Input Cluster (n=198) YAL002W VPS8 YBL043W ECM13 YBL069W AST1 YBL072C RPS8A YBL101C ECM21 YBR017C KAP104 YBR021W FUR4 YBR034C HMT1 YBR067C TIP1 YBR083W TEC1 YBR087W RFC5 YBR115C LYS2 YBR158W CST13 YBR196C PGI1 YBR203W YBR240C THI2 YBR291C CTP1 YBR297W MAL33 YCL038C AUT4 YCL073C YCR024C-A PMP1 YDL082W RPL13A YDL128W VCX1 YDL182W LYS20 YDL186W YDL188C PPH22 YDR034C LYS14 YDR041W RSM10 YDR043C NRG1 YDR091C RLI1 YDR139C RUB1 YDR214W AHA1 YDR222W YDR223W YDR233C RTN1 YDR277C MTH1 YDR292C SRP101 YDR293C SSD1 YDR295C PLO2 YDR296W MHR1 YDR298C ATP5 YDR342C HXT7 YDR345C HXT3 YDR399W HPT1 YDR499W LCD1 YDR524C AGE1 YDR525W-A SNA2 YEL012W UBC8 YEL017C-A PMP2 YEL017W YEL029C BUD16 YEL032W MCM3 YEL040W UTR2 YER028C YER059W PCL6 YER077C YER130C YER159C BUR6 YFL053W DAK2 YFL054C YFR005C SAD1 YFR055W YGL045W YGL157W YGL158W RCK1 YGL253W HXK2 YGR033C YGR086C YGR126W YGR189C CRH1 YGR191W HIP1 YGR194C XKS1 YGR240C PFK1 YGR250C YGR264C MES1 YGR278W CWC22 YGR281W YOR1 YHL008C YHL024W RIM4 YHR015W MIP6 YHR044C DOG1 YHR045W YHR048W YHR092C HXT4 YHR094C HXT1 YHR178W STB5 YHR179W OYE2 YHR200W RPN10 YIL030C SSM4 YIL090W YIL094C LYS12 YIL096C YIL108W YIL112W YIL119C RPI1 YIL172C YIR034C LYS1 YJL016W YJL044C GYP6 YJL112W MDV1 YJL163C YJL214W HXT8 YJL216C YJL219W HXT9 YJL221C FSP2 YJR047C ANB1 YJR048W CYC1 YJR137C ECM17 YJR153W PGU1 YKL051W YKL052C ASK1 YKL180W RPL17A YKL182W FAS1 YKL187C YKL197C PEX1 YKL198C PTK1 YKL201C MNN4 YKL205W LOS1 YKR038C KAE1 YKR041W YKR075C YLL027W ISA1 YLL028W TPO1 YLR027C AAT2 YLR044C PDC1 YLR074C BUD20 YLR075W RPL10 YLR110C CCW12 YLR121C YPS3 YLR179C YLR180W SAM1 YLR190W YLR224W YLR254C YLR259C HSP60 YLR325C RPL38 YLR326W YLR328W NMA1 YLR344W RPL26A YLR372W SUR4 YLR413W YLR431C YLR432W IMD3 YLR454W YML055W SPC2 YML056C IMD4 YML058W SML1 YML106W URA5 YML107C YMR008C PLB1 YMR011W HXT2 YMR015C ERG5 YMR017W SPO20 YMR028W TAP42 YMR036C MIH1 YMR052W FAR3 YMR110C YMR136W GAT2 YMR182C RGM1 YMR205C PFK2 YMR284W YKU70 YMR291W YMR296C LCB1 YMR325W YNL018C YNL034W YNL112W DBP2 YNL142W MEP2 YNL183C NPR1 YNL234W YNR019W ARE2 YNR030W ECM39 YNR050C LYS9 YNR070W PDR18 YOL011W PLB3 YOL014W YOL053W YOL059W GPD2 YOL136C PFK27 YOL151W GRE2 YOR047C STD1 YOR065W CYT1 YOR162C YRR1 YOR267C HRK1 YOR301W RAX1 YOR349W CIN1 YOR355W GDS1 YOR370C MRS6 YOR388C FDH1 YPL024W NCE4 YPL026C SKS1 YPL058C PDR12 YPL068C YPL144W YPL222W YPR030W CSR2 YPR149W NCE102 YPR164W MMS1 Genes Not Found: YHR214C-B YML045W MIPS Functional Classification Category p-value In Category from Cluster k f METABOLISM 9.3589e-06 FUR4 TIP1 LYS2 PGI1 CTP1 MAL33 LYS20 PPH22 LYS14 NRG1 MTH1 HXT7 HXT3 HPT1 DAK2 YFR055W YGL157W HXK2 HIP1 XKS1 PFK1 DOG1 HXT4 HXT1 LYS12 RPI1 YIL172C LYS1 HXT8 YJL216C HXT9 FSP2 ECM17 PGU1 FAS1 AAT2 PDC1 SAM1 SUR4 IMD3 IMD4 SML1 URA5 PLB1 HXT2 ERG5 PFK2 LCB1 NPR1 ARE2 LYS9 PLB3 GPD2 PFK27 GRE2 STD1 MRS6 SKS1 58 1066 TRANSPORT FACILITATION 1.38213e-05 FUR4 CTP1 AUT4 YCL073C PMP1 VCX1 RLI1 ATP5 HXT7 HXT3 PMP2 YFL054C HIP1 YOR1 YHR048W HXT4 HXT1 HXT8 HXT9 ISA1 TPO1 HXT2 MEP2 PDR18 PDR12 25 312 C-compound and carbohydrate metabolism 1.39129e-05 PGI1 CTP1 MAL33 LYS20 PPH22 NRG1 MTH1 HXT7 HXT3 DAK2 HXK2 XKS1 PFK1 DOG1 HXT4 HXT1 RPI1 YIL172C HXT8 YJL216C HXT9 FSP2 PGU1 PDC1 HXT2 PFK2 GPD2 PFK27 STD1 SKS1 30 415 C-compound, carbohydrate transport 4.03801e-05 CTP1 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 8 42 plasma membrane 0.000177571 FUR4 PMP1 HXT7 HXT3 PMP2 HIP1 YOR1 HXT4 HXT1 HXT8 HXT9 PLB1 HXT2 MEP2 14 145 C-compound and carbohydrate transporters 0.000531136 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 7 46 cellular import 0.00114992 FUR4 HXT7 HXT3 HIP1 HXT4 HXT1 HXT8 HXT9 HXT2 MEP2 10 100 regulation of C-compound and carbohydrate utilization 0.001356 MAL33 PPH22 NRG1 MTH1 HXK2 PFK1 RPI1 PFK2 PFK27 STD1 SKS1 11 120 transport mechanism 0.00199052 PMP1 RLI1 ATP5 PMP2 YOR1 ISA1 PDR18 PDR12 8 73 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 3.66799e-05 FUR4 PMP1 HXT7 HXT3 PMP2 HIP1 YOR1 HXT4 HXT1 HXT8 HXT9 YPS3 PLB1 HXT2 MEP2 PLB3 16 159 MIPS Protein Complexes Category p-value In Category from Cluster k f Phosphofructokinase 0.000993302 PFK1 PFK2 2 2 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.000142015 FUR4 AUT4 YCL073C HXT7 HXT3 HIP1 YHR048W HXT4 HXT1 HXT8 HXT9 TPO1 HXT2 MEP2 14 142 NPR/HAL5 family 0.00316301 PTK1 NPR1 HRK1 3 10 GO Molecular Function Category p-value In Category from Cluster k f mannose transporter [GO:0015578] 1.46809e-07 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 7 15 glucose transporter [GO:0005355] 4.20374e-07 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 7 17 monosaccharide transporter [GO:0015145] 1.03195e-06 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 7 19 hexose transporter [GO:0015149] 1.03195e-06 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 7 19 fructose transporter [GO:0005353] 2.24189e-06 HXT7 HXT3 HXT4 HXT8 HXT9 HXT2 6 14 carbohydrate transporter [GO:0015144] 1.90312e-05 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 7 28 carbohydrate kinase [GO:0019200] 6.94218e-05 HXK2 XKS1 PFK1 PFK2 PFK27 5 15 phosphofructokinase [GO:0008443] 0.000296423 PFK1 PFK2 PFK27 3 5 alpha-glucosidase [GO:0004558] 0.000989774 YIL172C YJL216C FSP2 3 7 6-phosphofructokinase [GO:0003872] 0.000993302 PFK1 PFK2 2 2 saccharopine dehydrogenase [GO:0004753] 0.000993302 LYS1 LYS9 2 2 lysophospholipase [GO:0004622] 0.00291776 PLB1 PLB3 2 3 transporter [GO:0005215] 0.00312226 AST1 FUR4 CTP1 YCL073C VCX1 ATP5 HXT7 HXT3 HIP1 YOR1 HXT4 HXT1 OYE2 HXT8 HXT9 CYC1 ECM17 HXT2 SPO20 MEP2 CYT1 PDR12 22 372 lipase [GO:0016298] 0.00424866 TIP1 PLB1 PLB3 3 11 electron transporter [GO:0005489] 0.00452147 OYE2 CYC1 ECM17 CYT1 4 22 GO Biological Process Category p-value In Category from Cluster k f hexose transport [GO:0008645] 9.12224e-09 MTH1 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 SKS1 9 22 monosaccharide transport [GO:0015749] 9.12224e-09 MTH1 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 SKS1 9 22 lysine biosynthesis [GO:0009085] 7.1623e-08 LYS2 LYS20 LYS14 LYS12 LYS1 LYS9 6 9 lysine metabolism [GO:0006553] 7.1623e-08 LYS2 LYS20 LYS14 LYS12 LYS1 LYS9 6 9 carbohydrate transport [GO:0008643] 2.10584e-07 MTH1 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 SKS1 9 30 lysine biosynthesis, aminoadipic pathway [GO:0019878] 1.55213e-06 LYS2 LYS20 LYS14 LYS1 LYS9 5 8 aspartate family amino acid biosynthesis [GO:0009067] 5.66934e-06 LYS2 LYS20 LYS14 LYS12 LYS1 LYS9 6 16 alcohol metabolism [GO:0006066] 1.76773e-05 PGI1 NRG1 DAK2 HXK2 XKS1 PFK1 DOG1 PDC1 PFK2 GPD2 PFK27 STD1 12 88 aspartate family amino acid metabolism [GO:0009066] 3.3588e-05 LYS2 LYS20 LYS14 LYS12 LYS1 AAT2 SAM1 LYS9 8 41 monosaccharide metabolism [GO:0005996] 0.000286862 PGI1 NRG1 HXK2 XKS1 PFK1 DOG1 PFK2 PFK27 STD1 9 69 carbohydrate catabolism [GO:0016052] 0.000695827 PGI1 PCL6 XKS1 PFK1 PGU1 PFK2 6 35 hexose metabolism [GO:0019318] 0.000750695 PGI1 NRG1 HXK2 PFK1 DOG1 PFK2 PFK27 STD1 8 63 transport [GO:0006810] 0.000967433 VPS8 AST1 KAP104 FUR4 HMT1 CTP1 AUT4 YCL073C PMP1 VCX1 MTH1 SRP101 ATP5 HXT7 HXT3 AGE1 PMP2 HIP1 YOR1 MIP6 HXT4 HXT1 GYP6 HXT8 HXT9 PTK1 LOS1 ISA1 HSP60 SUR4 HXT2 SPO20 MEP2 YRR1 MRS6 SKS1 PDR12 37 698 alcohol catabolism [GO:0046164] 0.00114541 PGI1 DAK2 XKS1 PFK1 PFK2 5 26 glucose metabolism [GO:0006006] 0.0023902 PGI1 NRG1 PFK1 DOG1 PFK2 STD1 6 44 GO Cellular Component Category p-value In Category from Cluster k f plasma membrane [GO:0005886] 0.000467142 FUR4 HXT7 HXT3 HIP1 YOR1 HXT4 HXT1 HXT8 HXT9 YPS3 HXT2 MEP2 PLB3 STD1 PDR12 15 178 6-phosphofructokinase complex [GO:0005945] 0.000993302 PFK1 PFK2 2 2 SMART Domains Category p-value In Category from Cluster k f Aamy 0.00226655 YIL172C YJL216C FSP2 3 9 PFam-A Domains Category p-value In Category from Cluster k f PF00083 (sugar_tr) 3.47218e-05 HXT7 HXT3 YHR048W HXT4 HXT1 HXT8 HXT9 TPO1 HXT2 9 53 PF00365 (PFK) 0.000993302 PFK1 PFK2 2 2 PF00128 (alpha-amylase) 0.00154688 YIL172C YJL216C FSP2 3 8 PF00722 (Glyco_hydro_16) 0.00291776 UTR2 CRH1 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YLR305C (STT4) 0.000993302 STD1 GDS1 2 2 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YPR174C 0.00291776 YEL017W RPI1 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YOL100W (PKH2) 0.000296423 HXT7 YGR033C YGR086C 3 5 YER173W (RAD24) 0.00316301 RFC5 AHA1 YLR413W 3 10 Cellzome Complexes Category p-value In Category from Cluster k f YIL038C (NOT3) 0.000989774 AHA1 PDC1 SAM1 3 7 YMR205C (PFK2) 0.000993302 PFK1 PFK2 2 2 YDR062W (LCB2) 0.0010033 KAP104 LYS12 SAM1 LCB1 4 15 YBL039C (URA7) 0.00166466 RPN10 LYS12 SAM1 FDH1 4 17 Proteome Localization--Observed Category p-value In Category from Cluster k f cyto 0.00130309 RPS8A ECM21 LYS2 PGI1 YBR203W PMP1 RPL13A PPH22 YDR222W SSD1 MHR1 HPT1 AGE1 UBC8 BUD16 MCM3 DAK2 YGL157W YGR086C PFK1 MES1 RIM4 OYE2 RPN10 YIL108W YIL112W RPI1 LYS1 YJL016W ECM17 YKL051W RPL17A FAS1 KAE1 YKR075C TPO1 PDC1 RPL10 YLR179C SAM1 YLR190W YLR224W NMA1 RPL26A YLR431C IMD3 SML1 URA5 MIH1 PFK2 YMR291W YNL018C NPR1 YNL234W LYS9 PFK27 YRR1 MRS6 YPL222W CSR2 60 1324 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.000231423 VPS8 ECM13 AST1 RPS8A KAP104 FUR4 RFC5 LYS2 PGI1 YBR203W THI2 CTP1 AUT4 RPL13A VCX1 LYS20 YDL186W PPH22 RLI1 RUB1 AHA1 YDR222W RTN1 SRP101 SSD1 MHR1 HXT7 HXT3 HPT1 AGE1 UBC8 YEL017W BUD16 UTR2 YER028C PCL6 DAK2 YFL054C YFR055W YGL045W YGL157W RCK1 HXK2 YGR033C YGR086C YGR126W HIP1 XKS1 PFK1 MES1 YOR1 YHL008C RIM4 DOG1 YHR048W HXT4 HXT1 STB5 OYE2 RPN10 SSM4 YIL108W YIL112W RPI1 LYS1 YJL016W GYP6 YJL163C HXT8 YJL216C HXT9 FSP2 ANB1 CYC1 ECM17 RPL17A FAS1 PEX1 KAE1 YKR075C TPO1 AAT2 PDC1 RPL10 YLR179C SAM1 YLR190W YLR224W YLR254C RPL38 NMA1 RPL26A SUR4 YLR431C IMD3 IMD4 SML1 URA5 HXT2 MIH1 FAR3 YMR110C PFK2 YMR291W YNL018C YNL034W MEP2 NPR1 YNL234W ARE2 LYS9 PDR18 PFK27 GRE2 YRR1 HRK1 RAX1 CIN1 MRS6 FDH1 SKS1 PDR12 YPL222W CSR2 NCE102 MMS1 126 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.00089971 VPS8 ECM13 AST1 RPS8A ECM21 HMT1 TIP1 TEC1 YBR203W THI2 MAL33 AUT4 PMP1 VCX1 LYS20 YDL186W PPH22 LYS14 NRG1 RUB1 AHA1 YDR222W YDR223W RTN1 MTH1 PLO2 HXT3 HPT1 SNA2 UBC8 PMP2 YEL017W UTR2 YER028C YER077C DAK2 YFL054C YFR055W YGL045W HXK2 YGR033C YGR086C YGR126W CRH1 XKS1 PFK1 YGR250C YOR1 YHL008C RIM4 MIP6 DOG1 YHR045W YHR048W HXT4 HXT1 STB5 OYE2 SSM4 YIL090W LYS12 YIL096C YIL108W YIL112W RPI1 LYS1 YJL016W GYP6 MDV1 YJL163C HXT8 YJL216C ANB1 CYC1 PGU1 YKL051W YKL187C PEX1 PTK1 MNN4 LOS1 YKR041W YKR075C ISA1 TPO1 AAT2 YPS3 YLR179C SAM1 YLR190W YLR224W YLR254C RPL38 YLR326W NMA1 RPL26A YLR413W YLR431C IMD3 YLR454W SPC2 IMD4 SML1 URA5 YML107C PLB1 HXT2 ERG5 SPO20 YMR110C GAT2 RGM1 PFK2 YKU70 YMR291W YNL034W MEP2 NPR1 ARE2 ECM39 LYS9 PDR18 YOL014W YOL053W GPD2 PFK27 GRE2 STD1 YRR1 HRK1 RAX1 SKS1 PDR12 YPL068C YPL144W YPL222W CSR2 NCE102 138 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f