Input Cluster (n=199) YAL025C MAK16 YBL029W YBL038W MRPL16 YBL039C URA7 YBL095W YBL098W BNA4 YBR021W FUR4 YBR028C YBR031W RPL4A YBR040W FIG1 YBR105C VID24 YBR106W PHO88 YBR127C VMA2 YBR161W YBR239C YCL038C AUT4 YCL047C YCL048W YCL073C YCR065W HCM1 YCR068W CVT17 YDL047W SIT4 YDL139C SCM3 YDL185W TFP1 YDL229W SSB1 YDR069C DOA4 YDR091C RLI1 YDR093W DNF2 YDR096W GIS1 YDR119W YDR211W GCD6 YDR214W AHA1 YDR222W YDR277C MTH1 YDR292C SRP101 YDR308C SRB7 YDR310C SUM1 YDR311W TFB1 YDR342C HXT7 YDR345C HXT3 YDR399W HPT1 YDR508C GNP1 YDR523C SPS1 YEL027W CUP5 YEL032W MCM3 YER036C KRE30 YER037W PHM8 YER089C PTC2 YER090W TRP2 YER110C KAP123 YER132C PMD1 YER159C BUR6 YFL017C GNA1 YGL030W RPL30 YGL056C SDS23 YGL158W RCK1 YGL162W SUT1 YGL223C COG1 YGR033C YGR034W RPL26B YGR068C YGR077C PEX8 YGR078C PAC10 YGR079W YGR106C YGR121C MEP1 YGR125W YGR127W YGR162W TIF4631 YGR175C ERG1 YGR206W YGR248W SOL4 YGR258C RAD2 YHR007C ERG11 YHR009C YHR031C RRM3 YHR032W YHR039C MSC7 YHR046C INM1 YHR047C AAP1' YHR071W PCL5 YHR082C KSP1 YHR143W-A RPC10 YHR205W SCH9 YHR206W SKN7 YIL009W FAA3 YIL060W YIL061C SNP1 YIL066C RNR3 YIL083C YIL094C LYS12 YIL096C YIL119C RPI1 YJL044C GYP6 YJL050W MTR4 YJL084C YJL089W SIP4 YJL165C HAL5 YJR047C ANB1 YJR048W CYC1 YJR103W URA8 YJR153W PGU1 YKL007W CAP1 YKL008C LAC1 YKL029C MAE1 YKL052C ASK1 YKL056C YKL068W NUP100 YKL108W SLD2 YKL201C MNN4 YKL217W JEN1 YKR011C YKR041W YKR045C YKR075C YKR098C UBP11 YKR099W BAS1 YKR106W YLL027W ISA1 YLL045C RPL8B YLR026C SED5 YLR063W YLR162W YLR223C IFH1 YLR224W YLR277C YSH1 YLR278C YLR316C TAD3 YLR318W EST2 YLR372W SUR4 YLR431C YLR432W IMD3 YLR446W YML043C RRN11 YML055W SPC2 YML056C IMD4 YML059C YML113W DAT1 YML114C TAF8 YML121W GTR1 YMR038C LYS7 YMR043W MCM1 YMR068W AVO2 YMR070W MOT3 YMR108W ILV2 YMR146C TIF34 YMR147W YMR182C RGM1 YMR205C PFK2 YMR278W YMR290C HAS1 YMR296C LCB1 YMR303C ADH2 YMR304W UBP15 YMR321C YNL068C FKH2 YNL078W NIS1 YNL079C TPM1 YNL112W DBP2 YNL141W AAH1 YNL142W MEP2 YNL180C RHO5 YNL201C PSY2 YNL261W ORC5 YNR013C PHO91 YNR017W MAS6 YNR048W YNR074C YNR075W COS10 YOL059W GPD2 YOL136C PFK27 YOL158C ENB1 YOR051C YOR054C YOR108W YOR178C GAC1 YOR230W WTM1 YOR270C VPH1 YOR302W YOR304C-A YOR305W YOR334W MRS2 YOR337W TEA1 YOR349W CIN1 YOR370C MRS6 YPL024W NCE4 YPL026C SKS1 YPL032C SVL3 YPL050C MNN9 YPL131W RPL5 YPL189W GUP2 YPL252C YAH1 YPL263C KEL3 YPL277C YPR010C RPA135 YPR022C YPR028W YOP1 YPR036W VMA13 YPR060C ARO7 Genes Not Found: YHR214C-B MIPS Functional Classification Category p-value In Category from Cluster k f TRANSPORT FACILITATION 1.51015e-05 FUR4 VMA2 AUT4 YCL073C TFP1 RLI1 DNF2 YDR119W HXT7 HXT3 GNP1 CUP5 KRE30 MEP1 YHR032W JEN1 YKR106W ISA1 MEP2 PHO91 MAS6 ENB1 VPH1 GUP2 VMA13 25 312 other cation transporters (Na, K, Ca , NH4, etc.) 0.000160057 VMA2 TFP1 CUP5 MEP1 MEP2 VPH1 VMA13 7 38 transport mechanism 0.000457272 VMA2 TFP1 RLI1 DNF2 CUP5 KRE30 ISA1 VPH1 VMA13 9 73 transport ATPases 0.00245165 VMA2 TFP1 DNF2 CUP5 VPH1 VMA13 6 44 cation transporters 0.0029873 VMA2 TFP1 CUP5 MEP1 MEP2 VPH1 VMA13 7 61 ion transporters 0.00313155 VMA2 TFP1 CUP5 MEP1 MEP2 PHO91 VPH1 VMA13 8 78 drug transporters 0.00458777 YCL073C YDR119W YHR032W YKR106W ENB1 5 35 homeostasis of protons 0.00458777 VMA2 TFP1 CUP5 VPH1 VMA13 5 35 detoxification 0.00489268 YCL073C YDR119W CUP5 ERG11 YHR032W YKR106W LYS7 MCM1 ENB1 9 102 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f H+-transporting ATPase, vacuolar 4.86587e-05 VMA2 TFP1 CUP5 VPH1 VMA13 5 14 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.000149823 FUR4 AUT4 YCL073C YDR119W HXT7 HXT3 GNP1 MEP1 YHR032W JEN1 YKR106W MEP2 PHO91 ENB1 14 142 RAN family 0.00294706 KSP1 SKS1 2 3 ion-transport ATPases 0.00344674 VMA2 TFP1 DNF2 CUP5 VPH1 VMA13 6 47 GO Molecular Function Category p-value In Category from Cluster k f transporter [GO:0005215] 0.000106265 FUR4 PHO88 VMA2 YCL073C TFP1 DNF2 HXT7 HXT3 GNP1 CUP5 KRE30 KAP123 MEP1 CYC1 LAC1 JEN1 YKR106W SED5 MEP2 PHO91 MAS6 ENB1 VPH1 MRS2 YAH1 VMA13 26 372 monooxygenase [GO:0004497] 0.00100339 BNA4 ERG1 2 2 CTP synthase [GO:0003883] 0.00100339 URA7 URA8 2 2 carrier [GO:0005386] 0.00163169 FUR4 VMA2 TFP1 DNF2 GNP1 CUP5 KRE30 KAP123 CYC1 ENB1 VPH1 YAH1 VMA13 13 160 hydrogen-/sodium-translocating ATPase [GO:0015442] 0.00228972 VMA2 TFP1 CUP5 VPH1 VMA13 5 30 hydrogen-transporting two-sector ATPase [GO:0003936] 0.00228972 VMA2 TFP1 CUP5 VPH1 VMA13 5 30 ammonium transporter [GO:0008519] 0.00294706 MEP1 MEP2 2 3 phosphate transporter [GO:0015114] 0.00294706 PHO88 PHO91 2 3 hydrolase, acting on acid anhydrides, catalyzing transmembrane movement of substances [GO:0016820] 0.0029873 VMA2 TFP1 DNF2 CUP5 KRE30 VPH1 VMA13 7 61 oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] 0.00344674 LYS12 MAE1 IMD3 IMD4 ADH2 GPD2 6 47 binding [GO:0005488] 0.00444909 VMA2 HCM1 TFP1 DNF2 GIS1 GCD6 SRB7 TFB1 CUP5 MCM3 KRE30 KAP123 BUR6 SUT1 RPL26B PEX8 PAC10 TIF4631 RAD2 ERG11 RRM3 SKN7 SNP1 MTR4 SIP4 ANB1 CAP1 BAS1 YSH1 EST2 RRN11 SPC2 DAT1 TAF8 GTR1 MCM1 MOT3 TIF34 RGM1 HAS1 FKH2 TPM1 DBP2 RHO5 ORC5 WTM1 VPH1 TEA1 RPL5 VMA13 50 1106 GO Biological Process Category p-value In Category from Cluster k f vacuolar acidification [GO:0007035] 0.000248205 VMA2 TFP1 CUP5 VPH1 VMA13 5 19 transport [GO:0006810] 0.000538099 FUR4 VID24 PHO88 AUT4 YCL073C CVT17 DNF2 MTH1 SRP101 HXT7 HXT3 GNP1 CUP5 KAP123 SUT1 COG1 PEX8 MEP1 GYP6 CAP1 NUP100 JEN1 YKR106W ISA1 SED5 SUR4 GTR1 LYS7 TPM1 MEP2 PHO91 MAS6 COS10 ENB1 MRS2 MRS6 SKS1 SVL3 38 698 hydrogen ion homeostasis [GO:0030641] 0.000971042 VMA2 TFP1 CUP5 VPH1 VMA13 5 25 regulation of pH [GO:0006885] 0.000971042 VMA2 TFP1 CUP5 VPH1 VMA13 5 25 phosphate transport [GO:0006817] 0.00229957 PHO88 GTR1 PHO91 3 9 monovalent inorganic cation homeostasis [GO:0030004] 0.00266076 VMA2 TFP1 CUP5 VPH1 VMA13 5 31 organic cation transport [GO:0015695] 0.00294706 MEP1 MEP2 2 3 ammonium transport [GO:0015696] 0.00294706 MEP1 MEP2 2 3 negative regulation of transcription from Pol II promoter [GO:0000122] 0.00307352 TFB1 BUR6 DAT1 RGM1 GAC1 5 32 vacuolar transport [GO:0007034] 0.00307352 VMA2 TFP1 CUP5 VPH1 VMA13 5 32 ion transport [GO:0006811] 0.00326014 PHO88 MEP1 JEN1 ISA1 GTR1 LYS7 MEP2 PHO91 ENB1 9 96 aromatic compound metabolism [GO:0006725] 0.00383716 URA7 TRP2 URA8 BAS1 AAH1 ARO7 6 48 monosaccharide transport [GO:0015749] 0.00460355 MTH1 HXT7 HXT3 SKS1 4 22 hexose transport [GO:0008645] 0.00460355 MTH1 HXT7 HXT3 SKS1 4 22 transcription from Pol II promoter [GO:0006366] 0.00467213 HCM1 SRB7 TFB1 BUR6 SUT1 RPC10 SIP4 BAS1 DAT1 TAF8 MCM1 RGM1 FKH2 GAC1 SKS1 15 223 GO Cellular Component Category p-value In Category from Cluster k f hydrogen-translocating V-type ATPase complex [GO:0016471] 0.000100786 VMA2 TFP1 CUP5 VPH1 VMA13 5 16 hydrogen-transporting ATPase V1 domain [GO:0000221] 0.0032087 VMA2 TFP1 VMA13 3 10 membrane [GO:0016020] 0.00487267 FUR4 VID24 PHO88 VMA2 YCL073C CVT17 TFP1 DNF2 SRP101 HXT7 HXT3 GNP1 CUP5 KAP123 PEX8 MEP1 NUP100 JEN1 YKR106W SUR4 HAS1 LCB1 MEP2 PHO91 MAS6 YNR074C COS10 ENB1 VPH1 MRS2 MRS6 GUP2 YOP1 VMA13 34 683 SMART Domains Category p-value In Category from Cluster k f CBS 0.00229957 SDS23 IMD3 IMD4 3 9 PFam-A Domains Category p-value In Category from Cluster k f PF00909 (Ammonium_transp) 0.00294706 MEP1 MEP2 2 3 PF01360 (Monooxygenase) 0.00294706 BNA4 ERG1 2 3 PF00571 (CBS) 0.0032087 SDS23 IMD3 IMD4 3 10 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f YJR103W (URA8) 0.00100339 URA7 URA8 2 2 Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YJR103W (URA8) 0.00294706 URA7 URA8 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YOL115W (TRF4) 0.0032087 MTR4 IMD3 IMD4 3 10 Cellzome Complexes Category p-value In Category from Cluster k f YNL313C 0.00100443 TFP1 KAP123 LYS12 3 7 YGR020C (VMA7) 0.0015696 TFP1 VPH1 VMA13 3 8 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f