Input Cluster (n=199) YAL017W PSK1 YAL018C YBL031W SHE1 YBL052C SAS3 YBL063W KIP1 YBR040W FIG1 YBR082C UBC4 YBR138C HDR1 YBR249C ARO4 YBR250W YCL014W BUD3 YCL016C DCC1 YCL027W FUS1 YCL068C YCL073C YCR004C YCP4 YCR021C HSP30 YCR075C ERS1 YCR084C TUP1 YCR086W CSM1 YDL028C MPS1 YDL055C PSA1 YDL084W SUB2 YDL215C GDH2 YDL240W LRG1 YDR027C LUV1 YDR146C SWI5 YDR216W ADR1 YDR222W YDR225W HTA1 YDR247W YDR259C YAP6 YDR263C DIN7 YDR292C SRP101 YDR312W SSF2 YDR322W MRPL35 YDR326C YDR367W YDR403W DIT1 YDR418W RPL12B YDR451C YHP1 YDR452W PPN1 YDR464W SPP41 YDR472W TRS31 YDR479C YDR480W DIG2 YEL001C YEL006W YEL009C GCN4 YEL027W CUP5 YEL061C CIN8 YER031C YPT31 YER032W FIR1 YER048C CAJ1 YER070W RNR1 YER103W SSA4 YER114C BOI2 YER124C DSE1 YER175C TMT1 YFL058W THI5 YGL001C ERG26 YGL021W ALK1 YGL028C SCW11 YGL101W YGL133W ITC1 YGL139W YGL184C STR3 YGL256W ADH4 YGL257C MNT2 YGR041W BUD9 YGR072W UPF3 YGR083C GCD2 YGR092W DBF2 YGR111W YGR138C TPO2 YGR140W CBF2 YGR240C PFK1 YGR263C YHL015W RPS20 YHL024W RIM4 YHL028W WSC4 YHR001W OSH7 YHR023W MYO1 YHR061C GIC1 YHR085W IPI1 YHR103W SBE22 YHR129C ARP1 YHR138C YHR172W SPC97 YIL050W PCL7 YIL051C MMF1 YIL126W STH1 YIL130W GIN1 YIL131C FKH1 YIL147C SLN1 YIR007W YIR010W DSN1 YIR019C MUC1 YIR042C YJL062W LAS21 YJL118W YJL121C RPE1 YJL134W LCB3 YJR001W YJR076C CDC11 YJR094C IME1 YJR112W NNF1 YJR135C MCM22 YJR138W IML1 YKL007W CAP1 YKL008C LAC1 YKL069W YKL096W CWP1 YKL108W SLD2 YKL149C DBR1 YKR009C FOX2 YKR096W YKR099W BAS1 YLL029W YLL032C YLL042C APG10 YLR013W GAT3 YLR042C YLR131C ACE2 YLR206W ENT2 YLR272C YCS4 YLR286C CTS1 YLR300W EXG1 YLR372W SUR4 YLR425W TUS1 YLR438W CAR2 YLR446W YML005W YML071C COG8 YML080W DUS1 YML092C PRE8 YML100W TSL1 YML118W NGL3 YMR031C YMR032W HOF1 YMR144W YMR187C YMR197C VTI1 YMR198W CIK1 YMR204C YMR215W GAS3 YMR256C COX7 YMR257C PET111 YMR295C YNL020C ARK1 YNL053W MSG5 YNL088W TOP2 YNL122C YNL126W SPC98 YNL130C CPT1 YNL283C WSC2 YNL332W THI12 YNR018W YOL023W IFM1 YOL030W GAS5 YOL048C YOL056W GPM3 YOL088C MPD2 YOL123W HRP1 YOL124C YOL128C YGK3 YOL132W GAS4 YOR030W DFG16 YOR051C YOR058C ASE1 YOR073W YOR177C MPC54 YOR188W MSB1 YOR233W KIN4 YOR242C SSP2 YOR312C RPL20B YOR315W YOR369C RPS12 YOR372C NDD1 YOR373W NUD1 YOR389W YPL016W SWI1 YPL017C YPL032C SVL3 YPL034W YPL116W HOS3 YPL117C IDI1 YPL128C TBF1 YPL140C MKK2 YPL141C YPL208W YPL209C IPL1 YPL216W YPL217C BMS1 YPL226W NEW1 YPL227C ALG5 YPL250C ICY2 YPL253C VIK1 YPR027C Genes Not Found: YML045W MIPS Functional Classification Category p-value In Category from Cluster k f fungal cell differentiation 8.48684e-06 SAS3 FIG1 UBC4 BUD3 FUS1 CSM1 LRG1 SWI5 SSF2 DIT1 DIG2 BOI2 BUD9 RIM4 MYO1 GIC1 SBE22 CDC11 IME1 CAP1 DBR1 EXG1 SUR4 MSG5 DFG16 MSB1 SWI1 SVL3 MKK2 29 382 cell differentiation 8.48684e-06 SAS3 FIG1 UBC4 BUD3 FUS1 CSM1 LRG1 SWI5 SSF2 DIT1 DIG2 BOI2 BUD9 RIM4 MYO1 GIC1 SBE22 CDC11 IME1 CAP1 DBR1 EXG1 SUR4 MSG5 DFG16 MSB1 SWI1 SVL3 MKK2 29 382 CELL FATE 2.67513e-05 SAS3 FIG1 UBC4 BUD3 FUS1 CSM1 LRG1 SWI5 SSF2 DIT1 DIG2 BOI2 BUD9 RIM4 MYO1 GIC1 SBE22 CDC11 IME1 CAP1 LAC1 DBR1 EXG1 SUR4 MSG5 DFG16 MSB1 SWI1 SVL3 MKK2 30 427 cell cycle 0.000423056 KIP1 DCC1 CSM1 MPS1 CIN8 DBF2 CBF2 RIM4 MYO1 ARP1 SPC97 STH1 CDC11 IME1 NNF1 MCM22 ACE2 CTS1 HOF1 CIK1 MSG5 SPC98 ASE1 MPC54 NDD1 NUD1 MKK2 IPL1 28 451 cytokinesis (cell division) 0.000714585 MYO1 CDC11 ACE2 CTS1 HOF1 NDD1 6 35 budding, cell polarity and filament formation 0.000952599 BUD3 BOI2 BUD9 MYO1 GIC1 SBE22 CDC11 CAP1 DBR1 SUR4 DFG16 MSB1 SVL3 MKK2 14 170 cytoskeleton-dependent transport 0.00140129 KIP1 CIN8 MYO1 ARP1 CIK1 5 27 pheromone response, mating-type determination, sex-specific proteins 0.00163169 SAS3 FIG1 UBC4 FUS1 SWI5 SSF2 DIG2 GIC1 CDC11 CAP1 EXG1 MSG5 SWI1 13 160 CELL CYCLE AND DNA PROCESSING 0.00237283 KIP1 HDR1 DCC1 CSM1 MPS1 CIN8 RNR1 DBF2 CBF2 RIM4 MYO1 ARP1 SPC97 STH1 CDC11 IME1 NNF1 MCM22 IML1 SLD2 ACE2 CTS1 HOF1 CIK1 MSG5 TOP2 SPC98 ASE1 MPC54 NDD1 NUD1 MKK2 IPL1 33 628 centrosome 0.00266076 SPC97 CIK1 SPC98 MPC54 NUD1 5 31 MIPS Phenotypes Category p-value In Category from Cluster k f Spindle mutants 0.00117162 MPS1 ARP1 SPC97 SPC98 ASE1 5 26 Cell morphology and organelle mutants 0.00121123 BUD3 TUP1 MPS1 PSA1 CUP5 YPT31 SCW11 BUD9 MYO1 ARP1 SPC97 MMF1 STH1 SLN1 MUC1 LAS21 CDC11 CAP1 CWP1 DBR1 FOX2 SUR4 VTI1 ARK1 SPC98 IFM1 DFG16 ASE1 SVL3 IPL1 30 530 other cell cycle defects 0.00230036 CSM1 MPS1 HTA1 RNR1 DBF2 CBF2 MYO1 SPC97 CDC11 IME1 IML1 HOF1 CIK1 SPC98 IPL1 15 207 Tubulin cytoskeleton mutants 0.00428518 MPS1 ARP1 SPC97 STH1 SPC98 ASE1 IPL1 7 65 Bud localization 0.00458777 BUD3 BUD9 MYO1 CDC11 SUR4 5 35 MIPS Subcellular Localization Category p-value In Category from Cluster k f cytoskeleton 1.41564e-05 KIP1 BUD3 CIN8 MYO1 SPC97 CDC11 CAP1 HOF1 CIK1 SPC98 ASE1 MPC54 NUD1 IPL1 14 115 tubulin cytoskeleton 0.000647601 KIP1 CIN8 CIK1 ASE1 IPL1 5 23 MIPS Protein Complexes Category p-value In Category from Cluster k f Microtubules 0.000431869 KIP1 CIN8 ARP1 CIK1 SPC98 ASE1 6 32 Cytoskeleton 0.000457272 KIP1 CIN8 MYO1 ARP1 CDC11 CAP1 CIK1 SPC98 ASE1 9 73 Tubulin-associated motorproteins 0.000768742 KIP1 CIN8 ARP1 CIK1 4 14 Kinesin-related motorproteins 0.0015696 KIP1 CIN8 CIK1 3 8 gamma-tubulin complex 0.00294706 SPC97 SPC98 2 3 Spindle pole body (SPB) 0.00307352 ARP1 SPC97 CIK1 SPC98 NUD1 5 32 MIPS Protein Classes Category p-value In Category from Cluster k f Protein Kinases 0.00386273 PSK1 MPS1 YDR247W DBF2 ARK1 YGK3 KIN4 MKK2 YPL141C IPL1 10 117 GO Molecular Function Category p-value In Category from Cluster k f microtubule binding [GO:0008017] 4.86587e-05 KIP1 CIN8 CIK1 ASE1 VIK1 5 14 microtubule motor [GO:0003777] 6.24827e-05 KIP1 CIN8 CIK1 VIK1 4 8 motor [GO:0003774] 0.00013912 KIP1 CIN8 MYO1 CIK1 VIK1 5 17 tubulin binding [GO:0015631] 0.000322475 KIP1 CIN8 CIK1 ASE1 VIK1 5 20 cytoskeletal protein binding [GO:0008092] 0.000389627 KIP1 CIN8 CAP1 ENT2 HOF1 CIK1 ASE1 VIK1 8 57 structural constituent of cytoskeleton [GO:0005200] 0.00425946 KIP1 ARP1 SPC97 CDC11 SPC98 NUD1 6 49 GO Biological Process Category p-value In Category from Cluster k f cell cycle [GO:0007049] 1.7174e-05 KIP1 BUD3 DCC1 CSM1 MPS1 SWI5 YHP1 CIN8 RNR1 SCW11 DBF2 CBF2 RIM4 MYO1 ARP1 STH1 FKH1 DSN1 CDC11 IME1 NNF1 MCM22 SLD2 ACE2 YCS4 CTS1 HOF1 CIK1 ARK1 TOP2 SPC98 ASE1 NDD1 IPL1 34 504 mitotic anaphase B [GO:0000092] 6.24827e-05 KIP1 CIN8 ARP1 ASE1 4 8 M phase [GO:0000279] 0.00011708 KIP1 BUD3 MPS1 YHP1 CIN8 SCW11 CBF2 RIM4 MYO1 ARP1 STH1 CDC11 IME1 YCS4 CTS1 HOF1 CIK1 ARK1 TOP2 SPC98 ASE1 21 270 cytoskeleton organization and biogenesis [GO:0007010] 0.000397496 KIP1 BUD3 MPS1 CIN8 BOI2 BUD9 GIC1 SPC97 CDC11 CAP1 ENT2 CIK1 ARK1 SPC98 ASE1 MSB1 NUD1 VIK1 18 233 cytokinesis [GO:0016288] 0.000547474 BUD3 SCW11 MYO1 CDC11 CTS1 HOF1 ARK1 7 46 chromosome segregation [GO:0007059] 0.000556117 CSM1 CIN8 DSN1 NNF1 MCM22 YCS4 CIK1 IPL1 8 60 mitotic anaphase [GO:0000090] 0.000970837 KIP1 CIN8 ARP1 YCS4 CIK1 ASE1 6 37 DNA replication and chromosome cycle [GO:0000067] 0.00172203 DCC1 CSM1 MPS1 CIN8 RNR1 RIM4 DSN1 NNF1 MCM22 SLD2 YCS4 CIK1 TOP2 SPC98 IPL1 15 201 microtubule-based process [GO:0007017] 0.00193388 KIP1 MPS1 CIN8 SPC97 CIK1 SPC98 ASE1 NUD1 VIK1 9 89 Rho protein signal transduction [GO:0007266] 0.00212688 BOI2 WSC4 GIC1 WSC2 4 18 cell growth and/or maintenance [GO:0008151] 0.00329331 SAS3 KIP1 FIG1 UBC4 ARO4 BUD3 DCC1 FUS1 YCL073C HSP30 ERS1 TUP1 CSM1 MPS1 PSA1 SUB2 GDH2 LRG1 LUV1 SWI5 ADR1 HTA1 YAP6 DIN7 SRP101 SSF2 MRPL35 DIT1 RPL12B YHP1 PPN1 SPP41 TRS31 DIG2 YEL006W GCN4 CUP5 CIN8 YPT31 FIR1 RNR1 SSA4 BOI2 DSE1 THI5 ERG26 SCW11 STR3 ADH4 MNT2 BUD9 UPF3 GCD2 DBF2 CBF2 PFK1 RPS20 RIM4 WSC4 OSH7 MYO1 GIC1 SBE22 ARP1 YHR138C SPC97 PCL7 MMF1 STH1 FKH1 SLN1 DSN1 MUC1 LAS21 RPE1 LCB3 CDC11 IME1 NNF1 MCM22 CAP1 CWP1 SLD2 DBR1 FOX2 BAS1 APG10 GAT3 ACE2 ENT2 YCS4 CTS1 EXG1 SUR4 TUS1 CAR2 COG8 DUS1 PRE8 TSL1 HOF1 VTI1 CIK1 COX7 PET111 ARK1 MSG5 TOP2 SPC98 CPT1 WSC2 THI12 IFM1 GPM3 MPD2 HRP1 YGK3 DFG16 ASE1 MPC54 MSB1 SSP2 RPL20B RPS12 NDD1 NUD1 SWI1 SVL3 IDI1 TBF1 MKK2 IPL1 BMS1 ALG5 VIK1 135 3657 microtubule cytoskeleton organization and biogenesis [GO:0000226] 0.00366834 KIP1 MPS1 CIN8 SPC97 CIK1 SPC98 ASE1 NUD1 8 80 axial budding [GO:0007120] 0.0038611 BUD3 MYO1 GIC1 CDC11 4 21 GO Cellular Component Category p-value In Category from Cluster k f cytoskeleton [GO:0005856] 3.43016e-09 KIP1 BUD3 MPS1 CIN8 DBF2 MYO1 GIC1 ARP1 SPC97 DSN1 CDC11 NNF1 CAP1 ENT2 HOF1 CIK1 ARK1 SPC98 ASE1 MPC54 NUD1 IPL1 VIK1 23 172 spindle [GO:0005819] 4.06277e-09 KIP1 MPS1 CIN8 DBF2 SPC97 DSN1 NNF1 CIK1 SPC98 ASE1 MPC54 NUD1 IPL1 VIK1 14 61 microtubule cytoskeleton [GO:0015630] 5.70817e-09 KIP1 MPS1 CIN8 DBF2 ARP1 SPC97 DSN1 NNF1 CIK1 SPC98 ASE1 MPC54 NUD1 IPL1 VIK1 15 73 spindle pole [GO:0030615] 2.02768e-07 KIP1 MPS1 DBF2 SPC97 DSN1 NNF1 CIK1 SPC98 MPC54 NUD1 VIK1 11 48 microtubule organizing center [GO:0005815] 7.40499e-06 KIP1 MPS1 DBF2 SPC97 CIK1 SPC98 MPC54 NUD1 VIK1 9 44 spindle pole body [GO:0005816] 7.40499e-06 KIP1 MPS1 DBF2 SPC97 CIK1 SPC98 MPC54 NUD1 VIK1 9 44 kinesin [GO:0005871] 1.40802e-05 KIP1 CIN8 CIK1 VIK1 4 6 microtubule associated protein [GO:0005875] 6.24827e-05 KIP1 CIN8 CIK1 VIK1 4 8 cell wall (sensu Fungi) [GO:0009277] 9.02468e-05 FIG1 CDC11 CWP1 YLR042C CTS1 EXG1 GAS3 GAS5 GAS4 SSP2 10 73 cell wall [GO:0005618] 0.000141945 FIG1 SCW11 CDC11 CWP1 YLR042C CTS1 EXG1 GAS3 GAS5 GAS4 SSP2 11 92 external protective structure [GO:0030312] 0.000141945 FIG1 SCW11 CDC11 CWP1 YLR042C CTS1 EXG1 GAS3 GAS5 GAS4 SSP2 11 92 spindle microtubule [GO:0005876] 0.000178265 KIP1 CIN8 ASE1 IPL1 4 10 extracellular [GO:0005576] 0.000296043 FIG1 CDC11 CWP1 YLR042C CTS1 EXG1 GAS3 GAS5 GAS4 SSP2 10 84 microtubule [GO:0005874] 0.000322475 KIP1 CIN8 CIK1 ASE1 IPL1 5 20 bud neck [GO:0005935] 0.000556117 BUD3 BOI2 DBF2 MYO1 GIC1 CDC11 HOF1 MSB1 8 60 bud [GO:0005933] 0.0017166 BUD3 BOI2 DBF2 MYO1 GIC1 CDC11 HOF1 MSB1 8 71 actin cytoskeleton [GO:0015629] 0.00209099 BUD3 MYO1 GIC1 ARP1 CDC11 CAP1 ENT2 HOF1 ARK1 9 90 site of polarized growth [GO:0030427] 0.0022424 BUD3 BOI2 DBF2 MYO1 GIC1 CDC11 HOF1 MSB1 8 74 site of polarized growth (sensu Fungi) [GO:0030483] 0.0022424 BUD3 BOI2 DBF2 MYO1 GIC1 CDC11 HOF1 MSB1 8 74 site of polarized growth (sensu Saccharomyces) [GO:0000134] 0.0022424 BUD3 BOI2 DBF2 MYO1 GIC1 CDC11 HOF1 MSB1 8 74 chromosome [GO:0005694] 0.00410645 SAS3 MPS1 HTA1 YHP1 CBF2 MCM22 YCS4 CIK1 TOP2 TBF1 10 118 SMART Domains Category p-value In Category from Cluster k f DDT 0.00100339 ITC1 YPL216W 2 2 COIL 0.00112017 KIP1 TUP1 CSM1 MPS1 SWI5 YAP6 SSF2 YDR326C SPP41 CIN8 CAJ1 SSA4 BOI2 ITC1 UPF3 GCD2 MYO1 DSN1 CDC11 NNF1 ACE2 ENT2 YCS4 COG8 YMR031C HOF1 YMR144W CIK1 IFM1 MPD2 ASE1 YOR073W MPC54 SWI1 SVL3 YPL208W YPL216W BMS1 NEW1 VIK1 40 776 PFam-A Domains Category p-value In Category from Cluster k f PF03198 (GAS1) 0.000300886 GAS3 GAS5 GAS4 3 5 PF02791 (DDT) 0.00100339 ITC1 YPL216W 2 2 PF00069 (pkinase) 0.00319966 PSK1 MPS1 YDR247W DBF2 ARK1 YGK3 KIN4 MKK2 YPL141C IPL1 10 114 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f YLR212C (TUB4) 0.000123242 PFK1 SPC97 SPC98 3 4 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - Large 0.00449122 DCC1 CAJ1 RNR1 ARP1 RPE1 YJR001W CAP1 YMR031C CIK1 WSC2 YOR073W HOS3 12 159 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f