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| -Genomic Data for REF-1 |
Links |
- Gene
- ref-1
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- Species
- $species
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- Domain
- bHLH
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- IHOP
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39863
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- Swiss-Prot
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Q22069
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- UniPROBE Accession Number
- $accession_id
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- Synonyms
- hlh-24
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- $refseq_designator
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NP_496204
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- Wormbase Protein ID
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WP:CE02306
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- EdgeDB Promoter
- Pref-1
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- Wormbase Gene ID
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WBGene00004334
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- Description (from Wormbase)
- ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1 is a target of MAB-3 transcriptional repression which in turn, promotes expression of LIN-32, a proneural bHLH transcription factor.
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| -PBM Motif Data for REF-1 |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
<dd><a href="./downloads/Cell09/REF-1/REF-1.pwm">View</a>   <a href="downfile.php?id=383&gene=REF-1&folder=Cell09&RC=0">Save</a></dd>
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- Top Kmer
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A..GCACGTG E.S. 0.472
CACGTGC..T E.S. 0.472
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- Downloads
-
Download the
zip
of all REF-1 PBM files
or view the
downloads directory
for individual files.
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| -REF-1 Datasets |
| Gene |
Homodimerizes |
Clone Type |
Last Modified |
Save |
View |
|
ref-1
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Yes |
Full length clone |
2016-03-24 |
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- REF-1 Insert Sequence
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1 VLISTPPPAY AHNRKTSQEK KRRDEINAKI KELQLLIQNE SDNEKMTQGD
51 VLNRAVEVVS RMETESPGPS SNPNRKGFFD GFRSIESLTY SFIKSLGVNS
101 DVCQDFVQRA KQFFDRERSS LLSTVSGKSK RRSESEILHS SMSYRSQSSS
151 PSTSESGITI DRKEVKKNRE QDRRDRQGEA FDALKNFIIE NKLMTSHQVE
201 KMQRLNTLDI IIAYIQNKKH NFVSRSDQEQ SLYAHAIAEG KKTAKNIAFQ
251 FFKGDRHLVV RCADLEKFFE FSLSPKPLFG FPSMPIPIPP PSFPIFPFRP
301 FPFFPMPMAP MATSPKSQQS PSYSLDSPPP SSDTSSSSIE TPSTPNENSN
351 SNPKASRKSK LFRPWE
- Mutations away from WormBase REF-1 wildtype:
- • Methioinine start not included in insert sequence
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