Input Cluster (n=197) YAL021C CCR4 YBL086C YBR028C YBR035C PDX3 YBR046C ZTA1 YBR072W HSP26 YBR162C TOS1 YBR162W-A YSY6 YBR261C YBR263W SHM1 YDL010W YDL012C YDL028C MPS1 YDL030W PRP9 YDL057W YDL079C MRK1 YDL092W SRP14 YDL093W PMT5 YDL179W PCL9 YDL195W SEC31 YDL197C ASF2 YDR052C DBF4 YDR055W PST1 YDR135C YCF1 YDR137W RGP1 YDR146C SWI5 YDR159W SAC3 YDR335W MSN5 YDR349C YPS7 YDR350C TCM10 YDR351W SBE2 YDR367W YDR446W ECM11 YDR530C APA2 YDR531W YEL070W YER053C YER075C PTP3 YER113C YER147C SCC4 YER148W SPT15 YER169W RPH1 YFL014W HSP12 YFL037W TUB2 YFL038C YPT1 YFL052W YFL067W YFL068W YFR017C YGL001C ERG26 YGL056C SDS23 YGL119W ABC1 YGL120C PRP43 YGL140C YGL163C RAD54 YGL190C CDC55 YGR023W MTL1 YGR068C YGR070W ROM1 YGR108W CLB1 YGR130C YGR131W YGR249W MGA1 YGR250C YGR260W TNA1 YGR279C SCW4 YHL034C SBP1 YHR030C SLT2 YHR051W COX6 YHR067W RMD12 YHR077C NMD2 YHR078W YHR086W NAM8 YHR136C SPL2 YHR137W ARO9 YHR169W DBP8 YHR172W SPC97 YHR178W STB5 YIL036W CST6 YIL057C YIL072W HOP1 YIL073C SPO22 YIL090W YIL091C YIL108W YIL123W SIM1 YIL147C SLN1 YIL165C YIR006C PAN1 YIR023W DAL81 YIR042C YJL033W HCA4 YJL149W YJL151C SNA3 YJL171C YJL178C YJR025C BNA1 YJR083C YJR084W CSN12 YJR147W HMS2 YJR151C DAN4 YKL075C YKL112W ABF1 YKL113C RAD27 YKL186C MTR2 YKL201C MNN4 YKL217W JEN1 YKR013W PRY2 YKR044W UIP5 YKR045C YKR051W YKR066C CCP1 YKR067W GPT2 YKR072C SIS2 YKR074W YLL019C KNS1 YLL054C YLR037C DAN2 YLR154C YLR155C ASP3-1 YLR156W YLR157C ASP3-2 YLR158C ASP3-3 YLR159W YLR160C ASP3-4 YLR161W YLR178C TFS1 YLR188W MDL1 YLR213C CRR1 YLR214W FRE1 YLR224W YLR228C ECM22 YLR247C YLR413W YML054C CYB2 YML063W RPS1B YML064C TEM1 YML086C ALO1 YML087C YML121W GTR1 YML123C PHO84 YMR029C YMR030W YMR037C MSN2 YMR049C ERB1 YMR108W ILV2 YMR169C ALD3 YMR172W HOT1 YMR201C RAD14 YMR202W ERG2 YMR237W YMR243C ZRC1 YMR244W YMR279C YMR309C NIP1 YNL037C IDH1 YNL078W NIS1 YNL079C TPM1 YNL123W YNR020C YNR047W YOL032W YOL042W NGL1 YOL043C NTG2 YOL056W GPM3 YOL091W SPO21 YOL124C YOL151W GRE2 YOR061W CKA2 YOR104W PIN2 YOR161C YOR185C GSP2 YOR186W YOR204W DED1 YOR306C MCH5 YOR317W FAA1 YOR324C YOR377W ATF1 YPL024W NCE4 YPL065W VPS28 YPL107W YPL116W HOS3 YPL186C UIP4 YPL222W YPL224C MMT2 YPL245W YPL246C YPL263C KEL3 YPL277C YPR017C DSS4 YPR018W RLF2 YPR030W CSR2 YPR061C YPR062W FCY1 YPR078C YPR079W MRL1 YPR175W DPB2 Genes Not Found: YJR028W YJR029W YLR035C-A MIPS Functional Classification Category p-value In Category from Cluster k f CLASSIFICATION NOT YET CLEAR-CUT 0.000914642 YBR028C ZTA1 MRK1 PCL9 YPS7 SCW4 SPL2 KNS1 YNR047W NCE4 HOS3 11 115 cell wall 0.00106538 DAN4 DAN2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 6 38 regulation of amino acid metabolism 0.00338017 CCR4 SAC3 ARO9 DAL81 ABF1 5 33 amino acid degradation (catabolism) 0.00439463 BNA1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 35 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f other small GTP-binding proteins 0.0028886 TEM1 GTR1 2 3 GO Molecular Function Category p-value In Category from Cluster k f asparaginase [GO:0004067] 1.35256e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] 0.00128056 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 16 monocarboxylic acid transporter [GO:0008028] 0.00418835 YCF1 JEN1 MCH5 3 11 hydrolase, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] 0.00497571 ASP3-1 ASP3-2 ASP3-3 ASP3-4 FCY1 5 36 GO Biological Process Category p-value In Category from Cluster k f asparagine catabolism [GO:0006530] 9.47842e-07 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 4 response to nitrogen starvation [GO:0006995] 4.62237e-06 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 5 asparagine metabolism [GO:0006528] 1.35256e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 aspartate family amino acid catabolism [GO:0009068] 6.00526e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 8 glutamine family amino acid catabolism [GO:0009065] 0.000171421 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 10 response to starvation [GO:0009267] 0.000384505 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 12 response to stress [GO:0006950] 0.00140857 HSP26 HSP12 RAD54 MNN4 CCP1 SIS2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ALO1 MSN2 ALD3 HOT1 CKA2 15 199 response to biotic stimulus [GO:0009607] 0.00210735 HSP12 RAD54 CCP1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ALO1 CKA2 9 91 amine catabolism [GO:0009310] 0.00253281 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 19 amino acid catabolism [GO:0009063] 0.00253281 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 19 glutamine family amino acid metabolism [GO:0009064] 0.00386361 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDH1 5 34 GO Cellular Component Category p-value In Category from Cluster k f periplasmic space (sensu Fungi) [GO:0030287] 0.00010544 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 9 external protective structure [GO:0030312] 0.000129736 PST1 SCW4 SIM1 YJL171C DAN4 DAN2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 CRR1 11 92 cell wall [GO:0005618] 0.000129736 PST1 SCW4 SIM1 YJL171C DAN4 DAN2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 CRR1 11 92 cell wall (sensu Fungi) [GO:0009277] 0.000424575 PST1 SCW4 YJL171C DAN4 DAN2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 9 73 extracellular [GO:0005576] 0.00119564 PST1 SCW4 YJL171C DAN4 DAN2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 9 84 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00710 (Asparaginase) 3.07831e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 7 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YIL113W (SDP1) 0.000983269 SLT2 KNS1 2 2 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YLR446W 0.00152437 MGA1 SLT2 YKR074W 3 8 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YLR238W 0.0028886 PHO84 YMR029C 2 3 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f en2 0.00277149 YDL010W SEC31 PST1 YPS7 YER113C YFL067W YGL140C MTL1 SCW4 YHR078W YIL090W SIM1 SLN1 SNA3 YJL171C DAN4 UIP5 YKR051W ASP3-1 ASP3-2 ASP3-3 CRR1 FRE1 YLR413W TEM1 YML087C ERG2 ZRC1 YMR244W PIN2 UIP4 YPL246C YPL277C DSS4 MRL1 35 692 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f