Input Cluster (n=199) YAR035W YAT1 YAR066W YBL002W HTB2 YBL003C HTA2 YBL015W ACH1 YBL063W KIP1 YBR001C NTH2 YBR006W UGA2 YBR070C YBR071W YBR077C YBR078W ECM33 YBR105C VID24 YBR106W PHO88 YBR145W ADH5 YBR240C THI2 YBR302C COS2 YCL040W GLK1 YCL043C PDI1 YCR005C CIT2 YCR018C SRD1 YCR065W HCM1 YCR104W PAU3 YDL010W YDL022W GPD1 YDL070W BDF2 YDL072C YDL197C ASF2 YDL222C YDL248W COS7 YDR047W HEM12 YDR058C TGL2 YDR072C IPT1 YDR171W HSP42 YDR224C HTB1 YDR225W HTA1 YDR242W AMD2 YDR247W YDR276C PMP3 YDR297W SUR2 YDR309C GIC2 YDR312W SSF2 YDR403W DIT1 YDR406W PDR15 YDR451C YHP1 YDR452W PPN1 YDR510W SMT3 YDR525W-A SNA2 YEL017C-A PMP2 YEL017W YER003C PMI40 YER004W YER011W TIR1 YER020W GPA2 YER070W RNR1 YER088C DOT6 YER145C FTR1 YER146W LSM5 YER152C YER184C YFL062W COS4 YFR017C YFR019W FAB1 YFR033C QCR6 YGL062W PYC1 YGL075C MPS2 YGL148W ARO2 YGL163C RAD54 YGL197W MDS3 YGL255W ZRT1 YGR016W YGR019W UGA1 YGR035C YGR067C YGR109C CLB6 YGR130C YGR131W YGR204W ADE3 YGR234W YHB1 YGR279C SCW4 YGR295C COS6 YHL048W COS8 YHR041C SRB2 YHR042W NCP1 YHR071W PCL5 YHR204W MNL1 YHR214W YHR216W IMD2 YIL026C IRR1 YIL099W SGA1 YIL101C XBP1 YIL160C POT1 YIL169C YJL006C CTK2 YJL026W RNR2 YJL042W MHP1 YJL181W YJL187C SWE1 YJL189W RPL39 YJL190C RPS22A YJL194W CDC6 YJL196C ELO1 YJR009C TDH2 YJR043C POL32 YJR113C RSM7 YJR115W YJR161C COS5 YKL032C IXR1 YKL045W PRI2 YKL052C ASK1 YKL096W-A CWP2 YKL112W ABF1 YKL113C RAD27 YKL152C GPM1 YKR095W MLP1 YLR110C CCW12 YLR139C SLS1 YLR162W YLR237W THI7 YLR278C YLR283W YLR297W YLR354C TAL1 YLR387C YLR389C STE23 YLR390W ECM19 YLR399C BDF1 YLR406C RPL31B YLR437C YLR438W CAR2 YML027W YOX1 YML058W SML1 YML091C RPM2 YML132W COS3 YMR015C ERG5 YMR069W YMR070W MOT3 YMR135C DCR1 YMR181C YMR195W ICY1 YMR244C-A YMR246W FAA4 YMR251W-A HOR7 YMR261C TPS3 YMR272C SCS7 YMR305C SCW10 YMR306W FKS3 YNL019C YNL030W HHF2 YNL031C HHT2 YNL033W YNL094W APP1 YNL095C YNL103W MET4 YNL104C LEU4 YNL181W YNL182C IPI3 YNL231C PDR16 YNL233W BNI4 YNL243W SLA2 YNL244C SUI1 YNL300W YNL304W YPT11 YNL336W COS1 YNR009W YNR015W SMM1 YOL011W PLB3 YOL012C HTZ1 YOL039W RPP2A YOL040C RPS15 YOL047C YOL155C YOR009W TIR4 YOR096W RPS7A YOR153W PDR5 YOR161C YOR192C YOR213C SAS5 YOR231W MKK1 YOR313C SPS4 YOR317W FAA1 YOR327C SNC2 YOR342C YOR349W CIN1 YPL014W YPL015C HST2 YPL057C SUR1 YPL068C YPL082C MOT1 YPL170W YPL177C CUP9 YPL192C PRM3 YPL250C ICY2 YPL255W BBP1 YPR054W SMK1 YPR063C YPR080W TEF1 YPR120C CLB5 YPR138C MEP3 Genes Not Found: YML100W-A MIPS Functional Classification Category p-value In Category from Cluster k f lipid, fatty-acid and isoprenoid metabolism 4.0018e-05 YAT1 ACH1 PDI1 TGL2 IPT1 SUR2 PPN1 FAB1 NCP1 POT1 ELO1 ERG5 FAA4 SCS7 PDR16 PLB3 PDR5 FAA1 SUR1 19 213 chromosome 5.95273e-05 HTB2 HTA2 HTB1 HTA1 HHF2 HHT2 HTZ1 SAS5 8 44 transcriptional control 0.00013054 HTB2 HTA2 THI2 HCM1 BDF2 ASF2 HTB1 HTA1 DOT6 YER184C XBP1 CTK2 IXR1 ABF1 YLR278C BDF1 MOT3 HHF2 HHT2 MET4 SAS5 HST2 MOT1 CUP9 24 334 deoxyribonucleotide metabolism 0.000273193 YDL010W RNR1 RNR2 SML1 4 11 lipid and fatty-acid transport 0.000412428 YAT1 PDI1 FAA4 PDR16 PDR5 5 21 METABOLISM 0.000644342 YAT1 ACH1 NTH2 UGA2 PHO88 ADH5 GLK1 PDI1 CIT2 YDL010W GPD1 HEM12 TGL2 IPT1 AMD2 SUR2 PPN1 PMI40 RNR1 FAB1 PYC1 ARO2 UGA1 ADE3 NCP1 MNL1 IMD2 SGA1 POT1 RNR2 ELO1 TDH2 ABF1 GPM1 THI7 TAL1 CAR2 SML1 ERG5 FAA4 TPS3 SCS7 FKS3 MET4 LEU4 PDR16 SLA2 PLB3 PDR5 YOR192C FAA1 SUR1 52 1066 DNA synthesis and replication 0.000736047 RNR1 CLB6 RNR2 CDC6 POL32 PRI2 ABF1 RAD27 SML1 CLB5 10 94 mRNA synthesis 0.000990482 HTB2 HTA2 THI2 HCM1 BDF2 ASF2 HTB1 HTA1 DOT6 YER184C SRB2 XBP1 CTK2 IXR1 ABF1 YLR278C BDF1 MOT3 HHF2 HHT2 MET4 SAS5 HST2 MOT1 CUP9 25 406 lipid, fatty-acid and isoprenoid biosynthesis 0.0043622 IPT1 SUR2 FAB1 NCP1 ELO1 ERG5 FAA4 SCS7 FAA1 SUR1 10 119 MIPS Phenotypes Category p-value In Category from Cluster k f other carbohydrate and lipid biosynthesis defects 1.26438e-05 SUR2 PMI40 NCP1 ELO1 ERG5 SCS7 FAA1 SUR1 8 36 Carbohydrate and lipid biosynthesis defects 9.73256e-05 SUR2 PMI40 NCP1 ELO1 ERG5 SCS7 FAA1 SUR1 8 47 Killer toxin hypersensitivity 0.0015696 ECM33 MHP1 ECM19 3 8 other cell morphology mutants 0.00201431 HTB2 HTA2 SUR2 IRR1 ECM19 BDF1 SUR1 7 57 MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f Nucleosomal protein complex 2.52734e-08 HTB2 HTA2 HTB1 HTA1 HHF2 HHT2 6 8 MIPS Protein Classes Category p-value In Category from Cluster k f Histones 8.6886e-09 HTB2 HTA2 HTB1 HTA1 HHF2 HHT2 HTZ1 7 11 H2 3.07376e-08 HTB2 HTA2 HTB1 HTA1 HTZ1 5 5 Transcription factors 0.000623506 THI2 SRD1 HCM1 YHP1 DOT6 YER184C YGR067C IXR1 ABF1 YLR278C YLR387C YOX1 MOT3 MET4 CUP9 15 182 Helix-turn-helix 0.000971042 HCM1 YHP1 DOT6 YOX1 CUP9 5 25 Homeodomain 0.00229957 YHP1 YOX1 CUP9 3 9 Cyclins 0.00460355 CLB6 PCL5 CTK2 CLB5 4 22 GO Molecular Function Category p-value In Category from Cluster k f structural constituent of cytoskeleton [GO:0005200] 0.00425946 KIP1 MPS2 MHP1 ASK1 SLA2 BBP1 6 49 GO Biological Process Category p-value In Category from Cluster k f chromatin assembly/disassembly [GO:0006333] 6.1075e-05 HTB2 HTA2 HTB1 HTA1 HHF2 HHT2 6 23 DNA metabolism [GO:0006259] 0.000632397 HTB2 HTA2 ASF2 HTB1 HTA1 RNR1 DOT6 RAD54 CLB6 RNR2 CDC6 POL32 IXR1 PRI2 ABF1 RAD27 HHF2 HHT2 HTZ1 SAS5 SPS4 HST2 CLB5 23 349 lipid metabolism [GO:0006629] 0.000847744 TGL2 IPT1 SUR2 FAB1 NCP1 POT1 ELO1 ERG5 FAA4 SCS7 PDR16 PLB3 FAA1 SUR1 14 168 inositolphosphoceramide metabolism [GO:0006673] 0.00100339 IPT1 SUR1 2 2 DNA packaging [GO:0006323] 0.00165296 HTB2 HTA2 ASF2 HTB1 HTA1 DOT6 ABF1 HHF2 HHT2 HTZ1 SAS5 HST2 12 141 establishment and/or maintenance of chromatin architecture [GO:0006325] 0.00165296 HTB2 HTA2 ASF2 HTB1 HTA1 DOT6 ABF1 HHF2 HHT2 HTZ1 SAS5 HST2 12 141 chromosome organization and biogenesis (sensu Eukarya) [GO:0007001] 0.00192935 HTB2 HTA2 ASF2 HTB1 HTA1 DOT6 RAD54 ABF1 HHF2 HHT2 HTZ1 SAS5 HST2 13 163 DNA replication [GO:0006260] 0.00225812 RNR1 CLB6 RNR2 CDC6 POL32 PRI2 ABF1 RAD27 CLB5 9 91 S phase of mitotic cell cycle [GO:0000084] 0.00262426 RNR1 CLB6 RNR2 CDC6 POL32 PRI2 ABF1 RAD27 CLB5 9 93 double-strand break repair via synthesis-dependent strand annealing [GO:0045003] 0.0032087 RAD54 PRI2 RAD27 3 10 cell growth and/or maintenance [GO:0008151] 0.00329331 YAT1 HTB2 HTA2 ACH1 KIP1 NTH2 UGA2 ECM33 VID24 PHO88 ADH5 THI2 GLK1 PDI1 CIT2 SRD1 HCM1 GPD1 ASF2 YDL222C HEM12 TGL2 IPT1 HSP42 HTB1 HTA1 PMP3 SUR2 GIC2 SSF2 DIT1 PDR15 YHP1 PPN1 SMT3 PMP2 PMI40 TIR1 GPA2 RNR1 DOT6 FTR1 LSM5 FAB1 QCR6 PYC1 MPS2 ARO2 RAD54 MDS3 ZRT1 UGA1 CLB6 ADE3 YHB1 SCW4 COS8 SRB2 NCP1 PCL5 MNL1 IMD2 IRR1 SGA1 XBP1 POT1 CTK2 RNR2 MHP1 SWE1 RPL39 RPS22A CDC6 ELO1 TDH2 POL32 RSM7 IXR1 PRI2 ASK1 CWP2 ABF1 RAD27 GPM1 MLP1 SLS1 THI7 TAL1 STE23 ECM19 BDF1 RPL31B CAR2 SML1 RPM2 ERG5 MOT3 FAA4 HOR7 TPS3 SCS7 SCW10 HHF2 HHT2 APP1 MET4 LEU4 PDR16 BNI4 SLA2 SUI1 SMM1 PLB3 HTZ1 RPP2A RPS15 RPS7A PDR5 YOR192C SAS5 MKK1 SPS4 FAA1 SNC2 CIN1 HST2 SUR1 MOT1 CUP9 PRM3 BBP1 SMK1 TEF1 CLB5 MEP3 135 3657 sporulation [GO:0030435] 0.00366834 DIT1 GPA2 MDS3 IRR1 SGA1 BDF1 SPS4 SMK1 8 80 sporulation (sensu Saccharomyces) [GO:0007151] 0.00428518 DIT1 GPA2 IRR1 SGA1 BDF1 SPS4 SMK1 7 65 GO Cellular Component Category p-value In Category from Cluster k f nucleosome [GO:0005718] 7.4943e-07 HTB2 HTA2 HTB1 HTA1 HHF2 HHT2 6 12 chromatin [GO:0005717] 2.00892e-06 HTB2 HTA2 HTB1 HTA1 ABF1 HHF2 HHT2 HTZ1 SAS5 9 38 chromosome [GO:0005694] 1.90785e-05 HTB2 HTA2 HTB1 HTA1 YHP1 IRR1 IXR1 ASK1 ABF1 HHF2 HHT2 HTZ1 SAS5 MOT1 14 118 extracellular [GO:0005576] 0.00128371 ECM33 SCW4 CWP2 CCW12 HOR7 SCW10 YNL300W PLB3 TIR4 9 84 cell wall (sensu Fungi) [GO:0009277] 0.00205474 ECM33 SCW4 CWP2 CCW12 HOR7 SCW10 YNL300W TIR4 8 73 external protective structure [GO:0030312] 0.00243573 ECM33 TIR1 SCW4 CWP2 CCW12 HOR7 SCW10 YNL300W TIR4 9 92 cell wall [GO:0005618] 0.00243573 ECM33 TIR1 SCW4 CWP2 CCW12 HOR7 SCW10 YNL300W TIR4 9 92 SMART Domains Category p-value In Category from Cluster k f H2A 3.1551e-05 HTA2 HTA1 HTZ1 3 3 H2B 0.00100339 HTB2 HTB1 2 2 CYCLIN 0.00212688 CLB6 PCL5 CTK2 CLB5 4 18 HOX 0.00229957 YHP1 YOX1 CUP9 3 9 PFam-A Domains Category p-value In Category from Cluster k f PF00125 (histone) 3.24654e-09 HTB2 HTA2 HTB1 HTA1 HHF2 HHT2 HTZ1 7 10 PF00674 (DUP) 4.26761e-07 COS2 COS7 COS4 COS6 COS8 COS5 COS3 COS1 8 24 PF00134 (cyclin) 0.00132964 CLB6 PCL5 CTK2 CLB5 4 16 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YCR005C (CIT2) 0.00100339 CIT2 MHP1 2 2 YER133W (GLC7) 0.00430951 BDF2 MHP1 BNI4 3 11 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YNL088W (TOP2) 0.00294706 SMT3 FAA4 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YOL054W (PSH1) 0.000563004 HTB2 HTA2 HTB1 HTA1 4 13 Cellzome Complexes Category p-value In Category from Cluster k f YDL070W (BDF2) 0.00100339 BDF2 BDF1 2 2 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f en2 0.000907245 YAR066W YBR070C COS2 PDI1 CIT2 PAU3 YDL010W YDL072C YDL222C COS7 IPT1 TIR1 FTR1 COS4 FAB1 SCW4 COS6 COS8 SGA1 POT1 YIL169C COS5 CCW12 ECM19 COS3 SCW10 YNL019C YNL033W YNL095C SLA2 YNL300W COS1 PLB3 YOL047C TIR4 SNC2 SUR1 37 692 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f