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| -Genomic Data for Xbp1 |
Links |
- Protein
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- UniPROBE Accession Number
- UP01403
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- Species
- Mus musculus
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- Domain
- BRLZ,bZIP_1,bZIP_2
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- Swiss-Prot
- O35426
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- Name and Synonyms
- Name: X-box-binding protein 1.
Synonyms:D11Ertd39e, Tax-responsive element-binding protein 5 homolog, Treb5, TREB5, TREB-5, XBP-1
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- IHOP
- 125971
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- NCBI RefSeq
- NP_001258659
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- Description
- Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland (PubMed:10425189, PubMed:10652269, PubMed:16362047, PubMed:17612490). Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions (PubMed:23529610). Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (PubMed:15486293).
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- JASPAR
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None Available
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| -PBM Motif Data for Xbp1 |
- PBM-Derived DNA Binding Site Motif
(Seed-And-Wobble)
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- PWM
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Save
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- Top Kmer
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ACACGTCA E.S. 0.495
TGACGTGT E.S. 0.495
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- Downloads
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Download the
zip
of all Xbp1 PBM files
or view the downloads directory for individual files.
Please note that the files which include probe sequence data are protected by an academic research use license,
which can be viewed here.
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| -Xbp1 Datasets |
| Gene |
Clone Type |
Last Modified |
Save |
View |
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Xbp1 |
DNA binding domain only |
2017-05-12 |
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- Xbp1 Insert Sequence
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1 SGTPQARKRQ RLTHLSPEEK ALRRKLKNRV AAQTARDRKK ARMSELEQQV
51 VDLEEENHKL QLENQLLREK THGLVVENQE LRTRLGMDTL DPDEV
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- References
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Data are analyzed by array designs with AMADID #s 016060, 015681 in Mariani et al., Cell Systems 2017
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