-Genomic Data Links
Protein
TBP
UniPROBE Accession Number
UP00029
Species
Homo sapiens
Domain
TBP
Name and Synonyms
TATA-box-binding protein
TATA-box factor, TATA sequence-binding protein, Transcription initiation factor TFIID TBP subunit, GTF2D; GTF2D1, HDL4, MGC117320, MGC126054, MGC126055, SCA17, TATA-binding factor, TATA-box-binding protein, TF2D, TFIID
Description
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.
-PBM Motif Data for TBP
Primary Motif (Seed-And-Wobble)
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Primary PWM
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Top Kmer
TATATATA E.S. 0.496
TATATATA E.S. 0.496
Secondary Motif (Seed-And-Wobble)
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Secondary PWM
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Top Kmer
ATATAAG.G E.S. 0.433
C.CTTATAT E.S. 0.433
Motif (BEEML-PBM) (AMADID # 015681)   (clone pTH0781)
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PWM
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Consensus
WTWWNNNNNN
NNNNNNWWAW
Motif (BEEML-PBM) (AMADID # 016060) (clone pTH0781)
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PWM
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Consensus
NNNNBVCCYS
SRGGBVNNNN
Downloads
Download the zip of all TBP PBM files or view the downloads directory for individual files.
Link to TFBSshape
This link will take you to the corresponding entry for TBP in TFBSshape, a database which provides information about the shape of the DNA at transcription factor binding sites.

http://rohslab.cmb.usc.edu/TFBSshape/?tfid=&geneID=29&sourceDB=uniprobe

-TBP Datasets
Clone ID Expression Array Version Expression Protocol Clone Type Last Modified Save View
pTH781 #1 AMADID #016060 Commercially Purified Protein DNA binding domain only 2016-03-24 save search
Clone ID Expression Array Version Expression Protocol Clone Type Last Modified Save View
pTH781 #1 AMADID #015681 Commercially Purified Protein DNA binding domain only 2016-03-24 save search
Clone pTH781 insert sequence
1    MTPITPATPA SESSGIVPQL QNIVSTVNLG CKLDLKTIAL RARNAEYNPK
51   RFAAVIMRIR EPRTTALIFS SGKMVCTGAK SEEQSRLAAR KYARVVQKLG
101  FPAKFLDFKI QNMVG

DNA Binding Domains (Pfam) for clone 781
Not Available
References
Data are analyzed by array designs with AMADID #s 016060, 015681 in Badis et al., Science 2009


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