-Genomic Data for PHOX2B Links
Protein
PHOX2B
UniPROBE Accession Number
UP00614
Species
Homo sapiens
Domain
Homeobox
Swiss-Prot
Q99453
Name and Synonyms
Name: paired mesoderm homeobox protein 2B.
Synonyms:NBLST2, NBPhox, Neuroblastoma Phox, Paired-like homeobox 2B, Paired mesoderm homeobox protein 2B, Phox2b, PHOX2B homeodomain protein, PMX2B
IHOP
94268
Description
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.
NCBI RefSeq
NP_003915
PHOX2B DNA binding domain
1   RRIRTTFTSA QLKELERVFA ETHYPDIYTR EELALKIDLT EARVQVWFQN
51  RRAKFRK
JASPAR
None Available
-PBM Motif Data for PHOX2B_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
G.TAATTA.C E.S. 0.494
G.TAATTA.C E.S. 0.494
Downloads
Download the zip of all PHOX2B_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PHOX2B_Q143R_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
G.TAATTA.C E.S. 0.495
G.TAATTA.C E.S. 0.495
Downloads
Download the zip of all PHOX2B_Q143R PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PHOX2B_R100L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
CA.TAATTA E.S. 0.452
TAATTA.TG E.S. 0.452
Downloads
Download the zip of all PHOX2B_R100L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PHOX2B_R141G_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
CA.TAATTA E.S. 0.448
TAATTA.TG E.S. 0.448
Downloads
Download the zip of all PHOX2B_R141G PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PHOX2B_R141Q_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
G.TAATTA.C E.S. 0.491
G.TAATTA.C E.S. 0.491
Downloads
Download the zip of all PHOX2B_R141Q PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for PHOX2B (all alleles)
Downloads
Download the zip of all PHOX2B PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PHOX2B Datasets
Clone Clone Type Last Modified Save View
PHOX2B_REF DNA binding domain only search save
PHOX2B_REF Insert Sequence
1   LFTDHGGLNE KRKQRRIRTT FTSAQLKELE RVFAETHYPD IYTREELALK
51  IDLTEARVQV WFQNRRAKFR KQERAAAAAA AAAKNG


PHOX2B_Q143R DNA binding domain only search save
PHOX2B_Q143R Insert Sequence
1   LFTDHGGLNE KRKQRRIRTT FTSAQLKELE RVFAETHYPD IYTREELALK
51  IDLTEARVRV WFQNRRAKFR KQERAAAAAA AAAKNG


PHOX2B_R100L DNA binding domain only search save
PHOX2B_R100L Insert Sequence
1   LFTDHGGLNE KRKQRLIRTT FTSAQLKELE RVFAETHYPD IYTREELALK
51  IDLTEARVQV WFQNRRAKFR KQERAAAAAA AAAKNG


PHOX2B_R141G DNA binding domain only search save
PHOX2B_R141G Insert Sequence
1   LFTDHGGLNE KRKQRRIRTT FTSAQLKELE RVFAETHYPD IYTREELALK
51  IDLTEAGVQV WFQNRRAKFR KQERAAAAAA AAAKNG


PHOX2B_R141Q DNA binding domain only search save
PHOX2B_R141Q Insert Sequence
1   LFTDHGGLNE KRKQRRIRTT FTSAQLKELE RVFAETHYPD IYTREELALK
51  IDLTEAQVQV WFQNRRAKFR KQERAAAAAA AAAKNG


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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