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| -Genomic Data for HLH-29 |
Links |
- Gene
- hlh-29
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- Species
- $species
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- Domain
- bHLH
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- IHOP
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49873
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- Swiss-Prot
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Q19917
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- UniPROBE Accession Number
- $accession_id
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- Synonyms
- None Available
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- $refseq_designator
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NP_510837
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- Wormbase Protein ID
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WP:CE07161
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- EdgeDB Promoter
- Phlh-29
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- Wormbase Gene ID
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WBGene00001968
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- Description (from Wormbase)
- hlh-29 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-26, and HLH-27) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-27, and perhaps HLH-28); HLH-29 is identical to residues 24-262 of HLH-28, shares near-identical promoter regions in a inverted duplex, and is likely to be highly redundant with HLH-28; HLH-29 (with HLH-28) is also required for late embryonic viability, and for normal fat metabolism, yolk protein transport, gonadal and vulval development, bordering behavior, and chemosensory responses, and repression of tax-4 and osm-9 transcription; lag-2 repression by HLH-29 may require UNC-37; HLH-29's paralogs include HLH-25 through HLH-28 and (more distantly) REF-1; hlh-29 is transcribed in the early MS and E lineages, probably due to MED-1/2 binding of clustered sites in the hlh-28/hlh-29 shared promoter region; HLH-29 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-29 is also expressed in all EMS granddaughters beginning at the 24-cell stage, in a SKN-1-dependent manner; furthermore, HLH-29 is expressed in amphid and phasmid neurons, ALA and PVT neurons, chemosensory and mechanosensory neurons, ASI, ASK, PHA, PQR, and neurons of the anterior pharynx, as well as in vulva, somatic gonad, rectal glands, intestine, and larval pharyngeal muscle PM1, ventral posterior coelomocytes, spermatheca, and vulval muscles; hlh-28/29 mRNA is present throughout development, but varies roughly 30-fold in quantity, with 3.5-fold more mRNA in L1 larvae than in adults; ectopic HLH-29 can rescue the intestinal defect of ref-1(RNAi) embryos; hlh-28/29 transcription is inhibited by LIN-12 and MED-1.
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| -PBM Motif Data for HLH-29 |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
<dd><a href="./downloads/Cell09/HLH-29/HLH-29.pwm">View</a>   <a href="downfile.php?id=368&gene=HLH-29&folder=Cell09&RC=0">Save</a></dd>
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- Top Kmer
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ACGCGTGG E.S. 0.490
CCACGCGT E.S. 0.490
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- Downloads
-
Download the
zip
of all HLH-29 PBM files
or view the
downloads directory
for individual files.
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| -HLH-29 Datasets |
| Gene |
Homodimerizes |
Clone Type |
Last Modified |
Save |
View |
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hlh-29
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Yes |
Full length clone |
2016-03-24 |
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- HLH-29 Insert Sequence
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1 PKVHQATFPK ASVHSVPYNQ TRKSVSERKR RDEINELLEN LKTIVQNPSD
51 SNEKISHETI LFRVFERVSG VDLETKFNST VDIPKAEGNT KEEKQKVKTK
101 REQIRRSKQD ICYTELGNFV HKNRLGNTEQ RNKLERVTVL QIILEYICQM
151 PEQSEAIEKE NSPMYQVYLE PTKCISPEQS VASPSPFLLS NTLAFFNQVA
201 QLHFIAKLQA MLPPTPVQTP EAHMKEQTNE EEDIDIIG
- Mutations away from WormBase HLH-29 wildtype:
- • Methioinine start not included in insert sequence
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