-Genomic Data for NR1H4 Links
Protein
NR1H4
UniPROBE Accession Number
UP00606
Species
Homo sapiens
Domain
zf-C4
Name and Synonyms
Name: bile acid receptor.
Synonyms:BAR, Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, FXR, HRR1, HRR-1, MGC163445, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RIP14, RXR-interacting protein 14
Description
This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
-PBM Motif Data for NR1H4_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
T.GAGGTCA E.S. 0.498
TGACCTC.A E.S. 0.498
Downloads
Download the zip of all NR1H4_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for NR1H4_C144R_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
Save
Top Kmer
T..ATTAATA E.S. 0.445
TATTAAT..A E.S. 0.445
Downloads
Download the zip of all NR1H4_C144R PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for NR1H4 (all alleles)
Downloads
Download the zip of all NR1H4 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-NR1H4 Datasets
Clone Clone Type Last Modified Save View
NR1H4_REF DNA binding domain only search save
NR1H4_REF Insert Sequence
1    PRMGASAGRI KGDELCVVCG DRASGYHYNA LTCEGCKGFF RRSITKNAVY
51   KCKNGGNCVM DMYMRRKCQE CRLRKCKEMG MLAECMYTGL LTEIQCKSKR
101  LRKNVKQHAD QTVNEDSEGR



NR1H4_C144R DNA binding domain only search save
NR1H4_C144R Insert Sequence
1    PRMGASAGRI KGDELCVVCG DRASGYHYNA LTREGCKGFF RRSITKNAVY
51   KCKNGGNCVM DMYMRRKCQE CRLRKCKEMG MLAECMYTGL LTEIQCKSKR
101  LRKNVKQHAD QTVNEDSEGR



References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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