1 CAR2 APT1 DAK1 ADH3 TPS3 YNL045W LEU4 NPR1 SLA2 YNL274C FUN34 PLB3 SUR1 YPR011C 54 1066 SUBCELLULAR LOCALISATION 0.000185236 ACH1 NCL1 KIP1 RHK1 GAL10 RPB5 AME1 THI2 CIT2 PMP1 HCM1 ABP1 MCD1 LYS20 OST4 PHO13 SNF11 APC4 GCD6 RTN1 LYS4 SUM1 TFB1 GRH1 SOM1 HXT13 DLD3 FLO8 SWI4 SCS2 COG3 SMX2 LPD1 PYC1 RPL28 RPS2 ARO2 RAD54 PAC10 SMI1 YAP1802 RPL8A SRB2 NCP1 NVJ1 IRR1 MET30 SYG1 RNR3 SDS3 COX5B NUP159 AXL2 RNR2 RPL39 RPS22A APS2 RSM7 MAE1 HSL1 TPK3 SIS2 SPT8 CDC45 YPS1 FKS1 DIC1 TAL1 ILV5 CAR2 CAC2 ADH3 CUS1 YHM2 TPS3 HHF2 HHT2 POR1 LEU4 SLA2 SUI1 MRPL10 MAS6 RPL3 RPS7A MPD1 CIN1 GRD19 HAP5 RPL21B MOT1 TFP3 HSP82 CLN2 DPB2 95 2256 DNA synthesis and replication 0.00065379 RNR1 CLB6 RNR3 RNR2 CDC45 CAC2 YHM2 CLN2 CLB5 DPB2 10 94 C-compound and carbohydrate metabolism 0.00108681 RHK1 GAL10 ADH5 CIT2 HEX3 LYS20 OST4 SNF11 PCM1 HXT13 SCS2 AAD6 PYC1 SMI1 YHR155W MAE1 CDA2 FKS1 DIC1 TAL1 DAK1 ADH3 TPS3 YNL274C FUN34 25 415 C-compound and carbohydrate utilization 0.00126491 RHK1 GAL10 ADH5 CIT2 HEX3 LYS20 OST4 PCM1 AAD6 PYC1 MAE1 CDA2 FKS1 TAL1 DAK1 ADH3 TPS3 YNL274C 18 261 other intracellular transport activities 0.00287754 YDR117C SBH2 NVJ1 PTK2 NPR1 5 32 cytoplasm 0.00375446 ACH1 GAL10 PHO13 GCD6 RTN1 DLD3 PYC1 RPL28 RPS2 ARO2 PAC10 RPL8A IRR1 RNR3 RNR2 RPL39 RPS22A TPK3 TAL1 CAR2 TPS3 LEU4 SUI1 RPL3 RPS7A GRD19 RPL21B HSP82 CLN2 29 554 deoxyribonucleotide metabolism 0.00412857 RNR1 RNR3 RNR2 3 11 MIPS Phenotypes Category p-value In Category from Cluster k f paromomycin 0.00220143 NCL1 RPS2 SUI1 3 9 MIPS Subcellular Localization Category p-value In Category from Cluster k f cytoplasm 0.00140687 ACH1 GAL10 PHO13 GCD6 RTN1 DLD3 COG3 BCK2 PYC1 RPL28 RPS2 ARO2 PAC10 RPL8A IRR1 RNR3 VTC4 RNR2 RPL39 RPS22A TPK3 TAL1 CAR2 TPS3 LEU4 SUI1 RPL3 RPS7A GRD19 RPL21B HSP82 CLN2 32 593 MIPS Protein Complexes Category p-value In Category from Cluster k f Ribonucleoside-diphosphate reductase 0.000117768 RNR1 RNR3 RNR2 3 4 Cdc28p complexes 0.00307287 CLB6 CLN2 CLB5 3 10 MIPS Protein Classes Category p-value In Category from Cluster k f GIN4 family 0.00285958 GIN4 HSL1 2 3 Cyclins 0.00436031 CLB6 PCL1 CLN2 CLB5 4 22 GO Molecular Function Category p-value In Category from Cluster k f oxidoreductase, acting on CH2 groups, disulfide as acceptor [GO:0016728] 0.000117768 RNR1 RNR3 RNR2 3 4 oxidoreductase, acting on CH2 groups [GO:0016725] 0.000117768 RNR1 RNR3 RNR2 3 4 ribonucleoside-diphosphate reductase [GO:0004748] 0.000117768 RNR1 RNR3 RNR2 3 4 enzyme [GO:0003824] 0.000302351 ACH1 NCL1 GAL10 ADH5 RPB5 "DUR1,2" CIT2 NDE2 LYS20 OST4 PHO13 TGL2 APC4 LYS4 DIT2 DIT1 APT2 GIN4 GLY1 PCM1 DLD3 GPA2 RNR1 LPD1 AAD6 FAB1 BNA6 PYC1 ARO2 RAD54 CLB6 FOL2 DED81 YHR020W TRA1 MET30 RNR3 COX5B DAL1 RNR2 SWE1 ESS1 PTK2 MAE1 HSL1 TPK3 YPS1 CDA2 FKS1 TAL1 ILV5 CAR2 APT1 DAK1 ADH3 TPS3 SCW10 SIW14 YNL045W LEU4 NPR1 PCL1 SMM1 PLB3 MPD1 MOT1 OYE3 TFP3 HSP82 CLN2 CLB5 DPB2 72 1604 adenine phosphoribosyltransferase [GO:0003999] 0.000973286 APT2 APT1 2 2 electron transporter [GO:0005489] 0.00436031 NDE2 LPD1 NCP1 OYE3 4 22 GO Biological Process Category p-value In Category from Cluster k f cell growth and/or maintenance [GO:0008151] 5.75503e-07 ACH1 NCL1 KIP1 RHK1 BOI1 GAL10 ADH5 RPB5 "DUR1,2" AME1 THI2 CIT2 PMP1 HCM1 ABP1 MCD1 HEX3 PRM7 NDE2 LYS20 OST4 PHO13 TGL2 SNF11 APC4 GCD6 LYS4 SUM1 TFB1 DIT2 DIT1 GIN4 GRH1 GLY1 PCM1 SOM1 HXT13 DLD3 SBH2 GPA2 RNR1 FLO8 SWI4 SCS2 COG3 BCK2 SMX2 LPD1 AAD6 FAB1 BNA6 PYC1 RPL28 RPS2 MON1 ARO2 RAD54 PAC10 CLB6 ZPR1 SMI1 YAP1802 FOL2 RPL8A DED81 SRB2 NCP1 SFB3 TRA1 IRR1 MET30 RNR3 SDS3 COX5B NUP159 POG1 AXL2 DAL1 VTC4 RNR2 SNX4 GYP6 SWE1 RPL39 RPS22A ESS1 HIT1 APS2 PTK2 RSM7 HMS2 MAE1 HSL1 TPK3 SIS2 ECM4 SPT8 CDC45 YPS1 CDA2 FKS1 DIC1 TAL1 ILV5 CSR1 CAR2 APT1 DAK1 CAC2 PDS5 ADH3 CUS1 YHM2 TPS3 SCW10 HHF2 HHT2 SIW14 YNL045W POR1 LEU4 NPR1 SLA2 SUI1 TOF1 MRPL10 PCL1 SMM1 MAS6 PLB3 RPL3 RPS7A MPD1 CIN1 GRD19 HAP5 CTF19 SUR1 RPL21B MOT1 NSL1 TFP3 HSP82 CLN2 YPR011C CLB5 DPB2 147 3657 regulation of cell cycle [GO:0000074] 2.04765e-05 APC4 SUM1 GIN4 GRH1 BCK2 CLB6 ZPR1 POG1 SWE1 HSL1 SIS2 CLN2 CLB5 13 105 mitotic cell cycle [GO:0000278] 0.000220111 KIP1 MCD1 APC4 SUM1 TFB1 GRH1 RNR1 CLB6 IRR1 RNR3 RNR2 SWE1 HSL1 SIS2 CDC45 PDS5 TOF1 CLN2 CLB5 DPB2 20 266 mitotic sister chromatid cohesion [GO:0007064] 0.000287627 MCD1 IRR1 PDS5 3 5 cell cycle [GO:0007049] 0.000408097 KIP1 HCM1 MCD1 APC4 SUM1 TFB1 GIN4 GRH1 RNR1 SWI4 BCK2 CLB6 ZPR1 IRR1 MET30 RNR3 POG1 RNR2 SWE1 HSL1 SIS2 CDC45 PDS5 TOF1 PCL1 CTF19 NSL1 CLN2 CLB5 DPB2 30 504 regulation of CDK activity [GO:0000079] 0.000965824 CLB6 SWE1 CLN2 CLB5 4 15 cell morphogenesis checkpoint [GO:0000078] 0.000973286 SWE1 HSL1 2 2 metabolism [GO:0008152] 0.00246522 ACH1 NCL1 RHK1 GAL10 ADH5 RPB5 "DUR1,2" THI2 CIT2 HCM1 HEX3 NDE2 LYS20 OST4 PHO13 TGL2 SNF11 APC4 GCD6 LYS4 SUM1 TFB1 GIN4 GLY1 PCM1 SOM1 DLD3 SBH2 RNR1 SCS2 COG3 SMX2 LPD1 AAD6 FAB1 BNA6 PYC1 RPL28 RPS2 MON1 ARO2 RAD54 CLB6 SMI1 FOL2 RPL8A DED81 SRB2 NCP1 SFB3 TRA1 MET30 RNR3 SDS3 COX5B NUP159 DAL1 RNR2 RPL39 RPS22A ESS1 HIT1 RSM7 MAE1 HSL1 TPK3 SPT8 CDC45 YPS1 FKS1 TAL1 ILV5 CAR2 APT1 DAK1 CAC2 ADH3 CUS1 TPS3 HHF2 HHT2 SIW14 YNL045W POR1 LEU4 NPR1 SLA2 SUI1 TOF1 MRPL10 SMM1 MAS6 PLB3 RPL3 RPS7A MPD1 GRD19 HAP5 SUR1 RPL21B MOT1 HSP82 CLB5 DPB2 104 2693 G2/M transition of mitotic cell cycle [GO:0000086] 0.00249012 CLB6 SWE1 HSL1 CLN2 CLB5 5 31 glycine metabolism [GO:0006544] 0.00285958 GLY1 LPD1 2 3 septin checkpoint [GO:0000135] 0.00285958 GIN4 HSL1 2 3 re-entry into mitotic cell cycle [GO:0000320] 0.00285958 POG1 CLN2 2 3 re-entry into mitotic cell cycle after pheromone arrest [GO:0000321] 0.00285958 POG1 CLN2 2 3 DNA replication and chromosome cycle [GO:0000067] 0.00399136 MCD1 APC4 RNR1 CLB6 IRR1 RNR3 RNR2 CDC45 PDS5 TOF1 CTF19 NSL1 CLB5 DPB2 14 201 GO Cellular Component Category p-value In Category from Cluster k f mitotic chromosome [GO:0005708] 0.000531427 MCD1 IRR1 PDS5 CTF19 4 13 cell [GO:0005623] 0.00056456 ACH1 NCL1 KIP1 RHK1 BOI1 GAL10 RPB5 CIT2 PMP1 HCM1 ABP1 MCD1 HEX3 PRM7 NDE2 LYS20 OST4 SNF11 APC4 GCD6 LYS4 SUM1 TFB1 GIN4 GRH1 PCM1 SOM1 HXT13 DLD3 SBH2 RNR1 FLO8 SWI4 SCS2 COG3 SMX2 LPD1 FAB1 PYC1 RPL28 RPS2 RAD54 PAC10 ZPR1 SMI1 YAP1802 FOL2 HSE1 RPL8A DED81 SRB2 NCP1 SFB3 TRA1 NVJ1 IRR1 MET30 SYG1 SDS3 COX5B NUP159 POG1 AXL2 DAL1 VTC4 RNR2 SNX4 YJL043W SWE1 RPL39 RPS22A APS2 RSM7 MAE1 HSL1 TPK3 SIS2 SPT8 CDC45 CDA2 FKS1 DIC1 TAL1 ILV5 YLR437C CAR2 CAC2 PDS5 ADH3 CUS1 YHM2 SCW10 HHF2 HHT2 POR1 LEU4 NPR1 SLA2 SUI1 TOF1 MRPL10 PCL1 FUN34 MAS6 PLB3 RPL3 RPS7A CIN1 GRD19 HAP5 CTF19 RPL21B MOT1 NSL1 TFP3 HSP82 CLN2 YPR011C CLB5 DPB2 120 3106 intracellular [GO:0005622] 0.00269754 ACH1 NCL1 KIP1 RHK1 GAL10 RPB5 CIT2 HCM1 ABP1 MCD1 HEX3 NDE2 LYS20 OST4 SNF11 APC4 GCD6 LYS4 SUM1 TFB1 GRH1 PCM1 SOM1 HXT13 DLD3 SBH2 RNR1 FLO8 SWI4 SCS2 COG3 SMX2 LPD1 FAB1 PYC1 RPL28 RPS2 RAD54 PAC10 ZPR1 SMI1 YAP1802 FOL2 HSE1 RPL8A DED81 SRB2 SFB3 TRA1 NVJ1 IRR1 MET30 SYG1 SDS3 COX5B NUP159 POG1 AXL2 DAL1 VTC4 RNR2 YJL043W SWE1 RPL39 RPS22A APS2 RSM7 MAE1 HSL1 TPK3 SIS2 SPT8 CDC45 FKS1 DIC1 TAL1 ILV5 YLR437C CAR2 CAC2 PDS5 ADH3 CUS1 YHM2 SCW10 HHF2 HHT2 POR1 LEU4 NPR1 SLA2 SUI1 MRPL10 PCL1 MAS6 PLB3 RPL3 RPS7A CIN1 GRD19 HAP5 CTF19 RPL21B MOT1 NSL1 TFP3 HSP82 CLN2 YPR011C CLB5 DPB2 111 2921 SMART Domains Category p-value In Category from Cluster k f CYCLIN 0.00201145 CLB6 PCL1 CLN2 CLB5 4 18 PFam-A Domains Category p-value In Category from Cluster k f PF00682 (HMGL-like) 0.000561999 LYS20 PYC1 LEU4 3 6 PF00317 (ribonuc_red_lg) 0.000973286 RNR1 RNR3 2 2 PF00256 (L15) 0.000973286 RPL28 MRPL10 2 2 PF02867 (ribonuc_red_lgC) 0.000973286 RNR1 RNR3 2 2 PF03477 (ATP-cone) 0.000973286 RNR1 RNR3 2 2 PF00134 (cyclin) 0.00125651 CLB6 PCL1 CLN2 CLB5 4 16 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YIR034C (LYS1) 3.01385e-05 FOL2 TAL1 POR1 3 3 YHR135C (YCK1) 0.00227081 FOL2 TPK3 ILV5 CAR2 POR1 OYE3 6 44 YDR490C (PKH1) 0.00285958 YGR086C TPK3 2 3 Cellzome Complexes Category p-value In Category from Cluster k f YER120W (SCS2) 0.00307287 SCS2 YGR086C FKS1 3 10 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f