-Genomic Data for PAX3 Links
Protein
PAX3
UniPROBE Accession Number
UP00609
Species
Homo sapiens
Domain
PAX
Swiss-Prot
P23760
Name and Synonyms
Name: paired box protein Pax-3.
Synonyms:CDHS, HuP2, HUP2, MGC120381, MGC120382, MGC120383, MGC120384, MGC134778, Paired box protein Pax-3, WS1, WS3
IHOP
90831
NCBI RefSeq
NP_852122
Description
This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
JASPAR
None Available
-PBM Motif Data for PAX3_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
AATCGATT E.S. 0.498
AATCGATT E.S. 0.498
Downloads
Download the zip of all PAX3_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PAX3_G48R_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
AATCGATT E.S. 0.496
AATCGATT E.S. 0.496
Downloads
Download the zip of all PAX3_G48R PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PAX3_N47H_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
AATCGATT E.S. 0.498
AATCGATT E.S. 0.498
Downloads
Download the zip of all PAX3_N47H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PAX3_N47K_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
AATCGATT E.S. 0.497
AATCGATT E.S. 0.497
Downloads
Download the zip of all PAX3_N47K PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PAX3_P50L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
AATCGATT E.S. 0.496
AATCGATT E.S. 0.496
Downloads
Download the zip of all PAX3_P50L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PAX3_R270C_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
ACA.TACAT E.S. 0.455
ATGTA.TGT E.S. 0.455
Downloads
Download the zip of all PAX3_R270C PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PAX3_R56L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
AATCGATT E.S. 0.497
AATCGATT E.S. 0.497
Downloads
Download the zip of all PAX3_R56L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for PAX3_Y90H_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
AATCGATT E.S. 0.498
AATCGATT E.S. 0.498
Downloads
Download the zip of all PAX3_Y90H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for PAX3 (all alleles)
Downloads
Download the zip of all PAX3 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PAX3 Datasets
Clone Clone Type Last Modified Save View
PAX3_REF DNA binding domain only search save
PAX3_REF Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFING RPLPNHIRHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RYQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NRRARWRKQA GANQLMAFNH LIPGG


PAX3_G48R DNA binding domain only search save
PAX3_G48R Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFINR RPLPNHIRHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RYQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NRRARWRKQA GANQLMAFNH LIPGG


PAX3_N47H DNA binding domain only search save
PAX3_N47H Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFIHG RPLPNHIRHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RYQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NRRARWRKQA GANQLMAFNH LIPGG


PAX3_N47K DNA binding domain only search save
PAX3_N47K Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFIKG RPLPNHIRHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RYQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NRRARWRKQA GANQLMAFNH LIPGG


PAX3_P50L DNA binding domain only search save
PAX3_P50L Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFING RLLPNHIRHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RYQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NRRARWRKQA GANQLMAFNH LIPGG


PAX3_R270C DNA binding domain only search save
PAX3_R270C Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFING RPLPNHIRHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RYQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NCRARWRKQA GANQLMAFNH LIPGG


PAX3_R56L DNA binding domain only search save
PAX3_R56L Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFING RPLPNHILHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RYQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NRRARWRKQA GANQLMAFNH LIPGG


PAX3_Y90H DNA binding domain only search save
PAX3_Y90H Insert Sequence
1    NYPRSGFPLE VSTPLGQGRV NQLGGVFING RPLPNHIRHK IVEMAHHGIR
51   PCVISRQLRV SHGCVSKILC RHQETGSIRP GAIGGSKPKQ VTTPDVEKKI
101  EEYKRENPGM FSWEIRDKLL KDAVCDRNTV PSVSSISRIL RSKFGKGEEE
151  EADLERKEAE ESEKKAKHSI DGILSERASA PQSDEGSDID SEPDLPLKRK
201  QRRSRTTFTA EQLEELERAF ERTHYPDIYT REELAQRAKL TEARVQVWFS
251  NRRARWRKQA GANQLMAFNH LIPGG


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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