Input Cluster (n=195) YAL001C TFC3 YAL017W PSK1 YAL018C YBL043W ECM13 YBR021W FUR4 YBR115C LYS2 YBR145W ADH5 YBR147W YBR249C ARO4 YBR254C TRS20 YBR255W YBR296C PHO89 YCL026C-A FRM2 YCL030C HIS4 YCR027C RHB1 YCR100C YDL025C YDL170W UGA3 YDL171C GLT1 YDL182W LYS20 YDL234C GYP7 YDL247W MPH2 YDR034C LYS14 YDR035W ARO3 YDR041W RSM10 YDR099W BMH2 YDR127W ARO1 YDR172W SUP35 YDR240C SNU56 YDR242W AMD2 YDR258C HSP78 YDR262W YDR281C PHM6 YDR300C PRO1 YDR301W CFT1 YDR317W YDR354W TRP4 YDR368W YPR1 YDR473C PRP3 YDR477W SNF1 YEL056W HAT2 YEL062W NPR2 YEL063C CAN1 YEL064C YEL071W DLD3 YER024W YAT2 YER052C HOM3 YER055C HIS1 YER057C HMF1 YER058W PET117 YER065C ICL1 YER069W "ARG5,6" YER124C DSE1 YER138W-A YER175C TMT1 YFL017W-A SMX2 YFL018C LPD1 YFR021W AUT10 YFR047C BNA6 YGL009C LEU1 YGL040C HEM2 YGL054C ERV14 YGL060W YGL061C DUO1 YGL117W YGL249W ZIP2 YGL255W ZRT1 YGR161C YGR191W HIP1 YGR258C RAD2 YGR262C BUD32 YGR267C FOL2 YGR273C YHR015W MIP6 YHR018C ARG4 YHR046C INM1 YHR094C HXT1 YHR149C YHR150W YHR161C YAP1801 YHR162W YHR181W YIL019W YIL078W THS1 YIL079C AIR1 YIL082W-A YIL093C RSM25 YIL116W HIS5 YIL164C NIT1 YIL166C YIR017C MET28 YIR018W YAP5 YIR034C LYS1 YJL066C MPM1 YJL089W SIP4 YJL090C DPB11 YJL133W MRS3 YJL160C YJL170C ASG7 YJL173C RFA3 YJL213W YJR010C-A SPC1 YJR011C YJR013W YJR025C BNA1 YJR095W SFC1 YJR109C CPA2 YJR110W YJR154W YJR160C MPH3 YKL015W PUT3 YKL016C ATP7 YKL060C FBA1 YKL110C KTI12 YKL113C RAD27 YKL119C VPH2 YKL127W PGM1 YKL160W YKL170W MRPL38 YKL218C SRY1 YKR052C MRS4 YKR072C SIS2 YKR076W ECM4 YLL006W MMM1 YLL018C DPS1 YLR011W LOT6 YLR152C YLR155C ASP3-1 YLR156W YLR157C ASP3-2 YLR158C ASP3-3 YLR159W YLR160C ASP3-4 YLR161W YLR174W IDP2 YLR242C ARV1 YLR333C RPS25B YLR355C ILV5 YLR425W TUS1 YML038C YMD8 YML074C FPR3 YML076C WAR1 YML116W ATR1 YML131W YMR026C PEX12 YMR062C ECM40 YMR063W RIM9 YMR095C SNO1 YMR096W SNZ1 YMR188C YMR189W GCV2 YMR243C ZRC1 YMR271C URA10 YNL004W HRB1 YNL036W NCE103 YNL037C IDH1 YNL040W YNL045W YNL091W NST1 YNL103W MET4 YNL104C LEU4 YNL125C ESBP6 YNL130C CPT1 YNL183C NPR1 YNL221C POP1 YNL239W LAP3 YNL240C NAR1 YNR069C YOL058W ARG1 YOL112W MSB4 YOL121C RPS19A YOR005C DNL4 YOR087W YVC1 YOR100C CRC1 YOR108W YOR128C ADE2 YOR130C ORT1 YOR185C GSP2 YOR222W ODC2 YOR265W RBL2 YOR280C FSH3 YOR302W YOR337W TEA1 YOR390W YPL033C YPL034W YPL092W SSU1 YPL135W ISU1 YPL146C YPL250C ICY2 YPL252C YAH1 YPL278C YPL279C YPR128C ANT1 YPR145W ASN1 Genes Not Found: YER138C YER160C YFL002W-A YJL113W YJL114W MIPS Functional Classification Category p-value In Category from Cluster k f amino acid metabolism 1e-14 LYS2 ARO4 HIS4 GLT1 LYS20 LYS14 ARO3 ARO1 PRO1 TRP4 CAN1 HOM3 HIS1 "ARG5,6" LPD1 LEU1 HIP1 ARG4 HIS5 MET28 LYS1 BNA1 CPA2 PUT3 SRY1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ILV5 ECM40 GCV2 MET4 LEU4 ARG1 YOR108W ORT1 FSH3 ASN1 39 204 amino acid biosynthesis 1.04361e-14 LYS2 ARO4 HIS4 GLT1 LYS20 ARO3 ARO1 PRO1 TRP4 HOM3 HIS1 "ARG5,6" LPD1 LEU1 ARG4 HIS5 LYS1 CPA2 ILV5 ECM40 LEU4 ARG1 YOR108W FSH3 ASN1 25 118 METABOLISM 9.82259e-12 FUR4 LYS2 ADH5 ARO4 PHO89 FRM2 HIS4 UGA3 GLT1 LYS20 MPH2 LYS14 ARO3 ARO1 AMD2 PRO1 TRP4 YPR1 SNF1 NPR2 CAN1 YAT2 HOM3 HIS1 ICL1 "ARG5,6" LPD1 BNA6 LEU1 HEM2 HIP1 FOL2 ARG4 INM1 HXT1 THS1 HIS5 MET28 LYS1 BNA1 SFC1 CPA2 MPH3 PUT3 FBA1 PGM1 SRY1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 ILV5 YML131W ECM40 GCV2 URA10 IDH1 YNL040W YNL045W MET4 LEU4 CPT1 NPR1 ARG1 YOR108W ADE2 ORT1 ODC2 FSH3 ISU1 ASN1 72 1066 amino acid degradation (catabolism) 8.13175e-05 BNA1 SRY1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 GCV2 7 35 nitrogen and sulfur metabolism 0.000203741 UGA3 GLT1 AMD2 NPR2 MET28 MET4 NPR1 ARG1 ISU1 9 67 regulation of nitrogen and sulphur utilization 0.00178987 UGA3 NPR2 MET28 MET4 NPR1 5 29 regulation of amino acid metabolism 0.00323447 LYS14 HIS1 MET28 PUT3 MET4 5 33 mitochondrial transport 0.00323919 YAT2 MRS3 SFC1 ATP7 MRS4 CRC1 ORT1 ODC2 8 80 cytoplasm 0.00348089 LYS2 ARO4 ARO3 ARO1 SUP35 PRO1 TRP4 SNF1 HAT2 DLD3 ICL1 LEU1 HEM2 ARG4 THS1 LYS1 CPA2 FBA1 PGM1 DPS1 IDP2 RPS25B LEU4 LAP3 ARG1 RPS19A GSP2 YOR302W ASN1 29 554 SUBCELLULAR LOCALISATION 0.00478318 TFC3 FUR4 LYS2 ARO4 TRS20 UGA3 LYS20 LYS14 ARO3 ARO1 SUP35 SNU56 HSP78 PRO1 CFT1 TRP4 PRP3 SNF1 HAT2 CAN1 DLD3 PET117 ICL1 "ARG5,6" SMX2 LPD1 LEU1 HEM2 ERV14 DUO1 HIP1 RAD2 ARG4 HXT1 YAP1801 THS1 MET28 YAP5 LYS1 SIP4 DPB11 MRS3 RFA3 SPC1 SFC1 CPA2 PUT3 ATP7 FBA1 RAD27 VPH2 PGM1 MRPL38 MRS4 SIS2 MMM1 DPS1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 ARV1 RPS25B ILV5 FPR3 WAR1 ATR1 PEX12 ECM40 GCV2 ZRC1 IDH1 MET4 LEU4 CPT1 POP1 LAP3 ARG1 RPS19A DNL4 ORT1 GSP2 RBL2 YOR302W TEA1 SSU1 ASN1 88 2256 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f mitochondria 0.00431001 ARO3 HSP78 YAT2 PET117 "ARG5,6" LPD1 MRS3 SFC1 ATP7 MRPL38 MRS4 MMM1 ILV5 ECM40 GCV2 IDH1 LEU4 CRC1 ORT1 ODC2 ISU1 YAH1 22 388 MIPS Protein Complexes Category p-value In Category from Cluster k f Met4/Met28/Met31 complex 0.00283071 MET28 MET4 2 3 Met4/Met28/Met32 complex 0.00283071 MET28 MET4 2 3 Cbf1/Met4/Met28 complex 0.00283071 MET28 MET4 2 3 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.00454357 FUR4 PHO89 CAN1 YEL064C HIP1 HXT1 YIL166C MPH3 ATR1 ZRC1 ESBP6 11 142 GO Molecular Function Category p-value In Category from Cluster k f hydrolase, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] 1.08914e-05 HIS4 AMD2 FOL2 NIT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 8 36 asparaginase [GO:0004067] 1.29873e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 lyase [GO:0016829] 7.06783e-05 ARO4 LYS20 ARO3 ARO1 ICL1 LEU1 HEM2 ARG4 FBA1 LEU4 ADE2 11 87 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] 9.15048e-05 AMD2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 16 phosphotransferase, carboxyl group as acceptor [GO:0016774] 0.00011598 PRO1 HOM3 "ARG5,6" 3 4 carbon-carbon lyase [GO:0016830] 0.000118101 ARO4 LYS20 ARO3 ICL1 FBA1 LEU4 ADE2 7 37 enzyme [GO:0003824] 0.000253292 PSK1 LYS2 ADH5 ARO4 HIS4 RHB1 GLT1 LYS20 MPH2 ARO3 ARO1 AMD2 HSP78 PRO1 TRP4 YPR1 SNF1 HAT2 DLD3 YAT2 HOM3 HIS1 ICL1 "ARG5,6" TMT1 LPD1 BNA6 LEU1 HEM2 RAD2 BUD32 FOL2 ARG4 INM1 THS1 HIS5 NIT1 LYS1 DPB11 BNA1 CPA2 YJR110W MPH3 ATP7 FBA1 RAD27 PGM1 DPS1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 ILV5 FPR3 ECM40 SNO1 GCV2 URA10 IDH1 YNL045W LEU4 CPT1 NPR1 POP1 LAP3 NAR1 ARG1 DNL4 ADE2 GSP2 ASN1 72 1604 transporter [GO:0005215] 0.000483942 FUR4 PHO89 MPH2 CAN1 LPD1 ZRT1 HIP1 HXT1 MRS3 SFC1 MPH3 ATP7 MRS4 YMD8 ATR1 ZRC1 ESBP6 YVC1 CRC1 ORT1 ODC2 SSU1 YAH1 ANT1 24 372 aldolase [GO:0016228] 0.0005536 ARO4 ARO3 FBA1 3 6 aldehyde-lyase [GO:0016832] 0.0005536 ARO4 ARO3 FBA1 3 6 transferase, transferring pentosyl groups [GO:0016763] 0.000712015 TRP4 HIS1 BNA6 URA10 4 14 2-dehydro-3-deoxyphosphoheptonate aldolase [GO:0003849] 0.000963355 ARO4 ARO3 2 2 oxidoreductase [GO:0016491] 0.00272806 LYS2 ADH5 HIS4 GLT1 YPR1 DLD3 "ARG5,6" LPD1 LYS1 BNA1 IDP2 ILV5 GCV2 IDH1 NAR1 15 215 protein-N(PI)-phosphohistidine-sugar phosphotransferase [GO:0008982] 0.00283071 MPH2 MPH3 2 3 group translocator [GO:0015455] 0.00283071 MPH2 MPH3 2 3 maltose porter [GO:0015581] 0.00283071 MPH2 MPH3 2 3 GO Biological Process Category p-value In Category from Cluster k f amino acid biosynthesis [GO:0008652] 1e-14 LYS2 ARO4 HIS4 GLT1 LYS20 LYS14 ARO3 ARO1 PRO1 TRP4 HIS1 "ARG5,6" LPD1 LEU1 ARG4 HIS5 MET28 LYS1 CPA2 IDP2 ILV5 ECM40 IDH1 LEU4 ARG1 ORT1 ASN1 27 89 amine biosynthesis [GO:0009309] 1e-14 LYS2 ARO4 HIS4 GLT1 LYS20 LYS14 ARO3 ARO1 PRO1 TRP4 HIS1 "ARG5,6" LPD1 LEU1 ARG4 HIS5 MET28 LYS1 CPA2 IDP2 ILV5 ECM40 IDH1 LEU4 ARG1 ORT1 ASN1 27 95 amino acid metabolism [GO:0006520] 1e-14 LYS2 ARO4 HIS4 GLT1 LYS20 LYS14 ARO3 ARO1 PRO1 TRP4 HOM3 HIS1 "ARG5,6" LPD1 LEU1 ARG4 HIS5 MET28 LYS1 CPA2 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 ILV5 ECM40 IDH1 MET4 LEU4 ARG1 ORT1 ASN1 34 140 amino acid and derivative metabolism [GO:0006519] 1e-14 LYS2 ARO4 HIS4 GLT1 LYS20 LYS14 ARO3 ARO1 PRO1 TRP4 HOM3 HIS1 "ARG5,6" LPD1 LEU1 ARG4 HIS5 MET28 LYS1 CPA2 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 ILV5 ECM40 IDH1 MET4 LEU4 ARG1 ORT1 ASN1 34 149 amine metabolism [GO:0009308] 1e-14 LYS2 ARO4 HIS4 GLT1 LYS20 LYS14 ARO3 ARO1 PRO1 TRP4 HOM3 HIS1 "ARG5,6" LPD1 LEU1 ARG4 HIS5 MET28 LYS1 CPA2 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 ILV5 ECM40 IDH1 MET4 LEU4 ARG1 ORT1 ASN1 34 151 glutamine family amino acid metabolism [GO:0009064] 8.99836e-12 GLT1 PRO1 ARG4 CPA2 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 IDH1 ARG1 ORT1 13 34 response to nitrogen starvation [GO:0006995] 2.77411e-08 SNF1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 5 asparagine metabolism [GO:0006528] 1.62238e-07 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ASN1 5 6 glutamine family amino acid biosynthesis [GO:0009084] 1.67482e-07 GLT1 PRO1 ARG4 CPA2 IDP2 IDH1 ARG1 ORT1 8 22 aspartate family amino acid metabolism [GO:0009066] 3.2683e-07 LYS2 LYS20 LYS14 HOM3 LYS1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ASN1 10 41 asparagine catabolism [GO:0006530] 9.09645e-07 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 4 nitrogen metabolism [GO:0006807] 3.24594e-06 UGA3 "ARG5,6" ARG4 CPA2 ECM40 NPR1 ARG1 ORT1 8 31 urea cycle intermediate metabolism [GO:0000051] 3.32872e-06 "ARG5,6" ARG4 CPA2 ECM40 ARG1 ORT1 6 15 biosynthesis [GO:0009058] 3.75451e-06 LYS2 ARO4 HIS4 GLT1 LYS20 LYS14 ARO3 RSM10 ARO1 SUP35 PRO1 TRP4 HIS1 "ARG5,6" LPD1 BNA6 LEU1 HEM2 FOL2 ARG4 THS1 RSM25 HIS5 MET28 LYS1 SIP4 BNA1 CPA2 FBA1 PGM1 MRPL38 DPS1 IDP2 RPS25B ILV5 ECM40 URA10 IDH1 LEU4 CPT1 ARG1 RPS19A ORT1 YAH1 ASN1 45 731 glutamine family amino acid catabolism [GO:0009065] 6.1515e-06 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 10 arginine biosynthesis [GO:0006526] 1.29873e-05 ARG4 CPA2 ARG1 ORT1 4 6 amine catabolism [GO:0009310] 1.62563e-05 LPD1 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 6 19 amino acid catabolism [GO:0009063] 1.62563e-05 LPD1 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 6 19 response to starvation [GO:0009267] 1.83712e-05 SNF1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 12 aspartate family amino acid catabolism [GO:0009068] 5.76928e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 8 lysine biosynthesis, aminoadipic pathway [GO:0019878] 5.76928e-05 LYS2 LYS20 LYS14 LYS1 4 8 aspartate family amino acid biosynthesis [GO:0009067] 9.15048e-05 LYS2 LYS20 LYS14 LYS1 ASN1 5 16 lysine biosynthesis [GO:0009085] 0.000101323 LYS2 LYS20 LYS14 LYS1 4 9 lysine metabolism [GO:0006553] 0.000101323 LYS2 LYS20 LYS14 LYS1 4 9 L-amino acid transport [GO:0015807] 0.00011598 RHB1 NPR2 HIP1 3 4 cell growth and/or maintenance [GO:0008151] 0.000184012 TFC3 ECM13 FUR4 LYS2 ADH5 ARO4 TRS20 PHO89 FRM2 HIS4 RHB1 UGA3 GLT1 LYS20 GYP7 MPH2 LYS14 ARO3 RSM10 BMH2 ARO1 SUP35 SNU56 HSP78 PRO1 CFT1 TRP4 YPR1 PRP3 SNF1 HAT2 NPR2 CAN1 DLD3 YAT2 HOM3 HIS1 PET117 ICL1 "ARG5,6" DSE1 SMX2 LPD1 AUT10 BNA6 LEU1 HEM2 ERV14 DUO1 ZIP2 ZRT1 HIP1 RAD2 BUD32 FOL2 MIP6 ARG4 INM1 HXT1 YAP1801 THS1 AIR1 RSM25 HIS5 MET28 YAP5 LYS1 SIP4 DPB11 MRS3 ASG7 RFA3 SPC1 BNA1 SFC1 CPA2 MPH3 PUT3 ATP7 FBA1 KTI12 RAD27 VPH2 PGM1 MRPL38 MRS4 SIS2 ECM4 MMM1 DPS1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 ARV1 RPS25B ILV5 TUS1 YMD8 ATR1 PEX12 ECM40 RIM9 SNO1 SNZ1 YMR188C GCV2 ZRC1 URA10 HRB1 IDH1 YNL045W NST1 MET4 LEU4 ESBP6 CPT1 NPR1 POP1 ARG1 MSB4 RPS19A DNL4 YVC1 CRC1 ADE2 ORT1 GSP2 ODC2 RBL2 TEA1 YPL033C SSU1 ISU1 YAH1 ANT1 ASN1 138 3657 arginine metabolism [GO:0006525] 0.000252643 ARG4 CPA2 ARG1 ORT1 4 11 basic amino acid transport [GO:0015802] 0.000283293 RHB1 CAN1 HIP1 3 5 leucine metabolism [GO:0006551] 0.0005536 LPD1 LEU1 LEU4 3 6 aromatic compound metabolism [GO:0006725] 0.000632297 ARO4 ARO3 ARO1 TRP4 FOL2 URA10 ADE2 7 48 organic acid metabolism [GO:0006082] 0.000710974 FRM2 DLD3 ICL1 LPD1 FOL2 IDP2 IDH1 CRC1 ANT1 9 79 carboxylic acid metabolism [GO:0019752] 0.000710974 FRM2 DLD3 ICL1 LPD1 FOL2 IDP2 IDH1 CRC1 ANT1 9 79 branched chain family amino acid metabolism [GO:0009081] 0.000712015 LPD1 LEU1 ILV5 LEU4 4 14 coenzymes and prosthetic group metabolism [GO:0006731] 0.00111254 LPD1 BNA6 HEM2 FOL2 BNA1 SNO1 SNZ1 ZRC1 YAH1 9 84 aromatic compound biosynthesis [GO:0019438] 0.00123278 ARO4 ARO3 ARO1 TRP4 4 16 aromatic amino acid family biosynthesis [GO:0009073] 0.00123278 ARO4 ARO3 ARO1 TRP4 4 16 aromatic amino acid family metabolism [GO:0009072] 0.00244017 ARO4 ARO3 ARO1 TRP4 4 19 branched chain family amino acid biosynthesis [GO:0009082] 0.00406932 LEU1 ILV5 LEU4 3 11 coenzyme metabolism [GO:0006732] 0.00493432 LPD1 BNA6 FOL2 BNA1 SNO1 SNZ1 ZRC1 7 68 GO Cellular Component Category p-value In Category from Cluster k f periplasmic space (sensu Fungi) [GO:0030287] 0.000101323 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 9 mitochondrial matrix [GO:0005759] 0.00178284 RSM10 HSP78 "ARG5,6" LPD1 RSM25 MRPL38 ECM40 YMR188C IDH1 ISU1 YAH1 11 126 mitochondrion [GO:0005739] 0.00291466 RSM10 HSP78 PET117 "ARG5,6" LPD1 RSM25 MPM1 MRS3 SFC1 ATP7 MRPL38 MRS4 MMM1 ILV5 ECM40 YMR188C GCV2 IDH1 LEU4 ESBP6 CRC1 ORT1 ODC2 ISU1 YAH1 25 448 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00710 (Asparaginase) 2.95657e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 7 PF00153 (mito_carr) 6.67941e-05 MRS3 SFC1 MRS4 CRC1 ORT1 ODC2 ANT1 7 34 PF00696 (aakinase) 0.00011598 PRO1 HOM3 "ARG5,6" 3 4 PF00682 (HMGL-like) 0.0005536 LYS20 LEU4 YOR108W 3 6 PF02537 (CRCB) 0.000963355 YOR390W YPL279C 2 2 PF00793 (DAHP_synth_1) 0.000963355 ARO4 ARO3 2 2 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f