-Genomic Data for HLH-2 Links
Gene
hlh-2
Species
$species
Domain
bHLH
UniPROBE Accession Number
$accession_id
Synonyms
None Available
Description (from Wormbase)
hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates.
-PBM Motif Data for HLH-2
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
<dd><a href="./downloads/Cell09/HLH-2/HLH-2.pwm">View</a> &nbsp;&nbsp;&nbsp&nbsp;&nbsp;<a href="downfile.php?id=384&gene=HLH-2&folder=Cell09&RC=0">Save</a></dd>
Top Kmer
AATATAAT E.S. 0.415
ATTATATT E.S. 0.415
Downloads
Download the zip of all HLH-2 PBM files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/CND-1 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
AACA.CTGT E.S. 0.480
ACAG.TGTT E.S. 0.480
Downloads
Download the zip of all HLH-2/CND-1 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-10 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
CACCTGTT E.S. 0.497
AACAGGTG E.S. 0.497
Downloads
Download the zip of all HLH-2/HLH-10 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-14 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
ACA.CTGTC E.S. 0.488
GACAG.TGT E.S. 0.488
Downloads
Download the zip of all HLH-2/HLH-14 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-15 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
CAGCTG.G.C E.S. 0.469
G.C.CAGCTG E.S. 0.469
Downloads
Download the zip of all HLH-2/HLH-15 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-19 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
ACAGCTGG E.S. 0.478
CCAGCTGT E.S. 0.478
Downloads
Download the zip of all HLH-2/HLH-19 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-3 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
CCACCTGC E.S. 0.498
GCAGGTGG E.S. 0.498
Downloads
Download the zip of all HLH-2/HLH-3 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-4 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
A.CACCTGC E.S. 0.499
GCAGGTG.T E.S. 0.499
Downloads
Download the zip of all HLH-2/HLH-4 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-8 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
AACAT.TGG E.S. 0.493
CCA.ATGTT E.S. 0.493
Downloads
Download the zip of all HLH-2/HLH-8 interaction files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/LIN-32 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
ACAGCTGT E.S. 0.496
ACAGCTGT E.S. 0.496
Downloads
Download the zip of all HLH-2/LIN-32 interaction files or view the downloads directory for individual files.
-HLH-2 Datasets
Gene Homodimerizes Clone Type Last Modified Save View
hlh-2 No Full length clone 2016-03-24 search save
HLH-2 Insert Sequence
1    ADPNSQLTSA TTVATAAIAQ PQVMLPNAYD YPYNIDPTTI QMPDYWSGYH
51   LNPYPPMQTT DIDYSSAFLP THPPTETPAS VAAPTSATSD IKPIHATSST
101  STTAPSTAPA PTSTTDVLEL KPTTAPATNS AETSAIVAPQ PLTNLTAPID
151  AMSSMYTWPQ TYPGYLPPSE DNKASEAVNP YISIPPTYTF GADPSVADFS
201  SYQQQLAGQP NGLGGDTNLV DYNHQFPPAG MSPHFDPNGY PGMTGMPPGS
251  SASSVRNDKS ASRATSRRRV QGPPSSGIPT RHSSSSRLSD NESMSDDKDT
301  DRRSQNNARE RVRVRDINSA FKELGRMCTQ HNQNTERNQT KLGILHNAVS
351  VITQLEEQVR QRNMNPKVMA GMKRKPDDDK MKMLDDNAPS AQFGHPRF


Mutations away from WormBase HLH-2 wildtype:
• Methioinine start not included in insert sequence

HLH-2 Interacts With Clone Type Last Modified Save View
CND-1 Full length clone 2008-07-23 search save
HLH-10 Full length clone 2008-07-23 search save
HLH-14 Not full length 2008-07-23 search save
HLH-15 Full length clone 2008-07-23 search save
HLH-19 Full length clone 2008-07-23 search save
HLH-3 Not full length 2008-07-23 search save
HLH-4 Full length clone 2008-07-23 search save
HLH-8 Full length clone 2008-07-23 search save
LIN-32 Not full length 2008-07-23 search save
Supported Browsers:IE 7.0.6001.18000, Firefox 3.5.11, Google Chrome 5.0.375.125 beta