Input Cluster (n=200) YAL003W EFB1 YAL005C SSA1 YAL064W YAR002W NUP60 YBL042C FUI1 YBL052C SAS3 YBL074C AAR2 YBL092W RPL32 YBL098W BNA4 YBR021W FUR4 YBR077C YBR105C VID24 YBR106W PHO88 YBR114W RAD16 YBR238C YCL047C YCL055W KAR4 YCL056C YCR024C-A PMP1 YCR065W HCM1 YCR066W RAD18 YDL047W SIT4 YDL053C YDL128W VCX1 YDR001C NTH1 YDR002W YRB1 YDR054C CDC34 YDR058C TGL2 YDR071C YDR072C IPT1 YDR096W GIS1 YDR099W BMH2 YDR170C SEC7 YDR198C YDR211W GCD6 YDR222W YDR234W LYS4 YDR275W YDR277C MTH1 YDR289C RTT103 YDR295C PLO2 YDR296W MHR1 YDR342C HXT7 YDR345C HXT3 YDR399W HPT1 YDR524C AGE1 YEL017C-A PMP2 YEL032W MCM3 YER028C YER036C KRE30 YER037W PHM8 YER049W YER112W LSM4 YER159C BUR6 YER166W DNF1 YER168C CCA1 YER169W RPH1 YER177W BMH1 YFR040W SAP155 YFR053C HXK1 YGL008C PMA1 YGL056C SDS23 YGL080W YGL133W ITC1 YGL158W RCK1 YGL209W MIG2 YGL215W CLG1 YGL256W ADH4 YGR033C YGR077C PEX8 YGR191W HIP1 YGR194C XKS1 YGR229C SMI1 YGR230W BNS1 YGR238C KEL2 YGR241C YAP1802 YGR243W YGR260W TNA1 YHL012W YHL013C YHL015W RPS20 YHR047C AAP1' YHR071W PCL5 YHR082C KSP1 YHR085W IPI1 YHR092C HXT4 YHR094C HXT1 YHR178W STB5 YHR206W SKN7 YHR210C YHR216W IMD2 YIL094C LYS12 YIL096C YIL108W YIL119C RPI1 YIL172C YJL016W YJL044C GYP6 YJL084C YJL089W SIP4 YJL133W MRS3 YJL149W YJL151C SNA3 YJL163C YJL193W YJL212C OPT1 YJL214W HXT8 YJL216C YJL217W YJL219W HXT9 YJL221C FSP2 YJR047C ANB1 YJR076C CDC11 YJR103W URA8 YJR109C CPA2 YKL056C YKL061W YKL062W MSN4 YKL110C KTI12 YKL120W OAC1 YKL130C SHE2 YKL198C PTK1 YKL201C MNN4 YKR075C YKR098C UBP11 YKR099W BAS1 YLL004W ORC3 YLL005C SPO75 YLL013C PUF3 YLL029W YLL055W YLR028C ADE16 YLR044C PDC1 YLR108C YLR224W YLR249W YEF3 YLR254C YLR372W SUR4 YLR431C YLR432W IMD3 YLR436C ECM30 YML035C AMD1 YML043C RRN11 YML055W SPC2 YML056C IMD4 YMR011W HXT2 YMR038C LYS7 YMR043W MCM1 YMR070W MOT3 YMR108W ILV2 YMR146C TIF34 YMR147W YMR182C RGM1 YMR205C PFK2 YMR278W YMR291W YMR296C LCB1 YMR303C ADH2 YMR304W UBP15 YMR321C YNL066W SUN4 YNL096C RPS7B YNL142W MEP2 YNL176C YNL190W YNL221C POP1 YNL246W VPS75 YNL301C RPL18B YNR003C RPC34 YNR004W YNR017W MAS6 YNR018W YOL012C HTZ1 YOL013C HRD1 YOL100W PKH2 YOL136C PFK27 YOL156W HXT11 YOL157C YOR008C SLG1 YOR051C YOR062C YOR101W RAS1 YOR214C YOR302W YOR355W GDS1 YOR370C MRS6 YPL024W NCE4 YPL032C SVL3 YPL057C SUR1 YPL116W HOS3 YPL117C IDI1 YPL184C YPL189W GUP2 YPL233W NSL1 YPR016C TIF6 YPR026W ATH1 YPR036W VMA13 YPR149W NCE102 YPR157W YPR192W AQY1 Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f C-compound and carbohydrate metabolism 7.39332e-08 NTH1 CDC34 MTH1 HXT7 HXT3 HXK1 MIG2 ADH4 XKS1 SMI1 YHL012W AAP1' HXT4 HXT1 YHR210C RPI1 YIL172C HXT8 YJL216C HXT9 FSP2 CDC11 MSN4 PDC1 HXT2 MCM1 PFK2 YMR278W ADH2 SUN4 PFK27 HXT11 YOL157C RAS1 ATH1 35 415 METABOLISM 2.8195e-06 FUI1 BNA4 FUR4 PHO88 NTH1 CDC34 TGL2 IPT1 LYS4 MTH1 HXT7 HXT3 HPT1 HXK1 MIG2 ADH4 HIP1 XKS1 SMI1 YHL012W AAP1' HXT4 HXT1 YHR210C IMD2 LYS12 RPI1 YIL172C HXT8 YJL216C HXT9 FSP2 CDC11 URA8 CPA2 MSN4 BAS1 PUF3 ADE16 PDC1 SUR4 IMD3 AMD1 IMD4 HXT2 MCM1 ILV2 PFK2 YMR278W LCB1 ADH2 SUN4 PFK27 HXT11 YOL157C RAS1 MRS6 SUR1 IDI1 ATH1 60 1066 plasma membrane 3.00369e-06 FUI1 FUR4 PMP1 HXT7 HXT3 PMP2 PMA1 HIP1 YAP1802 HXT4 HXT1 HXT8 HXT9 HXT2 MEP2 HXT11 SLG1 17 145 C-compound and carbohydrate transporters 1.13425e-05 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 GUP2 9 46 TRANSPORT FACILITATION 1.64884e-05 FUR4 PMP1 VCX1 HXT7 HXT3 PMP2 KRE30 DNF1 PMA1 HIP1 TNA1 HXT4 HXT1 OPT1 HXT8 HXT9 OAC1 YLL055W HXT2 MEP2 MAS6 HXT11 GUP2 VMA13 AQY1 25 312 C-compound, carbohydrate transport 4.3396e-05 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 8 42 cellular import 7.14857e-05 FUR4 HXT7 HXT3 HIP1 YAP1802 HXT4 HXT1 HXT8 HXT9 HXT2 MEP2 HXT11 12 100 metabolism of energy reserves (glycogen, trehalose) 0.000138411 NTH1 AAP1' YIL172C YJL216C FSP2 YOL157C ATH1 7 37 regulation of C-compound and carbohydrate utilization 0.000410123 CDC34 MTH1 MIG2 SMI1 AAP1' RPI1 CDC11 MSN4 MCM1 PFK2 PFK27 RAS1 12 120 cytoplasm 0.000631007 EFB1 SSA1 RPL32 NTH1 YRB1 SEC7 GCD6 MCM3 CCA1 HXK1 ADH4 KEL2 RPS20 YHR210C ANB1 CPA2 YKL056C MSN4 SHE2 PDC1 YEF3 LYS7 TIF34 PFK2 ADH2 RPS7B RPL18B RAS1 YOR302W MRS6 IDI1 TIF6 32 554 other cation transporters (Na, K, Ca , NH4, etc.) 0.00115248 PMP1 VCX1 PMP2 PMA1 MEP2 VMA13 6 38 nucleotide metabolism 0.00259919 FUI1 FUR4 HPT1 IMD2 URA8 BAS1 PUF3 ADE16 IMD3 AMD1 IMD4 RAS1 12 148 purine ribonucleotide metabolism 0.0028255 HPT1 IMD2 ADE16 IMD3 AMD1 IMD4 6 45 cation transporters 0.00307229 PMP1 VCX1 PMP2 PMA1 HIP1 MEP2 VMA13 7 61 ion transporters 0.00322967 PMP1 VCX1 PMP2 PMA1 HIP1 OAC1 MEP2 VMA13 8 78 homeostasis of protons 0.0046866 PMP1 VCX1 PMP2 PMA1 VMA13 5 35 MIPS Phenotypes Category p-value In Category from Cluster k f Rapamycin sensitivity 0.00101352 BMH2 BMH1 2 2 other nucleic acid metabolism defects 0.00159254 FUI1 FUR4 MCM3 3 8 MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 2.53309e-06 FUI1 FUR4 PMP1 HXT7 HXT3 PMP2 PMA1 HIP1 YAP1802 HXT4 HXT1 HXT8 HXT9 HXT2 MEP2 HXT11 SLG1 RAS1 18 159 cytoplasm 0.00379919 EFB1 SSA1 RPL32 NTH1 YRB1 SEC7 GCD6 MCM3 CCA1 HXK1 ADH4 KEL2 RPS20 YHR210C ANB1 CPA2 YKL056C MSN4 SHE2 ADE16 PDC1 YEF3 LYS7 TIF34 PFK2 ADH2 RPS7B RPL18B YOR302W MRS6 IDI1 31 593 MIPS Protein Complexes Category p-value In Category from Cluster k f H+-ATPase, plasma mebrane 0.000125104 PMP1 PMP2 PMA1 3 4 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.000158001 FUI1 FUR4 HXT7 HXT3 HIP1 TNA1 HXT4 HXT1 HXT8 HXT9 YLL055W HXT2 MEP2 HXT11 14 142 Cys2His2 zinc-finger 0.000271246 GIS1 YER028C RPH1 MIG2 MSN4 MOT3 RGM1 7 41 14-3-3 proteins 0.00101352 BMH2 BMH1 2 2 Transcription factors 0.00192745 SAS3 HCM1 GIS1 YER028C RPH1 MIG2 STB5 SKN7 SIP4 MSN4 BAS1 MCM1 MOT3 RGM1 14 182 Zinc-coordinating DNA-binding domains 0.00207705 SAS3 GIS1 YER028C RPH1 MIG2 STB5 SIP4 MSN4 MOT3 RGM1 10 107 GO Molecular Function Category p-value In Category from Cluster k f mannose transporter [GO:0015578] 4.97375e-09 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 8 15 glucose transporter [GO:0005355] 1.77806e-08 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 8 17 monosaccharide transporter [GO:0015145] 5.23138e-08 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 8 19 hexose transporter [GO:0015149] 5.23138e-08 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 8 19 fructose transporter [GO:0005353] 8.62245e-08 HXT7 HXT3 HXT4 HXT8 HXT9 HXT2 HXT11 7 14 carbohydrate transporter [GO:0015144] 1.67879e-06 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 8 28 hydrolase, hydrolyzing O-glycosyl compounds [GO:0004553] 4.15948e-05 NTH1 YIL172C YJL216C FSP2 AMD1 SUN4 ATH1 7 31 IMP dehydrogenase [GO:0003938] 0.000125104 IMD2 IMD3 IMD4 3 4 hydrolase, acting on glycosyl bonds [GO:0016798] 0.000138411 NTH1 YIL172C YJL216C FSP2 AMD1 SUN4 ATH1 7 37 galactose transporter [GO:0005354] 0.000596423 HXT1 HXT9 HXT11 3 6 transporter [GO:0005215] 0.000701058 FUI1 FUR4 PHO88 VCX1 HXT7 HXT3 KRE30 DNF1 PMA1 HIP1 TNA1 HXT4 HXT1 MRS3 OPT1 HXT8 HXT9 OAC1 HXT2 MEP2 MAS6 HXT11 VMA13 AQY1 24 372 alpha-glucosidase [GO:0004558] 0.00101923 YIL172C YJL216C FSP2 3 7 carbohydrate kinase [GO:0019200] 0.0010418 HXK1 XKS1 PFK2 PFK27 4 15 trehalase [GO:0015927] 0.0029765 NTH1 ATH1 2 3 alpha,alpha-trehalase [GO:0004555] 0.0029765 NTH1 ATH1 2 3 oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor [GO:0016616] 0.00353338 ADH4 IMD2 LYS12 IMD3 IMD4 ADH2 6 47 glucosidase [GO:0015926] 0.00468663 YIL172C YJL216C FSP2 SUN4 4 22 GO Biological Process Category p-value In Category from Cluster k f monosaccharide transport [GO:0015749] 9.96626e-09 MTH1 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 9 22 hexose transport [GO:0008645] 9.96626e-09 MTH1 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 9 22 carbohydrate transport [GO:0008643] 2.29528e-07 MTH1 HXT7 HXT3 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 9 30 transport [GO:0006810] 0.000293181 SSA1 NUP60 FUI1 FUR4 VID24 PHO88 PMP1 VCX1 YRB1 SEC7 MTH1 HXT7 HXT3 AGE1 PMP2 DNF1 PMA1 PEX8 HIP1 YAP1802 TNA1 HXT4 HXT1 GYP6 MRS3 HXT8 HXT9 OAC1 PTK1 SUR4 HXT2 LYS7 MEP2 VPS75 MAS6 HXT11 MRS6 SVL3 AQY1 39 698 purine nucleotide biosynthesis [GO:0006164] 0.000783414 HPT1 IMD2 ADE16 IMD3 4 14 inositolphosphoceramide metabolism [GO:0006673] 0.00101352 IPT1 SUR1 2 2 activation of MAPK (pseudohyphal growth) [GO:0000193] 0.00101352 BMH2 BMH1 2 2 RAS protein signal transduction [GO:0007265] 0.0010418 BMH2 BMH1 RPI1 RAS1 4 15 purine nucleotide metabolism [GO:0006163] 0.00135467 HPT1 IMD2 ADE16 IMD3 4 16 MAPKKK cascade (pseudohyphal growth) [GO:0000190] 0.0029765 BMH2 BMH1 2 3 activation of MAPK [GO:0000187] 0.0029765 BMH2 BMH1 2 3 ribonucleoside triphosphate biosynthesis [GO:0009201] 0.0029765 IMD2 IMD3 2 3 trehalose catabolism [GO:0005993] 0.0029765 NTH1 ATH1 2 3 purine nucleoside triphosphate biosynthesis [GO:0009145] 0.0029765 IMD2 IMD3 2 3 purine nucleoside triphosphate metabolism [GO:0009144] 0.0029765 IMD2 IMD3 2 3 GTP biosynthesis [GO:0006183] 0.0029765 IMD2 IMD3 2 3 GTP metabolism [GO:0046039] 0.0029765 IMD2 IMD3 2 3 purine ribonucleoside triphosphate metabolism [GO:0009205] 0.0029765 IMD2 IMD3 2 3 ribonucleoside triphosphate metabolism [GO:0009199] 0.0029765 IMD2 IMD3 2 3 purine ribonucleoside triphosphate biosynthesis [GO:0009206] 0.0029765 IMD2 IMD3 2 3 nucleotide biosynthesis [GO:0009165] 0.00326287 HPT1 IMD2 ADE16 IMD3 4 20 ion transport [GO:0006811] 0.00337119 PHO88 PMP1 VCX1 PMP2 PMA1 HIP1 OAC1 LYS7 MEP2 9 96 sphingolipid metabolism [GO:0006665] 0.00393128 IPT1 SUR4 LCB1 SUR1 4 21 purine ribonucleotide biosynthesis [GO:0009152] 0.00437089 IMD2 ADE16 IMD3 3 11 ribonucleotide biosynthesis [GO:0009260] 0.00437089 IMD2 ADE16 IMD3 3 11 GO Cellular Component Category p-value In Category from Cluster k f plasma membrane [GO:0005886] 0.000161084 FUI1 FUR4 HXT7 HXT3 DNF1 PMA1 HIP1 TNA1 HXT4 HXT1 HXT8 HXT9 HXT2 MEP2 HXT11 RAS1 16 178 SMART Domains Category p-value In Category from Cluster k f Aamy 0.000111843 YIL172C YJL216C FSP2 YOL157C 4 9 CBS 0.000111843 SDS23 IMD2 IMD3 IMD4 4 9 ZnF_C2H2 0.00094528 GIS1 YER028C RPH1 MIG2 MSN4 MOT3 RGM1 7 50 14_3_3 0.00101352 BMH2 BMH1 2 2 JmjN 0.0029765 GIS1 RPH1 2 3 PFam-A Domains Category p-value In Category from Cluster k f PF00083 (sugar_tr) 3.75931e-05 HXT7 HXT3 TNA1 HXT4 HXT1 HXT8 HXT9 HXT2 HXT11 9 53 PF00096 (zf-C2H2) 4.3396e-05 SAS3 GIS1 YER028C RPH1 MIG2 MSN4 MOT3 RGM1 8 42 PF00128 (alpha-amylase) 6.37246e-05 YIL172C YJL216C FSP2 YOL157C 4 8 PF01574 (IMPDH_N) 0.000125104 IMD2 IMD3 IMD4 3 4 PF00571 (CBS) 0.000181761 SDS23 IMD2 IMD3 IMD4 4 10 PF00478 (IMPDH_C) 0.000305393 IMD2 IMD3 IMD4 3 5 PF00244 (14-3-3) 0.00101352 BMH2 BMH1 2 2 PF03650 (UPF0041) 0.0029765 YGL080W YGR243W 2 3 PF02375 (jmjN) 0.0029765 GIS1 RPH1 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YEL013W (VAC8) 0.00101352 YKL061W YLR254C 2 2 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f YDR099W (BMH2) 0.00101923 NTH1 BMH2 BMH1 3 7 YDR062W (LCB2) 0.0010418 BMH2 BMH1 LYS12 LCB1 4 15 Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.000427821 EFB1 SSA1 YAL064W FUI1 RPL32 FUR4 YBR077C VID24 PHO88 YBR238C YCL047C SIT4 YDL053C VCX1 NTH1 YRB1 TGL2 YDR071C GIS1 BMH2 YDR198C GCD6 YDR222W LYS4 YDR275W MHR1 HXT7 HXT3 HPT1 AGE1 YER028C KRE30 PHM8 DNF1 BMH1 SAP155 HXK1 PMA1 YGL080W RCK1 CLG1 ADH4 YGR033C PEX8 HIP1 XKS1 BNS1 KEL2 YAP1802 YGR243W TNA1 YHL012W YHL013C RPS20 AAP1' KSP1 HXT4 HXT1 STB5 YHR210C IMD2 YIL108W RPI1 YJL016W GYP6 YJL084C SIP4 MRS3 YJL149W YJL163C OPT1 HXT8 YJL216C YJL217W HXT9 FSP2 ANB1 CDC11 URA8 CPA2 YKL056C YKL061W KTI12 SHE2 YKR075C UBP11 PUF3 YLL029W YLL055W ADE16 PDC1 YLR224W YEF3 YLR254C SUR4 YLR431C IMD3 ECM30 AMD1 IMD4 HXT2 LYS7 TIF34 YMR147W PFK2 YMR291W ADH2 UBP15 YMR321C RPS7B MEP2 YNL176C RPL18B YNR004W PFK27 HXT11 YOR062C MRS6 SVL3 IDI1 YPL184C NSL1 TIF6 ATH1 NCE102 AQY1 126 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f