Input Cluster (n=196) YAL047C SPC72 YBL043W ECM13 YBL055C YBL063W KIP1 YBL064C YBL069W AST1 YBR039W ATP3 YBR068C BAP2 YBR069C TAT1 YBR078W ECM33 YBR083W TEC1 YBR094W YBR105C VID24 YBR106W PHO88 YBR253W SRB6 YCL025C AGP1 YCR015C YCR027C RHB1 YCR061W YCR075C ERS1 YDL031W DBP10 YDL078C MDH3 YDL079C MRK1 YDL110C YDL124W YDL125C HNT1 YDL134C PPH21 YDL214C PRR2 YDL235C YPD1 YDL246C YDR022C CIS1 YDR043C NRG1 YDR046C BAP3 YDR072C IPT1 YDR098C GRX3 YDR123C INO2 YDR132C YDR153C ENT5 YDR158W HOM2 YDR170C SEC7 YDR186C YDR262W YDR272W GLO2 YDR297W SUR2 YDR322W MRPL35 YDR331W GPI8 YDR345C HXT3 YDR384C ATO3 YDR391C YDR392W SPT3 YDR443C SSN2 YDR525W-A SNA2 YEL012W UBC8 YEL034W HYP2 YEL040W UTR2 YEL046C GLY1 YER035W EDC2 YER048W-A YER091C MET6 YER092W IES5 YER137C YER167W BCK2 YFL021W GAT1 YFL030W YFL053W DAK2 YFL054C YFR017C YFR025C HIS2 YGL005C COG7 YGL009C LEU1 YGL035C MIG1 YGL058W RAD6 YGL179C YGL253W HXK2 YGR044C RME1 YGR126W YGR180C RNR4 YGR260W TNA1 YGR287C YHL009C YAP3 YHR015W MIP6 YHR031C RRM3 YHR032W YHR048W YHR049W FSH1 YHR051W COX6 YHR080C YHR081W LRP1 YHR163W SOL3 YHR198C YHR199C YHR200W RPN10 YHR208W BAT1 YIL065C FIS1 YIL149C MLP2 YIR002C MPH1 YIR003W YIR015W RPR2 YIR035C YIR037W HYR1 YJL081C ARP4 YJL105W SET4 YJL106W IME2 YJL153C INO1 YJL213W YJL214W HXT8 YJL216C YJR058C APS2 YJR059W PTK2 YJR159W SOR1 YKL008C LAC1 YKL048C ELM1 YKL051W YKL052C ASK1 YKL062W MSN4 YKL081W TEF4 YKL082C YKL117W SBA1 YKL180W RPL17A YKR041W YKR046C YKR071C DRE2 YKR075C YKR097W PCK1 YKR098C UBP11 YKR099W BAS1 YLR071C RGR1 YLR081W GAL2 YLR154C YLR174W IDP2 YLR193C YLR278C YLR283W YLR304C ACO1 YLR312C YLR312W-A MRPL15 YLR323C CWC24 YLR324W YLR355C ILV5 YLR357W RSC2 YLR377C FBP1 YML063W RPS1B YML064C TEM1 YML088W UFO1 YML120C NDI1 YML126C ERG13 YML127W RSC9 YML128C MSC1 YMR012W CLU1 YMR015C ERG5 YMR018W YMR108W ILV2 YMR121C RPL15B YMR135C DCR1 YMR182C RGM1 YMR251W-A HOR7 YMR303C ADH2 YMR304W UBP15 YNL045W YNL065W AQR1 YNL103W MET4 YNL104C LEU4 YNL137C NAM9 YNL239W LAP3 YNL240C NAR1 YNL241C ZWF1 YNR019W ARE2 YOL052C-A DDR2 YOL126C MDH2 YOR062C YOR064C YNG1 YOR119C RIO1 YOR120W GCY1 YOR138C YOR140W SFL1 YOR226C ISU2 YOR271C YOR292C YOR293W RPS10A YOR321W PMT3 YOR348C PUT4 YOR349W CIN1 YOR363C PIP2 YOR375C GDH1 YPL024W NCE4 YPL026C SKS1 YPL082C MOT1 YPL095C YPL144W YPL149W APG5 YPL222W YPL233W NSL1 YPR030W CSR2 YPR046W MCM16 YPR071W YPR151C Genes Not Found: YJL113W YJL114W YML045W YML100W-A MIPS Functional Classification Category p-value In Category from Cluster k f METABOLISM 1.65069e-08 BAP2 TAT1 PHO88 SRB6 AGP1 MDH3 YDL124W HNT1 PPH21 YDL246C NRG1 BAP3 IPT1 INO2 HOM2 GLO2 SUR2 GPI8 HXT3 ATO3 SSN2 HYP2 GLY1 MET6 GAT1 YFL030W DAK2 HIS2 LEU1 MIG1 HXK2 RNR4 YGR287C BAT1 YIR035C INO1 HXT8 YJL216C SOR1 MSN4 PCK1 BAS1 RGR1 GAL2 IDP2 ACO1 ILV5 FBP1 ERG13 ERG5 ILV2 ADH2 YNL045W MET4 LEU4 ZWF1 ARE2 MDH2 GCY1 ISU2 PMT3 PUT4 PIP2 GDH1 SKS1 65 1066 amino acid metabolism 4.793e-06 BAP2 TAT1 SRB6 AGP1 BAP3 HOM2 GLO2 GLY1 MET6 YFL030W HIS2 LEU1 BAT1 BAS1 ILV5 ILV2 MET4 LEU4 PUT4 GDH1 20 204 C-compound and carbohydrate metabolism 1.13326e-05 SRB6 MDH3 YDL124W PPH21 YDL246C NRG1 HXT3 ATO3 SSN2 DAK2 MIG1 HXK2 YGR287C INO1 HXT8 YJL216C SOR1 MSN4 PCK1 RGR1 GAL2 IDP2 ACO1 FBP1 ADH2 ZWF1 MDH2 GCY1 PMT3 SKS1 30 415 C-compound and carbohydrate utilization 0.000477824 MDH3 YDL124W YDL246C ATO3 DAK2 HXK2 YGR287C INO1 YJL216C SOR1 PCK1 IDP2 ACO1 FBP1 ADH2 ZWF1 MDH2 GCY1 PMT3 19 261 amino acid transport 0.000604152 BAP2 TAT1 AGP1 BAP3 PUT4 5 23 amino-acid transporters 0.000906614 BAP2 TAT1 AGP1 BAP3 PUT4 5 25 amino acid biosynthesis 0.00368502 HOM2 GLY1 MET6 YFL030W HIS2 LEU1 BAT1 ILV5 ILV2 LEU4 10 118 amino acid degradation (catabolism) 0.00430029 GLO2 GLY1 YFL030W BAT1 GDH1 5 35 MIPS Phenotypes Category p-value In Category from Cluster k f other carbohydrate and lipid biosynthesis defects 0.000771049 MDH3 INO2 SEC7 SUR2 GPI8 ERG5 6 36 Methionine auxotrophy (Met) 0.00220143 MET6 MET4 ZWF1 3 9 Carbohydrate and lipid biosynthesis defects 0.00319635 MDH3 INO2 SEC7 SUR2 GPI8 ERG5 6 47 MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Transcription factors 0.001592 TEC1 NRG1 INO2 GAT1 MIG1 RME1 YAP3 MSN4 BAS1 YLR278C RGM1 MET4 SFL1 PIP2 14 182 ELM family 0.00285958 YGL179C ELM1 2 3 Major facilitator superfamily proteins (MFS) 0.00472199 BAP2 TAT1 AGP1 HXT3 TNA1 YHR032W YHR048W HXT8 GAL2 AQR1 PUT4 11 142 GO Molecular Function Category p-value In Category from Cluster k f amino acid transporter [GO:0015171] 4.25543e-05 BAP2 TAT1 AGP1 ERS1 BAP3 PUT4 6 22 oxidoreductase [GO:0016491] 0.000120383 YBL064C MDH3 GRX3 HOM2 SUR2 RNR4 COX6 HYR1 SOR1 IDP2 ILV5 NDI1 ADH2 NAR1 ZWF1 MDH2 GCY1 GDH1 18 215 oxidoreductase, acting on CH-OH group of donors [GO:0016614] 0.00204561 MDH3 SOR1 IDP2 ILV5 ADH2 ZWF1 MDH2 7 58 transcription regulator [GO:0030528] 0.00347411 TEC1 SRB6 NRG1 INO2 SPT3 SSN2 GAT1 MIG1 RME1 YAP3 MSN4 BAS1 RGR1 RGM1 MET4 LAP3 SFL1 PIP2 18 286 GO Biological Process Category p-value In Category from Cluster k f amino acid transport [GO:0006865] 4.21315e-06 BAP2 TAT1 AGP1 RHB1 ERS1 BAP3 PUT4 7 23 branched chain family amino acid biosynthesis [GO:0009082] 1.1272e-05 LEU1 BAT1 ILV5 ILV2 LEU4 5 11 alcohol metabolism [GO:0006066] 1.59548e-05 NRG1 DAK2 MIG1 HXK2 INO1 SOR1 PCK1 GAL2 FBP1 ADH2 ZWF1 MDH2 12 88 hexose metabolism [GO:0019318] 2.14491e-05 NRG1 MIG1 HXK2 INO1 SOR1 PCK1 GAL2 FBP1 ZWF1 MDH2 10 63 branched chain family amino acid metabolism [GO:0009081] 4.52302e-05 LEU1 BAT1 ILV5 ILV2 LEU4 5 14 monosaccharide metabolism [GO:0005996] 4.84686e-05 NRG1 MIG1 HXK2 INO1 SOR1 PCK1 GAL2 FBP1 ZWF1 MDH2 10 69 amino acid biosynthesis [GO:0008652] 9.14177e-05 GLY1 HIS2 LEU1 BAT1 BAS1 IDP2 ACO1 ILV5 ILV2 LEU4 GDH1 11 89 amino acid metabolism [GO:0006520] 0.000109331 HOM2 GLY1 MET6 HIS2 LEU1 BAT1 BAS1 IDP2 ACO1 ILV5 ILV2 MET4 LEU4 GDH1 14 140 amine biosynthesis [GO:0009309] 0.00016594 GLY1 HIS2 LEU1 BAT1 BAS1 IDP2 ACO1 ILV5 ILV2 LEU4 GDH1 11 95 amino acid and derivative metabolism [GO:0006519] 0.000212938 HOM2 GLY1 MET6 HIS2 LEU1 BAT1 BAS1 IDP2 ACO1 ILV5 ILV2 MET4 LEU4 GDH1 14 149 amine metabolism [GO:0009308] 0.000245009 HOM2 GLY1 MET6 HIS2 LEU1 BAT1 BAS1 IDP2 ACO1 ILV5 ILV2 MET4 LEU4 GDH1 14 151 regulation of transcription from Pol II promoter [GO:0006357] 0.000462108 NRG1 INO2 SSN2 MIG1 YAP3 ARP4 RSC9 RGM1 MET4 SFL1 PIP2 SKS1 MOT1 13 142 transcription from Pol II promoter [GO:0006366] 0.000564778 SRB6 NRG1 INO2 SSN2 GAT1 MIG1 YAP3 ARP4 BAS1 RGR1 RSC9 RGM1 MET4 SFL1 PIP2 SKS1 MOT1 17 223 carbohydrate metabolism [GO:0005975] 0.0006092 MDH3 NRG1 GLO2 MIG1 HXK2 INO1 SOR1 PCK1 GAL2 IDP2 ACO1 FBP1 ZWF1 MDH2 14 165 main pathways of carbohydrate metabolism [GO:0006092] 0.0011962 MDH3 PCK1 IDP2 ACO1 FBP1 ZWF1 MDH2 7 53 glucose metabolism [GO:0006006] 0.00227081 NRG1 MIG1 PCK1 FBP1 ZWF1 MDH2 6 44 malate metabolism [GO:0006108] 0.00285958 MDH3 MDH2 2 3 TCA intermediate metabolism [GO:0006100] 0.00365571 MDH3 IDP2 ACO1 MDH2 4 21 GO Cellular Component Category p-value In Category from Cluster k f SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00324 (aa_permeases) 0.000485007 BAP2 TAT1 AGP1 BAP3 PUT4 5 22 PF00056 (ldh) 0.00285958 MDH3 MDH2 2 3 PF00107 (adh_zinc) 0.00365571 AST1 YDL246C SOR1 ADH2 4 21 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YDL246C 0.000973286 YDL246C SOR1 2 2 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YBR055C (PRP6) 0.000499629 MDH3 YDL124W HOM2 HYP2 BAT1 CLU1 GCY1 7 46 YOR043W (WHI2) 0.000973286 HYP2 CSR2 2 2 YNL128W (TEP1) 0.00285958 MLP2 ILV2 2 3 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f cell periphery 0.00361035 AST1 BAP2 ECM33 YCR061W YDL124W TNA1 MPH1 7 64 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f