-Genomic Data for CRX Links
Protein
CRX
UniPROBE Accession Number
UP00586
Species
Homo sapiens
Domain
Homeobox
Swiss-Prot
O43186
Name and Synonyms
Name: cone-rod homeobox protein.
Synonyms:Cone-rod homeobox protein, CORD2, CRD, LCA7, OTX3
IHOP
87439
Description
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.
NCBI RefSeq
NP_000545
CRX DNA binding domain
1   RRERTTFTRS QLEELEALFA KTQYPDVYAR EEVALKINLP ESRVQVWFKN
51  RRAKCRQ
JASPAR
None Available
-PBM Motif Data for CRX_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
CTAATCCC E.S. 0.497
GGGATTAG E.S. 0.497
Downloads
Download the zip of all CRX_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for CRX_E80A_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
CTAATCCC E.S. 0.498
GGGATTAG E.S. 0.498
Downloads
Download the zip of all CRX_E80A PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for CRX_R41Q_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
GATAATCC E.S. 0.497
GGATTATC E.S. 0.497
Downloads
Download the zip of all CRX_R41Q PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for CRX_R41W_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
GGAT.ATCC E.S. 0.497
GGAT.ATCC E.S. 0.497
Downloads
Download the zip of all CRX_R41W PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for CRX_R90W_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
AT..GGATTA E.S. 0.486
TAATCC..AT E.S. 0.486
Downloads
Download the zip of all CRX_R90W PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for CRX_V66I_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
A..CGGATTA E.S. 0.498
TAATCCG..T E.S. 0.498
Downloads
Download the zip of all CRX_V66I PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for CRX (all alleles)
Downloads
Download the zip of all CRX PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-CRX Datasets
Clone Clone Type Last Modified Save View
CRX_REF DNA binding domain only search save
CRX_REF Insert Sequence
1   MHQAVPYPSA PRKQRRERTT FTRSQLEELE ALFAKTQYPD VYAREEVALK
51  INLPESRVQV WFKNRRAKCR QQRQQQKQQQ QPPGGQ


CRX_E80A DNA binding domain only search save
CRX_E80A Insert Sequence
1   MHQAVPYPSA PRKQRRERTT FTRSQLEELE ALFAKTQYPD VYAREEVALK
51  INLPASRVQV WFKNRRAKCR QQRQQQKQQQ QPPGGQ


CRX_R41Q DNA binding domain only search save
CRX_R41Q Insert Sequence
1   MHQAVPYPSA PRKQRQERTT FTRSQLEELE ALFAKTQYPD VYAREEVALK
51  INLPESRVQV WFKNRRAKCR QQRQQQKQQQ QPPGGQ


CRX_R41W DNA binding domain only search save
CRX_R41W Insert Sequence
1   MHQAVPYPSA PRKQRWERTT FTRSQLEELE ALFAKTQYPD VYAREEVALK
51  INLPESRVQV WFKNRRAKCR QQRQQQKQQQ QPPGGQ


CRX_R90W DNA binding domain only search save
CRX_R90W Insert Sequence
1   MHQAVPYPSA PRKQRRERTT FTRSQLEELE ALFAKTQYPD VYAREEVALK
51  INLPESRVQV WFKNWRAKCR QQRQQQKQQQ QPPGGQ


CRX_V66I DNA binding domain only search save
CRX_V66I Insert Sequence
1   MHQAVPYPSA PRKQRRERTT FTRSQLEELE ALFAKTQYPD IYAREEVALK
51  INLPESRVQV WFKNRRAKCR QQRQQQKQQQ QPPGGQ


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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