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| -Genomic Data for HLH-1 |
Links |
- Gene
- hlh-1
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- Species
- $species
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- Domain
- bHLH
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- IHOP
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39103
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- Swiss-Prot
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P22980
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- UniPROBE Accession Number
- $accession_id
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- Synonyms
- MyoD1
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- $refseq_designator
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NP_001021893
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- Wormbase Protein ID
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WP:CE31766
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- EdgeDB Promoter
- Phlh-1
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- Wormbase Gene ID
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WBGene00001948
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- Description (from Wormbase)
- hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals exhibit weak and disorganized muscle contractions; however, ectopic expression of HLH-1 in the embryo is sufficient to convert nearly all embryonic cell types to a bodywall muscle-like fate; in regulating bodywall myogenesis, genetic studies indicate that HLH-1 acts together with the UNC-120/SRF and HND-1/HAND transcription factors, both of which can also induce muscle-like fates when overexpressed in embryos; in addition, in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in bodywall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development.
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| -PBM Motif Data for HLH-1 |
- PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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- PWM
<dd><a href="./downloads/Cell09/HLH-1/HLH-1.pwm">View</a>   <a href="downfile.php?id=387&gene=HLH-1&folder=Cell09&RC=0">Save</a></dd>
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- Top Kmer
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G.CAGCTG.C E.S. 0.497
G.CAGCTG.C E.S. 0.497
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- Downloads
-
Download the
zip
of all HLH-1 PBM files
or view the
downloads directory
for individual files.
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| -HLH-1 Datasets |
| Gene |
Homodimerizes |
Clone Type |
Last Modified |
Save |
View |
|
hlh-1
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Yes |
Full length clone |
2016-03-24 |
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- HLH-1 Insert Sequence
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1 NTETSTQSAP SDTYDTSIYY NSSPRVTAND ITTLTSFAAP APQVLDYANT
51 QYDIYRNQPA YYLPSYAPTA PTTFYSDFAN FNVTRSQDFA SVPAVANSSD
101 VKPIIIKQEK STPNATELII QSRVDSQHED TTTSTAGGAG VGGPRRTKLD
151 RRKAATMRER RRLRKVNEAF EVVKQRTCPN PNQRLPKVEI LRSAIDYINN
201 LERMLQQAGK MTKIMEQNQH LQMTQQINGA PPHDYVTSSH FASSSYNPEN
251 MFDDDDLTDS DDDRDHHKLG NAVDLRRRNS LDRLSRIVAS IPNEEAMTDE
301 QLLQPANDVI DGEKKLEML
- Mutations away from WormBase HLH-1 wildtype:
- • Methioinine start not included in insert sequence
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