Input Cluster (n=198) YAL001C TFC3 YAL062W GDH3 YBL003C HTA2 YBL030C PET9 YBL097W BRN1 YBL104C YBR057C MUM2 YBR118W TEF2 YBR183W YPC1 YBR185C MBA1 YBR186W PCH2 YBR203W YBR213W MET8 YBR239C YBR240C THI2 YBR275C RIF1 YBR295W PCA1 YCL004W PGS1 YCL017C NFS1 YCL039W YCL040W GLK1 YCL042W YCL043C PDI1 YCL045C YCL068C YCR034W FEN1 YCR050C YCR051W YCR059C YIH1 YCR060W YDL003W MCD1 YDL046W YDL124W YDL125C HNT1 YDL131W LYS21 YDL241W YDR023W SES1 YDR032C PST2 YDR040C ENA1 YDR194C MSS116 YDR226W ADK1 YDR234W LYS4 YDR240C SNU56 YDR253C MET32 YDR254W CHL4 YDR322W MRPL35 YDR367W YDR374C YDR382W RPP2B YDR427W RPN9 YDR451C YHP1 YDR462W MRPL28 YEL011W GLC3 YEL064C YER022W SRB4 YER026C CHO1 YER036C KRE30 YER037W PHM8 YER064C YER078C YER079W YFL017W-A SMX2 YFL018C LPD1 YFL022C FRS2 YFR001W LOC1 YFR011C YFR012W YGL001C ERG26 YGL036W YGL037C PNC1 YGL076C RPL7A YGL097W SRM1 YGL105W ARC1 YGL113W SLD3 YGL125W MET13 YGL128C CWC23 YGL184C STR3 YGL224C SDT1 YGL227W VID30 YGL263W COS12 YGR004W YGR052W YGR074W SMD1 YGR093W YGR175C ERG1 YGR179C OKP1 YGR195W SKI6 YGR234W YHB1 YGR255C COQ6 YGR256W GND2 YGR285C ZUO1 YGR286C BIO2 YHL035C YHR003C YHR028C DAP2 YHR030C SLT2 YHR085W IPI1 YHR100C YHR216W IMD2 YIL044C AGE2 YIL060W YIL061C SNP1 YIL099W SGA1 YIL101C XBP1 YIL115C NUP159 YIL173W VTH1 YIR004W DJP1 YJL006C CTK2 YJL062W LAS21 YJL149W YJL151C SNA3 YJL222W VTH2 YJR001W YJR010W MET3 YJR076C CDC11 YKL025C PAN3 YKL055C OAR1 YKL072W STB6 YKL140W TGL1 YKL141W SDH3 YKL152C GPM1 YKL166C TPK3 YKL182W FAS1 YKL193C SDS22 YKL194C MST1 YKL208W CBT1 YKR046C YKR060W YKR105C YLL012W YLL042C APG10 YLR012C YLR018C POM34 YLR049C YLR061W RPL22A YLR069C MEF1 YLR098C CHA4 YLR121C YPS3 YLR146C SPE4 YLR153C ACS2 YLR207W HRD3 YLR221C RSA3 YLR272C YCS4 YLR309C IMH1 YLR354C TAL1 YLR376C PSY3 YML016C PPZ1 YML042W CAT2 YML057W CMP2 YML066C SMA2 YML085C TUB1 YML087C YML125C YMR023C MSS1 YMR024W MRPL3 YMR056C AAC1 YMR058W FET3 YMR110C YMR112C MED11 YMR113W FOL3 YMR192W YMR196W YMR206W YNL014W HEF3 YNL102W POL1 YNL122C YNL231C PDR16 YNL316C PHA2 YNL323W LEM3 YNL325C FIG4 YNR035C ARC35 YOL038W PRE6 YOL041C NOP12 YOL048C YOL049W GSH2 YOL088C MPD2 YOL122C SMF1 YOR001W RRP6 YOR114W YOR128C ADE2 YOR136W IDH2 YOR177C MPC54 YOR223W YOR270C VPH1 YOR279C RFM1 YOR294W RRS1 YOR323C PRO2 YPL065W VPS28 YPL088W YPL125W KAP120 YPL159C YPL162C YPL165C SET6 YPL203W TPK2 YPL253C VIK1 YPR001W CIT3 YPR066W UBA3 YPR071W Genes Not Found: YBR012W-A YBR012W-B MIPS Functional Classification Category p-value In Category from Cluster k f METABOLISM 0.00182223 GDH3 PET9 YPC1 MET8 PGS1 GLK1 PDI1 FEN1 YDL124W HNT1 LYS21 ADK1 LYS4 MET32 GLC3 CHO1 LPD1 ERG26 MET13 STR3 ERG1 SKI6 COQ6 GND2 BIO2 YHR003C IMD2 SGA1 MET3 CDC11 OAR1 TGL1 GPM1 FAS1 YLL012W CHA4 SPE4 ACS2 TAL1 CAT2 AAC1 FOL3 PDR16 PHA2 GSH2 ADE2 IDH2 PRO2 YPL088W CIT3 50 1066 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f PKA family (cAMP dependent) 0.00291776 TPK3 TPK2 2 3 GO Molecular Function Category p-value In Category from Cluster k f oxidoreductase [GO:0016491] 0.00118538 GDH3 PDI1 LPD1 ERG26 MET13 ERG1 GND2 IMD2 OAR1 SDH3 FAS1 FET3 MPD2 IDH2 PRO2 YPL088W 16 215 enzyme [GO:0003824] 0.00124604 GDH3 YPC1 MET8 PCA1 PGS1 GLK1 PDI1 LYS21 SES1 ENA1 MSS116 ADK1 LYS4 RPN9 GLC3 CHO1 KRE30 LPD1 FRS2 ERG26 PNC1 MET13 STR3 SDT1 ERG1 SKI6 GND2 BIO2 DAP2 SLT2 IMD2 SGA1 CTK2 LAS21 MET3 PAN3 OAR1 TGL1 SDH3 GPM1 TPK3 FAS1 MST1 APG10 YPS3 SPE4 ACS2 HRD3 TAL1 PPZ1 CAT2 CMP2 FET3 FOL3 HEF3 POL1 PHA2 FIG4 PRE6 GSH2 MPD2 RRP6 ADE2 IDH2 VPH1 PRO2 YPL088W TPK2 CIT3 UBA3 70 1604 cyclic-nucleotide dependent protein kinase [GO:0004690] 0.00291776 TPK3 TPK2 2 3 cAMP-dependent protein kinase [GO:0004691] 0.00291776 TPK3 TPK2 2 3 GO Biological Process Category p-value In Category from Cluster k f amino acid and derivative metabolism [GO:0006519] 6.43502e-05 GDH3 YIH1 LYS21 LYS4 MET32 LPD1 MET13 STR3 MET3 CHA4 SPE4 CAT2 PHA2 IDH2 PRO2 15 149 amine metabolism [GO:0009308] 7.50844e-05 GDH3 YIH1 LYS21 LYS4 MET32 LPD1 MET13 STR3 MET3 CHA4 SPE4 CAT2 PHA2 IDH2 PRO2 15 151 amino acid metabolism [GO:0006520] 0.000121897 GDH3 YIH1 LYS21 LYS4 MET32 LPD1 MET13 STR3 MET3 CHA4 CAT2 PHA2 IDH2 PRO2 14 140 biosynthesis [GO:0009058] 0.000144903 GDH3 TEF2 MET8 THI2 PGS1 FEN1 LYS21 SES1 LYS4 MRPL35 RPP2B MRPL28 CHO1 LPD1 FRS2 ERG26 PNC1 RPL7A ARC1 MET13 STR3 ERG1 BIO2 IMD2 LAS21 GPM1 FAS1 MST1 RPL22A MEF1 SPE4 ACS2 MSS1 MRPL3 FOL3 HEF3 PDR16 PHA2 GSH2 IDH2 PRO2 41 731 coenzyme metabolism [GO:0006732] 0.000256338 NFS1 LPD1 PNC1 COQ6 SPE4 ACS2 TAL1 FOL3 GSH2 9 68 coenzymes and prosthetic group metabolism [GO:0006731] 0.000284244 MET8 NFS1 LPD1 PNC1 COQ6 SPE4 ACS2 TAL1 FOL3 GSH2 10 84 sulfur metabolism [GO:0006790] 0.000401129 MET8 MET32 MET13 STR3 BIO2 MET3 GSH2 7 44 organic acid biosynthesis [GO:0016053] 0.000754268 FEN1 LPD1 FAS1 ACS2 4 14 carboxylic acid biosynthesis [GO:0046394] 0.000754268 FEN1 LPD1 FAS1 ACS2 4 14 amine biosynthesis [GO:0009309] 0.000769636 GDH3 LYS21 LYS4 LPD1 MET13 STR3 SPE4 PHA2 IDH2 PRO2 10 95 organic acid metabolism [GO:0006082] 0.000793498 FEN1 LPD1 OAR1 SDH3 FAS1 ACS2 FOL3 IDH2 CIT3 9 79 carboxylic acid metabolism [GO:0019752] 0.000793498 FEN1 LPD1 OAR1 SDH3 FAS1 ACS2 FOL3 IDH2 CIT3 9 79 amino acid biosynthesis [GO:0008652] 0.00186791 GDH3 LYS21 LYS4 LPD1 MET13 STR3 PHA2 IDH2 PRO2 9 89 mitotic chromosome condensation [GO:0007076] 0.00226655 BRN1 MCD1 YCS4 3 9 mitotic prophase [GO:0000088] 0.00226655 BRN1 MCD1 YCS4 3 9 metabolism [GO:0008152] 0.00241479 TFC3 GDH3 HTA2 MUM2 TEF2 YPC1 MBA1 MET8 THI2 RIF1 PGS1 NFS1 GLK1 PDI1 FEN1 YIH1 LYS21 SES1 MSS116 LYS4 SNU56 MET32 MRPL35 RPP2B RPN9 YHP1 MRPL28 GLC3 SRB4 CHO1 SMX2 LPD1 FRS2 ERG26 PNC1 RPL7A SRM1 ARC1 SLD3 MET13 STR3 SDT1 VID30 SMD1 ERG1 SKI6 COQ6 GND2 ZUO1 BIO2 DAP2 SLT2 IMD2 AGE2 SNP1 NUP159 VTH1 DJP1 CTK2 LAS21 VTH2 MET3 PAN3 OAR1 TGL1 SDH3 GPM1 TPK3 FAS1 SDS22 MST1 CBT1 APG10 RPL22A MEF1 CHA4 YPS3 SPE4 ACS2 HRD3 TAL1 CAT2 MSS1 MRPL3 MED11 FOL3 HEF3 POL1 PDR16 PHA2 PRE6 NOP12 GSH2 MPD2 RRP6 ADE2 IDH2 VPH1 PRO2 VPS28 YPL088W KAP120 TPK2 CIT3 UBA3 105 2693 ADP transport [GO:0015866] 0.00291776 PET9 AAC1 2 3 nucleotide transport [GO:0006862] 0.00291776 PET9 AAC1 2 3 purine nucleotide transport [GO:0015865] 0.00291776 PET9 AAC1 2 3 ATP transport [GO:0015867] 0.00291776 PET9 AAC1 2 3 ATP/ADP exchange [GO:0006854] 0.00291776 PET9 AAC1 2 3 translational elongation [GO:0006414] 0.00379178 TEF2 RPP2B MEF1 HEF3 4 21 GO Cellular Component Category p-value In Category from Cluster k f cAMP-dependent protein kinase complex [GO:0005952] 0.00291776 TPK3 TPK2 2 3 cytoplasm [GO:0005737] 0.00345886 PET9 TEF2 YPC1 MBA1 PGS1 NFS1 GLK1 YCL042W PDI1 FEN1 HNT1 SES1 MSS116 ADK1 LYS4 MRPL35 RPP2B RPN9 MRPL28 CHO1 LPD1 FRS2 ERG26 RPL7A ARC1 MET13 ERG1 SKI6 COQ6 GND2 ZUO1 DAP2 SLT2 SGA1 DJP1 LAS21 CDC11 OAR1 TGL1 SDH3 GPM1 TPK3 FAS1 SDS22 MST1 YKR046C RPL22A MEF1 ACS2 HRD3 IMH1 TAL1 PPZ1 CAT2 CMP2 TUB1 MSS1 MRPL3 AAC1 HEF3 PDR16 LEM3 ARC35 PRE6 MPD2 SMF1 IDH2 MPC54 VPH1 PRO2 VPS28 KAP120 TPK2 VIK1 CIT3 75 1810 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00970 (FAD_binding_6) 0.000579045 YHB1 YML087C YML125C 3 6 PF00175 (NAD_binding) 0.00154688 YHB1 YML087C YML125C 3 8 PF01360 (Monooxygenase) 0.00291776 ERG1 COQ6 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YCR002C (CDC10) 0.000579045 LPD1 ARC1 CDC11 3 6 YGL035C (MIG1) 0.000993302 MSS116 NOP12 2 2 YNL053W (MSG5) 0.00291776 SLT2 TAL1 2 3 Cellzome Complexes Category p-value In Category from Cluster k f YFL017W-A (SMX2) 0.00166466 SNU56 SMX2 SMD1 SNP1 4 17 YPL203W (TPK2) 0.00291776 TPK3 TPK2 2 3 YBR057C (MUM2) 0.00291776 MUM2 YGL036W 2 3 YDR127W (ARO1) 0.00316301 RPN9 YHB1 IDH2 3 10 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f mit 0.00284182 MBA1 NFS1 YCL068C MSS116 MRPL35 MRPL28 YEL064C LPD1 YFR011C MET13 YGR004W COQ6 BIO2 YHR100C YIL060W OAR1 STB6 SDH3 MST1 CBT1 MEF1 PSY3 CAT2 MSS1 MRPL3 ARC35 YOL048C YOR114W IDH2 YPL159C SET6 CIT3 32 613 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f