|
|
| -Genomic Data for HLH-25 |
Links |
- Gene
- hlh-25
|
- Species
- $species
|
- Domain
- bHLH
|
- IHOP
-
47524
|
- Swiss-Prot
-
Q18054
|
- UniPROBE Accession Number
- $accession_id
|
- Synonyms
- None Available
|
- $refseq_designator
-
NP_495063
|
- Wormbase Protein ID
-
WP:CE04027
|
- EdgeDB Promoter
- Phlh-25
|
- Wormbase Gene ID
-
WBGene00001964
|
- Description (from Wormbase)
- hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-deficient genetic backgrounds; HLH-25 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-25 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage; ectopic HLH-25 can induce body muscle development in skn-1(RNAi);pal-1(RNAi) embryos that would otherwise lack muscle; HLH-25 is required for embryonic viability in mass RNAi assays.
|
| -PBM Motif Data for HLH-25 |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
-
|
- PWM
<dd><a href="./downloads/Cell09/HLH-25/HLH-25.pwm">View</a>   <a href="downfile.php?id=386&gene=HLH-25&folder=Cell09&RC=0">Save</a></dd>
|
- Top Kmer
-
C.CGTGTCC E.S. 0.497
GGACACG.G E.S. 0.497
|
- Downloads
-
Download the
zip
of all HLH-25 PBM files
or view the
downloads directory
for individual files.
|
| -HLH-25 Datasets |
| Gene |
Homodimerizes |
Clone Type |
Last Modified |
Save |
View |
|
hlh-25
|
Yes |
Not full length |
2016-03-24 |
|
|
- HLH-25 Insert Sequence
-
1 PKVIQSSMSD YRSVPYNQTP KSASERKRRN ITNELINECK TIVQKSEEEH
51 ISQEVVLFRI VKLVTGVNLE SNFSSNDLSE STRRKFDTES ERRKVKTERE
101 KIRRKKQDDC YAELKFFILN KQMGSYEQRL KLERITILEI IIDYIKHNSD
151 LLYPETIPQI LPLLAGKSTA TCENKENEKP KTRMEVKDLF PRLTFQEVQE
201 SPTSTSPLLT FPCIPMIPTT QFNVLSNYNT VPSIFSAPLR FILPSLQILT
251 PETSDEEENE ETLDIIN
- Mutations away from WormBase HLH-25 wildtype:
- • Methioinine start not included in insert sequence
|
|