-Genomic Data for KLF1 Links
Protein
KLF1
UniPROBE Accession Number
UP00599
Species
Homo sapiens
Domain
zf-C2H2
Swiss-Prot
Q13351
Name and Synonyms
Name: Krueppel-like factor 1.
Synonyms:EKLF, Erythroid krueppel-like transcription factor, HBFQTL6, INLU, Krueppel-like factor 1
IHOP
95738
NCBI RefSeq
NP_006554
Description
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation.
JASPAR
None Available
-PBM Motif Data for KLF1_REF_R2
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CCCCGCCC E.S. 0.494
GGGCGGGG E.S. 0.494
Downloads
Download the zip of all KLF1_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for KLF1_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CCCCGCCC E.S. 0.493
GGGCGGGG E.S. 0.493
Downloads
Download the zip of all KLF1_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for KLF1_E325K_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CCCCCCCC E.S. 0.498
GGGGGGGG E.S. 0.498
Downloads
Download the zip of all KLF1_E325K PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for KLF1_H299Y_R2
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CCGCCC..CC E.S. 0.460
GG..GGGCGG E.S. 0.460
Downloads
Download the zip of all KLF1_H299Y PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for KLF1_H299Y_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CCGCCC..CC E.S. 0.477
GG..GGGCGG E.S. 0.477
Downloads
Download the zip of all KLF1_H299Y PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for KLF1_R328H_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
TAAT..ATTA E.S. 0.448
TAAT..ATTA E.S. 0.448
Downloads
Download the zip of all KLF1_R328H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for KLF1_R328H_R2
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
CACAT.ACA E.S. 0.453
TGT.ATGTG E.S. 0.453
Downloads
Download the zip of all KLF1_R328H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for KLF1 (all alleles)
Downloads
Download the zip of all KLF1 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-KLF1 Datasets
Clone Clone Type Last Modified Save View
KLF1_REF DNA binding domain only search save
KLF1_REF Insert Sequence
1   SKRGRRSWAR KRQAAHTCAH PGCGKSYTKS SHLKAHLRTH TGEKPYACTW
51  EGCGWRFARS DELTRHYRKH TGQRPFRCQL CPRAFSRSDH LALHMKRHL


KLF1_E325K DNA binding domain only search save
KLF1_E325K Insert Sequence
1   SKRGRRSWAR KRQAAHTCAH PGCGKSYTKS SHLKAHLRTH TGEKPYACTW
51  EGCGWRFARS DKLTRHYRKH TGQRPFRCQL CPRAFSRSDH LALHMKRHL


KLF1_H299Y DNA binding domain only search save
KLF1_H299Y Insert Sequence
1   SKRGRRSWAR KRQAAHTCAH PGCGKSYTKS SHLKAYLRTH TGEKPYACTW
51  EGCGWRFARS DELTRHYRKH TGQRPFRCQL CPRAFSRSDH LALHMKRHL


KLF1_R328H DNA binding domain only search save
KLF1_R328H Insert Sequence
1   SKRGRRSWAR KRQAAHTCAH PGCGKSYTKS SHLKAHLRTH TGEKPYACTW
51  EGCGWRFARS DELTHHYRKH TGQRPFRCQL CPRAFSRSDH LALHMKRHL


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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