Input Cluster (n=198) YAL046C YAL047C SPC72 YBL063W KIP1 YBL064C YBL069W AST1 YBL092W RPL32 YBR021W FUR4 YBR039W ATP3 YBR062C YBR067C TIP1 YBR083W TEC1 YBR105C VID24 YBR106W PHO88 YBR137W YBR179C FZO1 YBR180W DTR1 YBR183W YPC1 YBR203W YBR256C RIB5 YCR027C RHB1 YCR052W RSC6 YCR061W YDL007W RPT2 YDL020C RPN4 YDL078C MDH3 YDL182W LYS20 YDL214C PRR2 YDL235C YPD1 YDL246C YDR036C YDR037W KRS1 YDR072C IPT1 YDR098C GRX3 YDR153C ENT5 YDR170C SEC7 YDR186C YDR243C PRP28 YDR244W PEX5 YDR277C MTH1 YDR297W SUR2 YDR298C ATP5 YDR299W BFR2 YDR322W MRPL35 YDR345C HXT3 YDR384C ATO3 YDR406W PDR15 YDR441C APT2 YDR525W-A SNA2 YEL012W UBC8 YEL017C-A PMP2 YEL017W YEL040W UTR2 YEL052W AFG1 YEL053C MAK10 YEL060C PRB1 YER015W FAA2 YER048W-A YER088C DOT6 YER098W UBP9 YER130C YER137C YFL016C MDJ1 YFL021W GAT1 YFL030W YFL053W DAK2 YFL054C YFR017C YGL009C LEU1 YGL035C MIG1 YGL054C ERV14 YGL055W OLE1 YGL056C SDS23 YGL058W RAD6 YGL158W RCK1 YGL209W MIG2 YGL235W YGL256W ADH4 YGL257C MNT2 YGR110W YGR126W YGR250C YGR260W TNA1 YGR281W YOR1 YGR287C YHL024W RIM4 YHR015W MIP6 YHR048W YHR051W COX6 YHR163W SOL3 YHR198C YIL148W RPL40A YIL149C MLP2 YIL172C YJL045W YJL153C INO1 YJL213W YJL214W HXT8 YJL216C YJL219W HXT9 YJL221C FSP2 YJR048W CYC1 YJR052W RAD7 YJR095W SFC1 YJR151C DAN4 YJR152W DAL5 YJR159W SOR1 YKL008C LAC1 YKL048C ELM1 YKL052C ASK1 YKL096W-A CWP2 YKL171W YKL180W RPL17A YKR009C FOX2 YKR015C YKR016W YKR041W YKR046C YKR074W YKR075C YKR097W PCK1 YKR098C UBP11 YLL018C-A COX19 YLL039C UBI4 YLR055C SPT8 YLR056W ERG3 YLR081W GAL2 YLR152C YLR154C YLR162W YLR174W IDP2 YLR283W YLR301W YLR304C ACO1 YLR312C YLR312W-A MRPL15 YLR323C CWC24 YLR324W YLR377C FBP1 YML042W CAT2 YML126C ERG13 YMR002W YMR011W HXT2 YMR015C ERG5 YMR097C MTG1 YMR135C DCR1 YMR251W-A HOR7 YMR303C ADH2 YMR315W YMR318C ADH6 YNL065W AQR1 YNL144C YNL234W YNL241C ZWF1 YNL304W YPT11 YNR001C CIT1 YNR013C PHO91 YNR014W YNR018W YNR019W ARE2 YOL012C HTZ1 YOL039W RPP2A YOL084W PHM7 YOL124C YOL126C MDH2 YOL127W RPL25 YOL128C YGK3 YOL136C PFK27 YOL142W RRP40 YOL143C RIB4 YOL156W HXT11 YOR062C YOR119C RIO1 YOR120W GCY1 YOR133W EFT1 YOR138C YOR140W SFL1 YOR153W PDR5 YOR180C DCI1 YOR250C CLP1 YOR273C TPO4 YOR349W CIN1 YOR363C PIP2 YPL014W YPL015C HST2 YPL016W SWI1 YPL024W NCE4 YPL026C SKS1 YPL057C SUR1 YPL075W GCR1 YPL089C RLM1 YPL144W YPL200W CSM4 YPL201C YPL222W YPL262W FUM1 YPR030W CSR2 YPR151C YPR196W Genes Not Found: YML045W YML100W-A MIPS Functional Classification Category p-value In Category from Cluster k f C-compound and carbohydrate metabolism 1.35467e-09 MDH3 LYS20 YDL246C MTH1 HXT3 ATO3 DAK2 MIG1 MIG2 ADH4 MNT2 YGR287C YIL172C YJL045W INO1 HXT8 YJL216C HXT9 FSP2 SFC1 SOR1 PCK1 GAL2 IDP2 ACO1 FBP1 HXT2 ADH2 ADH6 ZWF1 CIT1 MDH2 PFK27 HXT11 GCY1 SWI1 SKS1 GCR1 38 415 METABOLISM 1.5659e-07 FUR4 TIP1 PHO88 YPC1 RIB5 MDH3 LYS20 YDL246C IPT1 MTH1 SUR2 HXT3 ATO3 APT2 FAA2 GAT1 YFL030W DAK2 LEU1 MIG1 OLE1 MIG2 ADH4 MNT2 YGR287C YIL172C YJL045W INO1 HXT8 YJL216C HXT9 FSP2 SFC1 SOR1 FOX2 PCK1 ERG3 GAL2 IDP2 ACO1 FBP1 CAT2 ERG13 HXT2 ERG5 ADH2 ADH6 ZWF1 CIT1 PHO91 ARE2 MDH2 PFK27 RIB4 HXT11 GCY1 PDR5 DCI1 PIP2 SWI1 SKS1 SUR1 GCR1 63 1066 ENERGY 2.74292e-07 ATP3 MDH3 ATP5 ATO3 MAK10 ADH4 COX6 YIL172C YJL045W YJL216C FSP2 CYC1 FOX2 YKR016W YKR046C PCK1 IDP2 ACO1 FBP1 ADH2 ADH6 ZWF1 CIT1 MDH2 FUM1 25 252 C-compound and carbohydrate utilization 5.3723e-07 MDH3 LYS20 YDL246C ATO3 DAK2 ADH4 MNT2 YGR287C YIL172C YJL045W INO1 YJL216C FSP2 SOR1 PCK1 IDP2 ACO1 FBP1 ADH2 ADH6 ZWF1 CIT1 MDH2 PFK27 GCY1 25 261 C-compound, carbohydrate transport 0.000297911 HXT3 HXT8 HXT9 SFC1 GAL2 HXT2 HXT11 7 42 TRANSPORT FACILITATION 0.000307559 FUR4 ATP3 DTR1 ATP5 HXT3 PDR15 PMP2 YFL054C TNA1 YOR1 YHR048W HXT8 HXT9 SFC1 DAL5 GAL2 HXT2 AQR1 PHO91 HXT11 PDR5 TPO4 22 312 lipid, fatty-acid and isoprenoid metabolism 0.000373106 TIP1 YPC1 MDH3 IPT1 SUR2 FAA2 OLE1 FOX2 ERG3 CAT2 ERG13 ERG5 ARE2 PDR5 DCI1 PIP2 SUR1 17 213 C-compound and carbohydrate transporters 0.000531136 HXT3 HXT8 HXT9 SFC1 GAL2 HXT2 HXT11 7 46 tricarboxylic-acid pathway (citrate cycle, Krebs cycle, TCA cycle) 0.000949196 YJL045W IDP2 ACO1 CIT1 FUM1 5 25 lipid, fatty-acid and isoprenoid utilization 0.00114541 YPC1 MDH3 FAA2 FOX2 DCI1 5 26 peroxisome 0.00125924 MDH3 PEX5 FAA2 FOX2 CAT2 DCI1 6 39 lipid, fatty-acid and isoprenoid biosynthesis 0.00420927 YPC1 IPT1 SUR2 OLE1 ERG3 CAT2 ERG13 ERG5 ARE2 SUR1 10 119 drug transporters 0.00449046 DTR1 YOR1 YHR048W AQR1 TPO4 5 35 MIPS Phenotypes Category p-value In Category from Cluster k f other carbohydrate and lipid biosynthesis defects 0.000108244 MDH3 SEC7 SUR2 FAA2 OLE1 ERG5 SUR1 7 36 Carbohydrate and lipid biosynthesis defects 0.000607645 MDH3 SEC7 SUR2 FAA2 OLE1 ERG5 SUR1 7 47 other antibiotics 0.000993302 RAD6 YOR1 2 2 MIPS Subcellular Localization Category p-value In Category from Cluster k f peroxisomal matrix 0.000242428 MDH3 PEX5 FAA2 FOX2 CAT2 5 19 peroxisome 0.00144314 MDH3 PEX5 FAA2 FOX2 CAT2 DCI1 6 40 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.000142015 FUR4 DTR1 HXT3 TNA1 YHR048W HXT8 HXT9 DAL5 GAL2 HXT2 AQR1 PHO91 HXT11 TPO4 14 142 Ubiquitin-system proteins 0.00460065 UBC8 UBP9 RAD6 RPL40A UBP11 UBI4 6 50 GO Molecular Function Category p-value In Category from Cluster k f hexose transporter [GO:0015149] 1.77401e-05 HXT3 HXT8 HXT9 GAL2 HXT2 HXT11 6 19 monosaccharide transporter [GO:0015145] 1.77401e-05 HXT3 HXT8 HXT9 GAL2 HXT2 HXT11 6 19 alpha-glucosidase [GO:0004558] 3.14055e-05 YGR287C YIL172C YJL216C FSP2 4 7 fructose transporter [GO:0005353] 4.74941e-05 HXT3 HXT8 HXT9 HXT2 HXT11 5 14 mannose transporter [GO:0015578] 6.94218e-05 HXT3 HXT8 HXT9 HXT2 HXT11 5 15 oxidoreductase, acting on CH-OH group of donors [GO:0016614] 7.27746e-05 MDH3 ADH4 SOR1 FOX2 IDP2 ADH2 ADH6 ZWF1 MDH2 9 58 glucose transporter [GO:0005355] 0.000135845 HXT3 HXT8 HXT9 HXT2 HXT11 5 17 carbohydrate transporter [GO:0015144] 0.000194182 HXT3 HXT8 HXT9 GAL2 HXT2 HXT11 6 28 oxidoreductase [GO:0016491] 0.000416224 YBL064C MDH3 GRX3 SUR2 OLE1 ADH4 COX6 YJL045W SOR1 FOX2 ERG3 IDP2 ADH2 ADH6 ZWF1 MDH2 GCY1 17 215 enzyme [GO:0003824] 0.000427088 YBL064C ATP3 TIP1 FZO1 YPC1 RIB5 RHB1 RPT2 RPN4 MDH3 LYS20 PRR2 YPD1 KRS1 IPT1 GRX3 PRP28 SUR2 ATP5 PDR15 APT2 UBC8 AFG1 MAK10 PRB1 FAA2 UBP9 DAK2 LEU1 OLE1 RAD6 RCK1 ADH4 MNT2 YOR1 YGR287C COX6 YIL172C YJL045W INO1 YJL216C FSP2 RAD7 SOR1 ELM1 FOX2 PCK1 UBP11 ERG3 IDP2 ACO1 FBP1 CAT2 ERG13 ERG5 ADH2 ADH6 ZWF1 CIT1 ARE2 MDH2 YGK3 PFK27 RRP40 RIB4 RIO1 GCY1 PDR5 DCI1 HST2 SKS1 FUM1 72 1604 galactose transporter [GO:0005354] 0.000579045 HXT9 GAL2 HXT11 3 6 alcohol dehydrogenase [GO:0004022] 0.000579045 ADH4 ADH2 ADH6 3 6 oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] 0.000607645 ADH4 SOR1 FOX2 IDP2 ADH2 ADH6 ZWF1 7 47 riboflavin synthase [GO:0004746] 0.000993302 RIB5 RIB4 2 2 phosphate transporter [GO:0015114] 0.00291776 PHO88 PHO91 2 3 transporter [GO:0005215] 0.00312226 AST1 FUR4 ATP3 PHO88 ATP5 HXT3 PDR15 TNA1 YOR1 COX6 HXT8 HXT9 CYC1 SFC1 DAL5 LAC1 COX19 GAL2 HXT2 PHO91 HXT11 PDR5 22 372 anion transporter [GO:0008509] 0.00314629 PHO88 SFC1 DAL5 PHO91 4 20 glucosidase [GO:0015926] 0.00452147 YGR287C YIL172C YJL216C FSP2 4 22 GO Biological Process Category p-value In Category from Cluster k f carbohydrate transport [GO:0008643] 2.77458e-06 MTH1 HXT3 HXT8 HXT9 GAL2 HXT2 HXT11 SKS1 8 30 alcohol metabolism [GO:0006066] 3.14801e-06 DAK2 MIG1 MIG2 INO1 SOR1 PCK1 GAL2 FBP1 ADH2 ADH6 ZWF1 MDH2 PFK27 13 88 monosaccharide transport [GO:0015749] 3.22149e-06 MTH1 HXT3 HXT8 HXT9 HXT2 HXT11 SKS1 7 22 hexose transport [GO:0008645] 3.22149e-06 MTH1 HXT3 HXT8 HXT9 HXT2 HXT11 SKS1 7 22 hexose metabolism [GO:0019318] 2.3428e-05 MIG1 MIG2 INO1 SOR1 PCK1 GAL2 FBP1 ZWF1 MDH2 PFK27 10 63 TCA intermediate metabolism [GO:0006100] 3.36503e-05 MDH3 IDP2 ACO1 CIT1 MDH2 FUM1 6 21 main pathways of carbohydrate metabolism [GO:0006092] 3.47218e-05 MDH3 PCK1 IDP2 ACO1 FBP1 ZWF1 CIT1 MDH2 FUM1 9 53 monosaccharide metabolism [GO:0005996] 5.28477e-05 MIG1 MIG2 INO1 SOR1 PCK1 GAL2 FBP1 ZWF1 MDH2 PFK27 10 69 ceramide metabolism [GO:0006672] 0.000121399 YPC1 IPT1 SUR1 3 4 carbohydrate metabolism [GO:0005975] 0.000204712 MDH3 MIG1 MIG2 INO1 SOR1 PCK1 GAL2 IDP2 ACO1 FBP1 ZWF1 CIT1 MDH2 PFK27 FUM1 15 165 lipid metabolism [GO:0006629] 0.000249744 YPC1 MDH3 IPT1 SUR2 FAA2 DAK2 OLE1 FOX2 ERG3 CAT2 ERG13 ERG5 ARE2 DCI1 SUR1 15 168 sphingoid metabolism [GO:0046519] 0.000579045 YPC1 IPT1 SUR1 3 6 organic acid metabolism [GO:0006082] 0.000793498 MDH3 OLE1 FOX2 IDP2 ACO1 CIT1 MDH2 DCI1 FUM1 9 79 carboxylic acid metabolism [GO:0019752] 0.000793498 MDH3 OLE1 FOX2 IDP2 ACO1 CIT1 MDH2 DCI1 FUM1 9 79 inositolphosphoceramide metabolism [GO:0006673] 0.000993302 IPT1 SUR1 2 2 fatty acid beta-oxidation [GO:0006635] 0.00154688 MDH3 FOX2 DCI1 3 8 fatty acid oxidation [GO:0019395] 0.00226655 MDH3 FOX2 DCI1 3 9 glucose metabolism [GO:0006006] 0.0023902 MIG1 MIG2 PCK1 FBP1 ZWF1 MDH2 6 44 malate metabolism [GO:0006108] 0.00291776 MDH3 MDH2 2 3 sphingolipid metabolism [GO:0006665] 0.00379178 YPC1 IPT1 SUR2 SUR1 4 21 energy pathways [GO:0006091] 0.00431334 MDH3 ADH4 COX6 PCK1 IDP2 ACO1 FBP1 ADH2 ZWF1 CIT1 MDH2 FUM1 12 159 energy derivation by oxidation of organic compounds [GO:0015980] 0.00431334 MDH3 ADH4 COX6 PCK1 IDP2 ACO1 FBP1 ADH2 ZWF1 CIT1 MDH2 FUM1 12 159 GO Cellular Component Category p-value In Category from Cluster k f peroxisomal matrix [GO:0005782] 6.94218e-05 MDH3 FOX2 CAT2 MDH2 DCI1 5 15 peroxisome [GO:0005777] 0.000217189 MDH3 PEX5 FAA2 FOX2 CAT2 MDH2 DCI1 7 40 SMART Domains Category p-value In Category from Cluster k f Aamy 0.000107544 YGR287C YIL172C YJL216C FSP2 4 9 PFam-A Domains Category p-value In Category from Cluster k f PF00083 (sugar_tr) 4.70774e-06 DTR1 HXT3 TNA1 YHR048W HXT8 HXT9 GAL2 HXT2 AQR1 HXT11 10 53 PF00128 (alpha-amylase) 6.12588e-05 YGR287C YIL172C YJL216C FSP2 4 8 PF00107 (adh_zinc) 0.000402935 AST1 YDL246C SOR1 ADH2 ADH6 5 21 PF00378 (ECH) 0.00291776 YDR036C DCI1 2 3 PF01598 (Sterol_desat) 0.00291776 SUR2 ERG3 2 3 PF00056 (ldh) 0.00291776 MDH3 MDH2 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YDL246C 0.000993302 YDL246C SOR1 2 2 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YDR477W (SNF1) 0.00226655 SEC7 PRB1 UBI4 3 9 YDL145C (COP1) 0.00424866 ATP3 PRB1 YPL222W 3 11 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f cell periphery 0.0038191 AST1 TIP1 YCR061W YDR036C TNA1 YNR018W PDR5 7 64 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.00437153 YAL046C YBL064C AST1 RPL32 FUR4 YBR062C VID24 PHO88 FZO1 DTR1 YPC1 YBR203W RIB5 RHB1 RPT2 LYS20 PRR2 YDL246C KRS1 GRX3 ENT5 YDR186C SUR2 HXT3 ATO3 APT2 UBC8 YEL017W UTR2 MAK10 FAA2 UBP9 YER137C YFL030W DAK2 YFL054C YFR017C LEU1 ERV14 OLE1 RCK1 YGL235W ADH4 YGR110W YGR126W TNA1 YOR1 YGR287C RIM4 YHR048W SOL3 RPL40A YJL045W INO1 YJL213W HXT8 YJL216C HXT9 FSP2 CYC1 SFC1 DAL5 SOR1 YKL171W RPL17A YKR016W YKR046C YKR074W YKR075C PCK1 UBP11 UBI4 ERG3 GAL2 YLR152C YLR154C YLR162W IDP2 YLR301W YLR312C FBP1 ERG13 YMR002W HXT2 DCR1 ADH2 YMR315W ADH6 AQR1 YNL144C YNL234W ZWF1 PHO91 YNR014W ARE2 RPP2A YOL124C MDH2 RPL25 YGK3 PFK27 RIB4 HXT11 YOR062C RIO1 GCY1 EFT1 YOR138C SFL1 PDR5 TPO4 CIN1 YPL014W HST2 SKS1 CSM4 YPL201C YPL222W FUM1 CSR2 120 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.00383949 YAL046C KIP1 YBL064C AST1 YBR062C TIP1 TEC1 FZO1 DTR1 YPC1 YBR203W YCR061W LYS20 PRR2 YDR036C IPT1 GRX3 ENT5 YDR186C PEX5 MTH1 SUR2 HXT3 ATO3 PDR15 SNA2 UBC8 PMP2 YEL017W UTR2 AFG1 MAK10 PRB1 DOT6 UBP9 GAT1 YFL030W DAK2 YFL054C YFR017C LEU1 ERV14 SDS23 MIG2 YGL235W ADH4 MNT2 YGR110W YGR126W YGR250C TNA1 YOR1 YGR287C RIM4 MIP6 YHR048W COX6 SOL3 MLP2 YJL045W INO1 YJL213W HXT8 YJL216C CYC1 RAD7 SFC1 DAL5 LAC1 YKL171W FOX2 YKR015C YKR016W YKR041W YKR046C YKR074W YKR075C PCK1 UBP11 COX19 UBI4 GAL2 YLR152C YLR154C IDP2 YLR283W ACO1 YLR312C MRPL15 YLR324W FBP1 CAT2 YMR002W HXT2 ERG5 MTG1 DCR1 HOR7 ADH2 YMR315W ADH6 AQR1 YPT11 CIT1 PHO91 YNR014W YNR018W ARE2 HTZ1 RPP2A PHM7 YOL124C MDH2 YGK3 PFK27 RIB4 YOR062C GCY1 EFT1 YOR138C TPO4 PIP2 YPL014W HST2 SKS1 SUR1 RLM1 YPL144W CSM4 YPL201C YPL222W FUM1 CSR2 YPR151C YPR196W 135 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f