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| -Genomic Data for HLH-27 |
Links |
- Gene
- hlh-27
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- Species
- $species
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- Domain
- bHLH
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- IHOP
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47526
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- Swiss-Prot
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Q18056
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- UniPROBE Accession Number
- $accession_id
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- Synonyms
- None Available
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- $refseq_designator
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NP_495065
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- Wormbase Protein ID
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WP:CE04030
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- EdgeDB Promoter
- Phlh-27
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- Wormbase Gene ID
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WBGene00001966
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- Description (from Wormbase)
- hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is transcribed in the early MS lineage, probably due to MED-1/2 binding of clustered sites in the hlh-27 promoter region; HLH-27 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-27 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage, in a SKN-1-dependent manner; HLH-27 is required for embryonic viability in mass RNAi assays.
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| -PBM Motif Data for HLH-27 |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
<dd><a href="./downloads/Cell09/HLH-27/HLH-27.pwm">View</a>   <a href="downfile.php?id=364&gene=HLH-27&folder=Cell09&RC=0">Save</a></dd>
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- Top Kmer
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C.CGTGTCC E.S. 0.498
GGACACG.G E.S. 0.498
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- Downloads
-
Download the
zip
of all HLH-27 PBM files
or view the
downloads directory
for individual files.
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| -HLH-27 Datasets |
| Gene |
Homodimerizes |
Clone Type |
Last Modified |
Save |
View |
|
hlh-27
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Yes |
Not full length |
2016-03-24 |
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- HLH-27 Insert Sequence
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1 PKVIPSSMSD YRSVPYNQTP KSGSERKRRN ITNELINECK TIVQKSEEEH
51 ISQEVVLFRI VKLVTGVNLE SNFSSNDLSE STRRKFDTES ERRKVKTERE
101 KIRRKKQDDC YAELKFFILN KQMGSYEQRL KLERITILEI IIDYIKHNSD
151 LLYPETIPQI LPLLAGKSTA TCENKENEKP KTRMEVKDLF PRLTFQEVQE
201 SPTSTSPLLT FPCIPMIPTT QFNVLSNYNT VPSIFSAPLR FILPSLQILT
251 PETSDEEENE ETVDISN
- Mutations away from WormBase HLH-27 wildtype:
- • Methioinine start not included in insert sequence
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