Input Cluster (n=199) YAL001C TFC3 YAR002W NUP60 YBL098W BNA4 YBR040W FIG1 YBR054W YRO2 YBR087W RFC5 YBR239C YBR291C CTP1 YCL038C AUT4 YCL048W YCL073C YCR004C YCP4 YCR015C YCR024C YCR026C YCR042C TAF2 YCR090C YDL046W YDL128W VCX1 YDL139C SCM3 YDL140C RPO21 YDL171C GLT1 YDL223C HBT1 YDR001C NTH1 YDR002W YRB1 YDR012W RPL4B YDR021W FAL1 YDR023W SES1 YDR033W MRH1 YDR052C DBF4 YDR161W TCI1 YDR216W ADR1 YDR247W YDR292C SRP101 YDR308C SRB7 YDR311W TFB1 YDR322W MRPL35 YDR341C YDR342C HXT7 YDR383C NKP1 YDR399W HPT1 YDR419W RAD30 YDR464W SPP41 YDR524C AGE1 YEL009C GCN4 YEL026W SNU13 YEL027W CUP5 YER036C KRE30 YER037W PHM8 YER045C ACA1 YER110C KAP123 YER159C BUR6 YER165W PAB1 YFR001W LOC1 YFR011C YFR012W YFR023W PES4 YGL001C ERG26 YGL006W PMC1 YGL008C PMA1 YGL014W PUF4 YGL015C YGL037C PNC1 YGL081W YGL133W ITC1 YGL169W SUA5 YGL263W COS12 YGR033C YGR034W RPL26B YGR068C YGR070W ROM1 YGR085C RPL11B YGR125W YGR138C TPO2 YGR144W THI4 YGR177C ATF2 YGR187C HGH1 YGR195W SKI6 YGR229C SMI1 YGR240C PFK1 YGR253C PUP2 YGR285C ZUO1 YHL012W YHL013C YHL022C SPO11 YHR001W OSH7 YHR002W LEU5 YHR052W CIC1 YHR066W SSF1 YHR071W PCL5 YHR082C KSP1 YHR085W IPI1 YHR185C PFS1 YHR216W IMD2 YIL060W YIL061C SNP1 YIL096C YIL106W MOB1 YIL124W AYR1 YIR007W YJL038C YJL163C YJL200C YJR001W YJR047C ANB1 YJR102C VPS25 YJR103W URA8 YKL008C LAC1 YKL042W SPC42 YKL056C YKL061W YKL079W SMY1 YKL108W SLD2 YKL109W HAP4 YKL149C DBR1 YKL185W ASH1 YKL188C PXA2 YKR027W YKR089C YKR090W PXL1 YKR098C UBP11 YKR099W BAS1 YKR106W YLL015W BPT1 YLL027W ISA1 YLL042C APG10 YLR018C POM34 YLR019W PSR2 YLR044C PDC1 YLR238W YLR249W YEF3 YLR272C YCS4 YLR277C YSH1 YLR286C CTS1 YLR293C GSP1 YLR336C SGD1 YLR372W SUR4 YLR446W YLR455W YML035C AMD1 YML043C RRN11 YML092C PRE8 YML118W NGL3 YML121W GTR1 YMR043W MCM1 YMR049C ERB1 YMR108W ILV2 YMR132C YMR133W REC114 YMR182C RGM1 YMR185W YMR204C YMR216C SKY1 YMR217W GUA1 YMR234W RNH1 YMR259C YMR312W ELP6 YNL066W SUN4 YNL112W DBP2 YNL141W AAH1 YNL180C RHO5 YNL308C KRI1 YNL326C YNR003C RPC34 YNR004W YNR051C BRE5 YOL088C MPD2 YOL091W SPO21 YOL105C WSC3 YOL123W HRP1 YOR001W RRP6 YOR012W YOR051C YOR058C ASE1 YOR073W YOR108W YOR114W YOR177C MPC54 YOR233W KIN4 YOR308C SNU66 YOR341W RPA190 YOR355W GDS1 YOR370C MRS6 YOR389W YPL016W SWI1 YPL033C YPL116W HOS3 YPL117C IDI1 YPL128C TBF1 YPL154C PEP4 YPL184C YPR001W CIT3 YPR035W GLN1 YPR036W VMA13 YPR066W UBA3 YPR078C YPR079W MRL1 YPR119W CLB2 YPR149W NCE102 Genes Not Found: YHR214C-B MIPS Functional Classification Category p-value In Category from Cluster k f nucleus 0.000134832 TFC3 RFC5 YBR239C TAF2 RPO21 FAL1 DBF4 ADR1 SRB7 TFB1 GCN4 KAP123 BUR6 PAB1 PES4 ITC1 SMI1 PUP2 ZUO1 SPO11 SSF1 KSP1 SNP1 SLD2 HAP4 DBR1 ASH1 BAS1 YCS4 YSH1 GSP1 RRN11 PRE8 MCM1 REC114 RGM1 DBP2 RPC34 HRP1 ASE1 RPA190 SWI1 TBF1 43 774 transport mechanism 0.00205474 CUP5 KRE30 PMC1 PMA1 PXA2 BPT1 ISA1 VMA13 8 73 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f nucleus 0.000379491 TFC3 RFC5 YBR239C TAF2 RPO21 FAL1 DBF4 ADR1 SRB7 TFB1 GCN4 ACA1 KAP123 BUR6 PAB1 PES4 SMI1 PUP2 ZUO1 SPO11 SSF1 KSP1 SNP1 HAP4 DBR1 ASH1 BAS1 POM34 YCS4 YSH1 GSP1 RRN11 PRE8 MCM1 REC114 RGM1 DBP2 RPC34 HRP1 ASE1 SNU66 RPA190 SWI1 TBF1 44 836 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f RAN family 0.00294706 YDR247W KSP1 2 3 GO Molecular Function Category p-value In Category from Cluster k f mRNA binding [GO:0003729] 0.00313155 SNU13 PAB1 LOC1 PUF4 SNP1 YSH1 HRP1 SNU66 8 78 binding [GO:0005488] 0.00444909 TFC3 RFC5 TAF2 YRB1 FAL1 ADR1 SRB7 TFB1 GCN4 SNU13 CUP5 KRE30 ACA1 KAP123 BUR6 PAB1 LOC1 PMC1 PMA1 PUF4 RPL26B ROM1 SKI6 SPO11 OSH7 SNP1 ANB1 HAP4 DBR1 ASH1 PXA2 BAS1 YEF3 YSH1 GSP1 RRN11 GTR1 MCM1 RGM1 RNH1 ELP6 DBP2 RHO5 HRP1 RRP6 ASE1 SNU66 SWI1 TBF1 VMA13 50 1106 nucleic acid binding [GO:0003676] 0.00466669 TFC3 RFC5 TAF2 FAL1 ADR1 SRB7 TFB1 GCN4 SNU13 ACA1 PAB1 LOC1 PUF4 RPL26B SKI6 SPO11 SNP1 ANB1 HAP4 DBR1 ASH1 BAS1 YEF3 YSH1 RRN11 MCM1 RGM1 RNH1 ELP6 DBP2 HRP1 RRP6 SNU66 SWI1 TBF1 35 707 GO Biological Process Category p-value In Category from Cluster k f nucleobase, nucleoside, nucleotide and nucleic acid metabolism [GO:0006139] 0.000405454 TFC3 RFC5 TAF2 RPO21 YRB1 FAL1 DBF4 ADR1 SRB7 TFB1 HPT1 RAD30 SPP41 GCN4 SNU13 ACA1 BUR6 PES4 PUF4 PNC1 THI4 SKI6 SPO11 IMD2 SNP1 VPS25 URA8 SLD2 HAP4 DBR1 ASH1 BAS1 YSH1 GSP1 RRN11 MCM1 REC114 RGM1 SKY1 GUA1 RNH1 ELP6 AAH1 RPC34 HRP1 RRP6 SNU66 RPA190 SWI1 YPL033C TBF1 YPR078C 52 1046 transcription [GO:0006350] 0.00236777 TFC3 TAF2 RPO21 FAL1 ADR1 SRB7 TFB1 SPP41 GCN4 SNU13 ACA1 BUR6 PNC1 SKI6 VPS25 HAP4 ASH1 BAS1 GSP1 RRN11 MCM1 RGM1 ELP6 RPC34 RRP6 RPA190 TBF1 27 480 transcription, DNA-dependent [GO:0006351] 0.00495621 TFC3 TAF2 RPO21 FAL1 SRB7 TFB1 SPP41 GCN4 SNU13 ACA1 BUR6 PNC1 SKI6 VPS25 ASH1 BAS1 GSP1 RRN11 MCM1 RGM1 ELP6 RPC34 RRP6 RPA190 TBF1 25 457 GO Cellular Component Category p-value In Category from Cluster k f nucleus [GO:0005634] 7.79541e-05 TFC3 NUP60 RFC5 TAF2 RPO21 YRB1 FAL1 DBF4 ADR1 SRB7 TFB1 RAD30 GCN4 SNU13 ACA1 KAP123 BUR6 PAB1 LOC1 PES4 ITC1 SKI6 SMI1 SSF1 KSP1 SNP1 SLD2 HAP4 DBR1 ASH1 BAS1 POM34 YCS4 YSH1 CTS1 GSP1 SGD1 RRN11 GTR1 MCM1 RGM1 ELP6 KRI1 RPC34 HRP1 RRP6 YOR051C SNU66 RPA190 SWI1 HOS3 TBF1 CLB2 53 1007 cell [GO:0005623] 0.00494085 TFC3 NUP60 RFC5 CTP1 YCL073C YCR024C TAF2 VCX1 RPO21 HBT1 YRB1 RPL4B FAL1 SES1 MRH1 DBF4 ADR1 SRP101 SRB7 TFB1 MRPL35 YDR341C HXT7 RAD30 GCN4 SNU13 CUP5 ACA1 KAP123 BUR6 PAB1 LOC1 PES4 ERG26 PMC1 PMA1 ITC1 RPL26B ROM1 RPL11B THI4 ATF2 SKI6 SMI1 PFK1 PUP2 ZUO1 SPO11 LEU5 CIC1 SSF1 PCL5 KSP1 SNP1 MOB1 AYR1 ANB1 VPS25 URA8 LAC1 SPC42 SMY1 SLD2 HAP4 DBR1 ASH1 PXA2 BAS1 YKR106W ISA1 APG10 POM34 PSR2 YEF3 YCS4 YSH1 CTS1 GSP1 SGD1 SUR4 RRN11 PRE8 GTR1 MCM1 ILV2 RGM1 SKY1 RNH1 ELP6 SUN4 DBP2 AAH1 KRI1 RPC34 MPD2 SPO21 WSC3 HRP1 RRP6 YOR051C ASE1 MPC54 KIN4 SNU66 RPA190 MRS6 SWI1 HOS3 IDI1 TBF1 PEP4 CIT3 GLN1 VMA13 MRL1 CLB2 NCE102 117 3106 SMART Domains Category p-value In Category from Cluster k f RPOLA_N 0.00294706 RPO21 RPA190 2 3 PFam-A Domains Category p-value In Category from Cluster k f PF01036 (Bac_rhodopsin) 0.00294706 YRO2 MRH1 2 3 PF01854 (RNA_pol_A2) 0.00294706 RPO21 RPA190 2 3 PF00623 (RNA_pol_A) 0.00294706 RPO21 RPA190 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YPL002C (SNF8) 0.00294706 NKP1 VPS25 2 3 YGR092W (DBF2) 0.00294706 MOB1 YKL061W 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YBR017C (KAP104) 0.00458777 YRB1 ADR1 AYR1 GSP1 HRP1 5 35 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f mixed (cyto / nuc) 0.000282583 YCL073C FAL1 SRB7 SPP41 KAP123 BUR6 CIC1 SNP1 YJL200C SPC42 HAP4 ASH1 YKR106W REC114 RGM1 RPC34 HOS3 17 207 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f nuc 0.00086602 TFC3 NUP60 BNA4 YBR239C TAF2 SCM3 RPO21 FAL1 DBF4 ADR1 SRB7 TFB1 SPP41 GCN4 SNU13 ACA1 KAP123 BUR6 LOC1 PES4 ITC1 ROM1 SKI6 SMI1 ZUO1 SPO11 CIC1 SSF1 PCL5 IPI1 SNP1 YIL096C YJL200C SPC42 SLD2 HAP4 DBR1 ASH1 BAS1 YSH1 GSP1 YLR455W RRN11 MCM1 REC114 RGM1 YMR204C RNH1 DBP2 RHO5 KRI1 RPC34 SPO21 HRP1 RRP6 YOR051C ASE1 YOR073W MPC54 SNU66 RPA190 GDS1 SWI1 HOS3 TBF1 65 1435 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f Andersen et al. (2002) - Curr Bio 12:1- 0.00215171 RPL4B FAL1 SNU13 PAB1 RPL26B RPL11B SKI6 SSF1 YKL056C DBP2 HRP1 RRP6 RPA190 13 165