Input Cluster (n=200) YAL012W CYS3 YAL026C DRS2 YAR064W YBL085W BOI1 YBR011C IPP1 YBR039W ATP3 YBR049C REB1 YBR089C-A NHP6B YBR222C FAT2 YBR249C ARO4 YBR250W YCL034W LSB5 YCL035C GRX1 YCL040W GLK1 YCL042W YCL043C PDI1 YCR087C-A YCR088W ABP1 YCR092C MSH3 YCR093W CDC39 YDL006W PTC1 YDL020C RPN4 YDL038C YDL058W USO1 YDL059C RAD59 YDL073W YDL074C BRE1 YDL112W TRM3 YDL113C CVT20 YDR023W SES1 YDR055W PST1 YDR061W YDR113C PDS1 YDR115W YDR141C DOP1 YDR267C YDR268W MSW1 YDR368W YPR1 YDR382W RPP2B YDR438W YDR502C SAM2 YDR510W SMT3 YDR530C APA2 YDR531W YEL044W IES6 YEL046C GLY1 YEL072W RMD6 YEL076C YEL076C-A YER043C SAH1 YER057C HMF1 YER058W PET117 YER060W-A FCY22 YER062C HOR2 YER080W YER091C MET6 YER092W IES5 YER112W LSM4 YER114C BOI2 YER124C DSE1 YER177W BMH1 YFL017W-A SMX2 YFL018C LPD1 YFL023W BUD27 YFL024C EPL1 YFL031W HAC1 YFL033C RIM15 YFR001W LOC1 YFR030W MET10 YGL001C ERG26 YGL056C SDS23 YGR016W YGR154C YGR155W CYS4 YGR200C ELP2 YGR204W ADE3 YGR223C YGR224W AZR1 YGR286C BIO2 YHL004W MRP4 YHL036W MUP3 YHL038C CBP2 YHR001W-A QCR10 YHR041C SRB2 YHR042W NCP1 YHR082C KSP1 YHR083W YHR089C GAR1 YHR099W TRA1 YHR112C YHR113W YHR136C SPL2 YHR137W ARO9 YIL031W ULP2 YIL046W MET30 YIL047C SYG1 YIL088C YIL106W MOB1 YIL107C PFK26 YIL118W RHO3 YIL126W STH1 YIL127C YIR017C MET28 YIR018W YAP5 YJL054W TIM54 YJL060W BNA3 YJL101C GSH1 YJL133W MRS3 YJL149W YJL151C SNA3 YJL158C CIS3 YJL167W ERG20 YJL168C SET2 YJL186W MNN5 YJL187C SWE1 YJL209W CBP1 YJR001W YJR009C TDH2 YJR010W MET3 YJR113C RSM7 YJR137C ECM17 YJR138W IML1 YKL001C MET14 YKL007W CAP1 YKL008C LAC1 YKL015W PUT3 YKL016C ATP7 YKL139W CTK1 YKL191W DPH2 YKL192C ACP1 YKR072C SIS2 YLL004W ORC3 YLL005C SPO75 YLL010C PSR1 YLL021W SPA2 YLR050C YLR081W GAL2 YLR092W SUL2 YLR149C YLR150W STM1 YLR155C ASP3-1 YLR157C ASP3-2 YLR158C ASP3-3 YLR160C ASP3-4 YLR174W IDP2 YLR283W YML003W YML004C GLO1 YML017W PSP2 YML018C YML038C YMD8 YML121W GTR1 YMR083W ADH3 YMR196W YMR216C SKY1 YMR217W GUA1 YMR255W GFD1 YMR271C URA10 YMR301C ATM1 YMR308C PSE1 YNL036W NCE103 YNL037C IDH1 YNL063W YNL064C YDJ1 YNL094W APP1 YNL095C YNL220W ADE12 YNL221C POP1 YNL232W CSL4 YNL259C ATX1 YNL277W MET2 YNL282W POP3 YNR013C PHO91 YNR014W YOL064C MET22 YOR001W RRP6 YOR064C YNG1 YOR065W CYT1 YOR098C NUP1 YOR099W KTR1 YOR230W WTM1 YOR270C VPH1 YOR298C-A MBF1 YOR299W BUD7 YOR365C YOR367W SCP1 YOR378W YPL068C YPL096W PNG1 YPL139C UME1 YPL152W RRD2 YPL170W YPL171C OYE3 YPL190C NAB3 YPL204W HRR25 YPL206C YPL235W RVB2 YPL236C YPL250C ICY2 YPL254W HFI1 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f amino acid metabolism 1.86134e-10 CYS3 ARO4 SAM2 GLY1 MET6 LPD1 MET10 CYS4 ADE3 MUP3 YHR112C ARO9 MET30 MET28 MET3 ECM17 MET14 PUT3 DPH2 SUL2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 GLO1 MET2 MET22 27 204 amino acid biosynthesis 1.53113e-07 CYS3 ARO4 GLY1 MET6 LPD1 MET10 CYS4 ADE3 MUP3 YHR112C MET3 ECM17 MET14 DPH2 SUL2 MET2 MET22 17 118 METABOLISM 2.8195e-06 CYS3 IPP1 FAT2 ARO4 GLK1 PDI1 PTC1 YPR1 SAM2 APA2 GLY1 SAH1 FCY22 HOR2 MET6 LPD1 HAC1 MET10 ERG26 CYS4 ADE3 BIO2 MUP3 NCP1 YHR112C ARO9 MET30 PFK26 MET28 BNA3 ERG20 MNN5 TDH2 MET3 ECM17 MET14 PUT3 DPH2 ACP1 GAL2 SUL2 STM1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 GLO1 GTR1 ADH3 GUA1 URA10 IDH1 ADE12 CSL4 MET2 PHO91 MET22 KTR1 BUD7 60 1066 amino acid degradation (catabolism) 9.54358e-05 SAM2 GLY1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 GLO1 7 35 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f GO Molecular Function Category p-value In Category from Cluster k f hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] 6.00953e-06 BNA3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 PNG1 6 16 asparaginase [GO:0004067] 1.43638e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 enzyme [GO:0003824] 1.59044e-05 CYS3 DRS2 IPP1 ATP3 ARO4 GRX1 GLK1 PDI1 CDC39 PTC1 RPN4 TRM3 SES1 MSW1 YPR1 SAM2 APA2 GLY1 SAH1 HOR2 MET6 LPD1 EPL1 RIM15 MET10 ERG26 CYS4 ADE3 BIO2 QCR10 KSP1 TRA1 ARO9 ULP2 MET30 PFK26 RHO3 STH1 BNA3 GSH1 ERG20 SET2 MNN5 SWE1 TDH2 MET3 ECM17 MET14 ATP7 CTK1 PSR1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 GLO1 GTR1 ADH3 SKY1 GUA1 URA10 ATM1 IDH1 ADE12 POP1 CSL4 MET2 POP3 MET22 RRP6 KTR1 VPH1 PNG1 RRD2 OYE3 HRR25 RVB2 78 1604 oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor [GO:0016668] 3.20315e-05 LPD1 MET10 ECM17 3 3 electron transporter [GO:0005489] 4.76857e-05 LPD1 MET10 NCP1 ECM17 CYT1 OYE3 6 22 oxidoreductase, acting on sulfur group of donors [GO:0016667] 0.000596423 LPD1 MET10 ECM17 3 6 transporter [GO:0005215] 0.000701058 DRS2 ATP3 FAT2 FCY22 LPD1 MET10 AZR1 MUP3 QCR10 NCP1 TIM54 MRS3 ECM17 LAC1 ATP7 GAL2 SUL2 YMD8 ATM1 PSE1 PHO91 CYT1 VPH1 OYE3 24 372 hydrolase, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] 0.000857419 BNA3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 PNG1 6 36 sulfite reductase (NADPH) [GO:0004783] 0.00101352 MET10 ECM17 2 2 flavin-containing electron transporter [GO:0015933] 0.0010418 LPD1 MET10 ECM17 OYE3 4 15 hydrolase [GO:0016787] 0.00316089 DRS2 IPP1 ATP3 CDC39 PTC1 RPN4 APA2 SAH1 HOR2 ULP2 RHO3 STH1 BNA3 ATP7 PSR1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 GTR1 ATM1 POP1 CSL4 POP3 MET22 RRP6 VPH1 PNG1 RRD2 RVB2 30 561 GO Biological Process Category p-value In Category from Cluster k f sulfur metabolism [GO:0006790] 2.18403e-12 CYS3 SAM2 SAH1 MET6 MET10 CYS4 BIO2 MET28 GSH1 MET3 ECM17 MET14 GLO1 MET2 MET22 15 44 amino acid metabolism [GO:0006520] 2.28553e-09 CYS3 ARO4 SAM2 GLY1 SAH1 MET6 LPD1 CYS4 ARO9 MET28 MET3 MET14 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 IDH1 MET2 MET22 21 140 aspartate family amino acid metabolism [GO:0009066] 2.81454e-09 SAM2 GLY1 SAH1 MET6 MET3 MET14 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MET2 MET22 12 41 amino acid and derivative metabolism [GO:0006519] 7.26395e-09 CYS3 ARO4 SAM2 GLY1 SAH1 MET6 LPD1 CYS4 ARO9 MET28 MET3 MET14 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 IDH1 MET2 MET22 21 149 amine metabolism [GO:0009308] 9.27581e-09 CYS3 ARO4 SAM2 GLY1 SAH1 MET6 LPD1 CYS4 ARO9 MET28 MET3 MET14 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 IDH1 MET2 MET22 21 151 sulfur amino acid metabolism [GO:0000096] 1.03375e-08 CYS3 SAM2 SAH1 MET6 CYS4 MET28 MET3 MET14 MET2 MET22 10 29 asparagine catabolism [GO:0006530] 1.00738e-06 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 4 amine catabolism [GO:0009310] 1.10457e-06 GLY1 LPD1 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 7 19 amino acid catabolism [GO:0009063] 1.10457e-06 GLY1 LPD1 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 7 19 sulfate assimilation [GO:0000103] 1.63162e-06 MET10 MET3 ECM17 MET14 MET22 5 8 aspartate family amino acid catabolism [GO:0009068] 1.63162e-06 GLY1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 8 sulfur utilization [GO:0006791] 1.63162e-06 MET10 MET3 ECM17 MET14 MET22 5 8 methionine metabolism [GO:0006555] 1.65367e-06 SAM2 SAH1 MET6 MET3 MET14 MET2 MET22 7 20 serine family amino acid metabolism [GO:0009069] 3.85802e-06 CYS3 GLY1 SAH1 LPD1 CYS4 MET2 6 15 response to nitrogen starvation [GO:0006995] 4.91078e-06 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 5 glutamine family amino acid catabolism [GO:0009065] 6.96698e-06 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 10 asparagine metabolism [GO:0006528] 1.43638e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 sulfur amino acid biosynthesis [GO:0000097] 3.26781e-05 CYS4 MET28 MET2 MET22 4 7 cell growth and/or maintenance [GO:0008151] 3.34138e-05 CYS3 DRS2 BOI1 ATP3 REB1 NHP6B FAT2 ARO4 LSB5 GRX1 GLK1 PDI1 ABP1 MSH3 CDC39 PTC1 RPN4 USO1 RAD59 BRE1 TRM3 CVT20 SES1 PDS1 YDR115W DOP1 MSW1 YPR1 RPP2B SAM2 SMT3 APA2 GLY1 SAH1 PET117 HOR2 MET6 LSM4 BOI2 DSE1 BMH1 SMX2 LPD1 BUD27 EPL1 HAC1 RIM15 LOC1 MET10 ERG26 CYS4 ELP2 ADE3 AZR1 BIO2 MRP4 MUP3 CBP2 QCR10 SRB2 NCP1 KSP1 GAR1 TRA1 SPL2 ARO9 ULP2 MET30 MOB1 PFK26 RHO3 STH1 MET28 YAP5 TIM54 BNA3 GSH1 MRS3 CIS3 ERG20 SET2 MNN5 SWE1 CBP1 TDH2 MET3 RSM7 ECM17 MET14 CAP1 PUT3 ATP7 CTK1 DPH2 ACP1 SIS2 ORC3 SPO75 PSR1 SPA2 GAL2 SUL2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 GLO1 YMD8 GTR1 ADH3 SKY1 GUA1 GFD1 URA10 ATM1 PSE1 IDH1 YDJ1 APP1 ADE12 POP1 CSL4 ATX1 MET2 POP3 PHO91 MET22 RRP6 YNG1 CYT1 NUP1 KTR1 WTM1 VPH1 MBF1 BUD7 PNG1 UME1 RRD2 NAB3 HRR25 RVB2 HFI1 144 3657 glutamine family amino acid metabolism [GO:0009064] 7.8446e-05 PUT3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 IDH1 7 34 regulation of transcription from Pol II promoter [GO:0006357] 0.000158001 REB1 NHP6B CDC39 EPL1 HAC1 ELP2 TRA1 MET28 YAP5 PUT3 CTK1 MBF1 NAB3 RVB2 14 142 metabolism [GO:0008152] 0.000196701 CYS3 DRS2 REB1 NHP6B ARO4 GRX1 GLK1 PDI1 MSH3 CDC39 PTC1 RPN4 USO1 RAD59 TRM3 CVT20 SES1 PDS1 YDR115W MSW1 YPR1 RPP2B SAM2 SMT3 APA2 GLY1 SAH1 PET117 HOR2 MET6 LSM4 BMH1 SMX2 LPD1 EPL1 HAC1 RIM15 MET10 ERG26 CYS4 ELP2 ADE3 BIO2 MRP4 CBP2 QCR10 SRB2 NCP1 KSP1 GAR1 TRA1 ARO9 ULP2 MET30 PFK26 RHO3 STH1 MET28 YAP5 TIM54 BNA3 GSH1 MRS3 ERG20 SET2 MNN5 CBP1 TDH2 MET3 RSM7 ECM17 MET14 PUT3 CTK1 DPH2 ACP1 ORC3 GAL2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 IDP2 GLO1 ADH3 SKY1 GUA1 GFD1 URA10 PSE1 IDH1 YDJ1 ADE12 POP1 CSL4 ATX1 MET2 POP3 MET22 RRP6 YNG1 CYT1 NUP1 KTR1 VPH1 MBF1 PNG1 NAB3 HRR25 RVB2 HFI1 111 2693 response to starvation [GO:0009267] 0.000407383 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 12 serine family amino acid biosynthesis [GO:0009070] 0.00101923 GLY1 LPD1 CYS4 3 7 regulation of transcription, DNA-dependent [GO:0006355] 0.00160867 REB1 NHP6B CDC39 PTC1 EPL1 HAC1 ELP2 TRA1 MET28 YAP5 SET2 PUT3 CTK1 ORC3 MBF1 NAB3 RVB2 17 240 regulation of transcription [GO:0045449] 0.00183937 REB1 NHP6B CDC39 PTC1 EPL1 HAC1 ELP2 TRA1 MET28 YAP5 SET2 PUT3 CTK1 ORC3 MBF1 NAB3 RVB2 17 243 transcription from Pol II promoter [GO:0006366] 0.00192896 REB1 NHP6B CDC39 EPL1 HAC1 ELP2 SRB2 TRA1 MET28 YAP5 PUT3 CTK1 MBF1 NAB3 RVB2 HFI1 16 223 amino acid biosynthesis [GO:0008652] 0.00200172 ARO4 GLY1 LPD1 CYS4 MET28 IDP2 IDH1 MET2 MET22 9 89 regulation of meiosis [GO:0040020] 0.00267631 RIM15 SWE1 WTM1 UME1 4 19 homoserine metabolism [GO:0009092] 0.0029765 CYS3 MET2 2 3 cysteine metabolism [GO:0006534] 0.0029765 CYS3 CYS4 2 3 glycine metabolism [GO:0006544] 0.0029765 GLY1 LPD1 2 3 amine biosynthesis [GO:0009309] 0.00313984 ARO4 GLY1 LPD1 CYS4 MET28 IDP2 IDH1 MET2 MET22 9 95 cell communication [GO:0007154] 0.00344216 BOI1 GRX1 CDC39 PTC1 RAD59 HOR2 BOI2 BMH1 HAC1 SYG1 RHO3 CAP1 SIS2 SPA2 ASP3-1 ASP3-2 ASP3-3 ASP3-4 SKY1 ATX1 RRD2 21 348 response to stress [GO:0006950] 0.00437283 GRX1 RAD59 HOR2 HAC1 RIM15 CAP1 SIS2 PSR1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 ATX1 RRD2 14 199 GO Cellular Component Category p-value In Category from Cluster k f periplasmic space (sensu Fungi) [GO:0030287] 0.000111843 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 9 cell [GO:0005623] 0.00103017 DRS2 BOI1 ATP3 REB1 NHP6B FAT2 LSB5 GRX1 GLK1 YCL042W PDI1 ABP1 MSH3 CDC39 PTC1 RPN4 USO1 RAD59 CVT20 SES1 PDS1 YDR115W MSW1 RPP2B SMT3 HMF1 PET117 FCY22 MET6 LSM4 BOI2 SMX2 LPD1 EPL1 HAC1 LOC1 ERG26 SDS23 CYS4 ELP2 ADE3 AZR1 MRP4 MUP3 CBP2 QCR10 SRB2 NCP1 KSP1 GAR1 TRA1 YHR113W SPL2 ULP2 MET30 SYG1 MOB1 PFK26 RHO3 STH1 MET28 YAP5 TIM54 GSH1 MRS3 SNA3 CIS3 ERG20 SET2 MNN5 SWE1 CBP1 TDH2 RSM7 CAP1 LAC1 PUT3 ATP7 CTK1 ACP1 SIS2 ORC3 PSR1 SPA2 GAL2 SUL2 STM1 ASP3-1 IDP2 GTR1 ADH3 SKY1 GFD1 ATM1 PSE1 NCE103 IDH1 YDJ1 APP1 POP1 CSL4 ATX1 MET2 POP3 PHO91 YNR014W MET22 RRP6 YNG1 CYT1 NUP1 KTR1 WTM1 VPH1 MBF1 PNG1 UME1 NAB3 HRR25 RVB2 HFI1 121 3106 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00710 (Asparaginase) 3.26781e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 7 PF00667 (FAD_binding) 0.0029765 MET10 NCP1 2 3 PF00536 (SAM) 0.0029765 BOI1 BOI2 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YGL237C (HAP2) 6.40072e-05 IPP1 ATP3 SAH1 LOC1 CYS4 PSE1 YNL063W 7 33 YMR059W (SEN15) 0.001505 ATP3 GRX1 SES1 SAH1 MET6 CYS4 WTM1 7 54 YNL189W (SRP1) 0.00200157 REB1 TRA1 RRP6 NUP1 UME1 5 29 YPL149W (APG5) 0.0029765 CYS3 ERG20 2 3 YHR199C 0.0029765 ABP1 PSE1 2 3 Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f cyto 0.00284451 CYS3 DRS2 YAR064W IPP1 ARO4 GRX1 GLK1 YCL042W ABP1 CDC39 PTC1 USO1 SES1 SAM2 YDR531W SAH1 MET6 BOI2 LPD1 BUD27 MET10 CYS4 ELP2 ADE3 YHR112C YHR113W SPL2 ARO9 ULP2 MOB1 PFK26 GSH1 MRS3 YJR001W TDH2 ECM17 MET14 DPH2 SIS2 SPA2 YLR149C STM1 ASP3-4 PSP2 GTR1 YMR196W GUA1 GFD1 URA10 NCE103 YDJ1 ATX1 MET2 YNR014W MET22 BUD7 YOR378W RRD2 OYE3 59 1324 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f