Input Cluster (n=199) YAL039C CYC3 YAL053W YAL054C ACS1 YAL068C YAR068W YBL041W PRE7 YBL042C FUI1 YBL043W ECM13 YBL086C YBR019C GAL10 YBR020W GAL1 YBR043C AQR2 YBR068C BAP2 YBR069C TAT1 YBR089C-A NHP6B YBR112C CYC8 YBR132C AGP2 YBR222C FAT2 YBR245C ISW1 YBR302C COS2 YCL025C AGP1 YCL040W GLK1 YCL043C PDI1 YCR050C YCR061W YCR098C GIT1 YDL070W BDF2 YDL072C YDL087C LUC7 YDL173W YDL174C DLD1 YDL176W YDL185W TFP1 YDL215C GDH2 YDL222C YDR006C SOK1 YDR007W TRP1 YDR040C ENA1 YDR043C NRG1 YDR046C BAP3 YDR072C IPT1 YDR073W SNF11 YDR188W CCT6 YDR207C UME6 YDR208W MSS4 YDR222W YDR275W YDR309C GIC2 YDR384C ATO3 YDR391C YDR392W SPT3 YDR435C PPM1 YDR436W PPZ2 YDR508C GNP1 YDR510W SMT3 YDR536W STL1 YDR542W YEL044W IES6 YEL065W SIT1 YER162C RAD4 YER184C YER185W YFL062W COS4 YFR015C GSY1 YFR017C YFR037C RSC8 YFR055W YGL036W YGL051W YGL210W YPT32 YGL253W HXK2 YGL255W ZRT1 YGR019W UGA1 YGR035C YGR055W MUP1 YGR065C VHT1 YGR078C PAC10 YGR124W ASN2 YGR130C YGR131W YGR157W CHO2 YGR204W ADE3 YGR239C PEX21 YHL016C DUR3 YHL048W COS8 YHR033W YHR076W PTC7 YHR136C SPL2 YHR137W ARO9 YHR198C YHR199C YHR200W RPN10 YHR209W YIL033C BCY1 YIL047C SYG1 YIL113W SDP1 YIL114C POR2 YIL117C PRM5 YIL160C POT1 YIL169C YIR035C YJL056C ZAP1 YJL106W IME2 YJL115W ASF1 YJL143W TIM17 YJL189W RPL39 YJL190C RPS22A YJR043C POL32 YJR078W BNA2 YJR113C RSM7 YJR127C ZMS1 YJR161C COS5 YKL032C IXR1 YKL051W YKL052C ASK1 YKL146W YKL148C SDH1 YKL157W APE2 YKL159C RCN1 YKL184W SPE1 YKL217W JEN1 YKR027W YKR042W UTH1 YLL015W BPT1 YLL043W FPS1 YLL046C RNP1 YLL054C YLL058W YLR055C SPT8 YLR094C GIS3 YLR136C TIS11 YLR139C SLS1 YLR152C YLR193C YLR237W THI7 YLR266C PDR8 YLR267W BOP2 YLR283W YLR300W EXG1 YLR304C ACO1 YLR327C YLR380W CSR1 YLR401C YLR406C RPL31B YLR437C YLR438W CAR2 YML123C PHO84 YML132W COS3 YMR018W YMR062C ECM40 YMR070W MOT3 YMR095C SNO1 YMR096W SNZ1 YMR099C YMR107W YMR135C DCR1 YMR181C YMR246W FAA4 YMR251W-A HOR7 YMR265C YMR266W RSN1 YMR317W YNL046W YNL047C YNL066W SUN4 YNL135C FPR1 YNL151C RPC31 YNL304W YPT11 YNL305C YNR013C PHO91 YOL019W YOL020W TAT2 YOL021C DIS3 YOL081W IRA2 YOL125W YOL126C MDH2 YOL154W ZPS1 YOR107W RGS2 YOR108W YOR161C YOR193W YOR349W CIN1 YOR394W YPL014W YPL061W ALD6 YPL111W CAR1 YPL112C PEX25 YPL141C YPL265W DIP5 YPL274W SAM3 YPL282C YPR027C YPR052C NHP6A YPR054W SMK1 YPR074C TKL1 YPR115W YPR138C MEP3 YPR145W ASN1 YPR192W AQY1 Genes Not Found: YML100W-A MIPS Functional Classification Category p-value In Category from Cluster k f amino acid metabolism 3.02538e-11 BAP2 TAT1 AGP2 AGP1 GDH2 TRP1 BAP3 UME6 GNP1 YFR055W UGA1 MUP1 ASN2 ADE3 YHR033W ARO9 BNA2 APE2 YLL058W CAR2 ECM40 TAT2 YOR108W CAR1 DIP5 SAM3 TKL1 ASN1 28 204 amino acid transport 6.64631e-10 BAP2 TAT1 AGP2 AGP1 BAP3 GNP1 MUP1 TAT2 DIP5 SAM3 10 23 amino-acid transporters 1.79622e-09 BAP2 TAT1 AGP2 AGP1 BAP3 GNP1 MUP1 TAT2 DIP5 SAM3 10 25 METABOLISM 1.27174e-08 CYC3 ACS1 FUI1 YBL086C GAL10 GAL1 BAP2 TAT1 AGP2 FAT2 AGP1 GLK1 PDI1 GIT1 DLD1 GDH2 TRP1 NRG1 BAP3 IPT1 SNF11 UME6 MSS4 ATO3 GNP1 STL1 GSY1 YFR055W HXK2 UGA1 MUP1 ASN2 CHO2 ADE3 YHR033W ARO9 BCY1 POT1 YIR035C BNA2 SDH1 APE2 SPE1 JEN1 YKR027W FPS1 YLL058W THI7 EXG1 ACO1 CSR1 CAR2 PHO84 ECM40 FAA4 SUN4 PHO91 TAT2 IRA2 MDH2 YOR108W CAR1 DIP5 SAM3 TKL1 ASN1 66 1066 TRANSPORT FACILITATION 3.52949e-08 AQR2 BAP2 TAT1 AGP2 AGP1 GIT1 TFP1 ENA1 BAP3 GNP1 STL1 SIT1 ZRT1 MUP1 VHT1 DUR3 POR2 TIM17 YKL146W JEN1 BPT1 FPS1 THI7 PHO84 PHO91 TAT2 DIP5 SAM3 MEP3 AQY1 30 312 plasma membrane 4.96631e-05 FUI1 BAP2 TAT1 AGP1 GIT1 BAP3 MSS4 STL1 MUP1 DUR3 SYG1 PHO84 TAT2 IRA2 DIP5 15 145 amino acid biosynthesis 8.34464e-05 TRP1 YFR055W UGA1 MUP1 ASN2 ADE3 YHR033W YLL058W CAR2 ECM40 YOR108W TKL1 ASN1 13 118 transcriptional control 0.00197567 GAL1 CYC8 ISW1 BDF2 SOK1 NRG1 SNF11 UME6 SPT3 YER184C RSC8 BCY1 ZAP1 ASF1 IXR1 RCN1 YLL054C SPT8 PDR8 MOT3 YPR115W 21 334 ion transporters 0.00313155 TFP1 SIT1 ZRT1 VHT1 DUR3 PHO84 PHO91 MEP3 8 78 anion transporters (Cl, SO4, PO4, etc.) 0.0038611 DUR3 PHO84 PHO91 MEP3 4 21 lipid and fatty-acid transport 0.0038611 PDI1 GIT1 CSR1 FAA4 4 21 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 3.90199e-05 FUI1 BAP2 TAT1 AGP1 GIT1 BAP3 MSS4 STL1 SIT1 MUP1 DUR3 SYG1 PHO84 TAT2 IRA2 SAM3 16 159 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 2.71815e-09 FUI1 AQR2 BAP2 TAT1 AGP2 AGP1 GIT1 GNP1 STL1 SIT1 MUP1 DUR3 SYG1 YKL146W JEN1 THI7 PHO84 PHO91 TAT2 DIP5 MEP3 21 142 GO Molecular Function Category p-value In Category from Cluster k f amino acid transporter [GO:0015171] 3.86256e-10 BAP2 TAT1 AGP2 AGP1 BAP3 GNP1 MUP1 TAT2 DIP5 SAM3 10 22 transporter [GO:0005215] 5.36143e-07 FUI1 BAP2 TAT1 AGP2 FAT2 AGP1 GIT1 TFP1 ENA1 BAP3 GNP1 STL1 SIT1 ZRT1 MUP1 VHT1 DUR3 POR2 TIM17 JEN1 BPT1 FPS1 THI7 CSR1 PHO84 PHO91 TAT2 DIP5 SAM3 MEP3 AQY1 31 372 amine/polyamine transporter [GO:0005275] 1.59148e-06 AGP2 GNP1 MUP1 DUR3 DIP5 5 8 amino acid-polyamine transporter [GO:0005279] 1.40802e-05 AGP2 GNP1 MUP1 DIP5 4 6 polyamine transporter [GO:0015203] 1.40802e-05 AGP2 GNP1 MUP1 DIP5 4 6 asparagine synthase (glutamine-hydrolyzing) [GO:0004066] 0.00100339 ASN2 ASN1 2 2 vitamin/cofactor transporter [GO:0015223] 0.00100443 VHT1 THI7 SAM3 3 7 electrochemical potential-driven transporter [GO:0015290] 0.00163096 AGP2 GNP1 SIT1 ZRT1 MUP1 PHO84 DIP5 7 55 porter [GO:0015291] 0.00163096 AGP2 GNP1 SIT1 ZRT1 MUP1 PHO84 DIP5 7 55 alpha-type channel [GO:0015268] 0.0032087 DUR3 POR2 AQY1 3 10 transcriptional repressor [GO:0016564] 0.00430951 CYC8 NRG1 MOT3 3 11 channel/pore class transporter [GO:0015267] 0.00430951 DUR3 POR2 AQY1 3 11 GO Biological Process Category p-value In Category from Cluster k f amino acid transport [GO:0006865] 1.52391e-08 BAP2 TAT1 AGP1 BAP3 GNP1 MUP1 TAT2 DIP5 SAM3 9 23 asparagine biosynthesis [GO:0006529] 0.00100339 ASN2 ASN1 2 2 arginine catabolism [GO:0006527] 0.00100339 CAR2 CAR1 2 2 carbohydrate metabolism [GO:0005975] 0.00215171 GAL10 GAL1 GLK1 DLD1 NRG1 GSY1 HXK2 SDH1 EXG1 ACO1 MDH2 ALD6 TKL1 13 165 nitrogen metabolism [GO:0006807] 0.00266076 GDH2 UGA1 CAR2 ECM40 CAR1 5 31 GO Cellular Component Category p-value In Category from Cluster k f plasma membrane [GO:0005886] 1.28114e-09 FUI1 GAL1 BAP2 TAT1 AGP2 AGP1 GIT1 ENA1 BAP3 MSS4 GNP1 ZRT1 MUP1 VHT1 DUR3 SYG1 JEN1 FPS1 THI7 PHO84 TAT2 DIP5 SAM3 MEP3 24 178 membrane [GO:0016020] 0.000708782 FUI1 GAL1 BAP2 TAT1 AGP2 AGP1 GIT1 DLD1 TFP1 YDL222C ENA1 BAP3 MSS4 GNP1 STL1 ZRT1 MUP1 VHT1 DUR3 COS8 SYG1 POR2 PRM5 TIM17 SDH1 JEN1 UTH1 FPS1 SLS1 THI7 PHO84 PHO91 TAT2 PEX25 DIP5 SAM3 MEP3 37 683 integral plasma membrane protein [GO:0005887] 0.000971042 AGP2 ZRT1 MUP1 FPS1 PHO84 5 25 SMART Domains Category p-value In Category from Cluster k f HMG 0.00100443 NHP6B IXR1 NHP6A 3 7 TRANS 0.00370854 YAL053W FUI1 AQR2 BAP2 TAT1 AGP2 COS2 AGP1 YCR061W GIT1 YDL072C YDL222C ENA1 BAP3 IPT1 YDR275W ATO3 GNP1 STL1 SIT1 YER184C YER185W COS4 YGL051W ZRT1 MUP1 VHT1 YGR131W CHO2 DUR3 COS8 PTC7 SYG1 PRM5 TIM17 COS5 YKL051W YKL146W JEN1 BPT1 FPS1 YLR152C THI7 PHO84 COS3 RSN1 YNL046W YNL305C PHO91 YOL019W TAT2 YOR161C YOR394W DIP5 SAM3 YPL282C YPR027C MEP3 AQY1 59 1346 PFam-A Domains Category p-value In Category from Cluster k f PF00324 (aa_permeases) 3.86256e-10 BAP2 TAT1 AGP2 AGP1 BAP3 GNP1 MUP1 TAT2 DIP5 SAM3 10 22 PF00674 (DUP) 7.92983e-05 COS2 COS4 YGL051W COS8 COS5 COS3 6 24 PF00733 (Asn_synthase) 0.00100339 ASN2 ASN1 2 2 PF00505 (HMG_box) 0.00100443 NHP6B IXR1 NHP6A 3 7 PF00501 (AMP-binding) 0.00229957 ACS1 FAT2 FAA4 3 9 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f YDR142C (PEX7) 0.00294706 PEX21 POT1 2 3 Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YNL088W (TOP2) 0.00294706 SMT3 FAA4 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YOL126C (MDH2) 0.00100443 PDI1 EXG1 FAA4 3 7 YLL019C (KNS1) 0.00294706 TFP1 CAR2 2 3 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f cell periphery 0.000166002 BAP2 YCR061W GIT1 STL1 MUP1 APE2 FPS1 TAT2 IRA2 9 64 cyto 0.00412148 YBL086C GAL10 AGP1 GLK1 LUC7 TFP1 GDH2 YDL222C MSS4 YDR222W YDR275W GIC2 PPM1 PPZ2 GSY1 YFR017C YPT32 UGA1 ASN2 YGR130C ADE3 PEX21 YHR033W SPL2 ARO9 RPN10 YHR209W SDP1 POT1 YIR035C RPS22A BNA2 YKL051W SPE1 YLL058W GIS3 YLR437C CAR2 SNZ1 YMR099C DCR1 YMR181C FAA4 YNL046W YNL047C FPR1 YOL019W MDH2 ZPS1 YPL014W ALD6 CAR1 YPL141C YPR027C SMK1 TKL1 YPR115W ASN1 58 1324 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.00231013 CYC3 YAR068W PRE7 FUI1 ECM13 YBL086C GAL10 GAL1 AQR2 BAP2 TAT1 AGP2 AGP1 GLK1 YCR050C GIT1 LUC7 TFP1 GDH2 ENA1 BAP3 CCT6 YDR222W YDR275W GIC2 ATO3 SPT3 PPM1 PPZ2 GNP1 STL1 IES6 SIT1 GSY1 YFR017C YFR055W YGL051W YPT32 HXK2 ZRT1 UGA1 YGR035C MUP1 PAC10 ASN2 YGR130C CHO2 ADE3 PEX21 DUR3 YHR033W SPL2 ARO9 RPN10 YHR209W BCY1 SYG1 SDP1 YIR035C ZAP1 IME2 TIM17 RPL39 RPS22A BNA2 YKL146W RCN1 SPE1 JEN1 YKR027W UTH1 BPT1 FPS1 RNP1 YLL054C YLL058W GIS3 YLR152C THI7 PDR8 BOP2 YLR327C YLR401C RPL31B YLR437C CAR2 PHO84 SNO1 SNZ1 YMR099C YMR107W DCR1 YMR181C FAA4 YMR265C YMR317W YNL046W YNL047C FPR1 YNL305C PHO91 TAT2 IRA2 MDH2 ZPS1 RGS2 YOR161C CIN1 YOR394W YPL014W ALD6 CAR1 YPL141C DIP5 SAM3 YPL282C SMK1 TKL1 YPR115W MEP3 ASN1 AQY1 122 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.000139263 CYC3 YAL053W ACS1 YAL068C FUI1 ECM13 YBL086C GAL10 BAP2 CYC8 FAT2 ISW1 AGP1 GLK1 YCR050C YCR061W DLD1 YDL176W GDH2 YDL222C SOK1 TRP1 NRG1 BAP3 IPT1 SNF11 UME6 YDR222W YDR275W GIC2 ATO3 YDR391C PPM1 PPZ2 STL1 SIT1 GSY1 YFR017C YFR055W YGL036W YGL051W YPT32 HXK2 ZRT1 UGA1 YGR035C MUP1 ASN2 YGR130C YGR131W CHO2 ADE3 PEX21 DUR3 YHR033W PTC7 SPL2 ARO9 YHR199C YHR209W SYG1 SDP1 POR2 PRM5 YIR035C ZAP1 IME2 RPL39 RPS22A POL32 BNA2 ZMS1 YKL051W YKL146W SDH1 APE2 RCN1 SPE1 JEN1 YKR027W UTH1 BPT1 FPS1 RNP1 YLL058W TIS11 YLR152C YLR193C THI7 PDR8 BOP2 YLR283W EXG1 ACO1 YLR327C CSR1 YLR401C RPL31B YLR437C CAR2 PHO84 YMR018W ECM40 SNO1 SNZ1 YMR099C YMR107W DCR1 YMR181C FAA4 HOR7 YMR265C RSN1 YMR317W YNL046W YNL047C SUN4 YPT11 YNL305C PHO91 YOL019W TAT2 IRA2 YOL125W MDH2 YOR108W YOR161C YOR193W YPL014W ALD6 CAR1 PEX25 YPL141C SAM3 YPR027C NHP6A SMK1 TKL1 YPR115W MEP3 ASN1 AQY1 142 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f