Input Cluster (n=199) YAL005C SSA1 YAL025C MAK16 YAL028W YAL029C MYO4 YAL055W PEX22 YAL060W BDH1 YAR071W PHO11 YBL038W MRPL16 YBL039C URA7 YBR007C YBR054W YRO2 YBR084C-A RPL19A YBR085W AAC3 YBR105C VID24 YBR106W PHO88 YBR125C PTC4 YBR291C CTP1 YCL025C AGP1 YCL048W YCL055W KAR4 YCL056C YCL068C YCR038C BUD5 YCR046C IMG1 YCR047C BUD23 YCR048W ARE1 YCR065W HCM1 YDL035C GPR1 YDL047W SIT4 YDL093W PMT5 YDL168W SFA1 YDR033W MRH1 YDR069C DOA4 YDR096W GIS1 YDR198C YDR206W EBS1 YDR223W YDR305C HNT2 YDR313C PIB1 YDR326C YDR475C JIP4 YDR499W LCD1 YDR523C SPS1 YDR524C AGE1 YEL032W MCM3 YEL040W UTR2 YER016W BIM1 YER036C KRE30 YER049W YER151C UBP3 YER163C YER165W PAB1 YFL039C ACT1 YGL045W YGL080W YGL100W SEH1 YGL135W RPL1B YGL150C INO80 YGL158W RCK1 YGL187C COX4 YGL223C COG1 YGR060W ERG25 YGR068C YGR077C PEX8 YGR078C PAC10 YGR108W CLB1 YGR121C MEP1 YGR170W PSD2 YGR240C PFK1 YGR264C MES1 YGR280C PXR1 YHL033C RPL8A YHR004C NEM1 YHR031C RRM3 YHR032W YHR066W SSF1 YHR071W PCL5 YHR082C KSP1 YHR127W YHR149C YHR150W YHR161C YAP1801 YHR162W YHR177W YHR205W SCH9 YHR206W SKN7 YHR215W PHO12 YIL023C YIL034C CAP2 YIL056W YIL108W YIL112W YIL120W QDR1 YIL131C FKH1 YJL005W CYR1 YJL066C MPM1 YJL207C YJR047C ANB1 YJR048W CYC1 YJR057W CDC8 YJR103W URA8 YJR122W CAF17 YJR140C HIR3 YKL027W YKL029C MAE1 YKL060C FBA1 YKL071W YKL080W VMA5 YKL096W CWP1 YKL182W FAS1 YKL191W DPH2 YKL192C ACP1 YKL198C PTK1 YKL201C MNN4 YKL211C TRP3 YKL217W JEN1 YKR011C YKR098C UBP11 YLL012W YLL013C PUF3 YLL024C SSA2 YLL028W TPO1 YLL029W YLL031C GPI13 YLR018C POM34 YLR113W HOG1 YLR149C YLR219W MSC3 YLR249W YEF3 YLR256W HAP1 YLR307W CDA1 YLR432W IMD3 YML043C RRN11 YML056C IMD4 YML071C COG8 YMR004W MVP1 YMR070W MOT3 YMR108W ILV2 YMR119W ASI1 YMR125W STO1 YMR131C RRB1 YMR147W YMR158W YMR164C MSS11 YMR182C RGM1 YMR185W YMR201C RAD14 YMR202W ERG2 YMR205C PFK2 YMR216C SKY1 YMR241W YHM2 YMR265C YMR266W RSN1 YMR296C LCB1 YMR321C YNL014W HEF3 YNL068C FKH2 YNL079C TPM1 YNL192W CHS1 YNL201C PSY2 YNL233W BNI4 YNL286W CUS2 YNL301C RPL18B YNR017W MAS6 YNR051C BRE5 YNR069C YOL052C SPE2 YOL059W GPD2 YOL086C ADH1 YOL124C YOR043W WHI2 YOR107W RGS2 YOR134W BAG7 YOR192C YOR222W ODC2 YOR274W MOD5 YOR291W YOR299W BUD7 YOR308C SNU66 YOR341W RPA190 YOR389W YPL037C EGD1 YPL106C SSE1 YPL137C YPL154C PEP4 YPL159C YPL169C MEX67 YPL189W GUP2 YPL222W YPL239W YAR1 YPL271W ATP15 YPR009W SUT2 YPR060C ARO7 YPR079W MRL1 YPR103W PRE2 YPR149W NCE102 YPR157W YPR164W MMS1 YPR192W AQY1 Genes Not Found: YHR214C-B MIPS Functional Classification Category p-value In Category from Cluster k f sporulation and germination 0.000924159 YCL048W ARE1 DOA4 SPS1 SEH1 NEM1 CYR1 CDA1 CHS1 SPE2 PRE2 11 114 perception of nutrients and nutritional adaptation 0.000971042 GPR1 SCH9 CYR1 PTK1 SSE1 5 25 CELL FATE 0.00201161 MYO4 YCL048W KAR4 BUD5 ARE1 GPR1 SIT4 DOA4 SPS1 ACT1 SEH1 NEM1 SSF1 SCH9 SKN7 CAP2 CYR1 CDA1 TPM1 CHS1 BNI4 SPE2 WHI2 SSE1 PRE2 25 427 TRANSPORT FACILITATION 0.00201222 AAC3 CTP1 AGP1 KRE30 MEP1 YHR032W YIL056W QDR1 VMA5 ACP1 JEN1 TPO1 HEF3 MAS6 YOR192C ODC2 YOR291W GUP2 ATP15 AQY1 20 312 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f Phosphofructokinase 0.00100339 PFK1 PFK2 2 2 MIPS Protein Classes Category p-value In Category from Cluster k f Fork head/winged helix 0.000123242 HCM1 FKH1 FKH2 3 4 GO Molecular Function Category p-value In Category from Cluster k f tricarboxylate carrier [GO:0005371] 0.00100339 CTP1 YHM2 2 2 6-phosphofructokinase [GO:0003872] 0.00100339 PFK1 PFK2 2 2 CTP synthase [GO:0003883] 0.00100339 URA7 URA8 2 2 organic cation transporter [GO:0015101] 0.00100443 CTP1 MEP1 YHM2 3 7 oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] 0.00344674 BDH1 MAE1 IMD3 IMD4 GPD2 ADH1 6 47 GO Biological Process Category p-value In Category from Cluster k f G-protein coupled receptor protein signaling pathway [GO:0007186] 0.000587692 GPR1 CYR1 RGS2 3 6 tricarboxylic acid transport [GO:0006842] 0.00100339 CTP1 YHM2 2 2 cell growth and/or maintenance [GO:0008151] 0.00206668 SSA1 MAK16 MYO4 PEX22 BDH1 PHO11 MRPL16 URA7 RPL19A AAC3 VID24 PHO88 CTP1 AGP1 KAR4 BUD5 IMG1 BUD23 ARE1 HCM1 GPR1 SIT4 PMT5 SFA1 DOA4 EBS1 HNT2 PIB1 LCD1 SPS1 AGE1 MCM3 UTR2 BIM1 UBP3 PAB1 ACT1 SEH1 RPL1B INO80 RCK1 COX4 COG1 ERG25 PEX8 PAC10 CLB1 MEP1 PSD2 PFK1 MES1 RPL8A NEM1 RRM3 SSF1 PCL5 KSP1 YAP1801 SCH9 SKN7 CAP2 YIL112W QDR1 FKH1 CYR1 ANB1 CYC1 CDC8 URA8 HIR3 MAE1 FBA1 VMA5 CWP1 FAS1 DPH2 ACP1 PTK1 MNN4 TRP3 JEN1 PUF3 SSA2 GPI13 POM34 HOG1 MSC3 YEF3 HAP1 CDA1 IMD3 RRN11 COG8 MVP1 MOT3 ILV2 ASI1 STO1 RRB1 RGM1 RAD14 ERG2 PFK2 SKY1 YHM2 LCB1 HEF3 FKH2 TPM1 CHS1 BNI4 CUS2 RPL18B MAS6 SPE2 GPD2 ADH1 WHI2 YOR192C ODC2 MOD5 BUD7 SNU66 RPA190 EGD1 SSE1 PEP4 MEX67 ATP15 SUT2 ARO7 MRL1 PRE2 NCE102 MMS1 AQY1 136 3657 organic anion transport [GO:0015711] 0.0032087 CTP1 JEN1 YHM2 3 10 lipid biosynthesis [GO:0008610] 0.0037475 URA7 ERG25 PSD2 URA8 FAS1 ACP1 GPI13 ERG2 LCB1 9 98 GO Cellular Component Category p-value In Category from Cluster k f 6-phosphofructokinase complex [GO:0005945] 0.00100339 PFK1 PFK2 2 2 cytoplasm [GO:0005737] 0.00156951 SSA1 MYO4 PEX22 BDH1 MRPL16 URA7 RPL19A AAC3 VID24 CTP1 IMG1 ARE1 SIT4 PMT5 DOA4 PIB1 MCM3 UTR2 BIM1 UBP3 PAB1 ACT1 RPL1B COX4 COG1 ERG25 PEX8 PAC10 PSD2 PFK1 MES1 RPL8A YAP1801 CAP2 MPM1 ANB1 CYC1 CDC8 URA8 MAE1 FBA1 VMA5 FAS1 ACP1 SSA2 GPI13 HOG1 YEF3 IMD3 COG8 MVP1 ILV2 ASI1 STO1 ERG2 PFK2 SKY1 YHM2 LCB1 HEF3 TPM1 CHS1 BNI4 RPL18B MAS6 GPD2 ADH1 ODC2 MOD5 EGD1 SSE1 PEP4 MEX67 ATP15 MRL1 PRE2 NCE102 77 1810 intracellular [GO:0005622] 0.00219324 SSA1 MAK16 MYO4 PEX22 BDH1 MRPL16 URA7 RPL19A AAC3 VID24 CTP1 AGP1 KAR4 BUD5 IMG1 ARE1 HCM1 GPR1 SIT4 PMT5 MRH1 DOA4 EBS1 PIB1 LCD1 MCM3 UTR2 BIM1 UBP3 PAB1 ACT1 SEH1 RPL1B INO80 COX4 COG1 ERG25 PEX8 PAC10 MEP1 PSD2 PFK1 MES1 RPL8A RRM3 SSF1 PCL5 KSP1 YHR127W YAP1801 SKN7 CAP2 YIL112W QDR1 FKH1 CYR1 MPM1 ANB1 CYC1 CDC8 URA8 HIR3 MAE1 FBA1 VMA5 FAS1 ACP1 JEN1 SSA2 GPI13 POM34 HOG1 YEF3 HAP1 IMD3 RRN11 COG8 MVP1 MOT3 ILV2 ASI1 STO1 RRB1 RGM1 RAD14 ERG2 PFK2 SKY1 YHM2 LCB1 HEF3 FKH2 TPM1 CHS1 BNI4 CUS2 RPL18B MAS6 GPD2 ADH1 BAG7 ODC2 MOD5 SNU66 RPA190 EGD1 SSE1 PEP4 MEX67 ATP15 MRL1 PRE2 NCE102 113 2921 cell [GO:0005623] 0.00321478 SSA1 MAK16 MYO4 PEX22 BDH1 MRPL16 URA7 RPL19A AAC3 VID24 PHO88 CTP1 AGP1 KAR4 BUD5 IMG1 ARE1 HCM1 GPR1 SIT4 PMT5 MRH1 DOA4 EBS1 PIB1 LCD1 MCM3 UTR2 BIM1 UBP3 PAB1 ACT1 SEH1 RPL1B INO80 COX4 COG1 ERG25 PEX8 PAC10 MEP1 PSD2 PFK1 MES1 RPL8A NEM1 RRM3 SSF1 PCL5 KSP1 YHR127W YAP1801 SKN7 CAP2 YIL112W QDR1 FKH1 CYR1 MPM1 ANB1 CYC1 CDC8 URA8 HIR3 MAE1 FBA1 VMA5 FAS1 ACP1 JEN1 SSA2 GPI13 POM34 HOG1 YEF3 HAP1 CDA1 IMD3 RRN11 COG8 MVP1 MOT3 ILV2 ASI1 STO1 RRB1 RGM1 RAD14 ERG2 PFK2 SKY1 YHM2 LCB1 HEF3 FKH2 TPM1 CHS1 BNI4 CUS2 RPL18B MAS6 GPD2 ADH1 BAG7 YOR192C ODC2 MOD5 SNU66 RPA190 EGD1 SSE1 PEP4 MEX67 GUP2 ATP15 MRL1 PRE2 NCE102 118 3106 SMART Domains Category p-value In Category from Cluster k f FH 0.000123242 HCM1 FKH1 FKH2 3 4 PFam-A Domains Category p-value In Category from Cluster k f PF00250 (Fork_head) 0.000123242 HCM1 FKH1 FKH2 3 4 PF00365 (PFK) 0.00100339 PFK1 PFK2 2 2 PF00117 (GATase) 0.00229957 URA7 URA8 TRP3 3 9 PF03650 (UPF0041) 0.00294706 YGL080W YHR162W 2 3 PF01036 (Bac_rhodopsin) 0.00294706 YRO2 MRH1 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f YJR103W (URA8) 0.00100339 URA7 URA8 2 2 Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YLR459W (CDC91) 0.00100339 SSA2 RPL18B 2 2 YJR103W (URA8) 0.00294706 URA7 URA8 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f YAL029C (MYO4) 0.000399651 MYO4 ACT1 YEF3 ADH1 4 12 YMR205C (PFK2) 0.00100339 PFK1 PFK2 2 2 YNL138W (SRV2) 0.00294706 ACT1 CYR1 2 3 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.00360971 SSA1 MYO4 PEX22 BDH1 URA7 AAC3 VID24 PHO88 PTC4 CTP1 AGP1 ARE1 GPR1 SIT4 PMT5 SFA1 DOA4 GIS1 YDR198C EBS1 HNT2 PIB1 YDR326C SPS1 AGE1 UTR2 BIM1 KRE30 UBP3 YER163C PAB1 ACT1 YGL045W YGL080W RPL1B RCK1 COG1 ERG25 YGR068C PEX8 PAC10 CLB1 MEP1 PFK1 MES1 RPL8A RRM3 YHR032W KSP1 YHR127W YAP1801 YHR162W SCH9 CAP2 YIL056W YIL108W YIL112W QDR1 FKH1 ANB1 CYC1 CDC8 URA8 CAF17 HIR3 FBA1 YKL071W VMA5 FAS1 DPH2 TRP3 JEN1 YKR011C UBP11 YLL012W PUF3 SSA2 TPO1 YLL029W POM34 HOG1 YLR149C MSC3 YEF3 IMD3 IMD4 MVP1 RRB1 YMR147W MSS11 YMR185W PFK2 SKY1 YHM2 YMR265C YMR321C HEF3 CHS1 PSY2 BNI4 CUS2 RPL18B BRE5 ADH1 YOL124C WHI2 RGS2 BAG7 YOR192C YOR291W BUD7 SSE1 YPL137C YPL222W YAR1 ATP15 SUT2 PRE2 NCE102 MMS1 AQY1 121 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f