UniPROBE

Database Browser

Protein ▾	UniPROBE Accession Number	Domain	Species	Description	Publication	Save
GST-CSL-NOTCH1	UP00486		Homo sapiens		Del Bianco et al., PLoS ONE 2010
c-Myc_Max	UP00564		Homo sapiens		Guo et al., GB14	N/A
Abd-B	UP00503	Homeobox	Drosophila melanogaster	Abdominal B: The Abdominal-B gene, a member of the Drosophila bithorax complex, is required during development to specify the identity of parasegments 10-14.	Busser et al., Development 2012
Abf1	UP00452	BAF1_ABF1	Saccharomyces cerevisiae	ARS-Binding Factor 1: DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair	Gordan et al., Gen. Bio. 2011
ACA1_126960	UP00513	Fork_head	Acanthamoeba castellanii		Nakagawa et al., PNAS 2013
AEL327Wp	UP00516	Fork_head	Ashbya gossypii		Nakagawa et al., PNAS 2013
Aft1	UP00344	AFT	Saccharomyces cerevisiae	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability	Zhu et al., Genome Res 2009
Alx3	UP00108	Homeobox	Mus musculus	aristaless 3	Berger et al., Cell 2008
Alx4	UP00187	Homeobox	Mus musculus	aristaless 4	Berger et al., Cell 2008
AMAG_00796	UP00515	Fork_head	Allomyces macrogynus		Nakagawa et al., PNAS 2013
AMAG_02766	UP00514	Fork_head	Allomyces macrogynus		Nakagawa et al., PNAS 2013
ANAC019	UP00570	NAC	Arabidopsis thaliana	NAC domain-containing protein 19: Transcription factors that bind specifically to the 5'-CATGTG-3' motif	Lindemose et al, Nucleic Acids Res. 2014
ANAC055	UP00571	NAC	Arabidopsis thaliana	ATAF-like NAC-domain transcription factor: Transcription factors that bind specifically to the 5'-CATGTG-3' motif	Lindemose et al, Nucleic Acids Res. 2014
ANAC092	UP00572	NAC	Arabidopsis thaliana	NAC-domain transcription factor: Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5'-[ACG][CA]GT[AG](5-6n)[CT]AC[AG]-3' (PubMed:23340744). Promotes lateral root development (PubMed:16359384). Triggers the expression of senescence-associated genes during age-, salt- and dark-induced senescence through a regulatory network that may involve cross-talk with sal	Lindemose et al, Nucleic Acids Res. 2014
AncBcd	UP01486	Homeobox	N/A	Ancestral Bicoid: The maximum likelihood reconstruction of the Bcd protein in the last common ancestor of all cyclorrhaphan flies. Alt-all versions of the proteins are alternative reconstructions which incorporated plausible alternative amino acid states at all ambiguously reconstructed sites. All clones have 15 amino acid flanks surrounding the homeodomain from the Drosophila melanogaster Zen protein, except for the (B) clones, which have the flanking sequence from the from the Drosophila melanogaster Bcd protein.	Liu et al., eLife 2018
AncZB	UP01485	Homeobox	N/A	Ancestral Zen/Bicoid: The maximum likelihood reconstruction of the common ancestor of all Zen and Bcd proteins in cyclorrhaphan flies. Alt-all versions of the proteins are alternative reconstructions which incorporated plausible alternative amino acid states at all ambiguously reconstructed sites. All clones have 15 amino acid flanks surrounding the homeodomain from the Drosophila melanogaster Zen protein, except for the (B) clones, which have the flanking sequence from the from the Drosophila melanogaster Bcd protein.	Liu et al., eLife 2018
ANID_04521	UP00518	Fork_head	Aspergillus nidulans		Nakagawa et al., PNAS 2013
ANID_04985	UP00517	Fork_head	Aspergillus nidulans	A.nid Fox3	Nakagawa et al., PNAS 2013
Arid3a	UP00078	BRIGHT	Mus musculus	AT rich interactive domain 3A (Bright like)	Badis et al., Science 2009
Arid5a	UP00059	BRIGHT	Mus musculus	AT rich interactive domain 5A (Mrf1 like)	Badis et al., Science 2009
Aro80	UP00329	Zn2Cys6	Saccharomyces cerevisiae	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids	Zhu et al., Genome Res 2009
Arx	UP00152	Homeobox	Mus musculus	aristaless related homeobox gene (Drosophila)	Berger et al., Cell 2008
ARX	UP00584	Homeobox	Homo sapiens	homeobox protein ARX: Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate.	Barrera et al., Science 2016
Ascl2	UP00099	HLH	Mus musculus	achaete-scute complex homolog-like 2 (Drosophila)	Badis et al., Science 2009
Asg1	UP00350	Zn2Cys6	Saccharomyces cerevisiae	Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins	Zhu et al., Genome Res 2009
ATAF1	UP00573	NAC	Arabidopsis thaliana	putative transcriptional activator with NAC domain	Lindemose et al, Nucleic Acids Res. 2014
Atf1	UP00020	BRLZ, BZIP_1, BZIP_2	Mus musculus	activating transcription factor 1: Mus musculus activating transcription factor 1 (Atf1), mRNA	Badis et al., Science 2009
Bap	UP00504	Homeobox	Drosophila melanogaster	Bagpipe: Bagpipe is expressed in a segmented pattern in visceral muscle and in a subset of cardiac muscles. Itâ€™s Loss of activity results in segmental gaps in midgut visceral muscle.	Busser et al., Development 2012
Bapx1	UP00228	Homeobox	Mus musculus	bagpipe homeobox gene 1 homolog (Drosophila)	Berger et al., Cell 2008
Barhl1	UP00166	Homeobox	Mus musculus	BarH-like 1 (Drosophila)	Berger et al., Cell 2008
Barhl2	UP00145	Homeobox	Mus musculus	BarH-like 2 (Drosophila)	Berger et al., Cell 2008
Barx1	UP00181	Homeobox	Mus musculus	BarH-like homeobox 1	Berger et al., Cell 2008
Barx2	UP00151	Homeobox	Mus musculus	BarH-like homeobox 2	Berger et al., Cell 2008
Bas1	UP00355	Myb	Saccharomyces cerevisiae	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes	Zhu et al., Genome Res 2009
Bbx	UP00012	HMG_box	Mus musculus	bobby sox homolog (Drosophila)	Badis et al., Science 2009
BCL11A	UP01464	zf-C2H2, zf-H2C2_2	Homo sapiens	B cell CLL/lymphoma 11A: Repressor of fetal hemoglobin (HbF) level. Involved in brain development. Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver.	Liu et al., Cell 2018
BCL11B	UP01465	zf-C2H2, zf-H2C2_2	Homo sapiens	B cell CLL/lymphoma 11B: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes.	Liu et al., Cell 2018
BCL6	UP00585	zf-C2H2	Homo sapiens	B-cell lymphoma 6 protein: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.	Barrera et al., Science 2016
Bcl6b	UP00043	zf-C2H2	Mus musculus	B-cell CLL/lymphoma 6, member B: Mus musculus B-cell CLL/lymphoma 6, member B, mRNA	Badis et al., Science 2009
Bhlhb2	UP00050	HLH	Mus musculus	basic helix-loop-helix domain containing, class B2: Mus musculus basic helix-loop-helix domain containing, class B2	Badis et al., Science 2009
BPSS2315	UP00547	LuxR_C_like	Burkholderia pseudomallei K962	Response regulator protein	Nowak-Lovato et al., J Microbiol Meth 2012	N/A
Bsx	UP00138	Homeobox	Mus musculus	brain specific homeobox	Berger et al., Cell 2008
BTH_II2335	UP00546	LuxR_C_like	Burkholderia thailandensis E26	Dna-binding response regulator, LuxR family	Nowak-Lovato et al., J Microbiol Meth 2012	N/A
c-Myc	UP00559	bHLH	Homo sapiens	v-myc myelocytomatosis viral oncogene homolog (avian): Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	Guo et al., GB14	N/A
Cad1	UP00453	bZIP_1	Saccharomyces cerevisiae	CADmium resistance : AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA	Gordan et al., Gen. Bio. 2011
Cart1	UP00209	Homeobox	Mus musculus	cartilage homeo protein 1	Berger et al., Cell 2008
Cbf1	UP00309	HLH	Saccharomyces cerevisiae	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA	Zhu et al., Genome Res 2009
Cbf1	UP00397	HLH	Saccharomyces cerevisiae	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA	Berger et al., Nat Biotech 2006
Cdx1	UP00240	Homeobox	Mus musculus	caudal type homeo box 1	Berger et al., Cell 2008
Cdx2	UP00133	Homeobox	Mus musculus	caudal type homeo box 2	Berger et al., Cell 2008
CEBPB	UP01599	bZIP	Homo sapiens	CCAAT/enhancer-binding protein beta: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5\'-T[TG]NNGNAA[TG]-3\'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity)	Lai et al. 2020
CEH-22	UP00396	Homeobox	Caenorhabditis elegans	Homeobox protein ceh-22: C.Elegans Homeobox	Berger et al., Nat Biotech 2006
Cep3	UP00278	Zn2Cys6	Saccharomyces cerevisiae	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and ...	Zhu et al., Genome Res 2009
Cgd2_3490	UP00395	AP2	Cryptosporidium parvum	putative transcription factor Cryptosporidium parvum,single AP2 domain, orthologous to PF14_0633 in Plasmodium falciparum	De Silva et al., PNAS 2008
Cha4	UP00300	Zn2Cys6	Saccharomyces cerevisiae	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear clu...	Zhu et al., Genome Res 2009
CHES-1-like	UP00520	Fork_head	Drosophila melanogaster		Nakagawa et al., PNAS 2013
Cin5	UP00454	bZIP_1	Saccharomyces cerevisiae	Chromosome INstability : Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions	Gordan et al., Gen. Bio. 2011
CLAMP	UP00534	zf-H2C2_2	Drosophila melanogaster	Chromatin-linked adaptor for MSL proteins	Soruco et al., Genes Dev 2013
CND-1	UP00359	bHLH	Caenorhabditis elegans	C. elegans Neuro D homolog: cnd-1 encodes a basic helix-loop-helix protein that is most closely related to the vertebrate NeuroD transcription factors; during development, CND-1 is predicted to function as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding; CND-1::GFP expression begins in early embryogenesis (<20 cells) in four AB descendants and then continues in mitotically active AB-derived neuronal precursors, unidentified nuclei during gastrulation and enclosure, and postmitotic neurons in the head and ventral cord; at hatching CND-1::GFP expression is visible in ventral cord neurons, but this expression disappears completely by the end of the first larval stage; CND-1::GFP does not appear to be expressed in any non-neuronal ectodermal cells, as its expression does not overlap with that of LIN-26.	Grove et al., Cell 2009
COM2	UP00567	zf-C2H2	Saccharomyces cerevisiae	Cousin of Msn2: Transcription factor that binds IME1 Upstream Activation Signal (UAS)ru; COM2 transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; may bind the IME1 promoter under all growth conditions to negatively regulate its transcription in the absence of a positive regulator that binds more effectively; repressor activity may depend on phosphorylation by PKA;	Siggers et al., Mol. Cell 2014	N/A
Cphx	UP00198	Homeobox	Mus musculus	cytoplasmic polyadenylated homeobox	Berger et al., Cell 2008
Crx	UP00176	Homeobox	Mus musculus	cone-rod homeobox containing gene	Berger et al., Cell 2008
CRX	UP00586	Homeobox	Homo sapiens	cone-rod homeobox protein: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors.	Barrera et al., Science 2016
CSL	UP00484	LAG1-DNAbind	Homo sapiens	recombination signal binding protein for immunoglobulin kappa J region: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcriptio	Del Bianco et al., PLoS ONE 2010	N/A
Cst6	UP00455	bZIP_1	Saccharomyces cerevisiae	Chromosome STability : Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability	Gordan et al., Gen. Bio. 2011
Cup9	UP00308	Homeobox	Saccharomyces cerevisiae	Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p an...	Zhu et al., Genome Res 2009
Cutl1	UP00219	Homeobox	Mus musculus	cut-like 1 (Drosophila)	Berger et al., Cell 2008
Dbx1	UP00255	Homeobox	Mus musculus	developing brain homeobox 1	Berger et al., Cell 2008
Dbx2	UP00218	Homeobox	Mus musculus	developing brain homeobox 2	Berger et al., Cell 2008
DDF1	UP00555	AP2	Arabidopsis lyrata	DWARF AND DELAYED FLOWERING1: Orthologous to Arabidopsis thaliana DDF1	Lehti-Shiu et al., PP 2015
DDF2	UP00557	AP2	Arabidopsis lyrata	DWARF AND DELAYED FLOWERING2: Orthologous to Arabidopsis thaliana DDF2	Lehti-Shiu et al., PP 2015
Dlx1	UP00202	Homeobox	Mus musculus	distal-less homeobox 1	Berger et al., Cell 2008
Dlx2	UP00126	Homeobox	Mus musculus	distal-less homeobox 2	Berger et al., Cell 2008
Dlx3	UP00154	Homeobox	Mus musculus	distal-less homeobox 3	Berger et al., Cell 2008
Dlx4	UP00110	Homeobox	Mus musculus	distal-less homeobox 4	Berger et al., Cell 2008
Dlx5	UP00230	Homeobox	Mus musculus	distal-less homeobox 5	Berger et al., Cell 2008
Dmbx1	UP00111	Homeobox	Mus musculus	diencephalon/mesencephalon homeobox 1	Berger et al., Cell 2008
Dobox4	UP00232	Homeobox	Mus musculus	EST CN720839: E0811A05-5 NIA Mouse four-cell-Embryo cDNA library (Long) Mus musculus cDNA clone NIA:E0811A05 IMAGE:30906628 5-, mRNA sequence	Berger et al., Cell 2008
Dobox5	UP00143	Homeobox	Mus musculus	Formerly named ENSMUST00000057964.5	Berger et al., Cell 2008
Duxl	UP00227	Homeobox	Mus musculus	RIKEN cDNA 1110051B16 gene	Berger et al., Cell 2008
E2F2	UP00001	E2F_TDP	Mus musculus	E2F transcription factor 2	Badis et al., Science 2009
E2F3	UP00003	E2F_TDP	Mus musculus	E2F transcription factor 3	Badis et al., Science 2009
Ecm22	UP00305	Zn2Cys6	Saccharomyces cerevisiae	Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription	Zhu et al., Genome Res 2009
Ecm22	UP00495	Zn2Cys6	Saccharomyces cerevisiae	Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription	Gordan et al., Gen. Bio. 2011
Egr1	UP00007	zf-C2H2	Mus musculus	early growth response 1	Badis et al., Science 2009
EGR2	UP00587	zf-C2H2	Homo sapiens	E3 SUMO-protein ligase EGR2: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.	Barrera et al., Science 2016
Ehf	UP00015	ETS	Mus musculus	ets homologous factor: Mus musculus EHF (Ehf) mRNA, complete cds	Badis et al., Science 2009
Ehf	UP00403	ETS	Mus musculus	ets homologous factor: Mus musculus EHF (Ehf) mRNA, complete cds	Wei et al., EMBO J 2010
Elf2	UP00404	ETS	Mus musculus	ETS-related transcription factor Elf-2: Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter	Wei et al., EMBO J 2010
Elf3	UP00090	AT_hook, ETS	Mus musculus	E74-like factor 3: ETS-related transcription factor Elf-3 isoform 1	Badis et al., Science 2009
Elf3	UP00407	AT_hook, ETS	Mus musculus	E74-like factor 3: ETS-related transcription factor Elf-3 isoform 1	Wei et al., EMBO J 2010
Elf4	UP00413	ETS	Mus musculus	E74-like factor 4 (ets domain transcription factor) : ETS-related transcription factor Elf-4	Wei et al., EMBO J 2010
Elf5	UP00409	ETS	Mus musculus	E74-like factor 5: ETS-related transcription factor Elf-5	Wei et al., EMBO J 2010
Elk1	UP00410	ETS	Mus musculus	ELK1, member of ETS oncogene family : ETS domain-containing protein Elk-1	Wei et al., EMBO J 2010
Elk3	UP00420	ETS	Mus musculus	ELK3, member of ETS oncogene family: ETS domain-containing protein Elk-3	Wei et al., EMBO J 2010
Elk4	UP00415	ETS	Mus musculus	ELK4, member of ETS oncogene family: ETS domain-containing protein Elk-4	Wei et al., EMBO J 2010
Emx2	UP00201	Homeobox	Mus musculus	empty spiracles homolog 2 (Drosophila)	Berger et al., Cell 2008
En1	UP00167	Homeobox	Mus musculus	engrailed 1	Berger et al., Cell 2008
En2	UP00163	Homeobox	Mus musculus	engrailed 2	Berger et al., Cell 2008
Eomes	UP00068	TBOX	Mus musculus	Eomesodermin homolog (Xenopus laevis): Mus musculus similar to Eomesodermin homolog (LOC235673), mRNA	Badis et al., Science 2009
Erg	UP00411	ETS	Mus musculus	avian erythroblastosis virus E-26 (v-ets) oncogene related: transcriptional regulator ERG	Wei et al., EMBO J 2010
ESR1	UP01600	NR LBD, NR_C4	Homo sapiens	Estrogen receptor: Nuclear hormone receptor that is involved in regulation of eukaryotic gene expression, cellular proliferation, and differetiation in target tissues.	Lai et al. 2020
Esrra	UP00079	ZnF_C4	Mus musculus	estrogen related receptor, alpha: Mus musculus estrogen related receptor, alpha (Esrra), mRNA.	Badis et al., Science 2009
Esx1	UP00251	Homeobox	Mus musculus	extraembryonic, spermatogenesis, homeobox 1	Berger et al., Cell 2008
ESX1	UP00588	Homeobox	Homo sapiens	homeobox protein ESX1: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.	Barrera et al., Science 2016
Ets1	UP00414	ETS	Mus musculus	E26 avian leukemia oncogene 1, 5\' domain: protein C-ets-1 isoform 1	Wei et al., EMBO J 2010
Etv1	UP00421	ETS	Mus musculus	ets variant gene 1: ETS translocation variant 1	Wei et al., EMBO J 2010
Etv3	UP00422	ETS	Mus musculus	ets variant gene 3: ETS translocation variant 3	Wei et al., EMBO J 2010
Etv4	UP00417	ETS	Mus musculus	ets variant gene 4 (E1A enhancer binding protein, E1AF): ETS translocation variant 4	Wei et al., EMBO J 2010
Etv5	UP00412	ETS	Mus musculus	ets variant gene 5: ETS translocation variant 5	Wei et al., EMBO J 2010
Etv6	UP00418	ETS	Mus musculus	ets variant gene 6 (TEL oncogene): transcription factor ETV6	Wei et al., EMBO J 2010
Eve	UP00505	Homeobox	Drosophila melanogaster	Even skipped: Even skipped may play a role in determining neuronal identity. It may be directly involved in specifying identity of individual neurons and is required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes.	Busser et al., Development 2012
Evx1	UP00162	Homeobox	Mus musculus	even skipped homeotic gene 1 homolog	Berger et al., Cell 2008
Evx2	UP00132	Homeobox	Mus musculus	even skipped homeotic gene 2 homolog	Berger et al., Cell 2008
Fhl1	UP00303	Fork_head	Saccharomyces cerevisiae	Putative transcriptional regulator with similarity to DNA-binding domain of Drosophila forkhead; required for rRNA processing	Zhu et al., Genome Res 2009
Fkh1	UP00353	Fork_head	Saccharomyces cerevisiae	Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth; also involved in chromatin silencing at HML and HMR	Zhu et al., Genome Res 2009
Fkh2	UP00312	Fork_head	Saccharomyces cerevisiae	Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth; also involved in chromatin silencing at HML and HMR; potential Cdc28p substrate	Zhu et al., Genome Res 2009
Fli1	UP00416	ETS	Mus musculus	Friend leukemia integration 1: Friend leukemia integration 1 transcription factor	Wei et al., EMBO J 2010
Fos	UP00425	bZIP	Homo sapiens	FBJ murine osteosarcoma viral oncogene homolog: Proto-oncogene protein c-fos (Cellular oncogene fos)(G0/G1 switch regulatory protein 7)	Alibes et al., NAR 2010	N/A
Fox3_Mgra	UP00529	Fork_head	Mycosphaerella graminicola		Nakagawa et al., PNAS 2013
Fox3_Tmel	UP00533	Fork_head	Tuber melanosporum		Nakagawa et al., PNAS 2013
Foxa2	UP00073	Fork_head	Mus musculus	forkhead box A2: Mus musculus forkhead box A2 (Foxa2)	Badis et al., Science 2009
FOXA3	UP01601	Forkhead	Homo sapiens	Hepatocyte nuclear factor 3-gamma: A pioneer factor that opens compacted chromatin for other proteins to interact with nucleosomal core histones. Interacts with cis-acting regulatory regions and involved in glucose homeostasis.	Lai et al. 2020
FOXC1	UP00589	Forkhead	Homo sapiens	forkhead box protein C1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.	Barrera et al., Science 2016
Foxj1	UP00041	Fork_head	Mus musculus	forkhead box J1: forkhead box J1 [Mus musculus]	Badis et al., Science 2009
Foxj3	UP00039	Fork_head	Mus musculus	forkhead box J3: Mus musculus similar to Putative forkhead box protein KIAA1041 (LOC230700), mRNA	Badis et al., Science 2009
FoxJ3	UP01497	forkhead	Homo sapiens	Human Forkhead Protein FoxJ3: Human Forkhead Protein FoxJ3	Rogers et al., Mol Cell 2019
FoxJ3_N2	UP01500	forkhead	Chimera	Human FoxJ3 + Human FoxN2: Chimeric protein consisting of the FoxJ3 DBD with a substitution from the FoxN2 protein.	Rogers et al., Mol Cell 2019
FoxJ3_N3	UP01501	forkhead	Chimera	Human FoxJ3 + Human FoxN3: Chimeric protein consisting of the FoxJ3 DBD with a substitution from the FoxN3 protein.	Rogers et al., Mol Cell 2019
Foxk1	UP00025	Fork_head	Mus musculus	forkhead box K1: Mus musculus forkhead box K1 (Foxk1), transcript variant 1, mRNA.	Badis et al., Science 2009
Foxl1	UP00061	Fork_head	Mus musculus	forkhead box L1: M.musculus fkh-6 gene	Badis et al., Science 2009
Foxm1	UP00528	Fork_head	Mus musculus		Nakagawa et al., PNAS 2013
FoxM_Spur	UP00531	Fork_head	Strongylocentrotus purpuratus		Nakagawa et al., PNAS 2013
Foxn1	UP00526	Fork_head	Mus musculus		Nakagawa et al., PNAS 2013
FOXN1	UP01602	Forkhead	Homo sapiens	Forkhead box protein N1: Regulates development, differentiation, and function of thymic epithelial cells in prenatal also postnatal thymus.	Lai et al. 2020
FoxN1-4_Mbre	UP00525	Fork_head	Monosiga brevicollis		Nakagawa et al., PNAS 2013
FOXN2	UP00521	Fork_head	Homo sapiens		Nakagawa et al., PNAS 2013
FoxN2	UP01496	Fork_head	Homo sapiens		Rogers et al., Mol Cell 2019
FoxN2-3_Nvec	UP00530	Fork_head	Nematostella vectensis		Nakagawa et al., PNAS 2013
FoxN2-3_Tadh	UP00532	Fork_head	Trichoplax adhaerens		Nakagawa et al., PNAS 2013
FoxN2_J3	UP01499	forkhead	Chimera	Human FoxN2 + Human FoxJ3: Chimeric protein consisting of the FoxN2 DBD with a substitution from the FoxJ3 protein.	Rogers et al., Mol Cell 2019
FoxN3	UP01494	forkhead	Homo sapiens	Human Forkhead Protein FoxN3: Human Forkhead Protein FoxN3	Berger et al., Cell 2008	N/A
FoxN3	UP01495	forkhead	Homo sapiens	Human Forkhead Protein FoxN3: Human Forkhead Protein FoxN3	Rogers et al., Mol Cell 2019
FoxN3_J3	UP01498	forkhead	Chimera	Human FoxN3 + Human FoxJ3: Chimeric protein consisting of the FoxN3 DBD with a substitution from the FoxJ3 protein.	Rogers et al., Mol Cell 2019
FOXN4	UP00522	Fork_head	Homo sapiens		Nakagawa et al., PNAS 2013
FOXR1	UP00523	Fork_head	Homo sapiens		Nakagawa et al., PNAS 2013
FOXR1	UP01603	Fork_head	Homo sapiens		Lai et al. 2020
Gabpa	UP00013	ETS	Mus musculus	GA repeat binding protein, alpha: Mus musculus GA repeat binding protein, alpha	Badis et al., Science 2009
Gabpa	UP00408	ETS	Mus musculus	GA repeat binding protein, alpha: Mus musculus GA repeat binding protein, alpha	Wei et al., EMBO J 2010
Gal4	UP00322	Zn2Cys6	Saccharomyces cerevisiae	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p	Zhu et al., Genome Res 2009
Gat1	UP00287	GATA	Saccharomyces cerevisiae	Transcriptional activator of genes involved in nitrogen catabolite repression, member of the GATA family of DNA binding proteins; activity and localization regulated by nitrogen limitation and Ure2p	Zhu et al., Genome Res 2009
Gat3	UP00319	GATA	Saccharomyces cerevisiae	Protein containing GATA family zinc finger motifs	Zhu et al., Genome Res 2009
Gat4	UP00336	GATA	Saccharomyces cerevisiae	Protein containing GATA family zinc finger motifs	Zhu et al., Genome Res 2009
Gata3	UP00032	GATA	Mus musculus	GATA binding protein 3: Mus musculus GATA binding protein 3 (Gata3), mRNA.	Badis et al., Science 2009
GATA4	UP01604	GATA type znF	Homo sapiens	Transcription factor GATA-4: Plays a role in cardiac development. Binds to cardiac super-enhancers with TBX5 and promotes cardiomyocyte gene expression.	Lai et al. 2020
Gata5	UP00080	GATA	Mus musculus	GATA binding protein 5	Badis et al., Science 2009
Gata6	UP00100	GATA	Mus musculus	GATA binding protein 6	Badis et al., Science 2009
Gbx1	UP00204	Homeobox	Mus musculus	gastrulation brain homeobox 1	Berger et al., Cell 2008
Gbx2	UP00131	Homeobox	Mus musculus	gastrulation brain homeobox 2	Berger et al., Cell 2008
Gcm1	UP00070	GCM	Mus musculus	glial cells missing homolog 1 (Drosophila)	Badis et al., Science 2009
Gcn4	UP00285	bZIP	Saccharomyces cerevisiae	Gcn4p: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	Zhu et al., Genome Res 2009	N/A
Gcn4	UP00428	bZIP	Saccharomyces cerevisiae	Gcn4p: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels	Alibes et al., NAR 2010
Gcr1	UP00456	GCR1_C	Saccharomyces cerevisiae	GlyColysis Regulation : Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p	Gordan et al., Gen. Bio. 2011
GFI1	UP00591	zf-C2H2	Homo sapiens	zinc finger protein Gfi-1: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin- mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1- dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells.	Barrera et al., Science 2016
GFI1B	UP00592	zf-C2H2	Homo sapiens	zinc finger protein Gfi-1b: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down- regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma- satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation.	Barrera et al., Science 2016
Gli1	UP00538	zf-H2C2_2	Mus musculus	GLI-Kruppel family member GLI1: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.	Peterson et al., Genes Dev 2012
Gli2	UP00539	zf-H2C2_2	Mus musculus	GLI-Kruppel family member GLI2	Peterson et al., Genes Dev 2012
Gli3	UP00540	zf-H2C2_2	Mus musculus	GLI-Kruppel family member GLI3: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repres	Peterson et al., Genes Dev 2012
Glis2	UP00024	zf-C2H2	Mus musculus	GLIS family zinc finger 2: GLIS family zinc finger 2 (Glis2), mRNA	Badis et al., Science 2009
Gln3	UP00318	GATA	Saccharomyces cerevisiae	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source	Zhu et al., Genome Res 2009
Gm397	UP00042	zf-C2H2	Mus musculus	gene model 397, (NCBI): Mus musculus similar to Zinc finger protein 58 (Zfp-58) (Zinc finger protein Mfg-1) (LOC212386), mRNA	Badis et al., Science 2009
Gm4881	UP00424	ETS	Mus musculus	predicted gene 4881: Ensembl Gene ID:ENSMUSG00000042789,Transcript ID:ENSMUST00000061154.4,Protein ID:ENSMUSP00000056357	Wei et al., EMBO J 2010
Gm5454	UP00423	ETS	Mus musculus	Predicted gene 5454: Ensembl Gene ID: ENSMUSG00000047643, Transcript ID: ENSMUST00000052030, Protein ID: ENSMUSP00000055525	Wei et al., EMBO J 2010
Gmeb1	UP00084	SAND	Mus musculus	glucocorticoid modulatory element binding protein 1: transcription termination factor 1, mRNA (cDNA clone MGC:69635 IMAGE:6847867), complete cds	Badis et al., Science 2009
Gsc	UP00112	Homeobox	Mus musculus	goosecoid	Berger et al., Cell 2008
Gsh2	UP00127	Homeobox	Mus musculus	genomic screened homeo box 2	Berger et al., Cell 2008
Gsm1	UP00301	Zn2Cys6	Saccharomyces cerevisiae	Putative zinc cluster protein of unknown function; computationally predicted involvement in oxidative phosphorylation, based on patterns of expression and sequence analysis	Zhu et al., Genome Res 2009
GST-BcdHD1	UP01426	HD	Homo sapiens	GST-BcdHD1	Datta et al., 2017	N/A
GST-BcdHD2	UP01427	HD	Homo sapiens	GST-BcdHD2	Datta et al., 2017	N/A
GST-OtdHD1	UP01428	HD	Homo sapiens	GST-OtdHD1	Datta et al., 2017	N/A
GST-OtdHD2	UP01429	HD	Acanthamoeba castellanii	GST-OtdHD2	Datta et al., 2017	N/A
Gzf3	UP00347	GATA	Saccharomyces cerevisiae	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source;...	Zhu et al., Genome Res 2009
Hac1	UP00457	bZIP_2	Saccharomyces cerevisiae	Homologous to Atf/Creb1 : Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis	Gordan et al., Gen. Bio. 2011
Hal9	UP00315	Zn2Cys6	Saccharomyces cerevisiae	Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decrease...	Zhu et al., Genome Res 2009
Hap1	UP00458	Zn_clus	Saccharomyces cerevisiae	Heme Activator Protein : Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus	Gordan et al., Gen. Bio. 2011
Hbp1	UP00055	HMG_box	Mus musculus	high mobility group box transcription factor 1	Badis et al., Science 2009
Hdx	UP00148	Homeobox	Mus musculus	Highly divergent homeobox	Berger et al., Cell 2008
HESX1	UP00594	Homeobox	Homo sapiens	homeobox expressed in ES cells 1: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	Barrera et al., Science 2016
HESX1	UP01605	Homeobox	Homo sapiens	homeobox expressed in ES cells 1: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity).	Lai et al. 2020
Hic1	UP00035	zf-C2H2	Mus musculus	hypermethylated in cancer 1: Mus musculus hypermethylated in cancer 1 (Hic1)	Badis et al., Science 2009
HLH-1	UP00387	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals exhibit weak and disorganized muscle contractions; however, ectopic expression of HLH-1 in the embryo is sufficient to convert nearly all embryonic cell types to a bodywall muscle-like fate; in regulating bodywall myogenesis, genetic studies indicate that HLH-1 acts together with the UNC-120/SRF and HND-1/HAND transcription factors, both of which can also induce muscle-like fates when overexpressed in embryos; in addition, in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in bodywall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development.	Grove et al., Cell 2009
HLH-1	UP00548	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals exhibit weak and disorganized muscle contractions; however, ectopic expression of HLH-1 in the embryo is sufficient to convert nearly all embryonic cell types to a bodywall muscle-like fate; in regulating bodywall myogenesis, genetic studies indicate that HLH-1 acts together with the UNC-120/SRF and HND-1/HAND transcription factors, both of which can also induce muscle-like fates when overexpressed in embryos; in addition, in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in bodywall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development.	De Masi et al., NAR 2011
HLH-10	UP00358	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 10: none available	Grove et al., Cell 2009
HLH-11	UP00357	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 11: none available	Grove et al., Cell 2009
HLH-14	UP00363	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 14: hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa.	Grove et al., Cell 2009
HLH-15	UP00361	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 15 : none available	Grove et al., Cell 2009
HLH-19	UP00378	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 19 : none available	Grove et al., Cell 2009
HLH-2	UP00384	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 2: hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates.	Grove et al., Cell 2009
HLH-25	UP00386	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 25: hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-deficient genetic backgrounds; HLH-25 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-25 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage; ectopic HLH-25 can induce body muscle development in skn-1(RNAi);pal-1(RNAi) embryos that would otherwise lack muscle; HLH-25 is required for embryonic viability in mass RNAi assays.	Grove et al., Cell 2009
HLH-26	UP00370	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 26: hlh-26 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-26 may require UNC-37; HLH-26's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; HLH-26 is not visibly expressed in EMS descendants, and has no obvious function in mass RNAi assays.	Grove et al., Cell 2009
HLH-27	UP00364	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 27: hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is transcribed in the early MS lineage, probably due to MED-1/2 binding of clustered sites in the hlh-27 promoter region; HLH-27 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-27 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage, in a SKN-1-dependent manner; HLH-27 is required for embryonic viability in mass RNAi assays.	Grove et al., Cell 2009
HLH-29	UP00368	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 29: hlh-29 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-26, and HLH-27) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-27, and perhaps HLH-28); HLH-29 is identical to residues 24-262 of HLH-28, shares near-identical promoter regions in a inverted duplex, and is likely to be highly redundant with HLH-28; HLH-29 (with HLH-28) is also required for late embryonic viability, and for normal fat metabolism, yolk protein transport, gonadal and vulval development, bordering behavior, and chemosensory responses, and repression of tax-4 and osm-9 transcription; lag-2 repression by HLH-29 may require UNC-37; HLH-29's paralogs include HLH-25 through HLH-28 and (more distantly) REF-1; hlh-29 is transcribed in the early MS and E lineages, probably due to MED-1/2 binding of clustered sites in the hlh-28/hlh-29 shared promoter region; HLH-29 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-29 is also expressed in all EMS granddaughters beginning at the 24-cell stage, in a SKN-1-dependent manner; furthermore, HLH-29 is expressed in amphid and phasmid neurons, ALA and PVT neurons, chemosensory and mechanosensory neurons, ASI, ASK, PHA, PQR, and neurons of the anterior pharynx, as well as in vulva, somatic gonad, rectal glands, intestine, and larval pharyngeal muscle PM1, ventral posterior coelomocytes, spermatheca, and vulval muscles; hlh-28/29 mRNA is present throughout development, but varies roughly 30-fold in quantity, with 3.5-fold more mRNA in L1 larvae than in adults; ectopic HLH-29 can rescue the intestinal defect of ref-1(RNAi) embryos; hlh-28/29 transcription is inhibited by LIN-12 and MED-1.	Grove et al., Cell 2009
HLH-3	UP00379	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 3: hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors.	Grove et al., Cell 2009
HLH-30	UP00365	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 30: W02C12.3 is orthologous to the human gene TRANSCRIPTION FACTOR BINDING TO IGHM ENHANCER 3 (TFE3; OMIM:314310), which when mutated leads to disease.	Grove et al., Cell 2009
HLH-4	UP00369	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 4: none available	Grove et al., Cell 2009
HLH-8	UP00371	bHLH	Caenorhabditis elegans	Helix Loop Helix Protein 8: The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying.	Grove et al., Cell 2009
Hlx1	UP00225	Homeobox	Mus musculus	H2.0-like homeo box 1 (Drosophila)	Berger et al., Cell 2008
Hlxb9	UP00123	Homeobox	Mus musculus	homeobox gene HB9	Berger et al., Cell 2008
Hmbox1	UP00161	Homeobox	Mus musculus	homeobox containing 1	Berger et al., Cell 2008
Hmlalpha2	UP00459	Homeobox	Saccharomyces cerevisiae	Hidden Mat Left ALPHA : Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression	Gordan et al., Gen. Bio. 2011
Hmx1	UP00104	Homeobox	Mus musculus	H6 homeo box 1	Berger et al., Cell 2008
Hmx2	UP00155	Homeobox	Mus musculus	H6 homeo box 2	Berger et al., Cell 2008
Hmx3	UP00157	Homeobox	Mus musculus	H6 homeo box 3	Berger et al., Cell 2008
Hnf4a	UP00066	ZnF_C4	Mus musculus	hepatic nuclear factor 4, alpha: Mus musculus hepatic nuclear factor 4, alpha (Hnf4a), mRNA	Badis et al., Science 2009
HNF4A	UP01606	NR LBD, NR_C4	Homo sapiens	Hepatocyte nuclear factor 4- alpha: Controls expression of hepatic gene during transition of endodermal cells to hepatic progenitor cells. This facilitates recruitment of RNA pol II to the promoters of target genes.	Lai et al. 2020
Homez	UP00114	Homeobox	Mus musculus	homeodomain leucine zipper-encoding gene	Berger et al., Cell 2008
Hoxa1	UP00264	Homeobox	Mus musculus	homeo box A1	Berger et al., Cell 2008
Hoxa10	UP00217	Homeobox	Mus musculus	homeo box A10	Berger et al., Cell 2008
Hoxa11	UP00246	Homeobox	Mus musculus	homeo box A11	Berger et al., Cell 2008
Hoxa13	UP00183	Homeobox	Mus musculus	homeo box A13	Berger et al., Cell 2008
Hoxa2	UP00174	Homeobox	Mus musculus	homeo box A2	Berger et al., Cell 2008
Hoxa3	UP00391	Homeobox	Mus musculus	homeo box A3: Mus musculus homeo box A3 (Hoxa3)	Berger et al., Cell 2008
Hoxa3	UP00063	Homeobox	Mus musculus	homeo box A3: Mus musculus homeo box A3 (Hoxa3)	Badis et al., Science 2009
Hoxa4	UP00196	Homeobox	Mus musculus	homeo box A4	Berger et al., Cell 2008
Hoxa5	UP00189	Homeobox	Mus musculus	homeo box A5	Berger et al., Cell 2008
Hoxa6	UP00182	Homeobox	Mus musculus	homeo box A6	Berger et al., Cell 2008
Hoxa7	UP00164	Homeobox	Mus musculus	homeo box A7	Berger et al., Cell 2008
Hoxa9	UP00213	Homeobox	Mus musculus	homeo box A9	Berger et al., Cell 2008
Hoxb13	UP00134	Homeobox	Mus musculus	homeo box B13	Berger et al., Cell 2008
Hoxb3	UP00137	Homeobox	Mus musculus	homeo box B3	Berger et al., Cell 2008
Hoxb4	UP00144	Homeobox	Mus musculus	homeo box B4	Berger et al., Cell 2008
Hoxb5	UP00214	Homeobox	Mus musculus	homeo box B5	Berger et al., Cell 2008
Hoxb6	UP00259	Homeobox	Mus musculus	homeo box B6	Berger et al., Cell 2008
Hoxb7	UP00206	Homeobox	Mus musculus	homeo box B7	Berger et al., Cell 2008
HOXB7	UP00595	Homeobox	Homo sapiens	homeobox protein Hox-B7: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma.	Barrera et al., Science 2016
Hoxb8	UP00263	Homeobox	Mus musculus	homeo box B8	Berger et al., Cell 2008
Hoxb9	UP00207	Homeobox	Mus musculus	homeo box B9	Berger et al., Cell 2008
Hoxc10	UP00245	Homeobox	Mus musculus	homeo box C10	Berger et al., Cell 2008
Hoxc11	UP00235	Homeobox	Mus musculus	homeo box C11	Berger et al., Cell 2008
Hoxc12	UP00135	Homeobox	Mus musculus	homeo box C12	Berger et al., Cell 2008
Hoxc13	UP00173	Homeobox	Mus musculus	homeo box C13	Berger et al., Cell 2008
Hoxc4	UP00113	Homeobox	Mus musculus	homeo box C4	Berger et al., Cell 2008
HOXC4	UP00596	Homeobox	Homo sapiens	homeobox protein Hox-C4: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons.	Barrera et al., Science 2016
Hoxc5	UP00252	Homeobox	Mus musculus	homeo box C5	Berger et al., Cell 2008
Hoxc6	UP00260	Homeobox	Mus musculus	homeo box C6	Berger et al., Cell 2008
Hoxc8	UP00242	Homeobox	Mus musculus	homeo box C8	Berger et al., Cell 2008
Hoxc9	UP00197	Homeobox	Mus musculus	homeo box C9	Berger et al., Cell 2008
Hoxd1	UP00140	Homeobox	Mus musculus	homeo box D1	Berger et al., Cell 2008
Hoxd10	UP00121	Homeobox	Mus musculus	homeo box D10	Berger et al., Cell 2008
Hoxd11	UP00117	Homeobox	Mus musculus	homeo box D11	Berger et al., Cell 2008
Hoxd12	UP00177	Homeobox	Mus musculus	homeo box D12	Berger et al., Cell 2008
Hoxd13	UP00180	Homeobox	Mus musculus	homeo box D13	Berger et al., Cell 2008
HOXD13	UP00597	Homeobox	Homo sapiens	homeobox protein Hox-D13: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly.	Barrera et al., Science 2016
Hoxd3	UP00241	Homeobox	Mus musculus	homeo box D3: M.musculus Hoxd-3 mRNA	Berger et al., Cell 2008
Hoxd8	UP00168	Homeobox	Mus musculus	homeo box D8	Berger et al., Cell 2008
Ipf1	UP00124	Homeobox	Mus musculus	insulin promoter factor 1, homeodomain transcription factor	Berger et al., Cell 2008
IRC900814	UP00072	SAND	Mus musculus	Arhgef12	Badis et al., Science 2009
Irf3	UP00086	IRF	Mus musculus	interferon regulatory factor 3	Badis et al., Science 2009
Irf4	UP00018	IRF	Mus musculus	interferon regulatory factor 4	Badis et al., Science 2009
Irf5	UP00040	IRF	Mus musculus	interferon regulatory factor 5	Badis et al., Science 2009
Irf6	UP00011	IRF	Mus musculus	interferon regulatory factor 6	Badis et al., Science 2009
Irx2	UP00236	Homeobox	Mus musculus	Iroquois related homeobox 2 (Drosophila)	Berger et al., Cell 2008
Irx3	UP00223	Homeobox	Mus musculus	Iroquois related homeobox 3 (Drosophila)	Berger et al., Cell 2008
Irx4	UP00194	Homeobox	Mus musculus	Iroquois related homeobox 4 (Drosophila)	Berger et al., Cell 2008
Irx5	UP00250	Homeobox	Mus musculus	Iroquois related homeobox 5 (Drosophila)	Berger et al., Cell 2008
Irx6	UP00150	Homeobox	Mus musculus	Iroquois related homeobox 6 (Drosophila)	Berger et al., Cell 2008
Isgf3g	UP00074	IRF	Mus musculus	interferon dependent positive acting transcription factor 3 gamma: Mus musculus interferon dependent positive acting transcription factor 3 gamma (Isgf3g), mRNA	Badis et al., Science 2009
Isl2	UP00170	Homeobox	Mus musculus	insulin related protein 2 (islet 2)	Berger et al., Cell 2008
Isx	UP00243	Homeobox	Mus musculus	intestine-specific homeobox	Berger et al., Cell 2008
ISX	UP00598	Homeobox	Homo sapiens	intestine-specific homeobox: Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine.	Barrera et al., Science 2016
Jumeau	UP00519	Fork_head	Drosophila melanogaster		Nakagawa et al., PNAS 2013
Jun	UP00426	bZIP	Homo sapiens	Transcription factor AP-1: Transcription factor that recognizes and binds to the enhancer heptamer motif 5\'-TGA[CG]TCA-3\'	Alibes et al., NAR 2010	N/A
Jundm2	UP00103	BRLZ, BZIP_1, BZIP_2	Mus musculus	Jun dimerization protein 2: Mus musculus Jun dimerization protein 2 (Jundp2-pending), mRNA	Badis et al., Science 2009
KdpE	UP00541	trans_reg_C	Burkholderia thailandensis E26	DNA-binding response regulator KdpE	Nowak-Lovato et al., J Microbiol Meth 2012	N/A
KLF1	UP00599	zf-C2H2	Homo sapiens	Krueppel-like factor 1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.	Barrera et al., Science 2016
KLF1	UP01670	zf-C2H2	Homo sapiens	Krueppel-like factor 1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.	Lai et al. 2020
KLF11	UP00600	zf-C2H2	Homo sapiens	Krueppel-like factor 11: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis.	Barrera et al., Science 2016
Klf7	UP00093	zf-C2H2	Mus musculus	Kruppel-like factor 7 (ubiquitous): Mus musculus Kruppel-like factor 7 (ubiquitous) (Klf7), mRNA	Badis et al., Science 2009
KLLA0F08206p	UP00524	Fork_head	Kluyveromyces lactis		Nakagawa et al., PNAS 2013
Lbl	UP00506	Homeobox	Drosophila melanogaster	Ladybird late	Busser et al., Development 2012
Lbx2	UP00120	Homeobox	Mus musculus	ladybird homeobox homolog 2 (Drosophila)	Berger et al., Cell 2008
Lef1	UP00067	HMG_box	Mus musculus	lymphoid enhancer binding factor 1	Badis et al., Science 2009
Leu3	UP00277	Zn2Cys6	Saccharomyces cerevisiae	Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in ...	Zhu et al., Genome Res 2009
Lhx1	UP00262	Homeobox	Mus musculus	LIM homeobox protein 1	Berger et al., Cell 2008
Lhx2	UP00115	Homeobox	Mus musculus	LIM homeobox protein 2	Berger et al., Cell 2008
Lhx3	UP00130	Homeobox	Mus musculus	LIM homeobox protein 3	Berger et al., Cell 2008
Lhx4	UP00261	Homeobox	Mus musculus	LIM homeobox protein 4	Berger et al., Cell 2008
Lhx5	UP00212	Homeobox	Mus musculus	LIM homeobox protein 5	Berger et al., Cell 2008
Lhx6	UP00256	Homeobox	Mus musculus	LIM homeobox protein 6	Berger et al., Cell 2008
Lhx8	UP00184	Homeobox	Mus musculus	LIM homeobox protein 8	Berger et al., Cell 2008
Lhx9	UP00175	Homeobox	Mus musculus	LIM homeobox protein 9	Berger et al., Cell 2008
LIN-32	UP00381	bHLH	Caenorhabditis elegans	abnormal cell LINeage: lin-32 encodes a basic helix-loop-helix transcription factor that is required for development of several types of neurons, including the touch receptor neurons and the male sensory ray neurons.	Grove et al., Cell 2009
Lmd	UP00537	Zinc Finger C2H2	Drosophila melanogaster	Lame duck: Lame duck(Â LmdÂ ), a member of the Gli superfamily of transcription factors, is essential for the specification and differentiation of fusion- competent myoblasts.	Busser et al., PNAS 2012
Lmx1a	UP00188	Homeobox	Mus musculus	LIM homeobox transcription factor 1 alpha	Berger et al., Cell 2008
Lmx1b	UP00169	Homeobox	Mus musculus	LIM homeobox transcription factor 1 beta	Berger et al., Cell 2008
LUX	UP00552		Arabidopsis thaliana	Transcription factor LUX: Transcription factor that is essential for the generation of the circadian clock oscillation. Is necessary for activation of CCA1 and LHY expression. Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter. Directly regulates the expression of PRR9, a major component of the morning transcr	Helfer et al., Curr Biol 2011
LuxR	UP00392	HTH	Vibrio harveyi	HTH-type transcriptional regulator luxR: Regulatory protein of bacterial bioluminescence. It probably binds the autoinducer molecule and potentiates the transcription of the bioluminescence operon. (UniProt, 08/18/08)	Pompeani et al., Mol Microbiol 2008
Lys14	UP00282	Zn2Cys6	Saccharomyces cerevisiae	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer	Zhu et al., Genome Res 2009
Mafb	UP00045	BRLZ	Mus musculus	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian): Mus musculus v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA	Badis et al., Science 2009
Mafk	UP00044	BRLZ	Mus musculus	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)	Badis et al., Science 2009
MAL8P1.153	UP00429	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
MAML1	UP00485		Homo sapiens	mastermind-like 1 (Drosophila): Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation	Del Bianco et al., PLoS ONE 2010	N/A
Matalpha2	UP00307	Homeobox	Saccharomyces cerevisiae	Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATal...	Zhu et al., Genome Res 2009
Max	UP00060	HLH	Mus musculus	Max protein	Badis et al., Science 2009	N/A
Max	UP00562	bHLH	Homo sapiens	MYC associated factor X: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'.	Guo et al., GB14	N/A
Mbp1	UP00271	HTH APSES-type	Saccharomyces cerevisiae	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis	Zhu et al., Genome Res 2009
Mcm1	UP00326	MADS	Saccharomyces cerevisiae	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes	Zhu et al., Genome Res 2009
MDL-1	UP00382	bHLH	Caenorhabditis elegans	MAD-Like: mdl-1 encodes a basic helix-loop-helix (bHLH) protein similar to the vertebrate MAD transcriptional regulators; in vitro, MDL-1 can heterodimerize, and bind an E-box DNA sequence, with MXL-1, a C. elegans MAX-like bHLH protein; when expressed in rat embryonic fibroblasts, MDL-1 is able to suppress c-MYC/RAS-induced cell transformation, in a manner dependent upon an intact, predicted SIN3 interaction domain; mdl-1::gfp promoter fusions are expressed in a number of different tissues, including the posterior intestine, anterior and ventral cord neurons, pharyngeal and body wall muscles, somatic gonad precursors, and hypodermal cells; yeast one-hybrid and ChIP experiments indicate that DAF-3/Smad can bind the mdl-1 promoter; in addition, mdl-1 pharyngeal expression is specifically increased in daf-3(RNAi) animals, suggesting that DAF-3 directly negatively regulates mdl-1 transcription in pharyngeal tissue during dauer formation.	Grove et al., Cell 2009
Meis1	UP00186	Homeobox	Mus musculus	myeloid ecotropic viral integration site 1	Berger et al., Cell 2008
Meox1	UP00233	Homeobox	Mus musculus	mesenchyme homeobox 1	Berger et al., Cell 2008
Met32	UP00345	zf-C2H2	Saccharomyces cerevisiae	Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met31p	Zhu et al., Genome Res 2009
Mga1	UP00339	HSF_DNA-bind	Saccharomyces cerevisiae	Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants	Zhu et al., Genome Res 2009
Mig1	UP00291	zf-C2H2	Saccharomyces cerevisiae	Transcription factor involved in glucose repression; C2H2 zinc finger protein similar to mammalian Egr and Wilms tumor proteins	Zhu et al., Genome Res 2009
Mig2	UP00349	zf-C2H2	Saccharomyces cerevisiae	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter	Zhu et al., Genome Res 2009
Mig3	UP00317	zf-C2H2	Saccharomyces cerevisiae	Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, a...	Zhu et al., Genome Res 2009
Mot3	UP00460	zf-C2H2	Saccharomyces cerevisiae	Modifier of Transcription : Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcr	Gordan et al., Gen. Bio. 2011
Mrg1	UP00226	Homeobox	Mus musculus	myeloid ecotropic viral integration site-related gene 1	Berger et al., Cell 2008
Mrg2	UP00210	Homeobox	Mus musculus	myeloid ecotropic viral integration site-related gene 2	Berger et al., Cell 2008
Msh	UP00507	Homeobox	Drosophila melanogaster	Muscle segmentation homeobox: Msh plays a key role in the specification of proneural and promuscular cluster formation. It is required for the specification of dorsal and lateral muscle progenitor cells.	Busser et al., Development 2012
Msn1	UP00461	GCR1_C	Saccharomyces cerevisiae	Multicopy suppressor of SNF1 mutation : Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus	Gordan et al., Gen. Bio. 2011
MSN2	UP00565	zf-C2H2	Saccharomyces cerevisiae	Multicopy suppressor of SNF1 mutation: Stress-responsive transcriptional activator; activated in stress conditions, which results in translocation from cytoplasm to nucleus; transported back to cytoplasm once stress is removed; binds DNA at stress response elements of responsive genes, inducing gene expression; relative distribution to nucleus increases upon DNA replication stress; MSN2 has a paralog, MSN4, that aro	Siggers et al., Mol. Cell 2014	N/A
MSN2	UP00553	zf-C2H2	Saccharomyces cerevisiae	Multicopy suppressor of SNF1 mutation: Stress-responsive transcriptional activator; activated in stress conditions, which results in translocation from cytoplasm to nucleus; transported back to cytoplasm once stress is removed; binds DNA at stress response elements of responsive genes, inducing gene expression; relative distribution to nucleus increases upon DNA replication stress; MSN2 has a paralog, MSN4, that aro	Guo et al., GB14	N/A
MSN4	UP00569	zf-C2H2	Saccharomyces cerevisiae	Multicopy suppressor of SNF1 mutation: Stress-responsive transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; involved in diauxic shift; MSN4 has a paralog, MSN2, that arose from the whole genome duplication	Siggers et al., Mol. Cell 2014	N/A
Msx1	UP00234	Homeobox	Mus musculus	homeo box, msh-like 1	Berger et al., Cell 2008
Msx2	UP00156	Homeobox	Mus musculus	homeo box, msh-like 2	Berger et al., Cell 2008
MSX2	UP00603	Homeobox	Homo sapiens	homeobox protein MSX-2: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.	Barrera et al., Science 2016
Msx3	UP00171	Homeobox	Mus musculus	homeo box, msh-like 3	Berger et al., Cell 2008
Mtf1	UP00097	zf-C2H2	Mus musculus	metal response element binding transcription factor 1: Metal response element binding transcription factor 1	Badis et al., Science 2009
MTF2	UP01425	Mtf2_C	Homo sapiens	Metal response element binding transcription factor 2: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).	Li et al., Nature 2017
MXL-1	UP00373	bHLH	Caenorhabditis elegans	MaX-Like: mxl-1 encodes a basic helix-loop-helix protein similar to the vertebrate MAX transcriptional regulators; in vitro, MXL-1 can heterodimerize, and bind an E-box DNA sequence, with MDL-1, a C. elegans MAD-like bHLH protein; mxl-1::gfp reporter fusions are expressed in the posterior intestine and in head and tail neurons.	Grove et al., Cell 2009
MXL-3	UP00367	bHLH	Caenorhabditis elegans	MaX-Like: none available	Grove et al., Cell 2009
Myb	UP00092	SANT	Mus musculus	myeloblastosis oncogene: Mus musculus myeloblastosis oncogene (Myb)	Badis et al., Science 2009
Mybl1	UP00081	SANT	Mus musculus	myeloblastosis oncogene-like 1: myeloblastosis oncogene-like 1 (Mybl1), mRNA	Badis et al., Science 2009
Myf6	UP00036	BASIC, HLH	Mus musculus	myogenic factor 6	Badis et al., Science 2009
NAP	UP00574	NAC	Arabidopsis thaliana	NAC transcription factor protein family: Transcription factor of the NAC family involved in senescence. May function in the transition between active cell division and cell expansion.	Lindemose et al, Nucleic Acids Res. 2014
NarL	UP00544	LuxR_C_like	Burkholderia thailandensis E26	DNA-binding response regulator NarL	Nowak-Lovato et al., J Microbiol Meth 2012	N/A
Ndt80	UP00346	NDT80_PhoG	Saccharomyces cerevisiae	Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containin...	Zhu et al., Genome Res 2009
Nhp6a	UP00352	HMG_box	Saccharomyces cerevisiae	High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to ce...	Zhu et al., Genome Res 2009
Nhp6b	UP00325	HMG_box	Saccharomyces cerevisiae	High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to ce...	Zhu et al., Genome Res 2009
Nkx1-1	UP00220	Homeobox	Mus musculus	NK1 transcription factor related, locus 1 (Drosophila)	Berger et al., Cell 2008
Nkx1-2	UP00139	Homeobox	Mus musculus	NK1 transcription factor related, locus 2 (Drosophila)	Berger et al., Cell 2008
Nkx2-2	UP00231	Homeobox	Mus musculus	NK2 transcription factor related, locus 2 (Drosophila)	Berger et al., Cell 2008
Nkx2-3	UP00190	Homeobox	Mus musculus	NK2 transcription factor related, locus 3 (Drosophila)	Berger et al., Cell 2008
Nkx2-4	UP00107	Homeobox	Mus musculus	NK2 transcription factor related, locus 4 (Drosophila)	Berger et al., Cell 2008
Nkx2-5	UP00249	Homeobox	Mus musculus	NK2 transcription factor related, locus 5 (Drosophila)	Berger et al., Cell 2008
NKX2-5	UP00604	Homeobox	Homo sapiens	homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.	Barrera et al., Science 2016
NKX2-5	UP01607	Homeobox	Homo sapiens	homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.	Lai et al. 2020
Nkx2-6	UP00147	Homeobox	Mus musculus	NK2 transcription factor related, locus 6 (Drosophila)	Berger et al., Cell 2008
NKX2-8	UP00605	Homeobox	Homo sapiens	homeobox protein Nkx-2.8	Barrera et al., Science 2016
Nkx2-9	UP00119	Homeobox	Mus musculus	NK2 transcription factor related, locus 9 (Drosophila)	Berger et al., Cell 2008
Nkx3-1	UP00389	Homeobox	Mus musculus	NK-3 transcription factor, locus 1 (Drosophila): Mus musculus homeobox-containing protein Nkx-3.1 mRNA	Berger et al., Cell 2008
Nkx3-1	UP00017	Homeobox	Mus musculus	NK-3 transcription factor, locus 1 (Drosophila): Mus musculus homeobox-containing protein Nkx-3.1 mRNA	Badis et al., Science 2009
Nkx6-1	UP00200	Homeobox	Mus musculus	NK6 transcription factor related, locus 1 (Drosophila)	Berger et al., Cell 2008
Nkx6-3	UP00238	Homeobox	Mus musculus	NK6 transcription factor related, locus 3 (Drosophila)	Berger et al., Cell 2008
NOTCH1	UP00480		Homo sapiens	notch 1: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot	Del Bianco et al., PLoS ONE 2010	N/A
NOTCH2	UP00481		Homo sapiens	notch 2: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot	Del Bianco et al., PLoS ONE 2010	N/A
NOTCH3	UP00482		Homo sapiens	notch 3: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot	Del Bianco et al., PLoS ONE 2010	N/A
NOTCH4	UP00483		Homo sapiens	notch 4: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot	Del Bianco et al., PLoS ONE 2010	N/A
NR1H4	UP00606	zf-C4	Homo sapiens	bile acid receptor: This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.	Barrera et al., Science 2016
NR2E3	UP00607	zf-C4	Homo sapiens	photoreceptor-specific nuclear receptor: This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.	Barrera et al., Science 2016
Nr2f2	UP00009	ZnF_C4	Mus musculus	nuclear receptor subfamily 2, group F, member 2: Mus musculus nuclear receptor subfamily 2, group F, member 2 (Nr2f2), transcript variant 1, mRNA.	Badis et al., Science 2009
NRF1	UP01608		Homo sapiens	Nuclear respiratory factor 1: Activates the expression of the EIF2S1 gene and link the transcriptional modulation of key metabolic genes to cellular growth and development.	Lai et al. 2020
Nrg1	UP00270	zf-C2H2	Saccharomyces cerevisiae	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline p...	Zhu et al., Genome Res 2009
Nrg2	UP00462	zf-C2H2	Saccharomyces cerevisiae	Negative Regulator of Glucose-controlled genes : Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p	Gordan et al., Gen. Bio. 2011
NST2	UP00575	NAC	Arabidopsis thaliana	NAC transcription factor NST2: Transcription activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening of the anther endocethium, which is necessary for anther dehiscence. May also regulates the secondary cell wall lignification of other tissues such as tracheary elements	Lindemose et al, Nucleic Acids Res. 2014
NSY-7	UP00402	Distant similarity to homeodomain	Caenorhabditis elegans	NSY-7: Putative uncharacterized protein	Lesch et al., Genes Dev 2009
NTL6	UP00576	NAC	Arabidopsis thaliana	transcription factor NTL6: Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (PubMed:20156199, PubMed:19947982). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant	Lindemose et al, Nucleic Acids Res. 2014
NTL8	UP00577	NAC	Arabidopsis thaliana	protein NTM1-like 8: Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP), probably via metalloprotease activity. Regulates gibberellic acid-mediated salt-responsive repression of seed germination and flowering via FT, thus delaying seed germination under high salinity conditions.	Lindemose et al, Nucleic Acids Res. 2014
Oaf1	UP00298	Zn2Cys6	Saccharomyces cerevisiae	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis	Zhu et al., Genome Res 2009
Obox1	UP00216	Homeobox	Mus musculus	oocyte specific homeobox 1	Berger et al., Cell 2008
Obox2	UP00239	Homeobox	Mus musculus	oocyte specific homeobox 2	Berger et al., Cell 2008
Obox3	UP00160	Homeobox	Mus musculus	oocyte specific homeobox 3	Berger et al., Cell 2008
Obox5	UP00208	Homeobox	Mus musculus	oocyte specific homeobox 5	Berger et al., Cell 2008
Obox6	UP00109	Homeobox	Mus musculus	oocyte specific homeobox 6	Berger et al., Cell 2008
Oct-1	UP00399	POU	Homo sapiens	"POU domain, class 2, transcription factor 1": "POU domain, class 2, transcription factor 1"	Berger et al., Nat Biotech 2006
Og2x	UP00178	Homeobox	Mus musculus	OG2 homeobox gene	Berger et al., Cell 2008
OmpR	UP00543	trans_reg_C	Burkholderia thailandensis E26	DNA-binding response regulator OmpR	Nowak-Lovato et al., J Microbiol Meth 2012	N/A
Osr1	UP00027	zf-C2H2	Mus musculus	odd-skipped related 1 (Drosophila): Mus musculus HCM5520 gene, VIRTUAL TRANSCRIPT, partial sequence, genomic survey sequence	Badis et al., Science 2009
Osr2	UP00052	zf-C2H2	Mus musculus	odd-skipped related 2 (Drosophila): odd-skipped related 2 (Drosophila) (Osr2), mRNA	Badis et al., Science 2009
Otp	UP00237	Homeobox	Mus musculus	orthopedia homolog (Drosophila)	Berger et al., Cell 2008
Otx1	UP00229	Homeobox	Mus musculus	orthodenticle homolog 1 (Drosophila)	Berger et al., Cell 2008
Otx2	UP00267	Homeobox	Mus musculus	orthodenticle homolog 2 (Drosophila)	Berger et al., Cell 2008
OVOL2	UP00608	zf-C2H2	Homo sapiens	transcription factor Ovo-like 2: Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.	Barrera et al., Science 2016
PAX3	UP00609	PAX	Homo sapiens	paired box protein Pax-3: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.	Barrera et al., Science 2016
PAX3	UP01609	PAX	Homo sapiens	paired box protein Pax-3: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.	Lai et al. 2020
Pax4	UP00247	Homeobox, PAX	Mus musculus	paired box gene 4	Berger et al., Cell 2008
PAX4	UP00610	PAX	Homo sapiens	paired box protein Pax-4: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells.	Barrera et al., Science 2016
Pax6	UP00224	Homeobox, PAX	Mus musculus	paired box gene 6	Berger et al., Cell 2008
PAX6	UP00611	PAX	Homo sapiens	paired box protein Pax-6: This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.	Barrera et al., Science 2016
Pax7	UP00248	Homeobox, PAX	Mus musculus	paired box gene 7	Berger et al., Cell 2008
PAX7	UP00612	PAX	Homo sapiens	paired box protein Pax-7: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene.	Barrera et al., Science 2016
Pbf1	UP00328	Myb	Saccharomyces cerevisiae	Myb domain-containing protein YBL054W	Zhu et al., Genome Res 2009
Pbf2	UP00280	Myb	Saccharomyces cerevisiae	Protein of unknown function, involved in telomeric gene silencing and filamentation	Zhu et al., Genome Res 2009
Pbx1	UP00185	Homeobox	Mus musculus	pre B-cell leukemia transcription factor 1	Berger et al., Cell 2008
PBX4	UP00613	Homeobox	Homo sapiens	pre-B-cell leukemia transcription factor 4: This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]	Barrera et al., Science 2016
Pdr1	UP00290	Zn2Cys6	Saccharomyces cerevisiae	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance ...	Zhu et al., Genome Res 2009
Pdr3	UP00463	Zn_clus	Saccharomyces cerevisiae	Pleiotropic Drug Resistance : Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome	Gordan et al., Gen. Bio. 2011
PF07_0126	UP00430	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF10_0075	UP00443	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF11_0091	UP00431	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF11_0404	UP00432	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF11_0442	UP00433	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF13_0026	UP00434	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF13_0097	UP00435	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF13_0235	UP00436	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF13_0267	UP00437	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF14_0079	UP00438	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF14_0533	UP00439	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PF14_0633	UP00394	AP2	Plasmodium falciparum	putative Plasmodium falciparum transcription factor, single AP2 domain	De Silva et al., PNAS 2008
PFD0985w	UP00446	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PFE0840c	UP00440	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PFF0200c	UP00393	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, tandem double AP2 domain	De Silva et al., PNAS 2008
PFF0200c	UP00478	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, tandem double AP2 domain	Campbell et al., PLoS Pathog 2010
PFF0670w	UP00448	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PFL1075w	UP00441	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PFL1085w	UP00442	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
PFL1900w	UP00450	AP2	Plasmodium falciparum	transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain	Campbell et al., PLoS Pathog 2010
Phd1	UP00351	HTH APSES-type	Saccharomyces cerevisiae	Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental re..	Zhu et al., Genome Res 2009
PHF1	UP01424	Mtf2_C	Homo sapiens	PHD finger protein 1: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci. According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.	Li et al., Nature 2017
Pho2	UP00268	Homeobox	Saccharomyces cerevisiae	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction	Zhu et al., Genome Res 2009
Pho4	UP00332	HLH	Saccharomyces cerevisiae	Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability	Zhu et al., Genome Res 2009
PhoB	UP00542	trans_reg_C	Burkholderia thailandensis E26	Phosphate regulon transcriptional regulatory protein PhoB	Nowak-Lovato et al., J Microbiol Meth 2012	N/A
Phox2a	UP00221	Homeobox	Mus musculus	paired-like homeobox 2a	Berger et al., Cell 2008
Phox2b	UP00149	Homeobox	Mus musculus	paired-like homeobox 2b	Berger et al., Cell 2008
PHOX2B	UP00614	Homeobox	Homo sapiens	paired mesoderm homeobox protein 2B: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.	Barrera et al., Science 2016
Pitx1	UP00153	Homeobox	Mus musculus	paired-like homeodomain transcription factor 1	Berger et al., Cell 2008
Pitx2	UP00125	Homeobox	Mus musculus	paired-like homeodomain transcription factor 2	Berger et al., Cell 2008
PITX2	UP00615	Homeobox	Homo sapiens	pituitary homeobox 2: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]	Barrera et al., Science 2016
Pitx3	UP00265	Homeobox	Mus musculus	paired-like homeodomain transcription factor 3	Berger et al., Cell 2008
Pknox1	UP00203	Homeobox	Mus musculus	Pbx/knotted 1 homeobox	Berger et al., Cell 2008
Pknox2	UP00205	Homeobox	Mus musculus	Pbx/knotted 1 homeobox 2	Berger et al., Cell 2008
Plagl1	UP00088	zf-C2H2	Mus musculus	Pleiomorphic adenoma gene-like 1: Mus musculus similar to zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1), mRNA	Badis et al., Science 2009
PmTbr	UP00501	T-box	Patiria miniata	P. miniata Tbrain (T-box transcription factor)	Cheatle Jarvela et al., Mol Biol Evol 2014
Pou1f1	UP00158	Homeobox, POU	Mus musculus	pituitary specific transcription factor 1	Berger et al., Cell 2008
Pou2f1	UP00254	Homeobox, POU	Mus musculus	POU domain, class 2, transcription factor 1	Berger et al., Cell 2008
Pou2f2	UP00191	Homeobox, POU	Mus musculus	POU domain, class 2, transcription factor 2	Berger et al., Cell 2008
Pou2f3	UP00179	Homeobox, POU	Mus musculus	POU domain, class 2, transcription factor 3	Berger et al., Cell 2008
Pou3f1	UP00129	Homeobox, POU	Mus musculus	POU domain, class 3, transcription factor 1	Berger et al., Cell 2008
Pou3f2	UP00128	Homeobox, POU	Mus musculus	POU domain, class 3, transcription factor 2	Berger et al., Cell 2008
Pou3f3	UP00211	Homeobox, POU	Mus musculus	POU domain, class 3, transcription factor 3	Berger et al., Cell 2008
Pou3f4	UP00105	Homeobox, POU	Mus musculus	POU domain, class 3, transcription factor 4	Berger et al., Cell 2008
POU3F4	UP00616	POU	Homo sapiens	POU domain, class 3, transcription factor 4: This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]	Barrera et al., Science 2016
Pou4f3	UP00118	Homeobox, POU	Mus musculus	POU domain, class 4, transcription factor 3	Berger et al., Cell 2008
POU4F3	UP00617	POU	Homo sapiens	POU domain, class 4, transcription factor 3: This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009]	Barrera et al., Science 2016
POU5F1	UP01610	Homeobox	Homo sapiens	POU domain, class 5, transcription factor 1: Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development.	Lai et al. 2020
Pou6f1	UP00146	Homeobox, POU	Mus musculus	POU domain, class 6, transcription factor 1	Berger et al., Cell 2008
POU6F2	UP00618	POU	Homo sapiens	POU domain, class 6, transcription factor 2: This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]	Barrera et al., Science 2016
Prop1	UP00172	Homeobox	Mus musculus	paired like homeodomain factor 1	Berger et al., Cell 2008
PROP1	UP00619	Homeobox	Homo sapiens	homeobox protein prophet of Pit-1: This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011]	Barrera et al., Science 2016
Prrx1	UP00266	Homeobox	Mus musculus	paired related homeobox 1	Berger et al., Cell 2008
Prrx2	UP00136	Homeobox	Mus musculus	paired related homeobox 2	Berger et al., Cell 2008
Ptx1	UP00508	Homeobox	Drosophila melanogaster	Paired-type homeobox 1	Busser et al., Development 2012
Put3	UP00335	Zn2Cys6	Saccharomyces cerevisiae	"Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binu..."	Zhu et al., Genome Res 2009
Rap1	UP00321	Myb	Saccharomyces cerevisiae	"DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (sil..."	Zhu et al., Genome Res 2009
Rap1	UP00398	Myb	Saccharomyces cerevisiae	"DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (sil..."	Berger et al., Nat Biotech 2006
Rara	UP00048	ZnF_C4	Mus musculus	retinoic acid receptor, alpha	Badis et al., Science 2009
Rax	UP00253	Homeobox	Mus musculus	retina and anterior neural fold homeobox	Berger et al., Cell 2008
Rdr1	UP00269	Zn2Cys6	Saccharomyces cerevisiae	Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins	Zhu et al., Genome Res 2009
Rds1	UP00296	Zn2Cys6	Saccharomyces cerevisiae	Zinc cluster protein involved in conferring resistance to cycloheximide	Zhu et al., Genome Res 2009
Rds2	UP00302	Zn2Cys6	Saccharomyces cerevisiae	Zinc cluster protein involved in conferring resistance to ketoconazole	Zhu et al., Genome Res 2009
REF-1	UP00383	bHLH	Caenorhabditis elegans	REgulator of Fusion: ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1 is a target of MAB-3 transcriptional repression which in turn, promotes expression of LIN-32, a proneural bHLH transcription factor.	Grove et al., Cell 2009
Rfx3	UP00098	RFX	Mus musculus	regulatory factor X, 3 (influences HLA class II expression)	Badis et al., Science 2009
Rfx4	UP00056	RFX	Mus musculus	regulatory factor X, 4 (influences HLA class II expression)	Badis et al., Science 2009
Rfxdc2	UP00076	RFX	Mus musculus	regulatory factor X domain containing 2 homolog (human): AK138890	Badis et al., Science 2009
RGM1	UP00568	zf-C2H2	Saccharomyces cerevisiae	Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y' telomeric elements and subtelomeric COS genes; relocalizes to the cytosol in response	Siggers et al., Mol. Cell 2014	N/A
Rgt1	UP00288	Zn2Cys6	Saccharomyces cerevisiae	Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator ...	Zhu et al., Genome Res 2009
Rhox11	UP00193	Homeobox	Mus musculus	reproductive homeobox 11	Berger et al., Cell 2008
Rhox6	UP00116	Homeobox	Mus musculus	reproductive homeobox 6	Berger et al., Cell 2008
RisA	UP00545	trans_reg_C	Burkholderia thailandensis E26	DNA-binding response regulator RisA	Nowak-Lovato et al., J Microbiol Meth 2012	N/A
Rph1	UP00348	zf-C2H2	Saccharomyces cerevisiae	Transcriptional repressor of PHR1, which is a photolyase induced by DNA damage; binds to AG(4) (C(4)T) sequence upstream of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC...	Zhu et al., Genome Res 2009
Rpn4	UP00272	zf-C2H2	Saccharomyces cerevisiae	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally reg...	Zhu et al., Genome Res 2009
Rsc3	UP00286	Zn2Cys6	Saccharomyces cerevisiae	One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to	Zhu et al., Genome Res 2009
Rsc30	UP00279	Zn2Cys6	Saccharomyces cerevisiae	One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar...	Zhu et al., Genome Res 2009
Rtg3	UP00356	HLH	Saccharomyces cerevisiae	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways	Zhu et al., Genome Res 2009
RUNX2	UP01611	Runt	Homo sapiens	Runt-related transcription factor 2: It is involved in osteoblastic differentiation and skeletal morphogenesis.	Lai et al. 2020
Rxra	UP00053	ZnF_C4	Mus musculus	retinoid X receptor alpha: retinoid X receptor alpha (Rxra), mRNA	Badis et al., Science 2009
Sfl1	UP00320	HSF_DNA-bind	Saccharomyces cerevisiae	Transcription repressor involved in regulation of flocculation-related genes, inhibits transcription by recruiting general corepressor Cyc8p-Tup1p to different promoters; negatively regulated by cA...	Zhu et al., Genome Res 2009
Sfp1	UP00342	zf-C2H2	Saccharomyces cerevisiae	Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, in...	Zhu et al., Genome Res 2009
Sfpi1	UP00085	ETS	Mus musculus	SFFV proviral integration 1: Mus musculus SFFV proviral integration 1 (Sfpi1), mRNA	Badis et al., Science 2009
Sfpi1	UP00405	ETS	Mus musculus	SFFV proviral integration 1: Mus musculus SFFV proviral integration 1 (Sfpi1), mRNA	Wei et al., EMBO J 2010
Shox2	UP00257	Homeobox	Mus musculus	short stature homeobox 2	Berger et al., Cell 2008
Sip4	UP00273	Zn2Cys6	Saccharomyces cerevisiae	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1...	Zhu et al., Genome Res 2009
Six1	UP00192	Homeobox	Mus musculus	sine oculis-related homeobox 1 homolog (Drosophila)	Berger et al., Cell 2008
Six2	UP00159	Homeobox	Mus musculus	sine oculis-related homeobox 2 homolog (Drosophila)	Berger et al., Cell 2008
Six3	UP00195	Homeobox	Mus musculus	sine oculis-related homeobox 3 homolog (Drosophila): Mus musculus sine oculis-related homeobox 3 homolog (Drosophila) (Six3), mRNA.	Berger et al., Cell 2008
Six4	UP00199	Homeobox	Mus musculus	sine oculis-related homeobox 4 homolog (Drosophila)	Berger et al., Cell 2008
Six4	UP00509	Homeobox	Drosophila melanogaster	Six4	Busser et al., Development 2012
Six6	UP00388	Homeobox	Mus musculus	sine oculis-related homeobox 6 homolog (Drosophila)	Berger et al., Cell 2008
Six6	UP00008	Homeobox	Mus musculus	sine oculis-related homeobox 6 homolog (Drosophila)	Badis et al., Science 2009
SIX6	UP00620	Homeobox	Homo sapiens	homeobox protein SIX6: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]	Barrera et al., Science 2016
Skn7	UP00313	HSF_DNA-bind	Saccharomyces cerevisiae	Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress;	Zhu et al., Genome Res 2009
Sko1	UP00464	bZIP_1	Saccharomyces cerevisiae	Suppressor of Kinase Overexpression : Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses	Gordan et al., Gen. Bio. 2011
Slou	UP00510	Homeobox	Drosophila melanogaster	Slouch: Slou may play a role in specifying the identity of particular somatic muscles and neurons of the CNS.	Busser et al., Development 2012
Smad3	UP00000	DWA	Mus musculus	MAD homolog 3 (Drosophila)	Badis et al., Science 2009
Smp1	UP00294	MADS	Saccharomyces cerevisiae	Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors	Zhu et al., Genome Res 2009
SNAI2	UP00621	zf-C2H2	Homo sapiens	zinc finger protein SNAI2: Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.	Barrera et al., Science 2016
SND1	UP00578	NAC	Arabidopsis thaliana	NAC Domain transcription factor SND1: Transcriptional activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening and lignification of sclerenchymatous fibers and secondary xylem vessels (tracheary elements). Seems to repress the secondary cell wall thickening of xylary fibers. May also regulates the secondary cell wall lignification of other t	Lindemose et al, Nucleic Acids Res. 2014
Sox1	UP00069	HMG_box	Mus musculus	SRY-box containing gene 1	Badis et al., Science 2009
Sox11	UP00030	HMG_box	Mus musculus	SRY-box containing gene 11	Badis et al., Science 2009
Sox12	UP00101	HMG_box	Mus musculus	SRY-box containing gene 12	Badis et al., Science 2009
Sox13	UP00096	HMG_box	Mus musculus	SRY-box containing gene 13: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, mRNA (cDNA clone MGC:35934 IMAGE:3672913), complete cds	Badis et al., Science 2009
Sox14	UP00004	HMG_box	Mus musculus	SRY-box containing gene 14: Mus musculus SRY-box containing gene 14, mRNA	Badis et al., Science 2009
Sox15	UP00075	HMG_box	Mus musculus	SRY-box containing gene 15	Badis et al., Science 2009
Sox17	UP00014	HMG_box	Mus musculus	SRY-box containing gene 17	Badis et al., Science 2009
Sox18	UP00064	HMG_box	Mus musculus	SRY-box containing gene 18	Badis et al., Science 2009
SOX2	UP01612	HMG BOX	Homo sapiens	Transcription factor SOX-2: Forms a trimeric complex with OCT4 and controls expression of genes in embryonic development. It is critical for early embryogenesis and for embryonic stem cell pluripotency.	Lai et al. 2020
Sox21	UP00071	HMG_box	Mus musculus	SRY-box containing gene 21	Badis et al., Science 2009
Sox30	UP00023	HMG_box	Mus musculus	SRY-box containing gene 30: Mus musculus SRY-box containing gene 30 (Sox30)	Badis et al., Science 2009
Sox4	UP00062	HMG_box	Mus musculus	SRY-box containing gene 4: Mus musculus BAC Clone 262c6 RPCI-23, complete sequence	Badis et al., Science 2009	N/A
Sox4	UP00401	HMG_box	Homo sapiens	SRY (sex determining region Y)-box 4 : This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function	Scharer et al., Cancer Res 2009	N/A
Sox5	UP00091	HMG_box	Mus musculus	SRY-box containing gene 5	Badis et al., Science 2009
Sox7	UP00034	HMG_box	Mus musculus	SRY-box containing gene 7	Badis et al., Science 2009
Sox8	UP00051	HMG_box	Mus musculus	SRY-box containing gene 8: SRY-box containing gene 8, mRNA (cDNA clone MGC:78314 IMAGE:6306276), complete cds	Badis et al., Science 2009
Sp100	UP00049	SAND	Mus musculus	nuclear antigen Sp100: PREDICTED: Mus musculus nuclear antigen Sp100 (Sp100)	Badis et al., Science 2009
Sp4	UP00002	zf-C2H2	Mus musculus	trans-acting transcription factor 4: Mus musculus similar to trans-acting transcription factor 4 (LOC211769), mRNA	Badis et al., Science 2009
Spdef	UP00038	ETS	Mus musculus	SAM pointed domain containing ets transcription factor: Mus musculus prostate specific ets transcription factor (Pse-pending), mRNA	Badis et al., Science 2009
Spdef	UP00406	ETS	Mus musculus	SAM pointed domain containing ets transcription factor: Mus musculus prostate specific ets transcription factor (Pse-pending), mRNA	Wei et al., EMBO J 2010
Spic	UP00419	ETS	Mus musculus	Spi-C transcription factor (Spi-1/PU.1 related): transcription factor Spi-C	Wei et al., EMBO J 2010
Spt15	UP00337	TBP	Saccharomyces cerevisiae	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability	Zhu et al., Genome Res 2009
SpTbr	UP00502	T-box	Strongylocentrotus purpuratus	S. purpuratus Tbrain (T-box transcription factor)	Cheatle Jarvela et al., Mol Biol Evol 2014
Srd1	UP00304	GATA	Saccharomyces cerevisiae	Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation	Zhu et al., Genome Res 2009
Srf	UP00077	MADS	Mus musculus	serum response factor	Badis et al., Science 2009
Sry	UP00016	HMG_box	Mus musculus	sex determining region of Chr Y	Badis et al., Science 2009
Stb3	UP00275	Stb3	Saccharomyces cerevisiae	Protein that binds Sin3p in a two-hybrid assay	Zhu et al., Genome Res 2009
Stb4	UP00465	Zn_clus	Saccharomyces cerevisiae	Sin Three Binding protein : Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay	Gordan et al., Gen. Bio. 2011
Stb5	UP00466	Zn_clus	Saccharomyces cerevisiae	Sin Three Binding protein : Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro	Gordan et al., Gen. Bio. 2011
Ste12	UP00467	STE	Saccharomyces cerevisiae	STErile: Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth	Gordan et al., Gen. Bio. 2011
Stp1	UP00468	zf-C2H2	Saccharomyces cerevisiae	Species-specific tRNA Processing : Transcription factor, undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing	Gordan et al., Gen. Bio. 2011
Stp2	UP00338	zf-C2H2	Saccharomyces cerevisiae	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes	Zhu et al., Genome Res 2009
Stp4	UP00354	zf-C2H2	Saccharomyces cerevisiae	Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p	Zhu et al., Genome Res 2009
Sum1	UP00341	AT_hook	Saccharomyces cerevisiae	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint	Zhu et al., Genome Res 2009
Sut1	UP00469	Zn_clus	Saccharomyces cerevisiae	Sterol UpTake : Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression	Gordan et al., Gen. Bio. 2011
Sut2	UP00297	Zn2Cys6	Saccharomyces cerevisiae	Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p	Zhu et al., Genome Res 2009
Tbf1	UP00299	Myb	Saccharomyces cerevisiae	Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by...	Zhu et al., Genome Res 2009
TBP	UP00029	TBP	Homo sapiens	TATA-box-binding protein: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.	Badis et al., Science 2009
Tbs1	UP00306	Zn2Cys6	Saccharomyces cerevisiae	Probable Zn-finger protein	Zhu et al., Genome Res 2009
Tcf1	UP00390	Homeobox	Mus musculus	transcription factor 1: Mus musculus transcription factor 1 (Tcf1), mRNA.	Berger et al., Cell 2008
Tcf1	UP00089	Homeobox	Mus musculus	transcription factor 1: Mus musculus transcription factor 1 (Tcf1), mRNA.	Badis et al., Science 2009
Tcf2	UP00222	Homeobox	Mus musculus	transcription factor 2: TCF2 gene, VIRTUAL TRANSCRIPT, partial sequence, genomic survey sequence	Berger et al., Cell 2008
Tcf3	UP00058	HMG_box	Mus musculus	transcription factor 3	Badis et al., Science 2009
Tcf7	UP00054	HMG_box	Mus musculus	Transcription factor 7, T-cell specific	Badis et al., Science 2009
Tcf7l2	UP00083	HMG_box	Mus musculus	transcription factor 7-like 2, T-cell specific, HMG-box	Badis et al., Science 2009
Tcfap2a	UP00005	AP-2	Mus musculus	transcription factor AP-2, alpha: Mus musculus transcription factor AP-2, alpha, mRNA	Badis et al., Science 2009
Tcfap2b	UP00010	AP-2	Mus musculus	transcription factor AP-2 beta	Badis et al., Science 2009
Tcfap2c	UP00087	AP-2	Mus musculus	transcription factor AP-2, gamma: Mus musculus transcription factor AP-2, gamma, mRNA (cDNA clone MGC:5992 IMAGE:3592762), complete cds	Badis et al., Science 2009
Tcfap2e	UP00028	AP-2	Mus musculus	transcription factor AP-2, epsilon	Badis et al., Science 2009
Tcfe2a	UP00046	HLH	Mus musculus	transcription factor E2a	Badis et al., Science 2009
Tea1	UP00333	Zn2Cys6	Saccharomyces cerevisiae	Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein	Zhu et al., Genome Res 2009
Tec1	UP00340	TEA	Saccharomyces cerevisiae	Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member	Zhu et al., Genome Res 2009
Tgif1	UP00122	Homeobox	Mus musculus	TGFB-induced factor 2	Berger et al., Cell 2008
Tgif2	UP00258	Homeobox	Mus musculus	TGFB-induced factor 2	Berger et al., Cell 2008
TGME49_306620	UP00583	AP2	Toxoplasma gondii	TGME49_306620 AP2IX-9: AP2 domain transcription factor AP2IX-9. Domain 1 of 1. Amino acids 862-914.	Radke et al., PNAS 2013
Tin	UP00511	Homeobox	Drosophila melanogaster	Tinman: Tinman is required for the development of heart and visceral muscle and for the formation of somatic muscles and has crucial function in the early mesodermal subdivisions.	Busser et al., Development 2012
Titf1	UP00165	Homeobox	Mus musculus	thyroid transcription factor 1	Berger et al., Cell 2008
Tlx2	UP00244	Homeobox	Mus musculus	T-cell leukemia, homeobox 2	Berger et al., Cell 2008
Tye7	UP00324	HLH	Saccharomyces cerevisiae	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator	Zhu et al., Genome Res 2009
Ubx	UP00512	Homeobox	Drosophila melanogaster	Ultrabithorax: Ubx is a sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor.	Busser et al., Development 2012
Ume6	UP00334	Zn2Cys6	Saccharomyces cerevisiae	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms comp...	Zhu et al., Genome Res 2009
unc-130	UP01563	Forkhead	Caenorhabditis elegans	Fork-head domain-containing protein:	Mizeracka et al. 2019
Uncx4.1	UP00142	Homeobox	Mus musculus	Unc4.1 homeobox (C. elegans)	Berger et al., Cell 2008
Upc2	UP00470	Zn_clus	Saccharomyces cerevisiae	UPtake Control : Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion	Gordan et al., Gen. Bio. 2011
USF1	UP01613	bHLH	Homo sapiens	Upstream stimulatory factor 1: Binds symmetrical DNA sequence(E-boxes) (5\'-CACGTG-3\') that is in viral and cellular promoters.	Lai et al. 2020
Usv1	UP00343	zf-C2H2	Saccharomyces cerevisiae	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis	Zhu et al., Genome Res 2009
USV1	UP00566	zf-C2H2	Saccharomyces cerevisiae	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis	Siggers et al., Mol. Cell 2014	N/A
USV1	UP00554	zf-C2H2	Saccharomyces cerevisiae	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis	Guo et al., GB14	N/A
Vax1	UP00215	Homeobox	Mus musculus	ventral anterior homeobox containing gene 1	Berger et al., Cell 2008
Vax2	UP00106	Homeobox	Mus musculus	ventral anterior homeobox containing gene 2	Berger et al., Cell 2008
VAX2	UP00623	Homeobox	Homo sapiens	ventral anterior homeobox 2: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.	Barrera et al., Science 2016
VENTX	UP00624	Homeobox	Homo sapiens	homeobox protein VENTX: This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]	Barrera et al., Science 2016
VENTX	UP01614	Homeobox	Homo sapiens	homeobox protein VENTX: This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008]	Lai et al. 2020
Vhr1	UP00471	Vhr1	Saccharomyces cerevisiae	VHt1 Regulator : Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations	Gordan et al., Gen. Bio. 2011
Vhr2	UP00472	Vhr1	Saccharomyces cerevisiae	VHt1 Regulator : Non-essential nuclear protein; null mutation has global effects on transcription	Gordan et al., Gen. Bio. 2011
VND3	UP00579	NAC	Arabidopsis thaliana	NAC domain containing protein: Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, ge	Lindemose et al, Nucleic Acids Res. 2014
VND7	UP00580	NAC	Arabidopsis thaliana	vascular related NAC-domain protein 7: Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating pro	Lindemose et al, Nucleic Acids Res. 2014
VOZ2	UP00581	NAC	Arabidopsis thaliana	vascular plant one zinc finger protein 2: Transcriptional activator acting positively in the phytochrome B signaling pathway. Functions redundantly with VOZ1 to promote flowering downstream of phytochrome B (phyB). Down-regulates 'FLOWERING LOCUS C' (FLC) and up-regulates 'FLOWERING LOCUS T' (FT). Binds to the 38-bp cis-acting region of the AVP1 gene. Binds as a dimer to the palindromic sequence 5'-GCGTNNNNNNNACGC	Lindemose et al, Nucleic Acids Res. 2014
Vsx1	UP00141	Homeobox	Mus musculus	visual system homeobox 1 homolog (zebrafish)	Berger et al., Cell 2008
VSX1	UP00625	Homeobox	Homo sapiens	visual system homeobox 1: The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]	Barrera et al., Science 2016
VSX2	UP00626	Homeobox	Homo sapiens	visual system homeobox 2: This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).	Barrera et al., Science 2016
WRKY1	UP00582	WRKY	Arabidopsis thaliana	WRKY transcription factor 1: Transcription factor. Binds to a 5'-CGTTGACCGAG-3' consensus core sequence which contains a W box, a frequently occurring elicitor-responsive cis-acting element.	Lindemose et al, Nucleic Acids Res. 2014
WT1	UP00627	zf-C2H2	Homo sapiens	Wilms tumor protein: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]	Barrera et al., Science 2016
Xbp1	UP00330	HTH APSES-type	Saccharomyces cerevisiae	Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4...	Zhu et al., Genome Res 2009
Yap1	UP00327	bZIP	Saccharomyces cerevisiae	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxi...	Zhu et al., Genome Res 2009
Yap3	UP00473	bZIP_1	Saccharomyces cerevisiae	Yeast AP-1: Basic leucine zipper (bZIP) transcription factor	Gordan et al., Gen. Bio. 2011
Yap6	UP00316	bZIP	Saccharomyces cerevisiae	Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance	Zhu et al., Genome Res 2009
Ybr033w	UP00474	Zn_clus	Saccharomyces cerevisiae	Expression Dependent on Slt2 : Putative zinc cluster protein, predicted to be a transcription factor; YBR033W is not an essential gene	Gordan et al., Gen. Bio. 2011
Ybr239c	UP00331	Zn2Cys6	Saccharomyces cerevisiae	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene	Zhu et al., Genome Res 2009
Ydr520c	UP00323	Zn2Cys6	Saccharomyces cerevisiae	Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine	Zhu et al., Genome Res 2009
Yer130c	UP00284	zf-C2H2	Saccharomyces cerevisiae	Hypothetical protein	Zhu et al., Genome Res 2009
Yer184c	UP00475	Zn_clus	Saccharomyces cerevisiae	Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source	Gordan et al., Gen. Bio. 2011
Ygr067c	UP00293	zf-C2H2	Saccharomyces cerevisiae	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p	Zhu et al., Genome Res 2009
Ykl222c	UP00281	Zn2Cys6	Saccharomyces cerevisiae	Putative protein of unknown function; similar to transcriptional regulators from the zinc cluster (binuclear cluster) protein family; null mutant is sensitive to caffeine	Zhu et al., Genome Res 2009
Yll054c	UP00283	Zn2Cys6	Saccharomyces cerevisiae	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene	Zhu et al., Genome Res 2009
Ylr278c	UP00476	Zn_clus	Saccharomyces cerevisiae	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene	Gordan et al., Gen. Bio. 2011
Yml081w	UP00289	zf-C2H2	Saccharomyces cerevisiae	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene	Zhu et al., Genome Res 2009
Ynr063w	UP00292	Zn2Cys6	Saccharomyces cerevisiae	Putative zinc-cluster protein of unknown function	Zhu et al., Genome Res 2009
Yox1	UP00274	Homeobox	Saccharomyces cerevisiae	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycl...	Zhu et al., Genome Res 2009
Ypr013c	UP00311	zf-C2H2	Saccharomyces cerevisiae	Putative zinc finger protein; YPR013C is not an essential gene	Zhu et al., Genome Res 2009
Ypr015c	UP00276	zf-C2H2	Saccharomyces cerevisiae	Hypothetical protein	Zhu et al., Genome Res 2009
Ypr196w	UP00314	Zn2Cys6	Saccharomyces cerevisiae	nuclear protein (putative)	Zhu et al., Genome Res 2009
Yrm1	UP00295	Zn2Cys6	Saccharomyces cerevisiae	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes	Zhu et al., Genome Res 2009
Yrr1	UP00310	Zn2Cys6	Saccharomyces cerevisiae	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes	Zhu et al., Genome Res 2009
YY1	UP01615	C2H2 znf	Homo sapiens	Transcriptional repressor protein YY1: Plays a role in embryogenesis differentiation, replication, and cellular proliferation. It can direct and indirect activation or repressin by cofactor recruitment.	Lai et al. 2020
Zap1	UP00477	zf-C2H2	Saccharomyces cerevisiae	Zinc-responsive Activator Protein : Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains	Gordan et al., Gen. Bio. 2011
Zbtb12	UP00019	zf-C2H2	Mus musculus	zinc finger and BTB domain containing 12: Mus musculus zinc finger and BTB domain containing 12	Badis et al., Science 2009
Zbtb3	UP00031	zf-C2H2	Mus musculus	zinc finger and BTB domain containing 3: Mus musculus RIKEN cDNA 4930563M09 gene (4930563M09Rik), mRNA	Badis et al., Science 2009
Zbtb7b	UP00047	zf-C2H2	Mus musculus	Vzinc finger and BTB domain containing 7B: Mus musculus hypothetical gene supported by NM_009565	Badis et al., Science 2009
Zfp105	UP00037	zf-C2H2	Mus musculus	zinc finger protein 105: Mus musculus zinc finger protein 105 (Zfp105)	Badis et al., Science 2009
Zfp128	UP00094	zf-C2H2	Mus musculus	zinc finger protein 128: Zinc finger protein 128 [Mus musculus]	Badis et al., Science 2009
Zfp161	UP00065	zf-C2H2	Mus musculus	zinc finger protein 161: Mus musculus zinc finger protein 161	Badis et al., Science 2009
Zfp187	UP00082	zf-C2H2	Mus musculus	zinc finger protein 187: Mus musculus zinc finger protein 187	Badis et al., Science 2009
Zfp281	UP00021	zf-C2H2	Mus musculus	Zinc finger protein 281: Mus musculus zinc finger protein 281, mRNA	Badis et al., Science 2009
Zfp410	UP00033	zf-C2H2	Mus musculus	zinc finger protein 410: Mus musculus HCM3688 gene, VIRTUAL TRANSCRIPT, partial sequence, genomic survey sequence	Badis et al., Science 2009
Zfp691	UP00095	zf-C2H2	Mus musculus	Zinc finger protein 691: Mus musculus similar to hypothetical protein LOC51058 (LOC242652), mRNA	Badis et al., Science 2009
Zfp740	UP00022	zf-C2H2	Mus musculus	Zinc finger protein 740	Badis et al., Science 2009
Zic1	UP00102	zf-C2H2	Mus musculus	Zinc finger protein of the cerebellum 1: Mus musculus similar to zic protein member 1 (Zic1), mRNA	Badis et al., Science 2009
Zic2	UP00057	zf-C2H2	Mus musculus	Zic finger protein of the cerebellum 2: Mus musculus Zic finger protein of the cerebellum 2 (Zic2)	Badis et al., Science 2009
Zic3	UP00006	zf-C2H2	Mus musculus	zinc finger protein of the cerebellum 3: Mus musculus zinc finger protein of the cerebellum 3, mRNA (cDNA clone IMAGE:30112694), partial cds	Badis et al., Science 2009
Zif268	UP00400	zf-C2H2	Mus musculus	Transcription factor Zif268	Berger et al., Nat Biotech 2006
ZNF143	UP01616	C2H2 znf	Homo sapiens	Zinc finger protein 143: Activates the gene for selenocysteine tRNA and binds to the SPH motif of small nuclear RNA gene promoters.	Lai et al. 2020
ZNF200	UP00629	zf-C2H2	Homo sapiens	zinc finger protein 200: Could have a role in spermatogenesis.	Barrera et al., Science 2016
ZNF200	UP01669	zf-C2H2	Homo sapiens	zinc finger protein 200: Could have a role in spermatogenesis.	Lai et al. 2020	N/A
ZNF655	UP00630	zf-C2H2	Homo sapiens	zinc finger protein 655: This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]	Barrera et al., Science 2016
Zscan4	UP00026	zf-C2H2	Mus musculus	zinc finger and SCAN domain containing 4: Mus musculus BAC clone RP23-35L23 from chromosome 7, complete sequence.	Badis et al., Science 2009

Number of matches: 623

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