Input Cluster (n=200) YAL034C FUN19 YAL053W YBL038W MRPL16 YBL039C URA7 YBL046W YBL047C EDE1 YBL086C YBL101C ECM21 YBR038W CHS2 YBR044C TCM62 YBR072W HSP26 YBR086C IST2 YBR087W RFC5 YBR104W YMC2 YBR114W RAD16 YBR119W MUD1 YBR125C PTC4 YBR126C TPS1 YBR208C "DUR1,2" YBR214W SDS24 YBR223C TDP1 YBR257W POP4 YCL040W GLK1 YCL043C PDI1 YCR014C POL4 YCR065W HCM1 YCR098C GIT1 YCR104W PAU3 YDL024C DIA3 YDL027C YDL047W SIT4 YDL134C PPH21 YDL243C AAD4 YDR001C NTH1 YDR002W YRB1 YDR028C REG1 YDR035W ARO3 YDR041W RSM10 YDR074W TPS2 YDR099W BMH2 YDR135C YCF1 YDR258C HSP78 YDR276C PMP3 YDR335W MSN5 YDR435C PPM1 YDR436W PPZ2 YDR475C JIP4 YDR477W SNF1 YDR542W YEL002C WBP1 YEL026W SNU13 YEL044W IES6 YEL046C GLY1 YEL058W PCM1 YEL059C-A SOM1 YER036C KRE30 YER037W PHM8 YER067W YER103W SSA4 YER133W GLC7 YER149C PEA2 YER168C CCA1 YER169W RPH1 YER177W BMH1 YFL022C FRS2 YFL053W DAK2 YFL054C YFR013W IOC3 YFR053C HXK1 YGL037C PNC1 YGL126W SCS3 YGL157W YGL202W ARO8 YGL205W POX1 YGL206C CHC1 YGL249W ZIP2 YGR036C CAX4 YGR043C YGR053C YGR059W SPR3 YGR086C YGR088W CTT1 YGR122W YGR127W YGR141W VPS62 YGR154C YGR155W CYS4 YGR192C TDH3 YGR194C XKS1 YGR241C YAP1802 YGR249W MGA1 YGR255C COQ6 YGR256W GND2 YGR268C YGR270W YTA7 YGR283C YHL002W HSE1 YHL040C ARN1 YHL046C YHR071W PCL5 YHR072W ERG7 YHR087W YHR096C HXT5 YIL030C SSM4 YIL035C CKA1 YIL062C ARC15 YIL075C RPN2 YIL099W SGA1 YIL124W AYR1 YIR016W YIR038C GTT1 YJL037W YJL038C YJL066C MPM1 YJL139C YUR1 YJL149W YJL151C SNA3 YJL157C FAR1 YJL164C TPK1 YJL186W MNN5 YJL187C SWE1 YJL193W YJR036C HUL4 YJR142W YJR149W YKL050C YKL091C YKL107W YKL126W YPK1 YKL127W PGM1 YKL201C MNN4 YKR003W OSH6 YKR017C YKR074W YKR076W ECM4 YLL042C APG10 YLL048C YBT1 YLL057C YLL064C YLR031W YLR178C TFS1 YLR206W ENT2 YLR326W YLR336C SGD1 YLR337C VRP1 YLR345W YLR355C ILV5 YLR356W YLR361C DCR2 YLR415C YLR417W VPS36 YML019W OST6 YML035C AMD1 YMR008C PLB1 YMR031C YMR032W HOF1 YMR105C PGM2 YMR169C ALD3 YMR174C PAI3 YMR196W YMR216C SKY1 YMR251W YMR258C YMR278W YMR291W YMR296C LCB1 YNL015W PBI2 YNL051W COG5 YNL058C YNL100W YNL241C ZWF1 YNR002C FUN34 YNR076W PAU6 YOL020W TAT2 YOL021C DIS3 YOL120C RPL18A YOL125W YOR014W RTS1 YOR018W ROD1 YOR063W RPL3 YOR259C RPT4 YOR260W GCD1 YOR267C HRK1 YOR284W YOR302W YOR313C SPS4 YOR329C SCD5 YOR348C PUT4 YOR394W YPL054W LEE1 YPL055C LGE1 YPL186C UIP4 YPL230W YPL245W YPL246C YPL277C YPL282C YPR002W PDH1 YPR115W YPR149W NCE102 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f C-compound and carbohydrate metabolism 6.18836e-06 YBL086C CHS2 TPS1 GLK1 PPH21 AAD4 NTH1 REG1 TPS2 SNF1 WBP1 PCM1 GLC7 DAK2 HXK1 YGR043C TDH3 XKS1 GND2 HXT5 SGA1 AYR1 YUR1 MNN5 PGM1 YLR345W OST6 PGM2 YMR278W ZWF1 FUN34 31 415 C-compound and carbohydrate utilization 7.85331e-06 CHS2 TPS1 GLK1 AAD4 NTH1 TPS2 WBP1 PCM1 DAK2 HXK1 YGR043C TDH3 XKS1 GND2 SGA1 AYR1 YUR1 MNN5 PGM1 OST6 PGM2 YMR278W ZWF1 23 261 stress response 9.96234e-06 TCM62 HSP26 TPS1 PAU3 TPS2 HSP78 PPZ2 SNF1 SSA4 DAK2 CTT1 MGA1 YHL046C GTT1 PAI3 ZWF1 PAU6 RTS1 18 175 CELL RESCUE, DEFENSE AND VIRULENCE 6.64815e-05 TCM62 HSP26 TPS1 PAU3 TPS2 YCF1 HSP78 PPZ2 SNF1 SSA4 DAK2 CTT1 MGA1 ARN1 YHL046C GTT1 YLL057C PAI3 ZWF1 PAU6 RTS1 ROD1 22 278 METABOLISM 0.000109333 URA7 YBL086C CHS2 TPS1 "DUR1,2" GLK1 PDI1 GIT1 DIA3 PPH21 AAD4 NTH1 REG1 ARO3 TPS2 SNF1 WBP1 GLY1 PCM1 GLC7 DAK2 HXK1 SCS3 YGL157W ARO8 POX1 YGR043C CYS4 TDH3 XKS1 COQ6 GND2 ERG7 HXT5 SGA1 AYR1 YUR1 MNN5 YJR142W YJR149W PGM1 OSH6 YBT1 YLR345W ILV5 OST6 AMD1 PLB1 PGM2 YMR278W LCB1 ZWF1 FUN34 TAT2 PUT4 55 1066 metabolism of energy reserves (glycogen, trehalose) 0.000996582 TPS1 NTH1 TPS2 GLC7 PGM1 PGM2 6 37 pentose-phosphate pathway 0.00233288 YGR043C GND2 ZWF1 3 9 cytoplasm 0.00261617 URA7 HSP26 TPS1 GLK1 NTH1 YRB1 ARO3 TPS2 SNF1 SSA4 GLC7 CCA1 FRS2 IOC3 HXK1 CHC1 CTT1 TDH3 FAR1 TPK1 PGM1 PGM2 PAI3 PBI2 ZWF1 RPL18A RTS1 RPL3 GCD1 YOR302W 30 554 ENERGY 0.00270516 TPS1 GLK1 AAD4 NTH1 TPS2 GLC7 HXK1 POX1 YGR043C TDH3 GND2 PGM1 YLR345W AMD1 PGM2 ALD3 ZWF1 17 252 MIPS Phenotypes Category p-value In Category from Cluster k f Rapamycin sensitivity 0.00101352 BMH2 BMH1 2 2 MIPS Subcellular Localization Category p-value In Category from Cluster k f cytoplasm 0.00197337 URA7 HSP26 TPS1 GLK1 NTH1 YRB1 ARO3 TPS2 SNF1 SSA4 GLC7 CCA1 FRS2 IOC3 HXK1 CHC1 CTT1 TDH3 YTA7 FAR1 TPK1 PGM1 PGM2 ALD3 PAI3 PBI2 ZWF1 RPL18A RTS1 RPL3 GCD1 YOR302W 32 593 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f 14-3-3 proteins 0.00101352 BMH2 BMH1 2 2 PPP family 0.00437089 SIT4 PPZ2 GLC7 3 11 GO Molecular Function Category p-value In Category from Cluster k f protease inhibitor [GO:0030414] 3.20315e-05 TFS1 PAI3 PBI2 3 3 protein serine/threonine phosphatase [GO:0004722] 4.15948e-05 PTC4 SIT4 PPH21 REG1 PPZ2 GLC7 RTS1 7 31 intramolecular transferase [GO:0016866] 0.000111843 PCM1 ERG7 PGM1 PGM2 4 9 phosphatase [GO:0016302] 0.000339803 PTC4 DIA3 SIT4 PPH21 REG1 TPS2 PPZ2 GLC7 CAX4 RTS1 10 85 enzyme [GO:0003824] 0.000343559 MRPL16 URA7 CHS2 RFC5 RAD16 PTC4 TPS1 "DUR1,2" POP4 GLK1 PDI1 POL4 DIA3 SIT4 PPH21 AAD4 NTH1 REG1 ARO3 TPS2 HSP78 PPM1 PPZ2 SNF1 WBP1 GLY1 PCM1 KRE30 GLC7 CCA1 FRS2 DAK2 HXK1 PNC1 ARO8 POX1 CAX4 YGR043C CTT1 CYS4 TDH3 XKS1 GND2 YTA7 PCL5 ERG7 SSM4 CKA1 SGA1 AYR1 GTT1 YUR1 TPK1 MNN5 SWE1 HUL4 YPK1 PGM1 APG10 YBT1 ILV5 OST6 AMD1 PLB1 PGM2 ALD3 SKY1 LCB1 ZWF1 DIS3 RTS1 RPT4 HRK1 73 1604 enzyme inhibitor [GO:0004857] 0.000573823 FAR1 TFS1 PAI3 PBI2 4 13 protein phosphatase [GO:0004721] 0.000645308 PTC4 SIT4 PPH21 REG1 PPZ2 GLC7 RTS1 7 47 phosphoric monoester hydrolase [GO:0016791] 0.000934806 PTC4 DIA3 SIT4 PPH21 REG1 TPS2 PPZ2 GLC7 RTS1 9 80 endopeptidase inhibitor [GO:0004866] 0.00101352 PAI3 PBI2 2 2 phosphoglucomutase [GO:0004614] 0.00101352 PGM1 PGM2 2 2 intramolecular transferase, phosphotransferases [GO:0016868] 0.00101923 PCM1 PGM1 PGM2 3 7 GO Biological Process Category p-value In Category from Cluster k f carbohydrate metabolism [GO:0005975] 1.73732e-05 TPS1 GLK1 NTH1 REG1 TPS2 BMH2 SNF1 PCM1 GLC7 BMH1 HXK1 TDH3 XKS1 GND2 PGM1 PGM2 ZWF1 17 165 energy reserve metabolism [GO:0006112] 3.30883e-05 NTH1 REG1 BMH2 GLC7 BMH1 PGM1 PGM2 7 30 glycogen metabolism [GO:0005977] 0.000104471 REG1 BMH2 GLC7 BMH1 PGM1 PGM2 6 25 glucan metabolism [GO:0006073] 0.000733734 REG1 BMH2 GLC7 BMH1 PGM1 PGM2 6 35 activation of MAPK (pseudohyphal growth) [GO:0000193] 0.00101352 BMH2 BMH1 2 2 glucose 1-phosphate utilization [GO:0006008] 0.00101352 PGM1 PGM2 2 2 glucose 1-phosphate metabolism [GO:0019255] 0.00101352 PGM1 PGM2 2 2 glucose 6-phosphate utilization [GO:0006010] 0.00101352 PGM1 PGM2 2 2 trehalose metabolism [GO:0005991] 0.00101923 NTH1 PGM1 PGM2 3 7 monosaccharide metabolism [GO:0005996] 0.00147054 SNF1 HXK1 TDH3 XKS1 GND2 PGM1 PGM2 ZWF1 8 69 response to stress [GO:0006950] 0.00163866 CHS2 HSP26 IST2 TPS1 NTH1 TPS2 HSP78 SNF1 SSA4 GLC7 CTT1 CKA1 MNN4 VRP1 ALD3 15 199 alcohol metabolism [GO:0006066] 0.00184928 SNF1 DAK2 HXK1 TDH3 XKS1 GND2 PGM1 PGM2 ZWF1 9 88 glucose metabolism [GO:0006006] 0.00251429 SNF1 TDH3 GND2 PGM1 PGM2 ZWF1 6 44 MAPKKK cascade (pseudohyphal growth) [GO:0000190] 0.0029765 BMH2 BMH1 2 3 activation of MAPK [GO:0000187] 0.0029765 BMH2 BMH1 2 3 polysaccharide metabolism [GO:0005976] 0.00353338 REG1 BMH2 GLC7 BMH1 PGM1 PGM2 6 47 hexose metabolism [GO:0019318] 0.00369296 SNF1 HXK1 TDH3 GND2 PGM1 PGM2 ZWF1 7 63 endocytosis [GO:0006897] 0.00393309 EDE1 SDS24 YAP1802 YPK1 ENT2 VRP1 6 48 disaccharide metabolism [GO:0005984] 0.00437089 NTH1 PGM1 PGM2 3 11 GO Cellular Component Category p-value In Category from Cluster k f unlocalized [GO:0005941] 2.29528e-07 TPS1 PPH21 REG1 TPS2 GLC7 FRS2 CKA1 TPK1 RTS1 9 30 protein serine/threonine phosphatase complex [GO:0008287] 0.000573823 PPH21 REG1 GLC7 RTS1 4 13 actin cytoskeleton [GO:0015629] 0.00216403 EDE1 CHS2 PEA2 SPR3 YAP1802 ARC15 ENT2 VRP1 HOF1 9 90 bud neck [GO:0005935] 0.00279363 EDE1 CHS2 PEA2 SPR3 SWE1 YPK1 HOF1 7 60 cytoplasm [GO:0005737] 0.0029597 MRPL16 URA7 EDE1 CHS2 TCM62 HSP26 YMC2 TPS1 SDS24 GLK1 PDI1 SIT4 YRB1 REG1 RSM10 YCF1 HSP78 SNF1 WBP1 PCM1 SOM1 SSA4 PEA2 CCA1 FRS2 HXK1 POX1 CHC1 CAX4 SPR3 CTT1 CYS4 TDH3 YAP1802 COQ6 GND2 YGR268C HSE1 ARN1 ERG7 ARC15 RPN2 SGA1 AYR1 GTT1 MPM1 YUR1 FAR1 TPK1 MNN5 YPK1 PGM1 YKR074W YBT1 ENT2 VRP1 ILV5 VPS36 OST6 HOF1 PGM2 ALD3 PAI3 SKY1 LCB1 PBI2 COG5 ZWF1 DIS3 RPL18A RTS1 RPL3 RPT4 GCD1 YPR115W NCE102 76 1810 SMART Domains Category p-value In Category from Cluster k f PP2Ac 0.000407383 SIT4 PPH21 PPZ2 GLC7 4 12 14_3_3 0.00101352 BMH2 BMH1 2 2 PFam-A Domains Category p-value In Category from Cluster k f PF00408 (PGM_PMM) 1.00738e-06 PCM1 PGM1 PGM2 YMR278W 4 4 PF02878 (PGM_PMM_I) 1.00738e-06 PCM1 PGM1 PGM2 YMR278W 4 4 PF02879 (PGM_PMM_II) 3.20315e-05 PCM1 PGM1 PGM2 3 3 PF00660 (SRP1_TIP1) 3.30883e-05 PAU3 YDR542W YHL046C YLL064C PAU6 YOR394W YPL282C 7 30 PF00149 (Metallophos) 0.00042209 SIT4 PPH21 PPZ2 GLC7 DCR2 5 21 PF02880 (PGM_PMM_III) 0.00101352 PGM1 PGM2 2 2 PF00244 (14-3-3) 0.00101352 BMH2 BMH1 2 2 PF02809 (UIM) 0.0029765 HSE1 ENT2 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YNL189W (SRP1) 0.00157355 HSP26 GLK1 GLY1 BMH1 PNC1 CTT1 CYS4 TDH3 MGA1 YLR345W YOR284W 11 121 YHR123W (EPT1) 0.0029765 CHS2 GTT1 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f YMR311C (GLC8) 0.0029765 PPZ2 GLC7 2 3 Cellzome Complexes Category p-value In Category from Cluster k f YGL115W (SNF4) 0.000111843 REG1 SNF1 BMH1 CKA1 4 9 YOR014W (RTS1) 0.000596423 PPH21 TDH3 RTS1 3 6 YDR099W (BMH2) 0.00101923 NTH1 BMH2 BMH1 3 7 YBR126C (TPS1) 0.00135467 TPS1 REG1 TPS2 YMR251W 4 16 Proteome Localization--Observed Category p-value In Category from Cluster k f cyto 0.00464306 FUN19 YBL086C ECM21 CHS2 HSP26 TPS1 "DUR1,2" SDS24 GLK1 SIT4 PPH21 NTH1 YRB1 TPS2 MSN5 PPM1 PPZ2 PCM1 PHM8 SSA4 FRS2 DAK2 HXK1 PNC1 SCS3 YGL157W POX1 CHC1 YGR086C YGR122W CYS4 TDH3 GND2 YGR268C ARC15 AYR1 YIR016W HUL4 YKL107W YPK1 YKR074W ECM4 YLR031W VRP1 YLR356W VPS36 AMD1 PGM2 YMR196W YMR251W YMR291W YNL058C ZWF1 RPL18A RTS1 PUT4 LEE1 YPR115W 58 1324 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.0029717 FUN19 URA7 YBL086C CHS2 HSP26 IST2 RFC5 PTC4 TPS1 "DUR1,2" SDS24 GLK1 GIT1 YDL027C SIT4 PPH21 AAD4 NTH1 YRB1 ARO3 TPS2 BMH2 YCF1 PMP3 MSN5 PPM1 PPZ2 SNF1 IES6 GLY1 PCM1 KRE30 PHM8 YER067W SSA4 GLC7 PEA2 BMH1 FRS2 DAK2 YFL054C IOC3 HXK1 PNC1 YGL157W ARO8 CHC1 YGR043C YGR053C SPR3 YGR086C CTT1 YGR122W YGR127W CYS4 TDH3 XKS1 YAP1802 GND2 YGR268C HSE1 ARN1 ERG7 YHR087W HXT5 SSM4 ARC15 AYR1 YIR016W YJL149W FAR1 TPK1 SWE1 HUL4 YJR142W YKL050C YKL091C YKL107W YPK1 PGM1 OSH6 YKR017C YKR074W ECM4 APG10 YLL057C YLR031W ENT2 SGD1 YLR345W YLR356W YLR415C VPS36 AMD1 YMR031C PGM2 ALD3 PAI3 YMR196W SKY1 YMR251W YMR258C YMR291W PBI2 YNL058C ZWF1 FUN34 TAT2 RPL18A RTS1 RPL3 RPT4 GCD1 HRK1 PUT4 YOR394W LEE1 YPL245W YPL282C PDH1 YPR115W NCE102 122 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f