-Genomic Data for KLF1 Links
Protein
KLF1
UniPROBE Accession Number
UP01670
Species
Homo sapiens
Domain
zf-C2H2
Name and Synonyms
Name: Krueppel-like factor 1.
Synonyms:EKLF, Erythroid krueppel-like transcription factor, HBFQTL6, INLU, Krueppel-like factor 1
Description
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
-PBM Motif Data for KLF1_anti-GST
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CCCCGCCC E.S. 0.476
GGGCGGGG E.S. 0.476
Downloads
Download the zip of all KLF1_anti-GST PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for KLF1
Downloads
Download the zip of all KLF1 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-KLF1 Datasets
Clone Clone Type Last Modified Save View
KLF1 DNA binding domain only 2021-07-10 search save
KLF1 Insert Sequence
1    MATAETALPS ISTLTALGPF PDTQDDFLKW WRSEEAQDMG PGPPDPTEPP
51   LHVKSEDQPG EEEDDERGAD ATWDLDLLLT NFSGPEPGGA PQTCALAPSE
101  ASGAQYPPPP ETLGAYAGGP GLVAGLLGSE DHSGWVRPAL RARAPDAFVG
151  PALAPAPAPE PKALALQPVY PGPGAGSSGG YFPRTGLSVP AASGAPYGLL
201  SGYPAMYPAP QYQGHFQLFR GLQGPAPGPA TSPSFLSCLG PGTVGTGLGG
251  TAEDPGVIAE TAPSKRGRRS WARKRQAAHT CAHPGCGKSY TKSSHLKAHL
301  RTHTGEKPYA CTWEGCGWRF ARSDELTRHY RKHTGQRPFR CQLCPRAFSR
351  SDHLALHMKR HL



References
Data are analyzed by array design with AMADID # 030236 in Lai et al. 2020


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