Input Cluster (n=186) YAL016W TPD3 YAL037W YAL053W YAL054C ACS1 YAR027W UIP3 YBL029W YBR013C YBR043C AQR2 YBR054W YRO2 YBR061C TRM7 YBR180W DTR1 YBR208C "DUR1,2" YBR233W PBP2 YBR234C ARC40 YBR239C YBR245C ISW1 YBR286W APE3 YCL047C YCR068W CVT17 YCR075C ERS1 YCR093W CDC39 YDL056W MBP1 YDL137W ARF2 YDL183C YDL185W TFP1 YDL210W UGA4 YDR001C NTH1 YDR002W YRB1 YDR009W GAL3 YDR021W FAL1 YDR028C REG1 YDR041W RSM10 YDR089W YDR098C GRX3 YDR132C YDR242W AMD2 YDR264C AKR1 YDR265W PEX10 YDR284C DPP1 YDR298C ATP5 YDR317W YDR420W HKR1 YDR524C AGE1 YDR540C YEL012W UBC8 YEL041W YEL058W PCM1 YEL059C-A SOM1 YEL063C CAN1 YER002W NOP16 YER046W SPO73 YER072W VTC1 YER107C GLE2 YER138W-A YER164W CHD1 YER175C TMT1 YER183C FAU1 YFL008W SMC1 YFL010W-A AUA1 YFL051C YFR008W YFR009W GCN20 YFR025C HIS2 YFR041C YGL050W YGL053W PRM8 YGL054C ERV14 YGL169W SUA5 YGL196W YGR028W MSP1 YGR035C YGR125W YGR150C YGR155W CYS4 YGR161C YGR181W TIM13 YGR233C PHO81 YGR247W CPD1 YGR253C PUP2 YGR264C MES1 YHL015W RPS20 YHL016C DUR3 YHL036W MUP3 YHR074W QNS1 YHR094C HXT1 YHR101C BIG1 YHR102W KIC1 YHR146W CRP1 YHR149C YHR150W YHR176W YHR207C SET5 YHR208W BAT1 YIL030C SSM4 YIL037C PRM2 YIL084C SDS3 YIL146C ECM37 YIL164C NIT1 YIR005W IST3 YIR006C PAN1 YIR027C DAL1 YIR028W DAL4 YIR029W DAL2 YJL047C RTT101 YJL060W BNA3 YJL146W IDS2 YJL172W CPS1 YJR011C YJR024C YJR094W-A RPL43B YJR103W URA8 YJR152W DAL5 YKL049C CSE4 YKL067W YNK1 YKL069W YKL071W YKL103C LAP4 YKL116C PRR1 YKL138C MRPL31 YKR026C GCN3 YKR031C SPO14 YKR034W DAL80 YKR039W GAP1 YKR041W YLR020C YLR028C ADE16 YLR032W RAD5 YLR053C YLR113W HOG1 YLR138W NHA1 YLR155C ASP3-1 YLR157C ASP3-2 YLR158C ASP3-3 YLR160C ASP3-4 YLR163C MAS1 YLR164W YLR167W RPS31 YLR229C CDC42 YLR257W YLR298C YHC1 YLR299W ECM38 YLR411W CTR3 YML080W DUS1 YML086C ALO1 YMR005W TAF4 YMR012W CLU1 YMR088C YMR107W YMR110C YMR156C TPP1 YMR158W YMR167W MLH1 YMR271C URA10 YMR281W GPI12 YMR308C PSE1 YNL124W NAF1 YNL129W YNL130C CPT1 YNL142W MEP2 YNL163C RIA1 YNL172W APC1 YNL173C MDG1 YNR011C PRP2 YNR012W URK1 YNR065C YSN1 YNR072W HXT17 YOL013W-A YOL019W YOL044W PEX15 YOL104C NDJ1 YOL128C YGK3 YOR004W YOR012W YOR048C RAT1 YOR149C SMP3 YOR150W MRPL23 YOR179C YPL034W YPL054W LEE1 YPL159C YPL216W YPL217C BMS1 YPL226W NEW1 YPL254W HFI1 YPL257W YPR138C MEP3 Genes Not Found: YBL005W-A YBL005W-B YBR012W-A YBR012W-B YDR170W-A YER138C YER160C YFL002W-A YJR026W YJR027W YJR028W YJR029W YMR050C YMR051C MIPS Functional Classification Category p-value In Category from Cluster k f nitrogen and sulfur utilization 1.18032e-05 "DUR1,2" UGA4 AMD2 YHR176W DAL1 DAL2 BNA3 CPS1 8 38 nitrogen and sulfur metabolism 2.37461e-05 "DUR1,2" UGA4 AMD2 AUA1 YHR176W DAL1 DAL2 BNA3 CPS1 DAL80 10 67 plasma membrane 0.00034129 UGA4 HKR1 CAN1 DUR3 MUP3 HXT1 DAL4 DAL5 GAP1 CDC42 MEP2 MDG1 HXT17 13 145 amino acid degradation (catabolism) 0.000499276 "DUR1,2" BAT1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 6 35 cellular import 0.000710004 UGA4 CAN1 MUP3 HXT1 PAN1 DAL4 DAL5 GAP1 MEP2 HXT17 10 100 TRANSPORT FACILITATION 0.000875676 AQR2 DTR1 TFP1 UGA4 ATP5 CAN1 GCN20 DUR3 MUP3 HXT1 DAL4 DAL5 GAP1 NHA1 CTR3 YMR088C MEP2 HXT17 NEW1 MEP3 20 312 G-protein mediated signal transduction 0.0046435 CRP1 CDC42 MDG1 3 12 enzyme mediated signal transduction 0.0046435 CRP1 CDC42 MDG1 3 12 other cation transporters (Na, K, Ca , NH4, etc.) 0.0049442 TFP1 DUR3 NHA1 MEP2 MEP3 5 38 cell wall 0.0049442 YFL051C ASP3-1 ASP3-2 ASP3-3 ASP3-4 5 38 MIPS Phenotypes Category p-value In Category from Cluster k f MIPS Subcellular Localization Category p-value In Category from Cluster k f plasma membrane 0.000243852 UGA4 HKR1 CAN1 VTC1 DUR3 MUP3 HXT1 DAL4 DAL5 GAP1 CDC42 MEP2 MDG1 HXT17 14 159 vacuolar lumen 0.000481656 APE3 CPS1 LAP4 3 6 MIPS Protein Complexes Category p-value In Category from Cluster k f MIPS Protein Classes Category p-value In Category from Cluster k f Major facilitator superfamily proteins (MFS) 0.00027774 AQR2 DTR1 UGA4 CAN1 DUR3 MUP3 HXT1 DAL4 DAL5 GAP1 YMR088C MEP2 MEP3 13 142 GO Molecular Function Category p-value In Category from Cluster k f hydrolase, acting on carbon-nitrogen (but not peptide) bonds [GO:0016810] 3.68753e-09 "DUR1,2" AMD2 NIT1 DAL1 DAL2 BNA3 ADE16 ASP3-1 ASP3-2 ASP3-3 ASP3-4 11 36 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [GO:0016811] 1.6539e-07 "DUR1,2" AMD2 BNA3 ASP3-1 ASP3-2 ASP3-3 ASP3-4 7 16 hydrolase [GO:0016787] 7.99949e-07 TPD3 "DUR1,2" ISW1 APE3 CVT17 CDC39 ARF2 TFP1 NTH1 FAL1 REG1 AMD2 DPP1 ATP5 CHD1 SMC1 HIS2 MSP1 CPD1 PUP2 NIT1 DAL1 DAL2 BNA3 CPS1 LAP4 SPO14 ADE16 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MAS1 CDC42 MLH1 GPI12 PRP2 RAT1 38 561 asparaginase [GO:0004067] 1.07597e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 amino acid transporter [GO:0015171] 0.000380876 ERS1 UGA4 CAN1 MUP3 GAP1 5 22 L-amino acid transporter [GO:0015179] 0.000481656 ERS1 UGA4 MUP3 3 6 ammonium transporter [GO:0008519] 0.00257732 MEP2 MEP3 2 3 enzyme [GO:0003824] 0.004126 TPD3 ACS1 TRM7 "DUR1,2" ISW1 APE3 CVT17 CDC39 ARF2 TFP1 NTH1 FAL1 REG1 GRX3 AMD2 DPP1 ATP5 UBC8 PCM1 CHD1 TMT1 FAU1 SMC1 HIS2 MSP1 CYS4 CPD1 PUP2 MES1 QNS1 KIC1 BAT1 SSM4 NIT1 DAL1 DAL2 BNA3 CPS1 URA8 YNK1 LAP4 PRR1 SPO14 ADE16 RAD5 HOG1 ASP3-1 ASP3-2 ASP3-3 ASP3-4 MAS1 CDC42 ECM38 DUS1 ALO1 MLH1 URA10 GPI12 CPT1 APC1 PRP2 URK1 YGK3 RAT1 64 1604 GO Biological Process Category p-value In Category from Cluster k f asparagine catabolism [GO:0006530] 7.51849e-07 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 4 response to nitrogen starvation [GO:0006995] 3.67185e-06 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 5 asparagine metabolism [GO:0006528] 1.07597e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 6 aspartate family amino acid catabolism [GO:0009068] 4.79093e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 8 glutamine family amino acid catabolism [GO:0009065] 0.000137149 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 10 response to starvation [GO:0009267] 0.000308506 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 12 amino acid transport [GO:0006865] 0.000475072 ERS1 CAN1 AUA1 MUP3 GAP1 5 23 amine catabolism [GO:0009310] 0.0020523 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 19 amino acid catabolism [GO:0009063] 0.0020523 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 19 organic cation transport [GO:0015695] 0.00257732 MEP2 MEP3 2 3 ammonium transport [GO:0015696] 0.00257732 MEP2 MEP3 2 3 GO Cellular Component Category p-value In Category from Cluster k f periplasmic space (sensu Fungi) [GO:0030287] 8.4239e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 9 plasma membrane [GO:0005886] 0.000771104 HKR1 CAN1 DUR3 HXT1 PAN1 DAL5 GAP1 NHA1 CDC42 CTR3 MEP2 MDG1 HXT17 MEP3 14 178 membrane [GO:0016020] 0.000783011 UIP3 CVT17 ERS1 TFP1 UGA4 ATP5 HKR1 SOM1 CAN1 VTC1 GLE2 PRM8 ERV14 MSP1 DUR3 MUP3 HXT1 BIG1 SSM4 PRM2 PAN1 DAL4 DAL5 SPO14 GAP1 NHA1 ASP3-1 CDC42 CTR3 GPI12 MEP2 MDG1 HXT17 PEX15 MEP3 35 683 SMART Domains Category p-value In Category from Cluster k f PFam-A Domains Category p-value In Category from Cluster k f PF00710 (Asparaginase) 2.45233e-05 ASP3-1 ASP3-2 ASP3-3 ASP3-4 4 7 PF00338 (Ribosomal_S10) 0.000876263 RSM10 RPS20 2 2 PF01425 (Amidase) 0.00257732 "DUR1,2" AMD2 2 3 PF00909 (Ammonium_transp) 0.00257732 MEP2 MEP3 2 3 Yeast Two Hybrid - Uetz Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (core) Category p-value In Category from Cluster k f Yeast Two Hybrid - Ito (full) Category p-value In Category from Cluster k f YOR350C (MNE1) 0.000876263 RPS20 URA10 2 2 YLR147C (SMD3) 0.00257732 URA8 HXT17 2 3 Synthetic Genetic Array Analysis Category p-value In Category from Cluster k f MDS Proteomics Complexes Category p-value In Category from Cluster k f Cellzome Complexes Category p-value In Category from Cluster k f Proteome Localization--Observed Category p-value In Category from Cluster k f Proteome Localization--Predicted+Observed Category p-value In Category from Cluster k f Deletions Consortium (Essentiality, Morphology) Category p-value In Category from Cluster k f Morphology - WT 0.00288238 TPD3 YAL037W YAL053W ACS1 UIP3 YBL029W YBR013C YRO2 DTR1 "DUR1,2" PBP2 YBR239C ISW1 APE3 YCL047C CVT17 ERS1 MBP1 ARF2 YDL183C UGA4 NTH1 GAL3 YDR089W GRX3 YDR132C AMD2 PEX10 DPP1 YDR317W HKR1 UBC8 YEL041W CAN1 NOP16 SPO73 AUA1 YFL051C YFR008W GCN20 HIS2 YFR041C YGL050W PRM8 ERV14 YGL196W MSP1 YGR035C YGR125W YGR150C YGR161C TIM13 PHO81 CPD1 DUR3 MUP3 HXT1 CRP1 YHR150W YHR176W SET5 SSM4 PRM2 SDS3 ECM37 NIT1 IST3 DAL1 DAL4 DAL2 BNA3 IDS2 CPS1 YJR011C YJR024C RPL43B URA8 DAL5 YNK1 YKL069W YKL071W LAP4 PRR1 MRPL31 GCN3 SPO14 DAL80 GAP1 YKR041W YLR020C ADE16 RAD5 YLR053C HOG1 NHA1 YLR164W YLR257W ECM38 DUS1 ALO1 CLU1 YMR088C YMR107W YMR110C TPP1 YMR158W MLH1 URA10 YNL129W CPT1 MEP2 MDG1 URK1 YSN1 HXT17 YOL013W-A YOL019W PEX15 NDJ1 YGK3 YOR012W MRPL23 YPL034W LEE1 YPL159C YPL216W YPL257W MEP3 128 3689 Yeast Fitness Data Category p-value In Category from Cluster k f Published Complexes Category p-value In Category from Cluster k f