Input Cluster (n=200) YAR035W YAT1 YAR068W YBL005W PDR3 YBL006C YBL042C FUI1 YBL043W ECM13 YBR001C NTH2 YBR008C FLR1 YBR052C YBR082C UBC4 YBR105C VID24 YBR106W PHO88 YBR150C TBS1 YBR151W APD1 YBR203W YBR240C THI2 YCL063W YCL064C CHA1 YCR005C CIT2 YCR075C ERS1 YCR104W PAU3 YDL079C MRK1 YDL124W YDL125C HNT1 YDL182W LYS20 YDL186W YDL214C PRR2 YDL215C GDH2 YDR011W SNQ2 YDR072C IPT1 YDR158W HOM2 YDR207C UME6 YDR208W MSS4 YDR297W SUR2 YDR345C HXT3 YDR391C YDR392W SPT3 YDR406W PDR15 YDR462W MRPL28 YDR525W-A SNA2 YEL017C-A PMP2 YEL017W YEL029C BUD16 YEL046C GLY1 YEL076C YEL076C-A YER048C CAJ1 YER048W-A YER075C PTP3 YER112W LSM4 YER130C YER137C YER146W LSM5 YER152C YER176W ECM32 YFL053W DAK2 YFL054C YFR017C YGL009C LEU1 YGL056C SDS23 YGL158W RCK1 YGL179C YGL181W GTS1 YGL183C MND1 YGL209W MIG2 YGR017W YGR023W MTL1 YGR035C YGR055W MUP1 YGR110W YGR204W ADE3 YGR205W YGR223C YGR224W AZR1 YGR240C PFK1 YGR243W YGR250C YHR021C RPS27B YHR021W-A ECM12 YHR051W COX6 YHR096C HXT5 YHR136C SPL2 YHR137W ARO9 YHR178W STB5 YHR179W OYE2 YHR199C YHR200W RPN10 YIL013C PDR11 YIL029C YIL031W ULP2 YIL033C BCY1 YIL122W POG1 YIL148W RPL40A YIL149C MLP2 YIL172C YIR017C MET28 YIR018W YAP5 YIR034C LYS1 YIR035C YJL133W MRS3 YJL214W HXT8 YJL216C YJL219W HXT9 YJL221C FSP2 YJR115W YJR152W DAL5 YKL032C IXR1 YKL051W YKL052C ASK1 YKL096W-A CWP2 YKL141W SDH3 YKL146W YKL180W RPL17A YKL181W PRS1 YKL187C YKR006C MRPL13 YKR015C YKR075C YLL028W TPO1 YLL056C YLR004C YLR005W SSL1 YLR044C PDC1 YLR047C YLR048W RPS0B YLR074C BUD20 YLR075W RPL10 YLR081W GAL2 YLR121C YPS3 YLR139C SLS1 YLR153C ACS2 YLR162W YLR254C YLR278C YLR298C YHC1 YLR299W ECM38 YLR301W YLR346C YLR350W ORM2 YLR436C ECM30 YML026C RPS18B YML042W CAT2 YML058W SML1 YML073C RPL6A YMR015C ERG5 YMR136W GAT2 YMR195W ICY1 YMR244C-A YMR251W-A HOR7 YMR265C YMR266W RSN1 YMR272C SCS7 YMR291W YMR315W YNL018C YNL034W YNL047C YNL065W AQR1 YNL103W MET4 YNL134C YNL273W TOF1 YNL274C YNL299W TRF5 YNR001C CIT1 YNR013C PHO91 YNR019W ARE2 YOL012C HTZ1 YOL039W RPP2A YOL040C RPS15 YOL136C PFK27 YOL155C YOL156W HXT11 YOL157C YOR052C YOR064C YNG1 YOR084W YOR134W BAG7 YOR138C YOR140W SFL1 YOR153W PDR5 YOR161C YOR163W DDP1 YOR186W YOR312C RPL20B YOR349W CIN1 YOR370C MRS6 YOR374W ALD4 YOR382W FIT2 YPL024W NCE4 YPL048W CAM1 YPL049C DIG1 YPL055C LGE1 YPL068C YPL135W ISU1 YPL137C YPL183C YPL221W BOP1 YPL256C CLN2 YPR074C TKL1 YPR151C Genes Not Found: MIPS Functional Classification Category p-value In Category from Cluster k f METABOLISM 5.52313e-05 YAT1 FUI1 NTH2 PHO88 CHA1 CIT2 YDL124W HNT1 LYS20 GDH2 SNQ2 IPT1 HOM2 UME6 MSS4 SUR2 HXT3 GLY1 DAK2 LEU1 MIG2 MUP1 ADE3 PFK1 HXT5 ARO9 BCY1 YIL172C MET28 LYS1 YIR035C HXT8 YJL216C HXT9 FSP2 PRS1 PDC1 GAL2 ACS2 ECM38 CAT2 SML1 ERG5 SCS7 MET4 YNL274C CIT1 PHO91 ARE2 PFK27 HXT11 YOL157C PDR5 MRS6 ISU1 TKL1 56 1066 TRANSPORT FACILITATION 0.000133876 YAT1 FLR1 YBR052C SNQ2 HXT3 PDR15 PMP2 YFL054C MUP1 AZR1 HXT5 PDR11 HXT8 HXT9 DAL5 YKL146W TPO1 YLR004C GAL2 AQR1 PHO91 HXT11 PDR5 23 312 plasma membrane 0.000197383 FUI1 SNQ2 MSS4 HXT3 PMP2 MUP1 HXT5 PDR11 HXT8 HXT9 DAL5 GAL2 HXT11 PDR5 14 145 drug transporters 0.000733734 FLR1 YBR052C AZR1 PDR11 TPO1 AQR1 6 35 amino acid metabolism 0.000751345 CHA1 LYS20 GDH2 HOM2 UME6 GLY1 LEU1 MUP1 ADE3 ARO9 MET28 LYS1 PRS1 ECM38 MET4 TKL1 16 204 C-compound, carbohydrate transport 0.00196986 HXT3 HXT5 HXT8 HXT9 GAL2 HXT11 6 42 C-compound and carbohydrate metabolism 0.00311126 NTH2 CIT2 YDL124W LYS20 HXT3 DAK2 MIG2 PFK1 HXT5 BCY1 YIL172C HXT8 YJL216C HXT9 FSP2 PDC1 GAL2 ACS2 YNL274C CIT1 PFK27 HXT11 YOL157C TKL1 24 415 C-compound and carbohydrate transporters 0.00316469 HXT3 HXT5 HXT8 HXT9 GAL2 HXT11 6 46 regulation of amino acid metabolism 0.00360755 UME6 ARO9 MET28 ECM38 MET4 5 33 MIPS Phenotypes Category p-value In Category from Cluster k f Nitrogen utilization 0.00159254 GDH2 GLY1 CIT1 3 8 MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 0.000151393 FUI1 SNQ2 MSS4 HXT3 PMP2 MUP1 HXT5 PDR11 HXT8 HXT9 DAL5 GAL2 YPS3 HXT11 PDR5 15 159 MIPS Protein Complexes Category p-value In Category from Cluster k f Met4/Met28/Met31 complex 0.0029765 MET28 MET4 2 3 Met4/Met28/Met32 complex 0.0029765 MET28 MET4 2 3 Cbf1/Met4/Met28 complex 0.0029765 MET28 MET4 2 3 MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 2.24238e-06 FUI1 FLR1 HXT3 MUP1 AZR1 HXT5 PDR11 HXT8 HXT9 DAL5 YKL146W TPO1 YLR004C GAL2 AQR1 PHO91 HXT11 17 142 Transcription factors 0.000657145 PDR3 TBS1 THI2 UME6 YER130C GTS1 MIG2 STB5 MET28 YAP5 IXR1 SSL1 YLR278C MET4 SFL1 15 182 Zinc-coordinating DNA-binding domains 0.00207705 PDR3 TBS1 THI2 UME6 YER130C GTS1 MIG2 STB5 SSL1 YLR278C 10 107 GO Molecular Function Category p-value In Category from Cluster k f monosaccharide transporter [GO:0015145] 1.87889e-05 HXT3 HXT5 HXT8 HXT9 GAL2 HXT11 6 19 hexose transporter [GO:0015149] 1.87889e-05 HXT3 HXT5 HXT8 HXT9 GAL2 HXT11 6 19 fructose transporter [GO:0005353] 4.98453e-05 HXT3 HXT5 HXT8 HXT9 HXT11 5 14 mannose transporter [GO:0015578] 7.2839e-05 HXT3 HXT5 HXT8 HXT9 HXT11 5 15 glucose transporter [GO:0005355] 0.000142455 HXT3 HXT5 HXT8 HXT9 HXT11 5 17 carbohydrate transporter [GO:0015144] 0.000205152 HXT3 HXT5 HXT8 HXT9 GAL2 HXT11 6 28 galactose transporter [GO:0005354] 0.000596423 HXT9 GAL2 HXT11 3 6 alpha-glucosidase [GO:0004558] 0.00101923 YIL172C YJL216C FSP2 3 7 drug transporter [GO:0015238] 0.00159254 FLR1 SNQ2 PDR5 3 8 multidrug transporter [GO:0015239] 0.00159254 FLR1 SNQ2 PDR5 3 8 citrate (SI)-synthase [GO:0004108] 0.0029765 CIT2 CIT1 2 3 carnitine O-acyltransferase [GO:0016406] 0.0029765 YAT1 CAT2 2 3 carnitine O-acetyltransferase [GO:0004092] 0.0029765 YAT1 CAT2 2 3 phosphate transporter [GO:0015114] 0.0029765 PHO88 PHO91 2 3 O-acyltransferase [GO:0008374] 0.00325479 YAT1 CAT2 ARE2 3 10 GO Biological Process Category p-value In Category from Cluster k f carbohydrate transport [GO:0008643] 0.000306566 HXT3 HXT5 HXT8 HXT9 GAL2 HXT11 6 30 amino acid metabolism [GO:0006520] 0.000489019 CHA1 CIT2 LYS20 HOM2 GLY1 LEU1 ARO9 MET28 LYS1 PRS1 CAT2 MET4 CIT1 13 140 monosaccharide transport [GO:0015749] 0.000532208 HXT3 HXT5 HXT8 HXT9 HXT11 5 22 hexose transport [GO:0008645] 0.000532208 HXT3 HXT5 HXT8 HXT9 HXT11 5 22 response to chemical substance [GO:0042221] 0.000857419 PDR3 FLR1 SNQ2 GTS1 STB5 PDR5 6 36 amino acid and derivative metabolism [GO:0006519] 0.000885481 CHA1 CIT2 LYS20 HOM2 GLY1 LEU1 ARO9 MET28 LYS1 PRS1 CAT2 MET4 CIT1 13 149 amine metabolism [GO:0009308] 0.0010031 CHA1 CIT2 LYS20 HOM2 GLY1 LEU1 ARO9 MET28 LYS1 PRS1 CAT2 MET4 CIT1 13 151 alcohol metabolism [GO:0006066] 0.00184928 YAT1 DAK2 MIG2 PFK1 PDC1 GAL2 PFK27 ALD4 TKL1 9 88 re-entry into mitotic cell cycle [GO:0000320] 0.0029765 POG1 CLN2 2 3 re-entry into mitotic cell cycle after pheromone arrest [GO:0000321] 0.0029765 POG1 CLN2 2 3 GO Cellular Component Category p-value In Category from Cluster k f plasma membrane [GO:0005886] 0.000519738 FUI1 FLR1 SNQ2 MSS4 HXT3 MTL1 MUP1 HXT5 HXT8 HXT9 DAL5 GAL2 YPS3 HXT11 PDR5 15 178 SMART Domains Category p-value In Category from Cluster k f Aamy 0.000111843 YIL172C YJL216C FSP2 YOL157C 4 9 PFam-A Domains Category p-value In Category from Cluster k f PF00083 (sugar_tr) 3.75931e-05 FLR1 HXT3 HXT5 HXT8 HXT9 TPO1 GAL2 AQR1 HXT11 9 53 PF00128 (alpha-amylase) 6.37246e-05 YIL172C YJL216C FSP2 YOL157C 4 8 PF00755 (Carn_acyltransf) 0.0029765 YAT1 CAT2 2 3 PF00285 (citrate_synt) 0.0029765 CIT2 CIT1 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f cyto 0.000174483 YBL006C PHO88 YBR203W YCL063W CIT2 HNT1 PRR2 GDH2 HOM2 MSS4 BUD16 YER137C YER152C DAK2 YFR017C LEU1 YGL179C YGR017W YGR110W ADE3 YGR205W PFK1 YGR243W SPL2 ARO9 OYE2 RPN10 ULP2 LYS1 YIR035C MRS3 YJR115W YKL051W RPL17A YKR075C TPO1 YLL056C PDC1 RPL10 ECM38 YLR301W ECM30 SML1 YMR244C-A YMR291W YMR315W YNL018C YNL047C YNL134C YNL274C RPS15 PFK27 YOL155C YOR052C YOR084W YOR138C DDP1 YOR186W MRS6 CAM1 YPL137C YPL183C BOP1 TKL1 64 1324 Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f cyt 0.000427821 YAT1 YAR068W YBL006C FUI1 ECM13 NTH2 FLR1 UBC4 VID24 PHO88 APD1 YBR203W THI2 YDL124W HNT1 LYS20 YDL186W PRR2 GDH2 SNQ2 HOM2 SUR2 HXT3 SPT3 YEL017W BUD16 GLY1 CAJ1 PTP3 YER137C YER152C DAK2 YFL054C YFR017C LEU1 RCK1 YGL179C MND1 YGR017W YGR035C MUP1 YGR110W ADE3 YGR205W AZR1 PFK1 YGR243W RPS27B HXT5 SPL2 ARO9 STB5 OYE2 RPN10 PDR11 ULP2 BCY1 RPL40A MET28 LYS1 YIR035C MRS3 HXT8 YJL216C HXT9 FSP2 YJR115W DAL5 YKL146W RPL17A PRS1 YKR075C TPO1 YLL056C YLR004C PDC1 RPS0B RPL10 GAL2 YLR162W YLR254C ECM38 YLR301W YLR346C ECM30 RPS18B SML1 RPL6A ICY1 YMR265C SCS7 YMR291W YMR315W YNL018C YNL034W YNL047C AQR1 YNL134C TOF1 YNL274C TRF5 PHO91 ARE2 RPP2A RPS15 PFK27 YOL155C HXT11 YOR052C YOR084W BAG7 YOR138C SFL1 PDR5 YOR161C DDP1 YOR186W RPL20B CIN1 MRS6 FIT2 CAM1 YPL137C YPL183C CLN2 TKL1 126 3210 Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f