Protein Details

-Genomic Data for MTF2				Links
Protein MTF2	UniPROBE Accession Number UP01425	Species Homo sapiens	Domain Mtf2_C	Swiss-Prot Q9Y483
Name and Synonyms Name: Metal response element binding transcription factor 2. Synonyms:M96; PCL2; TDRD19A; dJ976O13.2; Metal regulatory transcription factor 2; Polycomb-like protein 2; RP5-976O13.1				IHOP 96338
				NCBI RefSeq NP_001157685
Description Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).				JASPAR None Available

-PBM Motif Data for MTF2_rep2
Primary Motif				Primary PWM Save
Primary Motif				Top Kmer CGGCGGG.C E.S. 0.485 G.CCCGCCG E.S. 0.485
Secondary Motif				Secondary PWM Save
Secondary Motif				Top Kmer ATCCGACA E.S. 0.479 TGTCGGAT E.S. 0.479
Downloads Download the zip of all MTF2_rep2 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

-PBM Motif Data for MTF2_rep1
Primary Motif				Primary PWM Save
Primary Motif				Top Kmer CACCCGAC E.S. 0.480 GTCGGGTG E.S. 0.480
Secondary Motif				Secondary PWM Save
Secondary Motif				Top Kmer C.CCGCCGC E.S. 0.458 GCGGCGG.G E.S. 0.458
Downloads Download the zip of all MTF2_rep1 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

-MTF2 Datasets
Run name		PBM version	Save	View
MTF2_rep2		AMADID # 016060
MTF2_rep1		AMADID # 016060
Gene	Clone Type	Last Modified	Save	View
MTF2	Not full length	2017-09-07
MTF2 Insert Sequence `1 QTLPYSVADL EWDAGHKTNV QQCYCYCGGP GDWYLKMLQC CKCKQWFHEA 51 CVQCLQKPML FGDRFYTFIC SVCSSGPEYL KRLPLQWVDI AHLCLYNLSV 101 IHKKKYFDSE LELMTYINEN WDRLHPGELA DTPKSERYEH VLEALNDYKT 151 MFMSGKEIKK KKHLFGLRIR VPPVPPNVAF KAEKEPEGTS`
References `Data are analyzed by array design with AMADID # 030236 in Li et al., Nature 2017`