-Genomic Data for NOTCH2 Links
Protein
NOTCH2
UniPROBE Accession Number
UP00481
Species
Homo sapiens
Domain
None Available
Name and Synonyms
Name: notch 2.
Synonyms:hN2; AGS2; HJCYS
Description
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot
-PBM Motif Data for MAML1-CSL-GST-NOTCH2_FigS1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
C..TGGGAAC E.S. 0.495
GTTCCCA..G E.S. 0.495
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
NNVTGDGARN
NYTCHCABNN
Downloads
Download the zip of all MAML1-CSL-GST-NOTCH2_FigS1 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for MAML1-CSL-GST-NOTCH2_Fig5
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CC.TGGGAA E.S. 0.492
TTCCCA.GG E.S. 0.492
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
NBVTGRGAAH
DTTCYCABVN
Downloads
Download the zip of all MAML1-CSL-GST-NOTCH2_Fig5 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-NOTCH2 Datasets
Complex Name Save View
MAML1-CSL-GST-NOTCH2 save view
Run name PBM version Save View
MAML1-CSL-GST-NOTCH2_FigS1 AMADID # 015681 save view
MAML1-CSL-GST-NOTCH2_Fig5 AMADID # 015681 save view
Gene Clone Type Last Modified Save View
NOTCH2 Not full length 2014-08-13 N/A N/A
Insert Sequence
1    KRKHGSLWLP EGFTLRRDAS NHKRREPVGQ DAVGLKNLSV QVSEANLIGT
51   GTSEHWVDDE GPQPKKVKAE DEALLSEEDD PIDRRPWTQQ HLEAADIRRT
101  PSLALTPPQA EQEVDVLDVN VRGPDGCTPL MLASLRGGSS DLSDEDEDAE
151  DSSANIITDL VYQGASLQAQ TDRTGEMALH LAARYSRADA AKRLLDAGAD
201  ANAQDNMGRC PLHAAVAADA QGVFQILIRN RVTDLDARMN DGTTPLILAA
251  RLAVEGMVAE LINCQADVNA VDDHGKSALH WAAAVNNVEA TLLLLKNGAN
301  RDMQDNKEET PLFLAARE G SYEAAKILLD HFANRDITDH MDRLPRDVAR
351  DRMHHDIVRL LDEYNVTPSP PGTVLTSA



References
Data are analyzed by array design with AMADID # 015681 in Del Bianco et al., PLoS ONE 2010


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