-Genomic Data for REF-1 Links
Gene
ref-1
Species
$species
Domain
bHLH
UniPROBE Accession Number
$accession_id
Synonyms
hlh-24
Description (from Wormbase)
ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1 is a target of MAB-3 transcriptional repression which in turn, promotes expression of LIN-32, a proneural bHLH transcription factor.
-PBM Motif Data for REF-1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
<dd><a href="./downloads/Cell09/REF-1/REF-1.pwm">View</a> &nbsp;&nbsp;&nbsp&nbsp;&nbsp;<a href="downfile.php?id=383&gene=REF-1&folder=Cell09&RC=0">Save</a></dd>
Top Kmer
A..GCACGTG E.S. 0.472
CACGTGC..T E.S. 0.472
Downloads
Download the zip of all REF-1 PBM files or view the downloads directory for individual files.
-REF-1 Datasets
Gene Homodimerizes Clone Type Last Modified Save View
ref-1 Yes Full length clone 2016-03-24 search save
REF-1 Insert Sequence
1    VLISTPPPAY AHNRKTSQEK KRRDEINAKI KELQLLIQNE SDNEKMTQGD
51   VLNRAVEVVS RMETESPGPS SNPNRKGFFD GFRSIESLTY SFIKSLGVNS
101  DVCQDFVQRA KQFFDRERSS LLSTVSGKSK RRSESEILHS SMSYRSQSSS
151  PSTSESGITI DRKEVKKNRE QDRRDRQGEA FDALKNFIIE NKLMTSHQVE
201  KMQRLNTLDI IIAYIQNKKH NFVSRSDQEQ SLYAHAIAEG KKTAKNIAFQ
251  FFKGDRHLVV RCADLEKFFE FSLSPKPLFG FPSMPIPIPP PSFPIFPFRP
301  FPFFPMPMAP MATSPKSQQS PSYSLDSPPP SSDTSSSSIE TPSTPNENSN
351  SNPKASRKSK LFRPWE


Mutations away from WormBase REF-1 wildtype:
• Methioinine start not included in insert sequence

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