Input Cluster (n=200) YAL002W VPS8 YAL064W YBL043W ECM13 YBR008C FLR1 YBR021W FUR4 YBR043C AQR2 YBR050C REG2 YBR062C YBR067C TIP1 YBR105C VID24 YBR106W PHO88 YBR114W RAD16 YBR143C SUP45 YBR203W YBR238C YBR269C YBR297W MAL33 YCR005C CIT2 YCR024C-A PMP1 YCR061W YCR065W HCM1 YDL083C RPS16B YDL087C LUC7 YDL125C HNT1 YDL128W VCX1 YDL155W CLB3 YDL183C YDL235C YPD1 YDL245C HXT15 YDR004W RAD57 YDR025W RPS11A YDR041W RSM10 YDR046C BAP3 YDR051C YDR058C TGL2 YDR071C YDR085C AFR1 YDR098C GRX3 YDR139C RUB1 YDR170C SEC7 YDR173C ARG82 YDR174W HMO1 YDR222W YDR277C MTH1 YDR292C SRP101 YDR293C SSD1 YDR297W SUR2 YDR298C ATP5 YDR299W BFR2 YDR305C HNT2 YDR317W YDR322W MRPL35 YDR345C HXT3 YDR370C YDR381W YRA1 YDR441C APT2 YDR525W-A SNA2 YEL017C-A PMP2 YEL017W YER028C YER031C YPT31 YER032W FIR1 YER037W PHM8 YER058W PET117 YER065C ICL1 YER088C DOT6 YER107C GLE2 YER167W BCK2 YFL053W DAK2 YFL054C YFL055W AGP3 YGL157W YGL158W RCK1 YGL202W ARO8 YGL209W MIG2 YGL253W HXK2 YGR030C POP6 YGR033C YGR123C PPT1 YGR142W BTN2 YGR240C PFK1 YGR292W MAL12 YHL021C YHL025W SNF6 YHL026C YHR015W MIP6 YHR023W MYO1 YHR031C RRM3 YHR044C DOG1 YHR047C AAP1' YHR094C HXT1 YHR163W SOL3 YHR178W STB5 YHR179W OYE2 YHR206W SKN7 YHR210C YHR216W IMD2 YIL077C YIL090W YIL112W YIL139C REV7 YIL162W SUC2 YIR028W DAL4 YJL012C VTC4 YJL019W MPS3 YJL020C BBC1 YJL043W YJL045W YJL084C YJL128C PBS2 YJL158C CIS3 YJL163C YJL212C OPT1 YJL214W HXT8 YJL216C YJL219W HXT9 YJR099W YUH1 YJR153W PGU1 YJR158W HXT16 YKL008C LAC1 YKL052C ASK1 YKL062W MSN4 YKL182W FAS1 YKR041W YKR071C DRE2 YKR072C SIS2 YKR075C YKR097W PCK1 YKR098C UBP11 YKR099W BAS1 YLR036C YLR044C PDC1 YLR108C YLR109W AHP1 YLR121C YPS3 YLR154C YLR249W YEF3 YLR258W GSY2 YLR301W YLR304C ACO1 YLR344W RPL26A YLR372W SUR4 YLR390W-A CCW14 YLR407W YLR410W VIP1 YLR432W IMD3 YLR436C ECM30 YML081W YMR002W YMR011W HXT2 YMR012W CLU1 YMR015C ERG5 YMR017W SPO20 YMR026C PEX12 YMR036C MIH1 YMR068W AVO2 YMR136W GAT2 YMR165C SMP2 YMR205C PFK2 YMR237W YMR272C SCS7 YMR291W YMR304W UBP15 YNL047C YNL065W AQR1 YNL066W SUN4 YNL118C DCP2 YNL144C YNL229C URE2 YNR001C CIT1 YNR019W ARE2 YNR059W MNT4 YOL040C RPS15 YOL047C YOL059W GPD2 YOL098C YOL124C YOL126C MDH2 YOL136C PFK27 YOL156W HXT11 YOR062C YOR134W BAG7 YOR138C YOR140W SFL1 YOR312C RPL20B YOR356W YOR370C MRS6 YPL024W NCE4 YPL026C SKS1 YPL075W GCR1 YPL196W OXR1 YPL198W RPL7B YPL199C YPL229W YPL239W YAR1 YPR015C YPR028W YOP1 YPR118W YPR192W AQY1 YPR196W Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f C-compound and carbohydrate metabolism 8.17302e-12 REG2 MAL33 CIT2 HXT15 MTH1 HXT3 ICL1 DAK2 MIG2 HXK2 PFK1 MAL12 SNF6 DOG1 AAP1' HXT1 YHR210C SUC2 YJL045W PBS2 HXT8 YJL216C HXT9 PGU1 HXT16 MSN4 PCK1 PDC1 GSY2 ACO1 HXT2 PFK2 YMR237W SUN4 CIT1 MNT4 GPD2 MDH2 PFK27 HXT11 SKS1 GCR1 42 415 METABOLISM 4.00139e-08 FUR4 REG2 TIP1 PHO88 MAL33 CIT2 HNT1 HXT15 BAP3 TGL2 ARG82 MTH1 SUR2 HNT2 HXT3 APT2 ICL1 DAK2 AGP3 YGL157W ARO8 MIG2 HXK2 PFK1 MAL12 SNF6 DOG1 AAP1' HXT1 YHR210C IMD2 SUC2 YJL045W PBS2 HXT8 YJL216C HXT9 PGU1 HXT16 MSN4 FAS1 PCK1 BAS1 PDC1 GSY2 ACO1 SUR4 IMD3 HXT2 ERG5 PFK2 YMR237W SCS7 SUN4 URE2 CIT1 ARE2 MNT4 GPD2 MDH2 PFK27 HXT11 MRS6 SKS1 GCR1 65 1066 regulation of C-compound and carbohydrate utilization 5.29101e-06 REG2 MAL33 MTH1 MIG2 HXK2 PFK1 SNF6 AAP1' PBS2 MSN4 GSY2 PFK2 PFK27 SKS1 GCR1 15 120 C-compound and carbohydrate utilization 7.85331e-06 CIT2 ICL1 DAK2 HXK2 PFK1 MAL12 DOG1 YHR210C SUC2 YJL045W YJL216C PGU1 PCK1 PDC1 GSY2 ACO1 PFK2 YMR237W CIT1 MNT4 GPD2 MDH2 PFK27 23 261 glyoxylate cycle 1.43638e-05 CIT2 ICL1 ACO1 MDH2 4 6 C-compound, carbohydrate transport 4.3396e-05 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 8 42 C-compound and carbohydrate transporters 8.59754e-05 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 8 46 cellular import 0.000312914 FUR4 BAP3 HXT3 YPT31 HXT1 DAL4 HXT8 HXT9 HXT16 HXT2 HXT11 11 100 TRANSPORT FACILITATION 0.000354659 FLR1 FUR4 AQR2 PMP1 VCX1 HXT15 BAP3 ATP5 HXT3 PMP2 YFL054C AGP3 HXT1 DAL4 OPT1 HXT8 HXT9 HXT16 HXT2 AQR1 HXT11 AQY1 22 312 ENERGY 0.000397093 CIT2 ATP5 ICL1 HXK2 PFK1 AAP1' OYE2 YJL045W YJL216C PCK1 PDC1 GSY2 ACO1 SMP2 PFK2 DCP2 CIT1 MDH2 YOR356W 19 252 plasma membrane 0.000684714 FUR4 PMP1 HXT15 BAP3 HXT3 PMP2 HXT1 DAL4 HXT8 HXT9 HXT16 HXT2 HXT11 13 145 glycolysis and gluconeogenesis 0.0046866 ICL1 HXK2 PFK1 PCK1 PFK2 5 35 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 0.000513432 FUR4 PMP1 HXT15 BAP3 HXT3 PMP2 HXT1 DAL4 HXT8 HXT9 HXT16 YPS3 HXT2 HXT11 14 159 cytoplasm 0.000989137 SUP45 RPS16B RPS11A SEC7 SSD1 ICL1 GLE2 BCK2 HXK2 BTN2 PFK1 MAL12 OYE2 YHR210C VTC4 YUH1 MSN4 FAS1 PCK1 PDC1 AHP1 YEF3 GSY2 ACO1 RPL26A CLU1 PFK2 YNL047C RPS15 MDH2 RPL20B MRS6 RPL7B 33 593 MIPS Protein Complexes Category p-value In Category from Cluster k f Phosphofructokinase 0.00101352 PFK1 PFK2 2 2 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.000560672 FLR1 FUR4 AQR2 HXT3 AGP3 HXT1 DAL4 HXT8 HXT9 HXT16 HXT2 AQR1 HXT11 13 142 Helix-turn-helix 0.000993261 HCM1 DOT6 SKN7 BAS1 SFL1 5 25 GO Molecular Function Category p-value In Category from Cluster k f mannose transporter [GO:0015578] 4.97375e-09 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 8 15 glucose transporter [GO:0005355] 1.77806e-08 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 8 17 hexose transporter [GO:0015149] 5.23138e-08 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 8 19 monosaccharide transporter [GO:0015145] 5.23138e-08 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 8 19 fructose transporter [GO:0005353] 8.62245e-08 HXT15 HXT3 HXT8 HXT9 HXT16 HXT2 HXT11 7 14 carbohydrate transporter [GO:0015144] 1.67879e-06 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 8 28 phosphofructokinase [GO:0008443] 0.000305393 PFK1 PFK2 PFK27 3 5 galactose transporter [GO:0005354] 0.000596423 HXT1 HXT9 HXT11 3 6 6-phosphofructokinase [GO:0003872] 0.00101352 PFK1 PFK2 2 2 carbohydrate kinase [GO:0019200] 0.0010418 HXK2 PFK1 PFK2 PFK27 4 15 hydrolase, hydrolyzing O-glycosyl compounds [GO:0004553] 0.00271949 MAL12 SUC2 YJL216C PGU1 SUN4 5 31 citrate (SI)-synthase [GO:0004108] 0.0029765 CIT2 CIT1 2 3 structural constituent of cell wall [GO:0005199] 0.00437089 TIP1 CIS3 CCW14 3 11 GO Biological Process Category p-value In Category from Cluster k f hexose transport [GO:0008645] 4.05858e-10 HXT15 MTH1 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 SKS1 10 22 monosaccharide transport [GO:0015749] 4.05858e-10 HXT15 MTH1 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 SKS1 10 22 carbohydrate transport [GO:0008643] 1.5079e-08 HXT15 MTH1 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 HXT11 SKS1 10 30 carbohydrate metabolism [GO:0005975] 1.73732e-05 MAL33 CIT2 ICL1 MIG2 HXK2 PFK1 MAL12 DOG1 SUC2 PGU1 PCK1 GSY2 ACO1 PFK2 CIT1 MDH2 PFK27 17 165 alcohol metabolism [GO:0006066] 9.87938e-05 DAK2 MIG2 HXK2 PFK1 DOG1 PCK1 PDC1 PFK2 GPD2 MDH2 PFK27 11 88 citrate metabolism [GO:0006101] 0.000125104 CIT2 ACO1 CIT1 3 4 main pathways of carbohydrate metabolism [GO:0006092] 0.00024113 CIT2 ICL1 PFK1 PCK1 ACO1 PFK2 CIT1 MDH2 8 53 glyoxylate cycle [GO:0006097] 0.000305393 CIT2 ICL1 MDH2 3 5 glyoxylate metabolism [GO:0046487] 0.000305393 CIT2 ICL1 MDH2 3 5 hexose metabolism [GO:0019318] 0.000801982 MIG2 HXK2 PFK1 DOG1 PCK1 PFK2 MDH2 PFK27 8 63 organic acid metabolism [GO:0006082] 0.000852745 CIT2 ICL1 FAS1 PDC1 ACO1 SUR4 SCS7 CIT1 MDH2 9 79 carboxylic acid metabolism [GO:0019752] 0.000852745 CIT2 ICL1 FAS1 PDC1 ACO1 SUR4 SCS7 CIT1 MDH2 9 79 monosaccharide metabolism [GO:0005996] 0.00147054 MIG2 HXK2 PFK1 DOG1 PCK1 PFK2 MDH2 PFK27 8 69 glucose metabolism [GO:0006006] 0.00251429 MIG2 PFK1 DOG1 PCK1 PFK2 MDH2 6 44 nucleobase transport [GO:0015851] 0.0029765 FUR4 DAL4 2 3 cell growth [GO:0016049] 0.0029765 DOT6 AVO2 2 3 purine nucleoside triphosphate biosynthesis [GO:0009145] 0.0029765 IMD2 IMD3 2 3 maltose metabolism [GO:0000023] 0.0029765 MAL33 MAL12 2 3 GTP biosynthesis [GO:0006183] 0.0029765 IMD2 IMD3 2 3 GTP metabolism [GO:0046039] 0.0029765 IMD2 IMD3 2 3 purine ribonucleoside triphosphate metabolism [GO:0009205] 0.0029765 IMD2 IMD3 2 3 ribonucleoside triphosphate metabolism [GO:0009199] 0.0029765 IMD2 IMD3 2 3 purine nucleoside triphosphate metabolism [GO:0009144] 0.0029765 IMD2 IMD3 2 3 purine ribonucleoside triphosphate biosynthesis [GO:0009206] 0.0029765 IMD2 IMD3 2 3 ribonucleoside triphosphate biosynthesis [GO:0009201] 0.0029765 IMD2 IMD3 2 3 TCA intermediate metabolism [GO:0006100] 0.00393128 CIT2 ACO1 CIT1 MDH2 4 21 disaccharide metabolism [GO:0005984] 0.00437089 MAL33 MAL12 SUC2 3 11 carbohydrate catabolism [GO:0016052] 0.0046866 PFK1 MAL12 SUC2 PGU1 PFK2 5 35 GO Cellular Component Category p-value In Category from Cluster k f 6-phosphofructokinase complex [GO:0005945] 0.00101352 PFK1 PFK2 2 2 plasma membrane [GO:0005886] 0.00156099 FLR1 FUR4 HXT15 BAP3 HXT3 AGP3 HXT1 CIS3 HXT8 HXT9 HXT16 YPS3 HXT2 HXT11 14 178 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00083 (sugar_tr) 5.15164e-06 FLR1 HXT15 HXT3 HXT1 HXT8 HXT9 HXT16 HXT2 AQR1 HXT11 10 53 PF00365 (PFK) 0.00101352 PFK1 PFK2 2 2 PF01230 (HIT) 0.00101352 HNT1 HNT2 2 2 PF00285 (citrate_synt) 0.0029765 CIT2 CIT1 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YBL101W-A 0.0029765 ECM13 URE2 2 3 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f YBR233W (PBP2) 0.000125104 HMO1 YRA1 YEF3 3 4 YMR205C (PFK2) 0.00101352 PFK1 PFK2 2 2 YAL027W 0.00325479 HMO1 YRA1 PDC1 3 10 Proteome Localization--Observed Category p-value In Category from Cluster k f cyto 0.00284451 PHO88 SUP45 YBR203W CIT2 PMP1 LUC7 HNT1 YDL183C YDR051C YDR222W SSD1 HNT2 YDR370C APT2 PHM8 DAK2 YGL157W PFK1 AAP1' OYE2 YHR210C IMD2 YIL112W BBC1 YJL043W YJL084C YUH1 FAS1 SIS2 YKR075C PCK1 YLR036C PDC1 AHP1 YEF3 GSY2 YLR301W RPL26A IMD3 ECM30 CLU1 PEX12 MIH1 AVO2 PFK2 YMR237W YMR291W UBP15 YNL047C URE2 RPS15 MDH2 PFK27 YOR138C MRS6 OXR1 RPL7B YPL199C YAR1 59 1324 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.000716179 VPS8 YAL064W ECM13 FLR1 FUR4 AQR2 YBR062C VID24 PHO88 SUP45 YBR203W YBR238C YBR269C RPS16B LUC7 HNT1 VCX1 YDL183C HXT15 RAD57 RPS11A BAP3 YDR051C TGL2 YDR071C AFR1 GRX3 RUB1 YDR222W SRP101 SSD1 SUR2 HNT2 YDR317W HXT3 YDR370C APT2 YEL017W YER028C PHM8 BCK2 DAK2 YFL054C AGP3 YGL157W RCK1 ARO8 HXK2 YGR033C PFK1 MAL12 MYO1 RRM3 DOG1 AAP1' HXT1 SOL3 STB5 OYE2 YHR210C IMD2 YIL112W REV7 DAL4 VTC4 BBC1 YJL043W YJL045W YJL084C YJL163C OPT1 HXT8 YJL216C HXT9 YUH1 HXT16 FAS1 YKR075C PCK1 UBP11 YLR036C PDC1 AHP1 YLR154C YEF3 GSY2 YLR301W RPL26A SUR4 IMD3 ECM30 YMR002W HXT2 CLU1 PEX12 MIH1 AVO2 PFK2 YMR237W SCS7 YMR291W UBP15 YNL047C AQR1 YNL144C URE2 ARE2 RPS15 YOL124C MDH2 PFK27 HXT11 YOR062C BAG7 YOR138C SFL1 RPL20B MRS6 SKS1 OXR1 RPL7B YPL199C YPL229W YAR1 AQY1 125 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.000203721 VPS8 ECM13 FLR1 REG2 YBR062C TIP1 YBR203W YBR238C YBR269C MAL33 CIT2 PMP1 YCR061W HNT1 VCX1 CLB3 YDL183C RPS11A BAP3 YDR051C TGL2 YDR071C AFR1 GRX3 RUB1 YDR222W MTH1 SUR2 HNT2 YDR317W HXT3 YDR370C SNA2 PMP2 YEL017W YER028C YPT31 FIR1 PHM8 PET117 ICL1 DOT6 DAK2 YFL054C AGP3 ARO8 MIG2 HXK2 YGR033C PPT1 BTN2 PFK1 MAL12 YHL021C YHL026C MIP6 DOG1 AAP1' HXT1 SOL3 STB5 OYE2 YHR210C YIL077C YIL090W YIL112W REV7 SUC2 DAL4 VTC4 BBC1 YJL043W YJL045W YJL084C PBS2 CIS3 YJL163C OPT1 HXT8 YJL216C YUH1 PGU1 LAC1 MSN4 YKR041W YKR075C PCK1 UBP11 BAS1 YLR036C YLR108C AHP1 YPS3 YLR154C GSY2 ACO1 RPL26A CCW14 YLR407W VIP1 IMD3 ECM30 YML081W YMR002W HXT2 CLU1 ERG5 SPO20 PEX12 AVO2 GAT2 PFK2 YMR237W YMR291W YNL047C AQR1 SUN4 URE2 CIT1 ARE2 MNT4 YOL047C GPD2 YOL098C YOL124C MDH2 PFK27 YOR062C BAG7 YOR138C RPL20B YOR356W SKS1 OXR1 RPL7B YPL199C YPL229W YPR015C YOP1 YPR118W AQY1 YPR196W 142 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f