Input Cluster (n=200) YAL002W VPS8 YAL003W EFB1 YAL025C MAK16 YAR002W NUP60 YBL074C AAR2 YBL081W YBL082C RHK1 YBR025C YBR031W RPL4A YBR079C RPG1 YBR086C IST2 YBR087W RFC5 YBR172C SMY2 YBR238C YBR291C CTP1 YCL037C SRO9 YCL054W SPB1 YCR015C YCR024C-A PMP1 YCR090C YDL014W NOP1 YDL015C TSC13 YDL082W RPL13A YDL083C RPS16B YDL122W UBP1 YDL146W YDL156W YDL157C YDL201W TRM8 YDL224C WHI4 YDL229W SSB1 YDR023W SES1 YDR066C YDR091C RLI1 YDR096W GIS1 YDR099W BMH2 YDR184C ATC1 YDR233C RTN1 YDR234W LYS4 YDR342C HXT7 YDR343C HXT6 YDR372C VPS74 YDR440W DOT1 YDR510W SMT3 YEL026W SNU13 YEL029C BUD16 YEL032W MCM3 YER007C-A YER056C FCY2 YER069W "ARG5,6" YER090W TRP2 YER091C MET6 YER169W RPH1 YFL012W YFL022C FRS2 YFR055W YGL006W PMC1 YGL008C PMA1 YGL044C RNA15 YGL078C DBP3 YGL202W ARO8 YGR034W RPL26B YGR065C VHT1 YGR123C PPT1 YGR125W YGR128C UTP8 YGR129W SYF2 YGR162W TIF4631 YGR170W PSD2 YGR177C ATF2 YGR187C HGH1 YGR210C YGR211W ZPR1 YGR229C SMI1 YGR258C RAD2 YGR286C BIO2 YHL033C RPL8A YHL039W YHR009C YHR019C DED81 YHR020W YHR022C YHR065C RRP3 YHR066W SSF1 YHR077C NMD2 YHR078W YHR089C GAR1 YHR149C YHR150W YIL078W THS1 YIL079C AIR1 YIL109C SEC24 YIL126W STH1 YJL011C RPC17 YJL033W HCA4 YJL044C GYP6 YJL148W RPA34 YJL165C HAL5 YJL167W ERG20 YJL168C SET2 YJL189W RPL39 YJL193W YJL200C YJR047C ANB1 YJR048W CYC1 YKL007W CAP1 YKL008C LAC1 YKL056C YKL068W NUP100 YKL106W AAT1 YKL205W LOS1 YKL218C SRY1 YKR042W UTH1 YLR002C NOC3 YLR029C RPL15A YLR047C YLR175W CBF5 YLR179C YLR180W SAM1 YLR197W SIK1 YLR242C ARV1 YLR278C YLR342W FKS1 YLR372W SUR4 YLR390W-A CCW14 YLR410W VIP1 YLR418C CDC73 YLR431C YLR432W IMD3 YML026C RPS18B YML043C RRN11 YML055W SPC2 YML056C IMD4 YML103C NUP188 YML106W URA5 YML107C YMR013C SEC59 YMR081C ISF1 YMR108W ILV2 YMR116C ASC1 YMR146C TIF34 YMR147W YMR180C CTL1 YMR182C RGM1 YMR216C SKY1 YMR217W GUA1 YMR260C TIF11 YMR296C LCB1 YMR300C ADE4 YMR308C PSE1 YMR309C NIP1 YMR312W ELP6 YNL005C MRP7 YNL016W PUB1 YNL058C YNL061W NOP2 YNL062C GCD10 YNL133C FYV6 YNL141W AAH1 YNL209W SSB2 YNL229C URE2 YNL308C KRI1 YNR029C YNR030W ECM39 YNR048W YNR050C LYS9 YNR071C YOL010W RCL1 YOL052C SPE2 YOL066C RIB2 YOL098C YOL121C RPS19A YOR001W RRP6 YOR007C SGT2 YOR063W RPL3 YOR101W RAS1 YOR140W SFL1 YOR209C NPT1 YOR210W RPB10 YOR224C RPB8 YOR267C HRK1 YOR291W YOR305W YOR310C NOP58 YOR342C YOR355W GDS1 YOR356W YPL081W RPS9A YPL183C YPL184C YPL226W NEW1 YPL227C ALG5 YPR010C RPA135 YPR036W VMA13 YPR060C ARO7 YPR069C SPE3 YPR070W MED1 YPR102C RPL11A YPR103W PRE2 YPR144C UTP19 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f PROTEIN SYNTHESIS 2.31123e-08 EFB1 RPL4A RPG1 SPB1 RPL13A RPS16B SSB1 SES1 FRS2 RPL26B TIF4631 RPL8A DED81 YHR020W NMD2 THS1 RPL39 ANB1 YKL056C RPL15A RPS18B ASC1 TIF34 TIF11 NIP1 MRP7 GCD10 SSB2 RPS19A RPL3 RPS9A NEW1 RPL11A 33 359 cytoplasm 1.43251e-06 EFB1 RPL4A RPG1 RPL13A RPS16B UBP1 SSB1 SES1 RTN1 VPS74 MCM3 TRP2 MET6 FRS2 RPL26B TIF4631 RPL8A NMD2 THS1 ERG20 RPL39 ANB1 YKL056C RPL15A RPS18B ASC1 TIF34 TIF11 NIP1 PUB1 GCD10 SSB2 LYS9 RPS19A RPL3 RAS1 RPS9A ARO7 RPL11A 39 554 rRNA transcription 7.99354e-06 NOP1 DBP3 RRP3 GAR1 HCA4 RPA34 CBF5 SIK1 RRN11 NOP2 RPB10 RPB8 NOP58 RPA135 14 109 translation 2.94648e-05 EFB1 RPG1 TIF4631 ANB1 ASC1 TIF34 TIF11 NIP1 GCD10 NEW1 10 64 rRNA processing 0.00015233 NOP1 DBP3 RRP3 GAR1 HCA4 CBF5 SIK1 NOP2 NOP58 9 63 SUBCELLULAR LOCALISATION 0.00123621 EFB1 MAK16 AAR2 RHK1 RPL4A RPG1 RFC5 SMY2 CTP1 SPB1 PMP1 NOP1 RPL13A RPS16B UBP1 SSB1 SES1 RTN1 LYS4 HXT7 HXT6 VPS74 MCM3 FCY2 "ARG5,6" TRP2 MET6 FRS2 PMC1 PMA1 RNA15 DBP3 RPL26B TIF4631 PSD2 SMI1 RAD2 RPL8A RRP3 SSF1 NMD2 GAR1 THS1 SEC24 STH1 RPA34 ERG20 RPL39 ANB1 CYC1 CAP1 YKL056C NUP100 AAT1 LOS1 RPL15A CBF5 SIK1 ARV1 FKS1 CDC73 RPS18B RRN11 SPC2 NUP188 SEC59 ILV2 ASC1 TIF34 RGM1 TIF11 PSE1 NIP1 MRP7 PUB1 NOP2 GCD10 SSB2 LYS9 RPS19A RPL3 RAS1 SFL1 RPB10 RPB8 NOP58 RPS9A ALG5 RPA135 VMA13 ARO7 RPL11A PRE2 93 2256 cell death 0.00325479 LAC1 UTH1 RAS1 3 10 ribosome biogenesis 0.0034766 RPL4A RPL13A RPS16B RPL26B RPL8A RPL39 YKL056C RPL15A RPS18B ASC1 MRP7 RPS19A RPL3 RPS9A RPL11A 15 215 amino acid biosynthesis 0.00425513 LYS4 "ARG5,6" TRP2 MET6 YFR055W AAT1 SAM1 ILV2 LYS9 ARO7 10 118 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f cytoplasm 1.16327e-06 EFB1 YBR025C RPL4A RPG1 SRO9 RPL13A RPS16B UBP1 SSB1 SES1 RTN1 VPS74 BUD16 MCM3 TRP2 MET6 FRS2 RPL26B TIF4631 RPL8A NMD2 THS1 ERG20 RPL39 ANB1 YKL056C RPL15A RPS18B ASC1 TIF34 TIF11 NIP1 PUB1 GCD10 SSB2 LYS9 RPS19A RPL3 RPS9A ARO7 RPL11A 41 593 nucleolus 2.30916e-05 NOP1 RRP3 SSF1 GAR1 CBF5 SIK1 NOP2 RCL1 NOP58 9 50 MIPS Protein Complexes Category p-value In Category from Cluster k f Translation complexes 6.64917e-06 EFB1 RPL4A RPG1 RPL13A RPS16B RPL26B TIF4631 RPL8A RPL39 ANB1 RPL15A RPS18B ASC1 TIF34 TIF11 NIP1 MRP7 GCD10 RPS19A RPL3 RPS9A RPL11A 22 240 Cytoplasmic translation initiation 1.56586e-05 RPG1 TIF4631 ANB1 TIF34 TIF11 NIP1 GCD10 7 27 Nop56p/Nop1p complex 3.20315e-05 NOP1 SIK1 NOP58 3 3 eIF3 3.26781e-05 RPG1 TIF34 NIP1 GCD10 4 7 Cytoplasmic ribosomes 0.000425292 RPL4A RPL13A RPS16B RPL26B RPL8A RPL39 RPL15A RPS18B ASC1 RPS19A RPL3 RPS9A RPL11A 13 138 RNA polymerase I 0.000783414 RPA34 RPB10 RPB8 RPA135 4 14 cytoplasmic ribosomal large subunit 0.0040846 RPL4A RPL13A RPL26B RPL8A RPL39 RPL15A RPL3 RPL11A 8 81 MIPS Protein Classes Category p-value In Category from Cluster k f GO Molecular Function Category p-value In Category from Cluster k f transferase [GO:0016740] 0.000218025 SPB1 TRM8 DOT1 "ARG5,6" MET6 ARO8 ATF2 BIO2 RPC17 RPA34 HAL5 ERG20 SET2 AAT1 SAM1 FKS1 URA5 SEC59 SKY1 LCB1 ADE4 MRP7 NOP2 GCD10 ECM39 NPT1 RPB10 RPB8 HRK1 ALG5 RPA135 SPE3 32 522 translation initiation factor [GO:0003743] 0.000251871 RPG1 TIF4631 ANB1 TIF34 TIF11 NIP1 6 29 translation factor, nucleic acid binding [GO:0008135] 0.000645308 EFB1 RPG1 TIF4631 ANB1 TIF34 TIF11 NIP1 7 47 DNA-directed RNA polymerase I [GO:0003900] 0.000783414 RPA34 RPB10 RPB8 RPA135 4 14 S-adenosylmethionine-dependent methyltransferase [GO:0008757] 0.00115248 SPB1 TRM8 DOT1 SET2 NOP2 GCD10 6 38 translation regulator [GO:0045182] 0.00119973 EFB1 RPG1 TIF4631 ANB1 TIF34 TIF11 NIP1 7 52 nucleic acid binding [GO:0003676] 0.00148136 EFB1 RPG1 RFC5 SRO9 NOP1 WHI4 GIS1 SNU13 MCM3 RPH1 RNA15 DBP3 RPL26B UTP8 TIF4631 RAD2 RRP3 GAR1 STH1 HCA4 ANB1 LOS1 NOC3 RPL15A SIK1 CDC73 RRN11 TIF34 RGM1 TIF11 NIP1 ELP6 PUB1 RRP6 SFL1 NOP58 MED1 37 707 ligase, forming phosphoric ester bonds [GO:0016886] 0.00151969 SES1 FRS2 DED81 YHR020W THS1 RCL1 6 40 enzyme [GO:0003824] 0.00168829 RFC5 SPB1 TSC13 UBP1 TRM8 SES1 LYS4 DOT1 MCM3 "ARG5,6" TRP2 MET6 FRS2 YFR055W PMC1 PMA1 DBP3 ARO8 PPT1 PSD2 ATF2 RAD2 BIO2 DED81 YHR020W RRP3 THS1 STH1 RPC17 HCA4 RPA34 HAL5 ERG20 SET2 YJL200C AAT1 CBF5 SAM1 FKS1 IMD3 IMD4 URA5 SEC59 ILV2 CTL1 SKY1 GUA1 LCB1 ADE4 MRP7 NOP2 GCD10 AAH1 ECM39 LYS9 RCL1 SPE2 RRP6 RAS1 NPT1 RPB10 RPB8 HRK1 YOR356W ALG5 RPA135 VMA13 ARO7 SPE3 PRE2 70 1604 RNA methyltransferase [GO:0008173] 0.00172766 SPB1 TRM8 NOP2 GCD10 4 17 snoRNA binding [GO:0030515] 0.00200157 NOP1 SNU13 UTP8 SIK1 NOP58 5 29 methyltransferase [GO:0008168] 0.00207275 SPB1 TRM8 DOT1 MET6 SET2 NOP2 GCD10 7 57 transferase, transferring one-carbon groups [GO:0016741] 0.00253479 SPB1 TRM8 DOT1 MET6 SET2 NOP2 GCD10 7 59 DNA-directed RNA polymerase [GO:0003899] 0.00314095 RPC17 RPA34 RPB10 RPB8 RPA135 5 32 GO Biological Process Category p-value In Category from Cluster k f transcription from Pol I promoter [GO:0006360] 4.11162e-09 SPB1 NOP1 SNU13 DBP3 UTP8 RRP3 GAR1 HCA4 RPA34 NOC3 CBF5 SIK1 RRN11 NOP2 RCL1 RRP6 RPB10 RPB8 NOP58 RPA135 20 131 biosynthesis [GO:0009058] 2.79535e-08 EFB1 RHK1 RPL4A RPG1 SRO9 RPL13A RPS16B SSB1 SES1 LYS4 "ARG5,6" TRP2 FRS2 RPL26B TIF4631 PSD2 SMI1 BIO2 RPL8A DED81 THS1 ERG20 RPL39 ANB1 RPL15A FKS1 SUR4 IMD3 RPS18B URA5 SEC59 ILV2 TIF34 TIF11 LCB1 NIP1 MRP7 GCD10 SSB2 ECM39 LYS9 SPE2 RIB2 RPS19A RPL3 NPT1 RPS9A ALG5 ARO7 SPE3 RPL11A 51 731 ribosome biogenesis and assembly [GO:0042254] 2.21827e-07 MAK16 SPB1 NOP1 SNU13 DBP3 UTP8 RRP3 SSF1 GAR1 HCA4 NOC3 CBF5 SIK1 NOP2 KRI1 RCL1 RRP6 RPL3 NOP58 RPL11A 20 165 ribosome biogenesis [GO:0007046] 4.53469e-07 MAK16 SPB1 NOP1 SNU13 DBP3 UTP8 RRP3 GAR1 HCA4 NOC3 CBF5 SIK1 NOP2 KRI1 RCL1 RRP6 NOP58 17 127 rRNA processing [GO:0006364] 4.9785e-07 SPB1 NOP1 SNU13 DBP3 UTP8 RRP3 GAR1 HCA4 NOC3 CBF5 SIK1 NOP2 RCL1 RRP6 NOP58 15 100 metabolism [GO:0008152] 6.39472e-07 EFB1 NUP60 AAR2 RHK1 RPL4A RPG1 RFC5 SRO9 SPB1 NOP1 TSC13 RPL13A RPS16B UBP1 TRM8 SSB1 SES1 BMH2 LYS4 VPS74 DOT1 SMT3 SNU13 MCM3 "ARG5,6" TRP2 MET6 RPH1 FRS2 RNA15 DBP3 ARO8 RPL26B PPT1 UTP8 SYF2 TIF4631 PSD2 ATF2 SMI1 RAD2 BIO2 RPL8A DED81 RRP3 NMD2 GAR1 THS1 AIR1 SEC24 STH1 RPC17 HCA4 RPA34 ERG20 SET2 RPL39 ANB1 CYC1 NUP100 AAT1 LOS1 NOC3 RPL15A CBF5 SAM1 SIK1 FKS1 SUR4 CDC73 IMD3 RPS18B RRN11 SPC2 NUP188 URA5 SEC59 ISF1 ILV2 TIF34 CTL1 RGM1 SKY1 GUA1 TIF11 LCB1 ADE4 PSE1 NIP1 ELP6 MRP7 PUB1 NOP2 GCD10 AAH1 SSB2 URE2 ECM39 LYS9 RCL1 SPE2 RIB2 RPS19A RRP6 RPL3 SFL1 NPT1 RPB10 RPB8 NOP58 GDS1 YOR356W RPS9A ALG5 RPA135 ARO7 SPE3 MED1 RPL11A PRE2 120 2693 cell growth and/or maintenance [GO:0008151] 2.06439e-06 VPS8 EFB1 MAK16 NUP60 AAR2 RHK1 RPL4A RPG1 IST2 RFC5 SMY2 CTP1 SRO9 SPB1 PMP1 NOP1 TSC13 RPL13A RPS16B UBP1 TRM8 WHI4 SSB1 SES1 BMH2 LYS4 HXT7 HXT6 VPS74 DOT1 SMT3 SNU13 BUD16 MCM3 FCY2 "ARG5,6" TRP2 MET6 RPH1 FRS2 YFR055W PMC1 PMA1 RNA15 DBP3 ARO8 RPL26B VHT1 PPT1 UTP8 SYF2 TIF4631 PSD2 ATF2 ZPR1 SMI1 RAD2 BIO2 RPL8A DED81 RRP3 SSF1 NMD2 GAR1 THS1 AIR1 SEC24 STH1 RPC17 HCA4 GYP6 RPA34 HAL5 ERG20 SET2 RPL39 ANB1 CYC1 CAP1 NUP100 AAT1 LOS1 UTH1 NOC3 RPL15A CBF5 SAM1 SIK1 ARV1 FKS1 SUR4 CCW14 VIP1 CDC73 IMD3 RPS18B RRN11 SPC2 NUP188 URA5 SEC59 ISF1 ILV2 TIF34 CTL1 RGM1 SKY1 GUA1 TIF11 LCB1 ADE4 PSE1 NIP1 ELP6 MRP7 PUB1 NOP2 GCD10 AAH1 SSB2 URE2 KRI1 ECM39 LYS9 RCL1 SPE2 RIB2 RPS19A RRP6 RPL3 RAS1 SFL1 NPT1 RPB10 RPB8 HRK1 NOP58 GDS1 YOR356W RPS9A ALG5 RPA135 VMA13 ARO7 SPE3 MED1 RPL11A PRE2 148 3657 protein biosynthesis [GO:0006412] 2.1645e-06 EFB1 RHK1 RPL4A RPG1 SRO9 RPL13A RPS16B SSB1 SES1 FRS2 RPL26B TIF4631 RPL8A DED81 THS1 RPL39 ANB1 RPL15A RPS18B SEC59 TIF34 TIF11 NIP1 MRP7 GCD10 SSB2 ECM39 RPS19A RPL3 RPS9A ALG5 RPL11A 32 415 macromolecule biosynthesis [GO:0009059] 3.10817e-06 EFB1 RHK1 RPL4A RPG1 SRO9 RPL13A RPS16B SSB1 SES1 FRS2 RPL26B TIF4631 RPL8A DED81 THS1 RPL39 ANB1 RPL15A RPS18B SEC59 TIF34 TIF11 NIP1 MRP7 GCD10 SSB2 ECM39 RPS19A RPL3 RPS9A ALG5 RPL11A 32 422 RNA processing [GO:0006396] 6.58148e-06 AAR2 SPB1 NOP1 TRM8 SNU13 RNA15 DBP3 UTP8 SYF2 RRP3 GAR1 HCA4 LOS1 NOC3 CBF5 SIK1 CTL1 SKY1 PUB1 NOP2 GCD10 RCL1 RRP6 NOP58 24 277 35S primary transcript processing [GO:0006365] 7.71422e-06 NOP1 DBP3 RRP3 GAR1 HCA4 CBF5 SIK1 RRP6 NOP58 9 44 RNA metabolism [GO:0016070] 1.55993e-05 AAR2 SPB1 NOP1 TRM8 SNU13 RNA15 DBP3 UTP8 SYF2 RRP3 NMD2 GAR1 HCA4 LOS1 NOC3 CBF5 SIK1 CTL1 SKY1 PUB1 NOP2 GCD10 RCL1 RRP6 NOP58 25 311 rRNA modification [GO:0000154] 0.000103216 NOP1 GAR1 CBF5 SIK1 NOP58 5 16 transcription, DNA-dependent [GO:0006351] 0.000104766 SPB1 NOP1 DOT1 SNU13 RPH1 DBP3 UTP8 RRP3 GAR1 RPC17 HCA4 RPA34 SET2 NOC3 CBF5 SIK1 CDC73 RRN11 RGM1 ELP6 NOP2 RCL1 RRP6 SFL1 NPT1 RPB10 RPB8 NOP58 RPA135 MED1 30 457 translational initiation [GO:0006413] 0.000138411 RPG1 TIF4631 ANB1 TIF34 TIF11 NIP1 GCD10 7 37 rRNA metabolism [GO:0016072] 0.000142455 NOP1 GAR1 CBF5 SIK1 NOP58 5 17 RNA modification [GO:0009451] 0.000195885 NOP1 TRM8 GAR1 CBF5 SIK1 GCD10 NOP58 7 39 nucleobase, nucleoside, nucleotide and nucleic acid metabolism [GO:0006139] 0.000245604 AAR2 RFC5 SPB1 NOP1 TRM8 DOT1 SNU13 MCM3 RPH1 RNA15 DBP3 UTP8 SYF2 RAD2 RRP3 NMD2 GAR1 AIR1 STH1 RPC17 HCA4 RPA34 SET2 NUP100 LOS1 NOC3 CBF5 SIK1 CDC73 IMD3 RRN11 NUP188 URA5 CTL1 RGM1 SKY1 GUA1 ADE4 PSE1 ELP6 PUB1 NOP2 GCD10 AAH1 RCL1 RRP6 SFL1 NPT1 RPB10 RPB8 NOP58 RPA135 MED1 53 1046 transcription [GO:0006350] 0.000251345 SPB1 NOP1 DOT1 SNU13 RPH1 DBP3 UTP8 RRP3 GAR1 RPC17 HCA4 RPA34 SET2 NOC3 CBF5 SIK1 CDC73 RRN11 RGM1 ELP6 NOP2 RCL1 RRP6 SFL1 NPT1 RPB10 RPB8 NOP58 RPA135 MED1 30 480 processing of 20S pre-rRNA [GO:0030490] 0.00234057 NOP1 SNU13 UTP8 SIK1 NOP58 5 30 aromatic compound metabolism [GO:0006725] 0.00393309 TRP2 ARO8 URA5 ADE4 AAH1 ARO7 6 48 ribosomal large subunit assembly and maintenance [GO:0000027] 0.0046866 NOP1 DBP3 SSF1 RPL3 RPL11A 5 35 GO Cellular Component Category p-value In Category from Cluster k f nucleolus [GO:0005730] 1.31371e-10 MAK16 SPB1 NOP1 SNU13 DBP3 UTP8 ZPR1 RRP3 SSF1 GAR1 HCA4 RPA34 NOC3 SIK1 RRN11 NOP2 KRI1 RCL1 RPB10 RPB8 NOP58 RPA135 22 133 ribonucleoprotein complex [GO:0030529] 2.90322e-06 EFB1 RPL4A RPG1 SRO9 NOP1 RPL13A RPS16B SSB1 SNU13 RPL26B UTP8 SYF2 TIF4631 RPL8A NMD2 GAR1 RPL39 ANB1 RPL15A SIK1 RPS18B TIF11 MRP7 PUB1 SSB2 RPS19A RPL3 NOP58 RPS9A RPL11A 30 380 ribosome [GO:0005840] 2.11152e-05 EFB1 RPL4A RPG1 SRO9 RPL13A RPS16B SSB1 RPL26B TIF4631 RPL8A NMD2 RPL39 ANB1 RPL15A RPS18B TIF11 MRP7 SSB2 RPS19A RPL3 RPS9A RPL11A 22 258 intracellular [GO:0005622] 4.23762e-05 EFB1 MAK16 NUP60 RHK1 YBR025C RPL4A RPG1 RFC5 CTP1 SRO9 SPB1 NOP1 TSC13 RPL13A RPS16B UBP1 SSB1 SES1 LYS4 HXT7 HXT6 DOT1 SMT3 SNU13 MCM3 FCY2 "ARG5,6" MET6 RPH1 FRS2 PMC1 PMA1 RNA15 DBP3 RPL26B VHT1 UTP8 SYF2 TIF4631 PSD2 ATF2 ZPR1 SMI1 RAD2 RPL8A YHR009C DED81 RRP3 SSF1 NMD2 GAR1 THS1 AIR1 SEC24 STH1 RPC17 HCA4 RPA34 ERG20 SET2 RPL39 ANB1 CYC1 CAP1 LAC1 NUP100 AAT1 LOS1 UTH1 NOC3 RPL15A YLR179C SAM1 SIK1 FKS1 SUR4 CDC73 IMD3 RPS18B RRN11 SPC2 NUP188 URA5 ILV2 ASC1 TIF34 CTL1 RGM1 SKY1 TIF11 LCB1 PSE1 NIP1 ELP6 MRP7 PUB1 NOP2 GCD10 AAH1 SSB2 KRI1 LYS9 RCL1 RPS19A RRP6 RPL3 RAS1 SFL1 NPT1 RPB10 RPB8 NOP58 YOR356W RPS9A ALG5 RPA135 VMA13 MED1 RPL11A PRE2 UTP19 121 2921 cell [GO:0005623] 6.97423e-05 VPS8 EFB1 MAK16 NUP60 RHK1 YBR025C RPL4A RPG1 RFC5 CTP1 SRO9 SPB1 PMP1 NOP1 TSC13 RPL13A RPS16B UBP1 SSB1 SES1 LYS4 HXT7 HXT6 DOT1 SMT3 SNU13 MCM3 FCY2 "ARG5,6" MET6 RPH1 FRS2 PMC1 PMA1 RNA15 DBP3 RPL26B VHT1 UTP8 SYF2 TIF4631 PSD2 ATF2 ZPR1 SMI1 RAD2 RPL8A YHR009C DED81 RRP3 SSF1 NMD2 GAR1 THS1 AIR1 SEC24 STH1 RPC17 HCA4 RPA34 ERG20 SET2 RPL39 ANB1 CYC1 CAP1 LAC1 NUP100 AAT1 LOS1 UTH1 NOC3 RPL15A YLR179C SAM1 SIK1 ARV1 FKS1 SUR4 CDC73 IMD3 RPS18B RRN11 SPC2 NUP188 URA5 SEC59 ILV2 ASC1 TIF34 CTL1 RGM1 SKY1 TIF11 LCB1 PSE1 NIP1 ELP6 MRP7 PUB1 NOP2 GCD10 AAH1 SSB2 URE2 KRI1 LYS9 RCL1 RPS19A RRP6 RPL3 RAS1 SFL1 NPT1 RPB10 RPB8 NOP58 YOR356W RPS9A ALG5 RPA135 VMA13 MED1 RPL11A PRE2 UTP19 126 3106 polysome [GO:0005844] 0.000111843 SRO9 SSB1 NMD2 SSB2 4 9 nucleus [GO:0005634] 0.000339313 MAK16 NUP60 RFC5 SPB1 NOP1 DOT1 SMT3 SNU13 MCM3 RPH1 RNA15 DBP3 UTP8 SYF2 ZPR1 SMI1 RAD2 RRP3 SSF1 GAR1 AIR1 STH1 RPC17 HCA4 RPA34 SET2 NUP100 LOS1 NOC3 SIK1 CDC73 RRN11 NUP188 CTL1 RGM1 PSE1 ELP6 PUB1 NOP2 GCD10 KRI1 RCL1 RRP6 SFL1 NPT1 RPB10 RPB8 NOP58 RPA135 MED1 UTP19 51 1007 eukaryotic translation initiation factor 3 complex [GO:0005852] 0.000596423 RPG1 TIF34 NIP1 3 6 DNA-directed RNA polymerase I complex [GO:0005736] 0.000783414 RPA34 RPB10 RPB8 RPA135 4 14 small nucleolar ribonucleoprotein complex [GO:0005732] 0.00200157 NOP1 SNU13 UTP8 SIK1 NOP58 5 29 cytosolic ribosome (sensu Eukarya) [GO:0005830] 0.0030707 RPL4A RPL13A RPS16B RPL26B RPL8A RPL39 RPL15A RPS18B RPS19A RPL3 RPS9A RPL11A 12 151 cytosolic large ribosomal subunit (sensu Eukarya) [GO:0005842] 0.00474504 RPL4A RPL13A RPL26B RPL8A RPL39 RPL15A RPL3 RPL11A 8 83 SMART Domains Category p-value In Category from Cluster k f JmjN 0.0029765 GIS1 RPH1 2 3 PFam-A Domains Category p-value In Category from Cluster k f PF00587 (tRNA-synt_2b) 0.00233288 SES1 YHR020W THS1 3 9 PF02375 (jmjN) 0.0029765 GIS1 RPH1 2 3 PF01798 (Nop) 0.0029765 SIK1 NOP58 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YNL154C (YCK2) 0.00101923 SPB1 CTL1 GDS1 3 7 YJL092W (HPR5) 0.0029765 SMT3 GDS1 2 3 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YOL115W (TRF4) 6.96698e-06 AIR1 SIK1 IMD3 IMD4 PSE1 5 10 YLR019W (PSR2) 0.00101352 HXT7 HXT6 2 2 YBL036C 0.00101923 SES1 HXT7 HXT6 3 7 YOL087C 0.0010418 RPG1 SES1 TIF34 NIP1 4 15 YNL244C (SUI1) 0.00119827 RPG1 DED81 ERG20 TIF34 NIP1 5 26 YDL213C (FYV14) 0.00119973 RLI1 TIF4631 CBF5 IMD3 NOP2 KRI1 NOP58 7 52 YMR059W (SEN15) 0.001505 YBR025C SES1 SNU13 MET6 FRS2 THS1 YKL056C 7 54 YOR080W (DIA2) 0.00360755 SPB1 MCM3 DED81 SSF1 KRI1 5 33 YER161C (SPT2) 0.00393128 NOP1 RLI1 TIF4631 SSF1 4 21 YIL035C (CKA1) 0.00436537 TIF4631 SSF1 NOC3 SIK1 NOP2 KRI1 6 49 Cellzome Complexes Category p-value In Category from Cluster k f YJL033W (HCA4) 1.32044e-05 SRO9 NOP1 HCA4 CBF5 SIK1 NOP58 6 18 YLR175W (CBF5) 2.07784e-05 NOP1 TIF4631 CBF5 SIK1 NIP1 5 12 YOR361C (PRT1) 6.37246e-05 RPG1 ASC1 TIF34 NIP1 4 8 YDR062W (LCB2) 7.2839e-05 BMH2 YHR020W SAM1 FKS1 LCB1 5 15 YGR162W (TIF4631) 7.2839e-05 SRO9 TIF4631 CBF5 ASC1 MRP7 5 15 YBR079C (RPG1) 0.000111843 RPG1 RLI1 TIF34 NIP1 4 9 YPR086W (SUA7) 0.000111843 RPG1 IST2 TIF34 NIP1 4 9 YBR247C (ENP1) 0.00119827 NOP1 CBF5 SAM1 RCL1 UTP19 5 26 YDL208W (NHP2) 0.00135467 AAR2 SRO9 NOP1 CBF5 4 16 YAL035W (FUN12) 0.00233288 NOP1 CBF5 NIP1 3 9 YNL088W (TOP2) 0.0029765 YBR025C RFC5 2 3 YJR014W 0.0029765 YER007C-A ASC1 2 3 YER090W (TRP2) 0.0029765 TRP2 SAM1 2 3 YOR341W (RPA190) 0.00325479 RPB10 RPB8 RPA135 3 10 YJR063W (RPA12) 0.00325479 RPB10 RPB8 RPA135 3 10 YGL120C (PRP43) 0.00325479 SRO9 NOP1 ASC1 3 10 YKL081W (TEF4) 0.00437089 EFB1 YBR025C NEW1 3 11 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f essential 0.002682 EFB1 MAK16 AAR2 RPG1 RFC5 SPB1 NOP1 TSC13 SES1 RLI1 SMT3 SNU13 MCM3 FRS2 PMA1 RNA15 VHT1 UTP8 ZPR1 DED81 YHR020W RRP3 THS1 SEC24 STH1 RPC17 HCA4 ERG20 NOC3 RPL15A CBF5 SIK1 RRN11 SEC59 TIF34 TIF11 LCB1 PSE1 NIP1 NOP2 GCD10 KRI1 RCL1 RIB2 RPL3 RPB10 RPB8 NOP58 RPA135 PRE2 UTP19 51 1101 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f Andersen et al. (2002) - Curr Bio 12:1- 4.32647e-06 MAK16 NOP1 SNU13 DBP3 RPL26B RRP3 SSF1 GAR1 HCA4 YKL056C CBF5 SIK1 RPS18B NOP2 RCL1 RRP6 RPL3 NOP58 18 165 Kressler et al. (1999) - Mol Cell Bio 19(12)7897- (C/D Box) 0.00233288 NOP1 SIK1 NOP58 3 9