Input Cluster (n=199) YAL012W CYS3 YAL065C YAL067C SEO1 YAR068W YBR011C IPP1 YBR013C YBR050C REG2 YBR052C YBR072W HSP26 YBR105C VID24 YBR125C PTC4 YBR201W DER1 YBR219C YBR293W YBR294W SUL1 YBR296C PHO89 YCR018C SRD1 YCR044C PER1 YDL010W YDL012C YDL021W GPM2 YDL031W DBP10 YDL055C PSA1 YDL058W USO1 YDL059C RAD59 YDL143W CCT4 YDL149W APG9 YDL198C YHM1 YDR047W HEM12 YDR098C GRX3 YDR111C YDR253C MET32 YDR254W CHL4 YDR263C DIN7 YDR306C YDR310C SUM1 YDR311W TFB1 YDR335W MSN5 YDR418W RPL12B YDR475C JIP4 YDR502C SAM2 YDR516C EMI2 YDR517W GRH1 YEL023C YEL054C RPL12A YEL071W DLD3 YER001W MNN1 YER035W EDC2 YER052C HOM3 YER061C CEM1 YER088C DOT6 YER091C MET6 YER092W IES5 YER125W RSP5 YER153C PET122 YER154W OXA1 YFL021W GAT1 YFL030W YFL037W TUB2 YFL038C YPT1 YFL039C ACT1 YFL055W AGP3 YFR007W YFR030W MET10 YGL125W MET13 YGL180W APG1 YGL184C STR3 YGL197W MDS3 YGL234W "ADE5,7" YGL236C MTO1 YGR055W MUP1 YGR087C PDC6 YGR091W PRP31 YGR125W YGR130C YGR131W YGR144W THI4 YGR157W CHO2 YGR180C RNR4 YGR197C SNG1 YGR198W YGR204W ADE3 YGR255C COQ6 YGR256W GND2 YGR258C RAD2 YHL036W MUP3 YHL038C CBP2 YHL040C ARN1 YHL043W ECM34 YHR005C-A MRS11 YHR034C YHR097C YHR101C BIG1 YHR102W KIC1 YHR183W GND1 YIL005W EPS1 YIL014W MNT3 YIL046W MET30 YIL055C YIL102C YIL140W AXL2 YIL159W BNR1 YIL164C NIT1 YIR017C MET28 YIR018W YAP5 YJL014W CCT3 YJL037W YJL038C YJL042W MHP1 YJL050W MTR4 YJL052W TDH1 YJL060W BNA3 YJL106W IME2 YJL115W ASF1 YJL143W TIM17 YJL200C YJL206C YJL210W PEX2 YJL212C OPT1 YJR010W MET3 YJR014W YJR017C ESS1 YJR112W NNF1 YKL094W YJU3 YKL096W CWP1 YKL198C PTK1 YKL208W CBT1 YKR005C YKR067W GPT2 YLL055W YLL057C YLL058W YLL061W MMP1 YLL062C MHT1 YLR012C YLR066W SPC3 YLR092W SUL2 YLR103C CDC45 YLR104W YLR133W CKI1 YLR151C PCD1 YLR162W YLR177W YLR179C YLR180W SAM1 YLR266C PDR8 YLR327C YML085C TUB1 YML088W UFO1 YML123C PHO84 YMR009W YMR023C MSS1 YMR036C MIH1 YMR086W YMR183C SSO2 YMR247C YMR296C LCB1 YMR297W PRC1 YMR318C ADH6 YNL014W HEF3 YNL015W PBI2 YNL191W YNL241C ZWF1 YNL271C BNI1 YNL277W MET2 YNL323W LEM3 YNL325C FIG4 YNL339C YRF1-6 YNR015W SMM1 YNR075W COS10 YOL007C YOL158C ENB1 YOL162W YOL164W YOR023C AHC1 YOR025W HST3 YOR068C YOR095C RKI1 YOR130C ORT1 YOR198C BFR1 YOR313C SPS4 YOR316C COT1 YOR378W YPL016W SWI1 YPL017C YPL022W RAD1 YPL023C MET12 YPL054W LEE1 YPL055C LGE1 YPL078C ATP4 YPL113C YPL149W APG5 YPL250C ICY2 YPL274W SAM3 YPR115W YPR152C YPR153W YPR158W YPR202W Genes Not Found: YML100W-A MIPS Functional Classification Category p-value In Category from Cluster k f amino acid metabolism 4.3027e-09 CYS3 SUL1 YDR111C MET32 SAM2 HOM3 MET6 YFL030W AGP3 MET10 MET13 STR3 MUP1 ADE3 MUP3 MET30 MET28 MET3 YLL058W MMP1 SUL2 SAM1 MET2 ORT1 SAM3 25 204 amino acid biosynthesis 1.42308e-07 CYS3 SUL1 YDR111C HOM3 MET6 YFL030W MET10 MET13 STR3 MUP1 ADE3 MUP3 MET3 YLL058W SUL2 SAM1 MET2 17 118 METABOLISM 2.35226e-06 CYS3 IPP1 REG2 SUL1 PHO89 YDL010W GPM2 PSA1 HEM12 YDR111C MET32 SAM2 EMI2 MNN1 HOM3 CEM1 MET6 GAT1 YFL030W AGP3 MET10 MET13 STR3 "ADE5,7" MUP1 PDC6 THI4 CHO2 RNR4 ADE3 COQ6 GND2 MUP3 BIG1 GND1 MNT3 MET30 MET28 TDH1 BNA3 MET3 YLL058W MMP1 SUL2 CKI1 PCD1 SAM1 PHO84 LCB1 ADH6 ZWF1 MET2 YOL007C RKI1 ORT1 SWI1 YPL017C MET12 YPL113C SAM3 60 1066 TRANSPORT FACILITATION 4.91152e-06 SEO1 YBR052C YBR293W SUL1 PHO89 APG9 YHM1 AGP3 MUP1 SNG1 MUP3 ARN1 TIM17 OPT1 GPT2 YLL055W MMP1 SUL2 PHO84 HEF3 ENB1 ORT1 COT1 YOR378W ATP4 SAM3 26 312 amino acid transport 6.1075e-05 AGP3 MUP1 MUP3 MMP1 ORT1 SAM3 6 23 amino-acid transporters 0.000101606 AGP3 MUP1 MUP3 MMP1 ORT1 SAM3 6 25 pentose-phosphate pathway 0.000109678 GND2 GND1 ZWF1 RKI1 4 9 anion transporters (Cl, SO4, PO4, etc.) 0.000412428 SEO1 SUL1 PHO89 SUL2 PHO84 5 21 homeostasis of anions 0.000563004 SUL1 PHO89 SUL2 PHO84 4 13 drug transporters 0.000714585 YBR052C YBR293W SNG1 ARN1 ENB1 YOR378W 6 35 nitrogen and sulfur metabolism 0.00117265 YDR111C MET32 GAT1 YFL030W MET10 MET28 BNA3 MET3 8 67 lysosomal and vacuolar degradation 0.00262786 VID24 APG1 PRC1 APG5 4 19 homeostasis of sulfates 0.00294706 SUL1 SUL2 2 3 MIPS Phenotypes Category p-value In Category from Cluster k f Methionine auxotrophy (Met) 0.000109678 MET6 MET13 MET28 ZWF1 4 9 Cytoskeleton mutants 0.00300006 USO1 TUB2 YPT1 ACT1 RNR4 KIC1 CCT3 MHP1 TUB1 BNI1 10 113 MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f Met4/Met28/Met32 complex 0.00294706 MET32 MET28 2 3 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 9.34093e-06 SEO1 YBR293W SUL1 PHO89 AGP3 MUP1 SNG1 MUP3 ARN1 YLL055W MMP1 SUL2 PHO84 ENB1 COT1 YOR378W 16 142 GO Molecular Function Category p-value In Category from Cluster k f sulfur amino acid transporter [GO:0000099] 4.81319e-06 MUP1 MUP3 MMP1 SAM3 4 5 amino acid transporter [GO:0015171] 4.63585e-05 AGP3 MUP1 MUP3 MMP1 ORT1 SAM3 6 22 L-amino acid transporter [GO:0015179] 0.000587692 MUP1 MUP3 ORT1 3 6 phosphogluconate dehydrogenase (decarboxylating) [GO:0004616] 0.00100339 GND2 GND1 2 2 methylenetetrahydrofolate reductase (NADPH) [GO:0004489] 0.00100339 MET13 MET12 2 2 methionine transporter [GO:0015191] 0.00100339 MUP1 MUP3 2 2 methionine adenosyltransferase [GO:0004478] 0.00100339 SAM2 SAM1 2 2 sulfate transporter [GO:0015116] 0.00294706 SUL1 SUL2 2 3 transporter [GO:0005215] 0.00332302 SEO1 SUL1 PHO89 YHM1 OXA1 AGP3 MET10 MUP1 MUP3 ARN1 MRS11 TIM17 OPT1 MMP1 SUL2 PHO84 SSO2 ENB1 ORT1 COT1 ATP4 SAM3 22 372 GO Biological Process Category p-value In Category from Cluster k f sulfur amino acid metabolism [GO:0000096] 9.80882e-13 CYS3 MET32 SAM2 HOM3 MET6 MET13 STR3 MET28 MET3 MHT1 SAM1 MET2 MET12 13 29 sulfur metabolism [GO:0006790] 2.0266e-12 CYS3 MET32 SAM2 HOM3 MET6 MET10 MET13 STR3 MET28 OPT1 MET3 MHT1 SAM1 MET2 MET12 15 44 methionine metabolism [GO:0006555] 3.4031e-09 SAM2 HOM3 MET6 MET13 STR3 MET3 SAM1 MET2 MET12 9 20 aspartate family amino acid metabolism [GO:0009066] 3.97481e-06 SAM2 HOM3 MET6 MET13 STR3 MET3 SAM1 MET2 MET12 9 41 sulfur amino acid biosynthesis [GO:0000097] 3.20371e-05 MET13 STR3 MET28 MET2 4 7 sulfur amino acid transport [GO:0000101] 0.000123242 MUP1 MMP1 SAM3 3 4 amino acid metabolism [GO:0006520] 0.000128638 CYS3 MET32 SAM2 HOM3 MET6 MET13 STR3 MET28 MET3 MHT1 SAM1 MET2 ORT1 MET12 14 140 amino acid and derivative metabolism [GO:0006519] 0.000249535 CYS3 MET32 SAM2 HOM3 MET6 MET13 STR3 MET28 MET3 MHT1 SAM1 MET2 ORT1 MET12 14 149 amine metabolism [GO:0009308] 0.000286861 CYS3 MET32 SAM2 HOM3 MET6 MET13 STR3 MET28 MET3 MHT1 SAM1 MET2 ORT1 MET12 14 151 amino acid transport [GO:0006865] 0.000647601 AGP3 MUP1 MUP3 MMP1 SAM3 5 23 inorganic anion transport [GO:0015698] 0.00102243 SUL1 PHO89 SUL2 PHO84 4 15 alcohol metabolism [GO:0006066] 0.00178636 GPM2 PSA1 PDC6 GND2 GND1 TDH1 ADH6 ZWF1 RKI1 9 88 glucose metabolism [GO:0006006] 0.00245165 GPM2 GND2 GND1 TDH1 ZWF1 RKI1 6 44 sulfate transport [GO:0008272] 0.00294706 SUL1 SUL2 2 3 nuclear congression [GO:0006946] 0.00294706 TUB2 TUB1 2 3 homologous chromosome segregation [GO:0007061] 0.00294706 TUB2 TUB1 2 3 homoserine metabolism [GO:0009092] 0.00294706 CYS3 MET2 2 3 nuclear migration (sensu Saccharomyces) [GO:0000065] 0.0032087 TUB2 TUB1 ORT1 3 10 hexose metabolism [GO:0019318] 0.00359177 GPM2 PSA1 GND2 GND1 TDH1 ZWF1 RKI1 7 63 nuclear migration (sensu Fungi) [GO:0030473] 0.00430951 TUB2 TUB1 ORT1 3 11 hexose catabolism [GO:0019320] 0.00460355 GPM2 TDH1 ZWF1 RKI1 4 22 glucose catabolism [GO:0006007] 0.00460355 GPM2 TDH1 ZWF1 RKI1 4 22 GO Cellular Component Category p-value In Category from Cluster k f polar microtubule [GO:0005827] 0.00294706 TUB2 TUB1 2 3 SMART Domains Category p-value In Category from Cluster k f WW 0.000587692 RSP5 ESS1 YPR152C 3 6 FH2 0.00100339 BNR1 BNI1 2 2 RL11 0.00294706 RPL12B RPL12A 2 3 PFam-A Domains Category p-value In Category from Cluster k f PF00916 (Sulfate_transp) 0.000123242 SUL1 YGR125W SUL2 3 4 PF01740 (STAS) 0.000123242 SUL1 YGR125W SUL2 3 4 PF00397 (WW) 0.000300886 RSP5 ESS1 YPR152C 3 5 PF00393 (6PGD) 0.00100339 GND2 GND1 2 2 PF00438 (S-AdoMet_synt) 0.00100339 SAM2 SAM1 2 2 PF03446 (NAD_binding_2) 0.00100339 GND2 GND1 2 2 PF02219 (MTHFR) 0.00100339 MET13 MET12 2 2 PF02773 (S-AdoMet_syntD3) 0.00100339 SAM2 SAM1 2 2 PF02181 (FH2) 0.00100339 BNR1 BNI1 2 2 PF02772 (S-AdoMet_syntD2) 0.00100339 SAM2 SAM1 2 2 PF01053 (Cys_Met_Meta_PP) 0.0015696 CYS3 STR3 YLL058W 3 8 PF00155 (aminotran_1_2) 0.00229957 YDR111C BNA3 LCB1 3 9 PF00298 (Ribosomal_L11) 0.00294706 RPL12B RPL12A 2 3 PF00324 (aa_permeases) 0.00460355 AGP3 MUP1 MMP1 SAM3 4 22 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YPL126W (NAN1) 0.00294706 GND2 GND1 2 3 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.00360971 CYS3 YAL065C SEO1 YAR068W IPP1 YBR013C HSP26 VID24 PTC4 YBR293W SUL1 SRD1 YDL012C GPM2 PSA1 USO1 CCT4 APG9 HEM12 GRX3 YDR111C YDR306C MSN5 RPL12B SAM2 EMI2 GRH1 YEL023C RPL12A DLD3 EDC2 HOM3 CEM1 MET6 IES5 YFL030W YPT1 ACT1 AGP3 YFR007W MET10 APG1 STR3 MDS3 "ADE5,7" MUP1 PDC6 YGR125W YGR130C CHO2 SNG1 YGR198W ADE3 GND2 ARN1 ECM34 YHR034C GND1 YIL055C YIL102C NIT1 MET28 CCT3 TDH1 BNA3 IME2 TIM17 YJL206C OPT1 MET3 YJR014W ESS1 YJU3 YKR005C GPT2 YLL055W YLL057C YLL058W MMP1 MHT1 SUL2 CKI1 PCD1 YLR162W YLR177W YLR179C SAM1 PDR8 YLR327C TUB1 UFO1 PHO84 YMR009W MIH1 YMR086W ADH6 HEF3 PBI2 YNL191W ZWF1 BNI1 MET2 LEM3 FIG4 YRF1-6 COS10 ENB1 YOL164W YOR068C RKI1 BFR1 YOR378W YPL017C MET12 LEE1 YPL113C ICY2 SAM3 YPR115W YPR152C YPR202W 121 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f