Input Cluster (n=187) YAL037W YAL054C ACS1 YAL062W GDH3 YAR027W UIP3 YBL049W YBR043C AQR2 YBR179C FZO1 YBR180W DTR1 YBR208C "DUR1,2" YBR234C ARC40 YBR239C YBR245C ISW1 YBR286W APE3 YCL068C YCR018C SRD1 YCR038C BUD5 YCR068W CVT17 YDL036C YDL137W ARF2 YDL170W UGA3 YDL171C GLT1 YDL210W UGA4 YDL238C YDR001C NTH1 YDR002W YRB1 YDR009W GAL3 YDR028C REG1 YDR041W RSM10 YDR069C DOA4 YDR089W YDR131C YDR132C YDR242W AMD2 YDR264C AKR1 YDR265W PEX10 YDR284C DPP1 YDR317W YDR322W MRPL35 YDR352W YDR454C GUK1 YDR524C AGE1 YDR540C YEL059C-A SOM1 YEL063C CAN1 YER002W NOP16 YER056C FCY2 YER060W FCY21 YER060W-A FCY22 YER071C YER072W VTC1 YER107C GLE2 YER164W CHD1 YFL008W SMC1 YFL010W-A AUA1 YFL021W GAT1 YFL051C YFR007W YFR025C HIS2 YFR041C YGL053W PRM8 YGL054C ERV14 YGL196W YGL203C KEX1 YGR028W MSP1 YGR080W TWF1 YGR125W YGR149W YGR150C YGR155W CYS4 YGR161C YGR174C CBP4 YGR181W TIM13 YHL015W RPS20 YHL016C DUR3 YHL036W MUP3 YHR074W QNS1 YHR101C BIG1 YHR102W KIC1 YHR112C YHR113W YHR146W CRP1 YHR207C SET5 YHR208W BAT1 YIL037C PRM2 YIL146C ECM37 YIL164C NIT1 YIR005W IST3 YIR027C DAL1 YIR028W DAL4 YIR029W DAL2 YIR031C DAL7 YIR032C DAL3 YIR033W MGA2 YJL047C RTT101 YJL060W BNA3 YJL146W IDS2 YJL161W YJL172W CPS1 YJR011C YJR024C YJR040W GEF1 YJR094W-A RPL43B YJR152W DAL5 YKL049C CSE4 YKL058W TOA2 YKL067W YNK1 YKL069W YKL103C LAP4 YKL138C MRPL31 YKL216W URA1 YKR028W SAP190 YKR031C SPO14 YKR034W DAL80 YKR039W GAP1 YLL039C UBI4 YLR020C YLR028C ADE16 YLR053C YLR138W NHA1 YLR155C ASP3-1 YLR157C ASP3-2 YLR158C ASP3-3 YLR160C ASP3-4 YLR163C MAS1 YLR164W YLR167W RPS31 YLR257W YLR298C YHC1 YLR299W ECM38 YLR351C NIT3 YLR403W SFP1 YLR411W CTR3 YML086C ALO1 YMR005W TAF4 YMR012W CLU1 YMR088C YMR107W YMR110C YMR118C YMR158W YMR167W MLH1 YMR208W ERG12 YMR255W GFD1 YMR281W GPI12 YMR308C PSE1 YNL040W YNL124W NAF1 YNL125C ESBP6 YNL129W YNL130C CPT1 YNL142W MEP2 YNL163C RIA1 YNL239W LAP3 YNL240C NAR1 YNR011C PRP2 YNR012W URK1 YNR048W YNR065C YSN1 YNR072W HXT17 YOL013W-A YOL019W YOL044W PEX15 YOL058W ARG1 YOL104C NDJ1 YOL114C YOL128C YGK3 YOR004W YOR012W YOR030W DFG16 YOR043W WHI2 YOR149C SMP3 YOR150W MRPL23 YOR179C YOR375C GDH1 YPL031C PHO85 YPL034W YPL054W LEE1 YPL150W YPL159C YPL216W YPL217C BMS1 YPL226W NEW1 YPL227C ALG5 YPL254W HFI1 YPL257W YPL265W DIP5 YPR138C MEP3 Genes Not Found: YBL005W-A YBL005W-B YBR012W-A YBR012W-B YDR170W-A YER138C YFL002W-A YJR026W YJR027W YJR028W YJR029W YMR050C YMR051C MIPS Functional Classification Category p-value In Category from Cluster k f nitrogen and sulfur metabolism 5.20894e-12 GDH3 "DUR1,2" UGA3 GLT1 UGA4 AMD2 AUA1 GAT1 DAL1 DAL2 DAL3 BNA3 CPS1 DAL80 NIT3 ARG1 GDH1 17 67 nitrogen and sulfur utilization 2.76464e-11 GDH3 "DUR1,2" GLT1 UGA4 AMD2 DAL1 DAL2 DAL3 BNA3 CPS1 NIT3 ARG1 GDH1 13 38 METABOLISM 2.88706e-06 ACS1 GDH3 "DUR1,2" YDL036C UGA3 GLT1 UGA4 NTH1 GAL3 REG1 AMD2 DPP1 GUK1 CAN1 FCY2 FCY21 FCY22 AUA1 GAT1 HIS2 CYS4 MUP3 BIG1 YHR112C BAT1 DAL1 DAL2 DAL7 DAL3 BNA3 CPS1 YNK1 URA1 SPO14 DAL80 GAP1 YLR020C ADE16 ASP3-1 ASP3-2 ASP3-3 ASP3-4 YLR164W ECM38 NIT3 ALO1 ERG12 GPI12 YNL040W CPT1 URK1 HXT17 ARG1 GDH1 PHO85 ALG5 DIP5 57 1066 amino acid degradation (catabolism) 6.38041e-06 GDH3 "DUR1,2" BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 GDH1 8 35 amino acid metabolism 8.92663e-06 GDH3 "DUR1,2" GLT1 CAN1 AUA1 HIS2 CYS4 MUP3 YHR112C BAT1 GAP1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ECM38 ARG1 GDH1 DIP5 19 204 plasma membrane 9.64837e-05 BUD5 UGA4 CAN1 FCY2 DUR3 MUP3 DAL4 GEF1 DAL5 GAP1 MEP2 LAP3 HXT17 DIP5 14 145 TRANSPORT FACILITATION 0.000134116 AQR2 DTR1 UGA4 CAN1 FCY2 FCY21 FCY22 DUR3 MUP3 DAL4 GEF1 DAL5 GAP1 NHA1 CTR3 YMR088C ESBP6 MEP2 HXT17 NEW1 DIP5 MEP3 22 312 nucleotide metabolism 0.000438995 "DUR1,2" GUK1 FCY2 FCY21 FCY22 DAL1 DAL2 DAL7 DAL3 YNK1 URA1 ADE16 URK1 13 148 amino-acid transporters 0.00073247 UGA4 CAN1 MUP3 GAP1 DIP5 5 25 cellular import 0.000740292 UGA4 CAN1 FCY2 MUP3 DAL4 GEF1 DAL5 GAP1 MEP2 HXT17 10 100 purine ribonucleotide metabolism 0.00201348 "DUR1,2" DAL1 DAL2 DAL7 DAL3 ADE16 6 45 anion transporters (Cl, SO4, PO4, etc.) 0.00308475 DUR3 GEF1 MEP2 MEP3 4 21 amino acid transport 0.00435644 CAN1 MUP3 GAP1 DIP5 4 23 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 0.00025786 BUD5 UGA4 CAN1 FCY2 VTC1 DUR3 MUP3 DAL4 GEF1 DAL5 GAP1 MEP2 LAP3 HXT17 14 159 vacuolar lumen 0.000489329 APE3 CPS1 LAP4 3 6 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 8.74789e-07 AQR2 DTR1 UGA4 CAN1 FCY2 FCY21 FCY22 DUR3 MUP3 DAL4 DAL5 GAP1 YMR088C ESBP6 MEP2 DIP5 MEP3 17 142 Cys4 zinc-fingers 0.000837539 SRD1 GAT1 DAL80 3 7 Proteases 0.00252671 APE3 DOA4 KEX1 LAP4 MAS1 LAP3 6 47 GO Molecular Function Category p-value In Category from Cluster k f hydrolase, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] 2.34564e-10 "DUR1,2" AMD2 NIT1 DAL1 DAL2 DAL3 BNA3 ADE16 ASP3-1 ASP3-2 ASP3-3 ASP3-4 12 36 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] 1.71601e-07 "DUR1,2" AMD2 BNA3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 7 16 solute\:cation symporter [GO:0015294] 2.56451e-06 UGA4 FCY2 FCY21 FCY22 DAL4 5 9 nucleobase transporter [GO:0015205] 3.75162e-06 FCY2 FCY21 FCY22 DAL4 4 5 nucleobase\:cation symporter [GO:0015391] 3.75162e-06 FCY2 FCY21 FCY22 DAL4 4 5 symporter [GO:0015293] 5.00509e-06 UGA4 FCY2 FCY21 FCY22 DAL4 5 10 asparaginase [GO:0004067] 1.0992e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 hydrolase [GO:0016787] 1.7051e-05 FZO1 "DUR1,2" ISW1 APE3 CVT17 ARF2 NTH1 REG1 DOA4 AMD2 DPP1 CHD1 SMC1 HIS2 KEX1 MSP1 NIT1 DAL1 DAL2 DAL3 BNA3 CPS1 LAP4 SAP190 SPO14 ADE16 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MAS1 MLH1 GPI12 LAP3 PRP2 35 561 cytosine-purine permease [GO:0015392] 2.6155e-05 FCY2 FCY21 FCY22 3 3 purine transporter [GO:0005345] 2.6155e-05 FCY2 FCY21 FCY22 3 3 cytosine transporter [GO:0015209] 2.6155e-05 FCY2 FCY21 FCY22 3 3 electrochemical potential-driven transporter [GO:0015290] 3.00297e-05 UGA4 FCY2 FCY21 FCY22 DAL4 GAP1 NHA1 CTR3 DIP5 9 55 porter [GO:0015291] 3.00297e-05 UGA4 FCY2 FCY21 FCY22 DAL4 GAP1 NHA1 CTR3 DIP5 9 55 nucleobase, nucleoside, nucleotide and nucleic acid transporter [GO:0015932] 4.8931e-05 FCY2 FCY21 FCY22 DAL4 4 8 pyrimidine transporter [GO:0005350] 0.000102315 FCY2 FCY21 FCY22 3 4 oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [GO:0016639] 0.000102315 GDH3 GLT1 GDH1 3 4 amino acid transporter [GO:0015171] 0.000390443 UGA4 CAN1 MUP3 GAP1 DIP5 5 22 oxidoreductase, acting on the CH-NH2 group of donors [GO:0016638] 0.0013107 GDH3 GLT1 GDH1 3 8 amine/polyamine transporter [GO:0005275] 0.0013107 DUR3 GAP1 DIP5 3 8 nucleobase, nucleoside, nucleotide kinase [GO:0019205] 0.0013107 GUK1 YNK1 URK1 3 8 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [GO:0016813] 0.0026049 DAL2 DAL3 2 3 ammonium transporter [GO:0008519] 0.0026049 MEP2 MEP3 2 3 transporter [GO:0005215] 0.00338833 UGA4 CAN1 FCY2 FCY21 FCY22 TIM13 DUR3 MUP3 DAL4 GEF1 DAL5 GAP1 NHA1 CTR3 PSE1 NAF1 ESBP6 MEP2 HXT17 DIP5 MEP3 21 372 GO Biological Process Category p-value In Category from Cluster k f asparagine catabolism [GO:0006530] 7.68283e-07 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 4 heterocycle catabolism [GO:0046700] 3.75162e-06 DAL1 DAL2 DAL7 DAL3 4 5 response to nitrogen starvation [GO:0006995] 3.75162e-06 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 5 allantoin metabolism [GO:0000255] 3.75162e-06 DAL1 DAL2 DAL7 DAL3 4 5 allantoin catabolism [GO:0000256] 3.75162e-06 DAL1 DAL2 DAL7 DAL3 4 5 glutamine family amino acid metabolism [GO:0009064] 5.04973e-06 GDH3 GLT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ARG1 GDH1 8 34 asparagine metabolism [GO:0006528] 1.0992e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 aspartate family amino acid catabolism [GO:0009068] 4.8931e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 8 glutamine family amino acid catabolism [GO:0009065] 0.000140037 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 10 response to starvation [GO:0009267] 0.000314922 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 12 amino acid transport [GO:0006865] 0.00048694 CAN1 AUA1 MUP3 GAP1 DIP5 5 23 nitrogen metabolism [GO:0006807] 0.00202619 "DUR1,2" UGA3 GAT1 CPS1 ARG1 5 31 amine catabolism [GO:0009310] 0.00209311 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 19 amino acid catabolism [GO:0009063] 0.00209311 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 19 ammonium transport [GO:0015696] 0.0026049 MEP2 MEP3 2 3 organic cation transport [GO:0015695] 0.0026049 MEP2 MEP3 2 3 nucleobase transport [GO:0015851] 0.0026049 FCY2 DAL4 2 3 amino acid metabolism [GO:0006520] 0.00295681 GDH3 GLT1 HIS2 CYS4 BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ARG1 GDH1 11 140 glutamine family amino acid biosynthesis [GO:0009084] 0.00368348 GDH3 GLT1 ARG1 GDH1 4 22 amino acid and derivative metabolism [GO:0006519] 0.00477037 GDH3 GLT1 HIS2 CYS4 BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ARG1 GDH1 11 149 GO Cellular Component Category p-value In Category from Cluster k f periplasmic space (sensu Fungi) [GO:0030287] 8.60242e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 9 membrane [GO:0016020] 0.000199651 UIP3 FZO1 CVT17 UGA4 SOM1 CAN1 FCY2 FCY21 FCY22 VTC1 GLE2 PRM8 ERV14 MSP1 CBP4 DUR3 MUP3 BIG1 PRM2 DAL4 DAL3 MGA2 DAL5 SPO14 GAP1 NHA1 ASP3-1 CTR3 GFD1 GPI12 ESBP6 MEP2 HXT17 PEX15 ALG5 DIP5 MEP3 37 683 integral membrane protein [GO:0016021] 0.00485068 CVT17 FCY21 FCY22 PRM8 BIG1 PRM2 GAP1 CTR3 8 89 SMART Domains Category p-value In Category from Cluster k f ZnF_GATA 0.00268719 SRD1 GAT1 DAL80 3 10 TRANS 0.00365398 UIP3 AQR2 DTR1 CVT17 UGA4 YDR089W AKR1 PEX10 DPP1 YDR352W CAN1 FCY2 FCY21 FCY22 VTC1 YFL051C YFR041C PRM8 ERV14 KEX1 YGR125W YGR149W CBP4 DUR3 MUP3 BIG1 PRM2 ECM37 DAL4 MGA2 CPS1 GEF1 DAL5 GAP1 YLR020C NHA1 ECM38 CTR3 YMR088C YMR110C YMR118C GPI12 ESBP6 CPT1 MEP2 YNR048W YSN1 HXT17 YOL013W-A YOL019W DFG16 SMP3 ALG5 YPL257W DIP5 MEP3 56 1346 PFam-A Domains Category p-value In Category from Cluster k f PF00710 (Asparaginase) 2.50495e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 7 PF02133 (Transp_cyt_pur) 0.000140037 FCY2 FCY21 FCY22 DAL4 4 10 PF00795 (CN_hydrolase) 0.000489329 QNS1 NIT1 NIT3 3 6 PF00338 (Ribosomal_S10) 0.000885736 RSM10 RPS20 2 2 PF02127 (Peptidase_M18) 0.000885736 YHR113W LAP4 2 2 PF00909 (Ammonium_transp) 0.0026049 MEP2 MEP3 2 3 PF01425 (Amidase) 0.0026049 "DUR1,2" AMD2 2 3 PF02812 (GLFV_dehydrog_N) 0.0026049 GDH3 GDH1 2 3 PF00208 (GLFV_dehydrog) 0.0026049 GDH3 GDH1 2 3 PF00320 (GATA) 0.00361428 SRD1 GAT1 DAL80 3 11 PF00324 (aa_permeases) 0.00368348 UGA4 CAN1 GAP1 DIP5 4 22 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YHL010C 0.0026049 YBL049W NHA1 2 3 YDR142C (PEX7) 0.00471407 FZO1 LAP4 NEW1 3 12 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.000284837 YAL037W ACS1 GDH3 UIP3 YBL049W FZO1 DTR1 "DUR1,2" YBR239C ISW1 APE3 CVT17 YDL036C ARF2 UGA3 GLT1 UGA4 YDL238C NTH1 GAL3 DOA4 YDR089W YDR131C YDR132C AMD2 PEX10 DPP1 YDR317W YDR352W CAN1 NOP16 FCY2 FCY21 FCY22 YER071C AUA1 GAT1 YFL051C YFR007W HIS2 YFR041C PRM8 ERV14 YGL196W KEX1 MSP1 TWF1 YGR125W YGR149W YGR150C YGR161C CBP4 TIM13 DUR3 MUP3 YHR112C YHR113W CRP1 SET5 PRM2 ECM37 NIT1 IST3 DAL1 DAL4 DAL2 DAL7 DAL3 MGA2 BNA3 IDS2 YJL161W CPS1 YJR011C YJR024C GEF1 RPL43B DAL5 YNK1 YKL069W LAP4 MRPL31 URA1 SAP190 SPO14 DAL80 GAP1 UBI4 YLR020C ADE16 YLR053C NHA1 YLR164W YLR257W ECM38 NIT3 SFP1 ALO1 CLU1 YMR088C YMR107W YMR110C YMR118C YMR158W MLH1 GFD1 ESBP6 YNL129W CPT1 MEP2 LAP3 URK1 YNR048W YSN1 HXT17 YOL013W-A YOL019W PEX15 ARG1 NDJ1 YOL114C YGK3 YOR012W DFG16 MRPL23 GDH1 YPL034W LEE1 YPL150W YPL159C YPL216W YPL257W MEP3 133 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f