Input Cluster (n=187) YAL037W YAL054C ACS1 YAL062W GDH3 YAR027W UIP3 YBL049W YBR043C AQR2 YBR179C FZO1 YBR180W DTR1 YBR208C "DUR1,2" YBR233W PBP2 YBR234C ARC40 YBR239C YBR245C ISW1 YBR286W APE3 YCL025C AGP1 YCL063W YCL064C CHA1 YCL068C YCR018C SRD1 YCR068W CVT17 YCR093W CDC39 YDL128W VCX1 YDL137W ARF2 YDL170W UGA3 YDL171C GLT1 YDL210W UGA4 YDL238C YDR001C NTH1 YDR002W YRB1 YDR009W GAL3 YDR028C REG1 YDR038C ENA5 YDR039C ENA2 YDR041W RSM10 YDR089W YDR098C GRX3 YDR131C YDR242W AMD2 YDR264C AKR1 YDR265W PEX10 YDR284C DPP1 YDR317W YDR322W MRPL35 YDR352W YDR435C PPM1 YDR524C AGE1 YDR540C YEL059C-A SOM1 YEL062W NPR2 YEL063C CAN1 YER002W NOP16 YER056C FCY2 YER060W FCY21 YER072W VTC1 YER107C GLE2 YER112W LSM4 YER164W CHD1 YFL008W SMC1 YFL010W-A AUA1 YFL021W GAT1 YFL051C YFR025C HIS2 YFR041C YGL053W PRM8 YGL054C ERV14 YGL196W YGL203C KEX1 YGL226C-A OST5 YGR008C STF2 YGR028W MSP1 YGR080W TWF1 YGR087C PDC6 YGR125W YGR149W YGR150C YGR155W CYS4 YGR161C YGR169C PUS6 YGR174C CBP4 YGR181W TIM13 YGR233C PHO81 YHL015W RPS20 YHL016C DUR3 YHL036W MUP3 YHR074W QNS1 YHR101C BIG1 YHR102W KIC1 YHR112C YHR113W YHR146W CRP1 YHR207C SET5 YHR208W BAT1 YIL037C PRM2 YIL118W RHO3 YIL121W YIL146C ECM37 YIL164C NIT1 YIR005W IST3 YIR027C DAL1 YIR028W DAL4 YIR029W DAL2 YIR031C DAL7 YIR032C DAL3 YIR033W MGA2 YJL060W BNA3 YJL146W IDS2 YJL172W CPS1 YJR011C YJR024C YJR040W GEF1 YJR094W-A RPL43B YJR152W DAL5 YKL049C CSE4 YKL067W YNK1 YKL069W YKL103C LAP4 YKL138C MRPL31 YKR028W SAP190 YKR031C SPO14 YKR034W DAL80 YKR039W GAP1 YLL039C UBI4 YLR020C YLR028C ADE16 YLR053C YLR113W HOG1 YLR138W NHA1 YLR155C ASP3-1 YLR157C ASP3-2 YLR158C ASP3-3 YLR160C ASP3-4 YLR163C MAS1 YLR164W YLR249W YEF3 YLR257W YLR298C YHC1 YLR299W ECM38 YLR403W SFP1 YLR411W CTR3 YML086C ALO1 YMR012W CLU1 YMR107W YMR110C YMR118C YMR158W YMR167W MLH1 YMR204C YNL040W YNL124W NAF1 YNL125C ESBP6 YNL129W YNL130C CPT1 YNL142W MEP2 YNL163C RIA1 YNL239W LAP3 YNL240C NAR1 YNR011C PRP2 YNR012W URK1 YNR048W YNR065C YSN1 YNR072W HXT17 YOL013W-A YOL019W YOL044W PEX15 YOL058W ARG1 YOL104C NDJ1 YOL114C YOL128C YGK3 YOR003W YSP3 YOR004W YOR030W DFG16 YOR043W WHI2 YOR149C SMP3 YOR150W MRPL23 YOR179C YOR375C GDH1 YPL031C PHO85 YPL034W YPL054W LEE1 YPL150W YPL216W YPL217C BMS1 YPL226W NEW1 YPL254W HFI1 YPL265W DIP5 YPR138C MEP3 YPR194C OPT2 Genes Not Found: YBL005W-A YBL005W-B YBR012W-A YBR012W-B YDR170W-A YER138C YFL002W-A YJR026W YJR027W YJR028W YJR029W YMR050C YMR051C MIPS Functional Classification Category p-value In Category from Cluster k f nitrogen and sulfur metabolism 5.20894e-12 GDH3 "DUR1,2" UGA3 GLT1 UGA4 AMD2 NPR2 AUA1 GAT1 DAL1 DAL2 DAL3 BNA3 CPS1 DAL80 ARG1 GDH1 17 67 nitrogen and sulfur utilization 4.81518e-10 GDH3 "DUR1,2" GLT1 UGA4 AMD2 DAL1 DAL2 DAL3 BNA3 CPS1 ARG1 GDH1 12 38 amino acid degradation (catabolism) 5.58652e-07 GDH3 "DUR1,2" CHA1 BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 GDH1 9 35 amino acid metabolism 5.62546e-07 GDH3 "DUR1,2" AGP1 CHA1 GLT1 CAN1 AUA1 HIS2 CYS4 MUP3 YHR112C BAT1 GAP1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ECM38 ARG1 GDH1 DIP5 21 204 TRANSPORT FACILITATION 1.50254e-06 AQR2 DTR1 AGP1 VCX1 UGA4 ENA5 ENA2 CAN1 FCY2 FCY21 DUR3 MUP3 YIL121W DAL4 GEF1 DAL5 GAP1 NHA1 CTR3 ESBP6 MEP2 HXT17 NEW1 DIP5 MEP3 OPT2 26 312 METABOLISM 2.88706e-06 ACS1 GDH3 "DUR1,2" AGP1 CHA1 UGA3 GLT1 UGA4 NTH1 GAL3 REG1 AMD2 DPP1 NPR2 CAN1 FCY2 FCY21 AUA1 GAT1 HIS2 OST5 PDC6 CYS4 PUS6 PHO81 MUP3 BIG1 YHR112C BAT1 DAL1 DAL2 DAL7 DAL3 BNA3 CPS1 YNK1 SPO14 DAL80 GAP1 YLR020C ADE16 HOG1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 YLR164W ECM38 ALO1 YNL040W CPT1 URK1 HXT17 ARG1 GDH1 PHO85 DIP5 57 1066 amino-acid transporters 7.18604e-05 AGP1 UGA4 CAN1 MUP3 GAP1 DIP5 6 25 plasma membrane 9.64837e-05 AGP1 UGA4 CAN1 FCY2 DUR3 MUP3 DAL4 GEF1 DAL5 GAP1 MEP2 LAP3 HXT17 DIP5 14 145 homeostasis of other cations 0.00048694 VCX1 ENA5 ENA2 DUR3 NHA1 5 23 amino acid transport 0.00048694 AGP1 CAN1 MUP3 GAP1 DIP5 5 23 cellular import 0.000740292 UGA4 CAN1 FCY2 MUP3 DAL4 GEF1 DAL5 GAP1 MEP2 HXT17 10 100 regulation of nitrogen and sulphur utilization 0.00148621 UGA3 NPR2 AUA1 GAT1 DAL80 5 29 purine ribonucleotide metabolism 0.00201348 "DUR1,2" DAL1 DAL2 DAL7 DAL3 ADE16 6 45 lysosomal and vacuolar degradation 0.00209311 APE3 CPS1 LAP4 YSP3 4 19 anion transporters (Cl, SO4, PO4, etc.) 0.00308475 DUR3 GEF1 MEP2 MEP3 4 21 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 0.00025786 AGP1 UGA4 CAN1 FCY2 VTC1 DUR3 MUP3 DAL4 GEF1 DAL5 GAP1 MEP2 LAP3 HXT17 14 159 vacuolar lumen 0.000489329 APE3 CPS1 LAP4 3 6 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 8.74789e-07 AQR2 DTR1 AGP1 UGA4 CAN1 FCY2 FCY21 DUR3 MUP3 YIL121W DAL4 DAL5 GAP1 ESBP6 MEP2 DIP5 MEP3 17 142 Cys4 zinc-fingers 0.000837539 SRD1 GAT1 DAL80 3 7 Proteases 0.00252671 APE3 KEX1 LAP4 MAS1 LAP3 YSP3 6 47 GO Molecular Function Category p-value In Category from Cluster k f hydrolase, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] 2.34564e-10 "DUR1,2" AMD2 NIT1 DAL1 DAL2 DAL3 BNA3 ADE16 ASP3-1 ASP3-2 ASP3-3 ASP3-4 12 36 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] 1.71601e-07 "DUR1,2" AMD2 BNA3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 7 16 hydrolase [GO:0016787] 9.20994e-07 FZO1 "DUR1,2" ISW1 APE3 CVT17 CDC39 ARF2 NTH1 REG1 ENA5 ENA2 AMD2 DPP1 CHD1 SMC1 HIS2 KEX1 MSP1 RHO3 NIT1 DAL1 DAL2 DAL3 BNA3 CPS1 LAP4 SAP190 SPO14 ADE16 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MAS1 MLH1 LAP3 PRP2 YSP3 38 561 asparaginase [GO:0004067] 1.0992e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 electrochemical potential-driven transporter [GO:0015290] 3.00297e-05 VCX1 UGA4 FCY2 FCY21 DAL4 GAP1 NHA1 CTR3 DIP5 9 55 porter [GO:0015291] 3.00297e-05 VCX1 UGA4 FCY2 FCY21 DAL4 GAP1 NHA1 CTR3 DIP5 9 55 amino acid transporter [GO:0015171] 3.26245e-05 AGP1 UGA4 CAN1 MUP3 GAP1 DIP5 6 22 solute\:cation symporter [GO:0015294] 8.60242e-05 UGA4 FCY2 FCY21 DAL4 4 9 oxidoreductase, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [GO:0016639] 0.000102315 GDH3 GLT1 GDH1 3 4 symporter [GO:0015293] 0.000140037 UGA4 FCY2 FCY21 DAL4 4 10 nucleobase\:cation symporter [GO:0015391] 0.000250161 FCY2 FCY21 DAL4 3 5 nucleobase transporter [GO:0015205] 0.000250161 FCY2 FCY21 DAL4 3 5 transporter [GO:0005215] 0.000257624 AGP1 VCX1 UGA4 ENA5 ENA2 CAN1 FCY2 FCY21 TIM13 DUR3 MUP3 DAL4 GEF1 DAL5 GAP1 NHA1 CTR3 NAF1 ESBP6 MEP2 HXT17 DIP5 MEP3 OPT2 24 372 nucleobase, nucleoside, nucleotide and nucleic acid transporter [GO:0015932] 0.0013107 FCY2 FCY21 DAL4 3 8 oxidoreductase, acting on the CH-NH2 group of donors [GO:0016638] 0.0013107 GDH3 GLT1 GDH1 3 8 amine/polyamine transporter [GO:0005275] 0.0013107 DUR3 GAP1 DIP5 3 8 purine transporter [GO:0005345] 0.0026049 FCY2 FCY21 2 3 cytosine transporter [GO:0015209] 0.0026049 FCY2 FCY21 2 3 cytosine-purine permease [GO:0015392] 0.0026049 FCY2 FCY21 2 3 ammonium transporter [GO:0008519] 0.0026049 MEP2 MEP3 2 3 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [GO:0016813] 0.0026049 DAL2 DAL3 2 3 GO Biological Process Category p-value In Category from Cluster k f asparagine catabolism [GO:0006530] 7.68283e-07 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 4 amino acid transport [GO:0006865] 3.07848e-06 AGP1 NPR2 CAN1 AUA1 MUP3 GAP1 DIP5 7 23 allantoin metabolism [GO:0000255] 3.75162e-06 DAL1 DAL2 DAL7 DAL3 4 5 allantoin catabolism [GO:0000256] 3.75162e-06 DAL1 DAL2 DAL7 DAL3 4 5 response to nitrogen starvation [GO:0006995] 3.75162e-06 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 5 heterocycle catabolism [GO:0046700] 3.75162e-06 DAL1 DAL2 DAL7 DAL3 4 5 glutamine family amino acid metabolism [GO:0009064] 5.04973e-06 GDH3 GLT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ARG1 GDH1 8 34 asparagine metabolism [GO:0006528] 1.0992e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 aspartate family amino acid catabolism [GO:0009068] 4.8931e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 8 glutamine family amino acid catabolism [GO:0009065] 0.000140037 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 10 amine catabolism [GO:0009310] 0.000185438 CHA1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 19 amino acid catabolism [GO:0009063] 0.000185438 CHA1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 19 response to starvation [GO:0009267] 0.000314922 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 12 urea transport [GO:0015840] 0.000885736 NPR2 DUR3 2 2 amino acid metabolism [GO:0006520] 0.000906204 GDH3 CHA1 GLT1 HIS2 CYS4 BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ARG1 GDH1 12 140 catabolism [GO:0009056] 0.000931874 APE3 CHA1 CDC39 NTH1 YRB1 SOM1 DAL1 DAL2 DAL7 DAL3 CPS1 LAP4 UBI4 ASP3-1 ASP3-2 ASP3-3 ASP3-4 YGK3 YSP3 19 289 transport [GO:0006810] 0.00127768 AGP1 CVT17 VCX1 ARF2 UGA4 YRB1 ENA5 ENA2 AKR1 AGE1 NPR2 CAN1 FCY2 GLE2 AUA1 ERV14 STF2 MSP1 TIM13 DUR3 MUP3 RHO3 DAL4 DAL5 GAP1 MAS1 CTR3 NAF1 ESBP6 MEP2 HXT17 PEX15 DIP5 MEP3 OPT2 35 698 amino acid and derivative metabolism [GO:0006519] 0.00156144 GDH3 CHA1 GLT1 HIS2 CYS4 BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ARG1 GDH1 12 149 amine metabolism [GO:0009308] 0.00175052 GDH3 CHA1 GLT1 HIS2 CYS4 BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ARG1 GDH1 12 151 nitrogen metabolism [GO:0006807] 0.00202619 "DUR1,2" UGA3 GAT1 CPS1 ARG1 5 31 sodium transport [GO:0006814] 0.0026049 ENA5 ENA2 2 3 nucleobase transport [GO:0015851] 0.0026049 FCY2 DAL4 2 3 organic cation transport [GO:0015695] 0.0026049 MEP2 MEP3 2 3 ammonium transport [GO:0015696] 0.0026049 MEP2 MEP3 2 3 glutamine family amino acid biosynthesis [GO:0009084] 0.00368348 GDH3 GLT1 ARG1 GDH1 4 22 cell growth and/or maintenance [GO:0008151] 0.0040466 ACS1 GDH3 FZO1 "DUR1,2" ARC40 ISW1 APE3 AGP1 CHA1 SRD1 CVT17 CDC39 VCX1 ARF2 UGA3 GLT1 UGA4 NTH1 YRB1 GAL3 REG1 ENA5 ENA2 RSM10 GRX3 AKR1 PEX10 DPP1 MRPL35 PPM1 AGE1 SOM1 NPR2 CAN1 NOP16 FCY2 VTC1 GLE2 LSM4 CHD1 SMC1 AUA1 GAT1 HIS2 PRM8 ERV14 KEX1 OST5 STF2 MSP1 TWF1 PDC6 CYS4 PUS6 CBP4 TIM13 PHO81 RPS20 DUR3 MUP3 BIG1 KIC1 BAT1 PRM2 RHO3 ECM37 IST3 DAL1 DAL4 DAL2 DAL7 DAL3 MGA2 BNA3 IDS2 CPS1 GEF1 RPL43B DAL5 CSE4 LAP4 MRPL31 SAP190 SPO14 DAL80 GAP1 UBI4 ADE16 HOG1 NHA1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MAS1 YEF3 YHC1 ECM38 SFP1 CTR3 ALO1 CLU1 MLH1 NAF1 ESBP6 CPT1 MEP2 RIA1 PRP2 URK1 HXT17 PEX15 ARG1 NDJ1 YGK3 YSP3 DFG16 WHI2 SMP3 MRPL23 GDH1 PHO85 BMS1 HFI1 DIP5 MEP3 OPT2 127 3657 cation transport [GO:0006812] 0.00499176 VCX1 ENA5 ENA2 STF2 CTR3 MEP2 MEP3 7 71 GO Cellular Component Category p-value In Category from Cluster k f membrane [GO:0016020] 4.03374e-05 UIP3 FZO1 AGP1 CVT17 VCX1 UGA4 ENA5 ENA2 SOM1 CAN1 FCY2 FCY21 VTC1 GLE2 PRM8 ERV14 OST5 STF2 MSP1 CBP4 DUR3 MUP3 BIG1 PRM2 DAL4 DAL3 MGA2 DAL5 SPO14 GAP1 NHA1 ASP3-1 CTR3 ESBP6 MEP2 HXT17 PEX15 DIP5 MEP3 39 683 periplasmic space (sensu Fungi) [GO:0030287] 8.60242e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 9 plasma membrane [GO:0005886] 0.000813112 AGP1 ENA5 ENA2 CAN1 FCY2 DUR3 DAL5 GAP1 NHA1 CTR3 MEP2 HXT17 DIP5 MEP3 14 178 SMART Domains Category p-value In Category from Cluster k f TRANS 0.00127458 UIP3 AQR2 DTR1 AGP1 CVT17 VCX1 UGA4 ENA5 ENA2 YDR089W AKR1 PEX10 DPP1 YDR352W CAN1 FCY2 FCY21 VTC1 YFL051C YFR041C PRM8 ERV14 KEX1 OST5 YGR125W YGR149W CBP4 DUR3 MUP3 BIG1 PRM2 YIL121W ECM37 DAL4 MGA2 CPS1 GEF1 DAL5 GAP1 YLR020C NHA1 ECM38 CTR3 YMR110C YMR118C ESBP6 CPT1 MEP2 YNR048W YSN1 HXT17 YOL013W-A YOL019W DFG16 SMP3 DIP5 MEP3 OPT2 58 1346 ZnF_GATA 0.00268719 SRD1 GAT1 DAL80 3 10 PFam-A Domains Category p-value In Category from Cluster k f PF00710 (Asparaginase) 2.50495e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 7 PF00324 (aa_permeases) 0.000390443 AGP1 UGA4 CAN1 GAP1 DIP5 5 22 PF00338 (Ribosomal_S10) 0.000885736 RSM10 RPS20 2 2 PF02127 (Peptidase_M18) 0.000885736 YHR113W LAP4 2 2 PF00909 (Ammonium_transp) 0.0026049 MEP2 MEP3 2 3 PF01425 (Amidase) 0.0026049 "DUR1,2" AMD2 2 3 PF02812 (GLFV_dehydrog_N) 0.0026049 GDH3 GDH1 2 3 PF00208 (GLFV_dehydrog) 0.0026049 GDH3 GDH1 2 3 PF02133 (Transp_cyt_pur) 0.00268719 FCY2 FCY21 DAL4 3 10 PF00320 (GATA) 0.00361428 SRD1 GAT1 DAL80 3 11 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YHL010C 0.0026049 YBL049W NHA1 2 3 YDR142C (PEX7) 0.00471407 FZO1 LAP4 NEW1 3 12 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 2.24038e-05 YAL037W ACS1 GDH3 UIP3 YBL049W FZO1 DTR1 "DUR1,2" PBP2 YBR239C ISW1 APE3 AGP1 YCL063W CHA1 CVT17 VCX1 ARF2 UGA3 GLT1 UGA4 YDL238C NTH1 GAL3 YDR089W GRX3 YDR131C AMD2 PEX10 DPP1 YDR317W YDR352W PPM1 NPR2 CAN1 NOP16 FCY2 FCY21 AUA1 GAT1 YFL051C HIS2 YFR041C PRM8 ERV14 YGL196W KEX1 OST5 STF2 MSP1 TWF1 PDC6 YGR125W YGR149W YGR150C YGR161C PUS6 CBP4 TIM13 PHO81 DUR3 MUP3 YHR112C YHR113W CRP1 SET5 PRM2 YIL121W ECM37 NIT1 IST3 DAL1 DAL4 DAL2 DAL7 DAL3 MGA2 BNA3 IDS2 CPS1 YJR011C YJR024C GEF1 RPL43B DAL5 YNK1 YKL069W LAP4 MRPL31 SAP190 SPO14 DAL80 GAP1 UBI4 YLR020C ADE16 YLR053C HOG1 NHA1 YLR164W YLR257W ECM38 SFP1 ALO1 CLU1 YMR107W YMR110C YMR118C YMR158W MLH1 YMR204C ESBP6 YNL129W CPT1 MEP2 LAP3 URK1 YNR048W YSN1 HXT17 YOL013W-A YOL019W PEX15 ARG1 NDJ1 YOL114C YGK3 YSP3 DFG16 MRPL23 GDH1 YPL034W LEE1 YPL150W YPL216W MEP3 OPT2 137 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f