Input Cluster (n=199) YAL025C MAK16 YAL026C DRS2 YAR002W NUP60 YBL029W YBL038W MRPL16 YBL039C URA7 YBL068W PRS4 YBL095W YBR028C YBR031W RPL4A YBR039W ATP3 YBR040W FIG1 YBR161W YBR222C FAT2 YCL038C AUT4 YCL040W GLK1 YCL043C PDI1 YCL048W YCL073C YCR065W HCM1 YDL047W SIT4 YDL058W USO1 YDL059C RAD59 YDL139C SCM3 YDL185W TFP1 YDL229W SSB1 YDR069C DOA4 YDR141C DOP1 YDR211W GCD6 YDR214W AHA1 YDR311W TFB1 YDR342C HXT7 YDR383C NKP1 YDR399W HPT1 YDR438W YDR530C APA2 YDR531W YEL032W MCM3 YEL043W YER080W YER091C MET6 YER092W IES5 YER099C PRS2 YER100W UBC6 YER110C KAP123 YER112W LSM4 YER114C BOI2 YER124C DSE1 YFL017C GNA1 YFL023W BUD27 YFL024C EPL1 YFL031W HAC1 YFL033C RIM15 YFR001W LOC1 YGL001C ERG26 YGL008C PMA1 YGL056C SDS23 YGL223C COG1 YGR068C YGR078C PAC10 YGR079W YGR106C YGR109C CLB6 YGR125W YGR127W YGR206W YGR229C SMI1 YGR230W BNS1 YGR258C RAD2 YHL004W MRP4 YHR001W-A QCR10 YHR009C YHR039C MSC7 YHR065C RRP3 YHR066W SSF1 YHR071W PCL5 YHR082C KSP1 YHR083W YHR136C SPL2 YHR137W ARO9 YHR143W-A RPC10 YHR149C YHR150W YHR205W SCH9 YHR215W PHO12 YIL009W FAA3 YIL046W MET30 YIL047C SYG1 YIL060W YIL061C SNP1 YIL094C LYS12 YIL096C YIL126W STH1 YIR006C PAN1 YIR007W YJL044C GYP6 YJL133W MRS3 YJL149W YJL151C SNA3 YJL167W ERG20 YJL168C SET2 YJL186W MNN5 YJL187C SWE1 YJL200C YJR001W YJR010W MET3 YJR047C ANB1 YJR113C RSM7 YKL007W CAP1 YKL008C LAC1 YKL015W PUT3 YKL016C ATP7 YKL027W YKL029C MAE1 YKL068W NUP100 YKL108W SLD2 YKL191W DPH2 YKL192C ACP1 YKL201C MNN4 YKL217W JEN1 YKR041W YKR045C YKR098C UBP11 YKR099W BAS1 YLL010C PSR1 YLL045C RPL8B YLR026C SED5 YLR063W YLR092W SUL2 YLR149C YLR150W STM1 YLR155C ASP3-1 YLR157C ASP3-2 YLR158C ASP3-3 YLR160C ASP3-4 YLR181C VTA1 YLR182W SWI6 YLR249W YEF3 YLR409C UTP21 YLR410W VIP1 YLR446W YML017W PSP2 YML018C YML035C AMD1 YML055W SPC2 YML056C IMD4 YML059C YML121W GTR1 YMR043W MCM1 YMR108W ILV2 YMR132C YMR133W REC114 YMR146C TIF34 YMR147W YMR182C RGM1 YMR216C SKY1 YMR217W GUA1 YMR244W YMR255W GFD1 YMR274C RCE1 YMR278W YMR321C YNL020C ARK1 YNL036W NCE103 YNL037C IDH1 YNL063W YNL064C YDJ1 YNL112W DBP2 YNL141W AAH1 YNL142W MEP2 YNL180C RHO5 YNL261W ORC5 YNL277W MET2 YNL282W POP3 YNR074C YNR075W COS10 YOL100W PKH2 YOR014W RTS1 YOR054C YOR065W CYT1 YOR098C NUP1 YOR099W KTR1 YOR108W YOR180C DCI1 YOR270C VPH1 YOR334W MRS2 YOR337W TEA1 YOR341W RPA190 YOR370C MRS6 YPL050C MNN9 YPL065W VPS28 YPL068C YPL189W GUP2 YPL277C YPR010C RPA135 YPR022C YPR036W VMA13 YPR078C YPR079W MRL1 Genes Not Found: YHR214C-B MIPS Functional Classification Category p-value In Category from Cluster k f amino acid metabolism 0.000237394 MET6 ARO9 MET30 LYS12 MET3 PUT3 DPH2 BAS1 SUL2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MCM1 ILV2 MET2 YOR108W 17 204 transport ATPases 0.000413583 DRS2 ATP3 TFP1 PMA1 ATP7 VPH1 VMA13 7 44 purine ribonucleotide metabolism 0.000476792 PRS4 HPT1 PRS2 AMD1 IMD4 GUA1 AAH1 7 45 homeostasis of protons 0.000714585 ATP3 TFP1 PMA1 ATP7 VPH1 VMA13 6 35 cell wall 0.00112286 FIG1 GNA1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 6 38 other cation transporters (Na, K, Ca , NH4, etc.) 0.00112286 DRS2 TFP1 PMA1 MEP2 VPH1 VMA13 6 38 METABOLISM 0.0035034 URA7 PRS4 FAT2 GLK1 PDI1 HXT7 HPT1 APA2 MET6 PRS2 HAC1 ERG26 SMI1 ARO9 PHO12 FAA3 MET30 LYS12 ERG20 MNN5 MET3 PUT3 YKL027W MAE1 DPH2 ACP1 JEN1 BAS1 SUL2 STM1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 AMD1 IMD4 GTR1 MCM1 ILV2 GUA1 YMR278W IDH1 AAH1 MET2 KTR1 YOR108W DCI1 MRS6 MNN9 49 1066 regulation of amino acid metabolism 0.00353056 ARO9 MET30 PUT3 BAS1 MCM1 5 33 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f ion-transport ATPases 0.000626251 DRS2 ATP3 TFP1 PMA1 ATP7 VPH1 VMA13 7 47 AGC group 0.00169595 YBR028C RIM15 SCH9 PKH2 4 17 other AGC group protein kinases 0.00294706 YBR028C RIM15 2 3 GO Molecular Function Category p-value In Category from Cluster k f asparaginase [GO:0004067] 1.40802e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 enzyme [GO:0003824] 0.000161671 DRS2 MRPL16 URA7 PRS4 ATP3 GLK1 PDI1 SIT4 TFP1 DOA4 HPT1 APA2 MCM3 MET6 PRS2 UBC6 GNA1 EPL1 RIM15 ERG26 PMA1 CLB6 RAD2 QCR10 RRP3 PCL5 KSP1 ARO9 RPC10 SCH9 PHO12 FAA3 MET30 LYS12 STH1 ERG20 SET2 MNN5 SWE1 YJL200C MET3 ATP7 MAE1 UBP11 PSR1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 AMD1 IMD4 GTR1 ILV2 SKY1 GUA1 RCE1 ARK1 IDH1 DBP2 AAH1 RHO5 ORC5 MET2 POP3 YNR074C PKH2 RTS1 KTR1 DCI1 VPH1 RPA190 MNN9 RPA135 VMA13 74 1604 hydrogen-transporting two-sector ATPase [GO:0003936] 0.000298362 ATP3 TFP1 PMA1 ATP7 VPH1 VMA13 6 30 hydrogen-/sodium-translocating ATPase [GO:0015442] 0.000298362 ATP3 TFP1 PMA1 ATP7 VPH1 VMA13 6 30 hydrolase, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] 0.000835156 ASP3-1 ASP3-2 ASP3-3 ASP3-4 AMD1 AAH1 6 36 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] 0.00132964 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 16 hydrolase, acting on acid anhydrides, catalyzing transmembrane movement of substances [GO:0016820] 0.0029873 DRS2 ATP3 TFP1 PMA1 ATP7 VPH1 VMA13 7 61 transferase [GO:0016740] 0.00389175 MRPL16 PRS4 GLK1 HPT1 MET6 PRS2 GNA1 EPL1 RIM15 CLB6 PCL5 KSP1 ARO9 RPC10 SCH9 ERG20 SET2 MNN5 SWE1 MET3 SKY1 ARK1 MET2 PKH2 KTR1 RPA190 MNN9 RPA135 28 522 GO Biological Process Category p-value In Category from Cluster k f asparagine catabolism [GO:0006530] 9.87228e-07 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 4 response to nitrogen starvation [GO:0006995] 4.81319e-06 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 5 amine metabolism [GO:0009308] 4.91417e-06 PRS4 MET6 PRS2 GNA1 ARO9 LYS12 MET3 PUT3 MAE1 BAS1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ILV2 IDH1 MET2 17 151 glutamine family amino acid catabolism [GO:0009065] 6.79743e-06 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 10 amino acid metabolism [GO:0006520] 7.77175e-06 PRS4 MET6 PRS2 ARO9 LYS12 MET3 PUT3 MAE1 BAS1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ILV2 IDH1 MET2 16 140 asparagine metabolism [GO:0006528] 1.40802e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 amino acid and derivative metabolism [GO:0006519] 1.73016e-05 PRS4 MET6 PRS2 ARO9 LYS12 MET3 PUT3 MAE1 BAS1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ILV2 IDH1 MET2 16 149 aspartate family amino acid metabolism [GO:0009066] 3.48283e-05 MET6 LYS12 MET3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MET2 8 41 aspartate family amino acid catabolism [GO:0009068] 6.24827e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 8 amine catabolism [GO:0009310] 0.000248205 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 19 amino acid catabolism [GO:0009063] 0.000248205 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 19 response to starvation [GO:0009267] 0.000399651 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 12 glutamine family amino acid metabolism [GO:0009064] 0.000607935 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDH1 6 34 nucleotide metabolism [GO:0009117] 0.000971042 PRS4 HPT1 APA2 PRS2 GUA1 5 25 purine nucleotide metabolism [GO:0006163] 0.00132964 PRS4 HPT1 PRS2 GUA1 4 16 nucleobase metabolism [GO:0009112] 0.00166253 URA7 PRS4 PRS2 BAS1 AAH1 5 28 cell growth and/or maintenance [GO:0008151] 0.00206668 MAK16 DRS2 NUP60 MRPL16 URA7 PRS4 RPL4A ATP3 FIG1 FAT2 AUT4 GLK1 PDI1 YCL073C HCM1 SIT4 USO1 RAD59 TFP1 SSB1 DOA4 DOP1 GCD6 TFB1 HXT7 HPT1 APA2 MCM3 MET6 PRS2 UBC6 KAP123 LSM4 BOI2 DSE1 GNA1 BUD27 EPL1 HAC1 RIM15 LOC1 ERG26 PMA1 COG1 PAC10 CLB6 SMI1 BNS1 RAD2 MRP4 QCR10 MSC7 RRP3 SSF1 PCL5 KSP1 SPL2 ARO9 RPC10 SCH9 FAA3 MET30 SNP1 LYS12 STH1 PAN1 GYP6 MRS3 ERG20 SET2 MNN5 SWE1 MET3 ANB1 RSM7 CAP1 PUT3 ATP7 MAE1 NUP100 SLD2 DPH2 ACP1 MNN4 JEN1 BAS1 PSR1 RPL8B SED5 SUL2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 SWI6 YEF3 VIP1 AMD1 SPC2 GTR1 MCM1 ILV2 REC114 TIF34 RGM1 SKY1 GUA1 GFD1 RCE1 ARK1 IDH1 YDJ1 AAH1 MEP2 ORC5 MET2 POP3 YNR074C COS10 PKH2 RTS1 CYT1 NUP1 KTR1 DCI1 VPH1 MRS2 TEA1 RPA190 MRS6 MNN9 VPS28 RPA135 VMA13 YPR078C MRL1 136 3657 nucleobase biosynthesis [GO:0046112] 0.00262786 URA7 PRS4 PRS2 BAS1 4 19 purine nucleoside monophosphate metabolism [GO:0009126] 0.0032087 PRS4 PRS2 GUA1 3 10 ribonucleoside monophosphate metabolism [GO:0009161] 0.0032087 PRS4 PRS2 GUA1 3 10 purine ribonucleoside monophosphate metabolism [GO:0009167] 0.0032087 PRS4 PRS2 GUA1 3 10 aromatic compound metabolism [GO:0006725] 0.00383716 URA7 PRS4 PRS2 ARO9 BAS1 AAH1 6 48 nucleoside monophosphate metabolism [GO:0009123] 0.00430951 PRS4 PRS2 GUA1 3 11 GO Cellular Component Category p-value In Category from Cluster k f periplasmic space (sensu Fungi) [GO:0030287] 0.000109678 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 9 cell [GO:0005623] 0.00205075 MAK16 DRS2 NUP60 MRPL16 URA7 PRS4 RPL4A ATP3 FAT2 GLK1 PDI1 YCL073C HCM1 SIT4 USO1 RAD59 TFP1 SSB1 DOA4 GCD6 TFB1 HXT7 MCM3 MET6 PRS2 UBC6 KAP123 LSM4 BOI2 EPL1 HAC1 LOC1 ERG26 PMA1 SDS23 COG1 PAC10 SMI1 RAD2 MRP4 QCR10 YHR009C RRP3 SSF1 PCL5 KSP1 SPL2 RPC10 MET30 SYG1 SNP1 LYS12 STH1 PAN1 MRS3 SNA3 ERG20 SET2 MNN5 SWE1 ANB1 RSM7 CAP1 LAC1 PUT3 ATP7 MAE1 NUP100 SLD2 ACP1 JEN1 YKR045C BAS1 PSR1 RPL8B SED5 SUL2 STM1 ASP3-1 SWI6 YEF3 SPC2 GTR1 MCM1 ILV2 TIF34 RGM1 SKY1 GFD1 RCE1 ARK1 NCE103 IDH1 YDJ1 DBP2 AAH1 MEP2 ORC5 MET2 POP3 YNR074C COS10 PKH2 RTS1 CYT1 NUP1 KTR1 DCI1 VPH1 MRS2 TEA1 RPA190 MRS6 MNN9 VPS28 GUP2 RPA135 VMA13 MRL1 119 3106 intracellular [GO:0005622] 0.00219324 MAK16 DRS2 NUP60 MRPL16 URA7 PRS4 RPL4A ATP3 FAT2 GLK1 PDI1 HCM1 SIT4 RAD59 TFP1 SSB1 DOA4 GCD6 TFB1 HXT7 MCM3 MET6 PRS2 UBC6 KAP123 LSM4 EPL1 HAC1 LOC1 ERG26 PMA1 SDS23 COG1 PAC10 SMI1 RAD2 MRP4 QCR10 YHR009C RRP3 SSF1 PCL5 KSP1 SPL2 RPC10 MET30 SYG1 SNP1 LYS12 STH1 PAN1 MRS3 ERG20 SET2 MNN5 SWE1 ANB1 RSM7 CAP1 LAC1 PUT3 ATP7 MAE1 NUP100 SLD2 ACP1 JEN1 YKR045C BAS1 PSR1 RPL8B SED5 SUL2 STM1 ASP3-1 SWI6 YEF3 SPC2 GTR1 MCM1 ILV2 TIF34 RGM1 SKY1 GFD1 RCE1 ARK1 NCE103 IDH1 YDJ1 AAH1 MEP2 ORC5 MET2 POP3 YNR074C COS10 PKH2 RTS1 CYT1 NUP1 KTR1 DCI1 VPH1 MRS2 TEA1 RPA190 MRS6 MNN9 VPS28 RPA135 VMA13 MRL1 113 2921 nuclear membrane [GO:0005635] 0.00288721 NUP60 UBC6 KAP123 NUP100 ASP3-1 GFD1 COS10 NUP1 8 77 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00710 (Asparaginase) 3.20371e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 7 PF02996 (DUF232) 0.00294706 BUD27 PAC10 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YAL015C (NTG1) 0.0032087 AHA1 TIF34 IDH1 3 10 Cellzome Complexes Category p-value In Category from Cluster k f YNL313C 0.00100443 TFP1 KAP123 LYS12 3 7 YGR020C (VMA7) 0.0015696 TFP1 VPH1 VMA13 3 8 Proteome Localization--Observed Category p-value In Category from Cluster k f en2 0.000970837 FAT2 PDI1 SYG1 SNA3 DCI1 MRL1 6 37 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f