Input Cluster (n=200) YAL040C CLN3 YAR018C KIN3 YAR042W SWH1 YBL003C HTA2 YBL093C ROX3 YBR009C HHF1 YBR010W HHT1 YBR067C TIP1 YBR069C TAT1 YBR158W CST13 YCL024W KCC4 YCL040W GLK1 YCL049C YCR024C-A PMP1 YCR065W HCM1 YCR091W KIN82 YDL020C RPN4 YDL128W VCX1 YDL156W YDL200C MGT1 YDL248W COS7 YDR033W MRH1 YDR034W-B YDR054C CDC34 YDR085C AFR1 YDR146C SWI5 YDR147W EKI1 YDR368W YPR1 YDR399W HPT1 YDR403W DIT1 YDR429C TIF35 YDR451C YHP1 YDR452W PPN1 YDR461W MFA1 YDR494W RSM28 YDR525W-A SNA2 YDR536W STL1 YEL032W MCM3 YEL040W UTR2 YEL049W PAU2 YEL075C YER001W MNN1 YER011W TIR1 YER033C ZRG8 YER149C PEA2 YER150W SPI1 YER159C BUR6 YFL014W HSP12 YFL020C PAU5 YFL026W STE2 YFL027C GYP8 YFR022W YGL039W YGL089C MF(ALPHA)2 YGL201C MCM6 YGR014W MSB2 YGR047C TFC4 YGR048W UFD1 YGR078C PAC10 YGR086C YGR180C RNR4 YGR189C CRH1 YGR192C TDH3 YGR279C SCW4 YGR296W YRF1-3 YHL019C APM2 YHL025W SNF6 YHL028W WSC4 YHL029C YHL048W COS8 YHR005C-A MRS11 YHR022C YHR049W FSH1 YHR082C KSP1 YHR087W YHR139C SPS100 YHR144C DCD1 YHR149C YHR150W YHR151C YHR152W SPO12 YHR179W OYE2 YHR215W PHO12 YIL005W EPS1 YIL106W MOB1 YIL113W SDP1 YIL114C POR2 YIL119C RPI1 YIL122W POG1 YIL123W SIM1 YIL128W MET18 YIL129C TAO3 YIL158W YIR019C MUC1 YJL006C CTK2 YJL016W YJL084C YJL106W IME2 YJL159W HSP150 YJR004C SAG1 YJR040W GEF1 YJR135C MCM22 YKL035W UGP1 YKL163W PIR3 YKL185W ASH1 YKL209C STE6 YKL216W URA1 YKR038C KAE1 YKR042W UTH1 YLL006W MMM1 YLL039C UBI4 YLR019W PSR2 YLR020C YLR035C MLH2 YLR040C YLR084C RAX2 YLR179C YLR180W SAM1 YLR189C UGT51 YLR190W YLR201C YLR219W MSC3 YLR258W GSY2 YLR304C ACO1 YLR328W NMA1 YLR418C CDC73 YML007W YAP1 YML027W YOX1 YML053C YML058W SML1 YML078W CPR3 YML109W ZDS2 YML110C COQ5 YMR005W TAF4 YMR031C YMR032W HOF1 YMR084W YMR135C DCR1 YMR149W SWP1 YMR180C CTL1 YMR251W-A HOR7 YMR255W GFD1 YMR305C SCW10 YNL021W HDA1 YNL042W BOP3 YNL160W YGP1 YNL289W PCL1 YNL298W CLA4 YNL327W EGT2 YNL328C MDJ2 YNL336W COS1 YNL339C YRF1-6 YNR028W CPR8 YNR067C DSE4 YOL011W PLB3 YOL081W IRA2 YOL129W VPS68 YOL136C PFK27 YOL155C YOR009W TIR4 YOR043W WHI2 YOR066W YOR086C YOR094W ARF3 YOR101W RAS1 YOR126C IAH1 YOR127W RGA1 YOR212W STE4 YOR229W WTM2 YOR230W WTM1 YOR246C YOR247W SRL1 YOR269W PAC1 YOR274W MOD5 YOR304C-A YOR308C SNU66 YOR349W CIN1 YOR355W GDS1 YPL014W YPL015C HST2 YPL021W ECM23 YPL056C YPL097W MSY1 YPL154C PEP4 YPL183W-A YPL184C YPL187W MF(ALPHA)1 YPL221W BOP1 YPL223C GRE1 YPL255W BBP1 YPL271W ATP15 YPL283C YRF1-7 YPR026W ATH1 YPR035W GLN1 YPR078C YPR119W CLB2 YPR138C MEP3 YPR156C TPO3 YPR163C TIF3 YPR164W MMS1 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f stress response 5.83285e-07 CLN3 ROX3 TIP1 MRH1 PAU2 TIR1 HSP12 PAU5 WSC4 HSP150 PIR3 UTH1 UBI4 YAP1 HOR7 YGP1 MDJ2 TIR4 GRE1 ATH1 20 175 extracellular / secretion proteins 1.65367e-06 MFA1 MF(ALPHA)2 PHO12 MUC1 HSP150 YGP1 MF(ALPHA)1 7 20 CELL RESCUE, DEFENSE AND VIRULENCE 2.21244e-05 CLN3 ROX3 TIP1 MRH1 PAU2 TIR1 HSP12 PAU5 YFR022W WSC4 HSP150 PIR3 UTH1 UBI4 YAP1 HOR7 YGP1 MDJ2 TIR4 SRL1 GRE1 ATH1 TPO3 23 278 CELL FATE 2.9517e-05 CLN3 AFR1 SWI5 DIT1 MFA1 PEA2 STE2 MF(ALPHA)2 MSB2 SNF6 SPS100 SPO12 SIM1 IME2 HSP150 SAG1 ASH1 STE6 UTH1 UBI4 ZDS2 EGT2 WHI2 RAS1 RGA1 STE4 YOR304C-A MF(ALPHA)1 BBP1 CLB2 30 427 cell wall 0.000165134 TIP1 TIR1 CRH1 SPS100 MUC1 HSP150 PIR3 7 38 fungal cell differentiation 0.00043572 CLN3 AFR1 SWI5 DIT1 MFA1 PEA2 STE2 MF(ALPHA)2 MSB2 SNF6 SPS100 SPO12 IME2 HSP150 SAG1 ASH1 STE6 UBI4 ZDS2 RGA1 STE4 YOR304C-A MF(ALPHA)1 BBP1 CLB2 25 382 cell differentiation 0.00043572 CLN3 AFR1 SWI5 DIT1 MFA1 PEA2 STE2 MF(ALPHA)2 MSB2 SNF6 SPS100 SPO12 IME2 HSP150 SAG1 ASH1 STE6 UBI4 ZDS2 RGA1 STE4 YOR304C-A MF(ALPHA)1 BBP1 CLB2 25 382 pheromone response, mating-type determination, sex-specific proteins 0.00170709 AFR1 SWI5 MFA1 PEA2 STE2 MF(ALPHA)2 SNF6 SAG1 ASH1 STE6 RGA1 STE4 MF(ALPHA)1 13 160 plasma membrane 0.00218848 TAT1 PMP1 MRH1 STL1 STE2 MSB2 APM2 SAG1 GEF1 STE6 IRA2 STE4 12 145 MIPS Phenotypes Category p-value In Category from Cluster k f other mating and sporulation defects 0.001505 AFR1 PEA2 PAC10 SPS100 UBI4 CDC73 STE4 7 54 MIPS Subcellular Localization Category p-value In Category from Cluster k f cell wall 2.48165e-07 TIP1 UTR2 TIR1 CRH1 SCW4 SPS100 MUC1 HSP150 PIR3 SCW10 10 39 extracellular 1.10457e-06 MFA1 MF(ALPHA)2 PHO12 MUC1 HSP150 YGP1 MF(ALPHA)1 7 19 plasma membrane 0.000513432 TAT1 PMP1 MRH1 STL1 STE2 MSB2 APM2 SAG1 GEF1 STE6 PLB3 IRA2 RAS1 STE4 14 159 MIPS Protein Complexes Category p-value In Category from Cluster k f Nucleosomal protein complex 0.00159254 HTA2 HHF1 HHT1 3 8 MIPS Protein Classes Category p-value In Category from Cluster k f Histones 0.00437089 HTA2 HHF1 HHT1 3 11 Cyclins 0.00468663 CLN3 CTK2 PCL1 CLB2 4 22 GO Molecular Function Category p-value In Category from Cluster k f pheromone [GO:0005186] 0.000125104 MFA1 MF(ALPHA)2 MF(ALPHA)1 3 4 receptor binding [GO:0005102] 0.000125104 MFA1 MF(ALPHA)2 MF(ALPHA)1 3 4 structural constituent of cell wall [GO:0005199] 0.000278515 TIP1 TIR1 HSP150 PIR3 4 11 signal transducer [GO:0004871] 0.000563408 COS7 AFR1 MFA1 STE2 MF(ALPHA)2 RPI1 MUC1 SAG1 IRA2 RGA1 MF(ALPHA)1 11 107 anion channel [GO:0005253] 0.0029765 POR2 GEF1 2 3 phosphotransferase, alcohol group as acceptor [GO:0016773] 0.00434988 CLN3 KIN3 KCC4 GLK1 KIN82 EKI1 KSP1 CTK2 IME2 PCL1 CLA4 PFK27 CLB2 13 178 GO Biological Process Category p-value In Category from Cluster k f development [GO:0007275] 6.11773e-05 AFR1 MFA1 STE2 MF(ALPHA)2 SCW4 TAO3 MUC1 SAG1 ASH1 STE6 ZDS2 SCW10 HDA1 WHI2 RGA1 STE4 ECM23 MF(ALPHA)1 18 200 pheromone response (sensu Saccharomyces) [GO:0007328] 7.8446e-05 AFR1 MFA1 STE2 MF(ALPHA)2 RGA1 STE4 MF(ALPHA)1 7 34 pheromone response (sensu Fungi) [GO:0030434] 7.8446e-05 AFR1 MFA1 STE2 MF(ALPHA)2 RGA1 STE4 MF(ALPHA)1 7 34 pheromone response [GO:0019236] 0.000100812 AFR1 MFA1 STE2 MF(ALPHA)2 STE6 RGA1 STE4 MF(ALPHA)1 8 47 perception of chemical substance [GO:0009593] 0.00015855 AFR1 MFA1 STE2 MF(ALPHA)2 STE6 RGA1 STE4 MF(ALPHA)1 8 50 perception of abiotic stimulus [GO:0009582] 0.00015855 AFR1 MFA1 STE2 MF(ALPHA)2 STE6 RGA1 STE4 MF(ALPHA)1 8 50 perception of external stimulus [GO:0009581] 0.00015855 AFR1 MFA1 STE2 MF(ALPHA)2 STE6 RGA1 STE4 MF(ALPHA)1 8 50 chemosensory perception [GO:0007606] 0.00015855 AFR1 MFA1 STE2 MF(ALPHA)2 STE6 RGA1 STE4 MF(ALPHA)1 8 50 sensory perception [GO:0007600] 0.00015855 AFR1 MFA1 STE2 MF(ALPHA)2 STE6 RGA1 STE4 MF(ALPHA)1 8 50 mating (sensu Saccharomyces) [GO:0007322] 0.000372292 AFR1 MFA1 STE2 MF(ALPHA)2 SCW4 SAG1 STE6 SCW10 RGA1 STE4 MF(ALPHA)1 11 102 reproduction [GO:0000003] 0.000405365 AFR1 MFA1 STE2 MF(ALPHA)2 SCW4 SAG1 STE6 SCW10 RGA1 STE4 MF(ALPHA)1 11 103 mating (sensu Fungi) [GO:0030461] 0.000405365 AFR1 MFA1 STE2 MF(ALPHA)2 SCW4 SAG1 STE6 SCW10 RGA1 STE4 MF(ALPHA)1 11 103 cell-cell fusion [GO:0006947] 0.00044087 AFR1 MFA1 STE2 MF(ALPHA)2 SCW4 SAG1 STE6 SCW10 RGA1 STE4 MF(ALPHA)1 11 104 small GTPase mediated signal transduction [GO:0007264] 0.001505 PEA2 WSC4 RPI1 CLA4 IRA2 RAS1 RGA1 7 54 cell communication [GO:0007154] 0.00153571 AFR1 MFA1 PEA2 HSP12 STE2 MF(ALPHA)2 WSC4 COS8 SDP1 RPI1 MUC1 SAG1 STE6 YAP1 SML1 CLA4 IRA2 RAS1 RGA1 STE4 PEP4 MF(ALPHA)1 22 348 regulation of meiosis [GO:0040020] 0.00267631 YHP1 IME2 WTM2 WTM1 4 19 cell growth and/or maintenance [GO:0008151] 0.00277865 CLN3 HTA2 ROX3 HHF1 HHT1 TIP1 TAT1 KCC4 GLK1 PMP1 HCM1 RPN4 VCX1 MGT1 CDC34 AFR1 SWI5 EKI1 YPR1 HPT1 DIT1 TIF35 YHP1 PPN1 MFA1 STL1 MCM3 UTR2 MNN1 TIR1 PEA2 BUR6 HSP12 STE2 MF(ALPHA)2 MCM6 MSB2 TFC4 UFD1 PAC10 RNR4 TDH3 SCW4 APM2 SNF6 WSC4 COS8 MRS11 KSP1 SPS100 DCD1 SPO12 EPS1 MOB1 SDP1 POR2 RPI1 POG1 SIM1 MET18 TAO3 MUC1 CTK2 IME2 HSP150 SAG1 GEF1 MCM22 UGP1 PIR3 ASH1 STE6 URA1 UTH1 MMM1 UBI4 PSR2 MLH2 RAX2 SAM1 UGT51 MSC3 GSY2 ACO1 NMA1 CDC73 YAP1 SML1 CPR3 ZDS2 COQ5 TAF4 HOF1 SWP1 CTL1 HOR7 GFD1 SCW10 HDA1 YGP1 PCL1 CLA4 EGT2 MDJ2 DSE4 PLB3 VPS68 PFK27 WHI2 ARF3 RAS1 IAH1 RGA1 STE4 WTM2 WTM1 SRL1 PAC1 MOD5 SNU66 CIN1 GDS1 HST2 ECM23 PEP4 YPL183W-A MF(ALPHA)1 BBP1 ATP15 ATH1 GLN1 YPR078C CLB2 MEP3 TIF3 MMS1 136 3657 transduction of mating signal (sensu Fungi) [GO:0030454] 0.00393128 AFR1 MFA1 RGA1 STE4 4 21 signal transduction of mating signal (sensu Saccharomyces) [GO:0007330] 0.00393128 AFR1 MFA1 RGA1 STE4 4 21 signal transduction [GO:0007165] 0.00418856 AFR1 MFA1 PEA2 WSC4 SDP1 RPI1 CLA4 IRA2 RAS1 RGA1 STE4 11 137 cell adhesion [GO:0007155] 0.00437089 HSP12 MUC1 SAG1 3 11 cell cycle [GO:0007049] 0.00499994 CLN3 KCC4 HCM1 CDC34 SWI5 YHP1 MCM3 MCM6 RNR4 SPO12 MOB1 POG1 SIM1 IME2 MCM22 MSC3 HOF1 PCL1 CLA4 EGT2 DSE4 WTM2 WTM1 PAC1 YPR078C CLB2 MMS1 27 504 GO Cellular Component Category p-value In Category from Cluster k f external protective structure [GO:0030312] 4.74381e-11 TIP1 UTR2 TIR1 SPI1 CRH1 SCW4 SPS100 SIM1 HSP150 SAG1 PIR3 UTH1 YLR040C RAX2 HOR7 SCW10 YGP1 EGT2 TIR4 19 92 cell wall [GO:0005618] 4.74381e-11 TIP1 UTR2 TIR1 SPI1 CRH1 SCW4 SPS100 SIM1 HSP150 SAG1 PIR3 UTH1 YLR040C RAX2 HOR7 SCW10 YGP1 EGT2 TIR4 19 92 extracellular [GO:0005576] 7.29385e-10 TIP1 MFA1 UTR2 MF(ALPHA)2 SCW4 SPS100 SAG1 YLR040C RAX2 HOR7 SCW10 YGP1 EGT2 DSE4 PLB3 TIR4 MF(ALPHA)1 17 84 cell wall (sensu Fungi) [GO:0009277] 2.66684e-06 TIP1 UTR2 SCW4 SPS100 SAG1 YLR040C RAX2 HOR7 SCW10 YGP1 EGT2 TIR4 12 73 SMART Domains Category p-value In Category from Cluster k f CYCLIN 0.00216637 CLN3 CTK2 PCL1 CLB2 4 18 PFam-A Domains Category p-value In Category from Cluster k f PF00134 (cyclin) 0.00135467 CLN3 CTK2 PCL1 CLB2 4 16 PF00399 (yeast_PIR) 0.00233288 TIR1 HSP150 PIR3 3 9 PF00660 (SRP1_TIP1) 0.00234057 TIP1 PAU2 TIR1 PAU5 TIR4 5 30 PF00722 (Glyco_hydro_16) 0.0029765 UTR2 CRH1 2 3 PF00125 (histone) 0.00325479 HTA2 HHF1 HHT1 3 10 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YER059W (PCL6) 0.00101352 YJL084C YLR190W 2 2 YBR274W (CHK1) 0.00101352 GSY2 GFD1 2 2 YLR438W (CAR2) 0.0029765 SNF6 NMA1 2 3 YGL254W (FZF1) 0.0029765 TFC4 PHO12 2 3 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f en2 1.01688e-05 TIP1 COS7 MRH1 MFA1 PAU2 MNN1 TIR1 PAU5 MF(ALPHA)2 MSB2 CRH1 SCW4 WSC4 COS8 SPS100 YHR149C YHR151C PHO12 EPS1 SIM1 YIL158W MUC1 HSP150 SAG1 PIR3 STE6 YLR020C RAX2 SWP1 SCW10 YGP1 CLA4 EGT2 COS1 CPR8 DSE4 PLB3 VPS68 TIR4 RAS1 PEP4 MF(ALPHA)1 BOP1 43 692 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.00274784 KIN3 SWH1 HHF1 HHT1 TIP1 KCC4 GLK1 YCL049C PMP1 KIN82 VCX1 YDL156W MGT1 MRH1 AFR1 EKI1 YPR1 HPT1 DIT1 MFA1 SNA2 STL1 UTR2 PAU2 MNN1 TIR1 ZRG8 HSP12 GYP8 YFR022W YGL039W MF(ALPHA)2 MSB2 YGR086C CRH1 TDH3 SCW4 APM2 WSC4 YHL029C YHR022C FSH1 KSP1 YHR087W SPS100 YHR150W SPO12 OYE2 SDP1 POR2 RPI1 SIM1 MET18 MUC1 CTK2 YJL016W YJL084C IME2 HSP150 SAG1 GEF1 MCM22 PIR3 ASH1 URA1 UTH1 UBI4 PSR2 YLR020C MLH2 YLR040C RAX2 YLR179C SAM1 UGT51 YLR190W YLR201C MSC3 GSY2 ACO1 NMA1 CDC73 YAP1 YOX1 YML053C SML1 CPR3 ZDS2 COQ5 HOF1 YMR084W DCR1 CTL1 HOR7 GFD1 SCW10 YGP1 PCL1 EGT2 MDJ2 COS1 YRF1-6 CPR8 DSE4 IRA2 VPS68 PFK27 YOL155C TIR4 YOR066W YOR086C ARF3 RAS1 IAH1 RGA1 WTM2 WTM1 YOR246C SRL1 PAC1 YOR304C-A SNU66 YPL014W HST2 ECM23 YPL056C PEP4 YPL183W-A YPL184C MF(ALPHA)1 BOP1 GRE1 ATH1 YPR078C MEP3 TPO3 TIF3 137 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f