Database Browser

Check Box Protein ▾ UniPROBE Accession Number Domain Species Description Publication Save View
GST-CSL-NOTCH1 UP00486 Homo sapiens Del Bianco et al., PLoS ONE 2010 Save View Details
Abd-B UP00503 Homeobox Drosophila melanogaster Abdominal B: The Abdominal-B gene, a member of the Drosophila bithorax complex, is required during development to specify the identity of parasegments 10-14. Busser et al., Development 2012 Save View Details
Abf1 UP00452 BAF1_ABF1 Saccharomyces cerevisiae ARS-Binding Factor 1: DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair Gordan et al., Gen. Bio. 2011 Save View Details
ACA1_126960 UP00513 Fork_head Acanthamoeba castellanii Nakagawa et al., PNAS 2013 Save View Details
AEL327Wp UP00516 Fork_head Ashbya gossypii Nakagawa et al., PNAS 2013 Save View Details
Aft1 UP00344 AFT Saccharomyces cerevisiae Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability Zhu et al., Genome Res 2009 Save View Details
Ahctf1 UP01352 AT_hook Mus musculus AT hook containing transcription factor 1: Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues (PubMed:11952839). Mariani et al., Cell Systems 2017 Save View Details
Alx3 UP00108 Homeobox Mus musculus aristaless 3 Berger et al., Cell 2008 Save View Details
Alx4 UP00187 Homeobox Mus musculus aristaless 4 Berger et al., Cell 2008 Save View Details
AMAG_00796 UP00515 Fork_head Allomyces macrogynus Nakagawa et al., PNAS 2013 Save View Details
AMAG_02766 UP00514 Fork_head Allomyces macrogynus Nakagawa et al., PNAS 2013 Save View Details
ANAC019 UP00570 NAC Arabidopsis thaliana NAC domain-containing protein 19: Transcription factors that bind specifically to the 5'-CATGTG-3' motif Lindemose et al, Nucleic Acids Res. 2014 Save View Details
ANAC055 UP00571 NAC Arabidopsis thaliana ATAF-like NAC-domain transcription factor: Transcription factors that bind specifically to the 5'-CATGTG-3' motif Lindemose et al, Nucleic Acids Res. 2014 Save View Details
ANAC092 UP00572 NAC Arabidopsis thaliana NAC-domain transcription factor: Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5'-[ACG][CA]GT[AG](5-6n)[CT]AC[AG]-3' (PubMed:23340744). Promotes lateral root development (PubMed:16359384). Triggers the expression of senescence-associated genes during age-, salt- and dark-induced senescence through a regulatory network that may involve cross-talk with sal Lindemose et al, Nucleic Acids Res. 2014 Save View Details
AncBcd UP01486 Homeobox N/A Ancestral Bicoid: The maximum likelihood reconstruction of the Bcd protein in the last common ancestor of all cyclorrhaphan flies. Alt-all versions of the proteins are alternative reconstructions which incorporated plausible alternative amino acid states at all ambiguously reconstructed sites. All clones have 15 amino acid flanks surrounding the homeodomain from the Drosophila melanogaster Zen protein, except for the (B) clones, which have the flanking sequence from the from the Drosophila melanogaster Bcd protein. Liu et al., eLife 2018 Save View Details
AncZB UP01485 Homeobox N/A Ancestral Zen/Bicoid: The maximum likelihood reconstruction of the common ancestor of all Zen and Bcd proteins in cyclorrhaphan flies. Alt-all versions of the proteins are alternative reconstructions which incorporated plausible alternative amino acid states at all ambiguously reconstructed sites. All clones have 15 amino acid flanks surrounding the homeodomain from the Drosophila melanogaster Zen protein, except for the (B) clones, which have the flanking sequence from the from the Drosophila melanogaster Bcd protein. Liu et al., eLife 2018 Save View Details
ANID_04521 UP00518 Fork_head Aspergillus nidulans Nakagawa et al., PNAS 2013 Save View Details
ANID_04985 UP00517 Fork_head Aspergillus nidulans A.nid Fox3 Nakagawa et al., PNAS 2013 Save View Details
Ar UP01353 zf-C4 Mus musculus dihydrotestosterone receptor: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. Mariani et al., Cell Systems 2017 Save View Details
Arid3a UP00078 BRIGHT Mus musculus AT rich interactive domain 3A (Bright like) Badis et al., Science 2009 Save View Details
Arid5a UP00059 BRIGHT Mus musculus AT rich interactive domain 5A (Mrf1 like) Badis et al., Science 2009 Save View Details
Arid5b UP01409 ARID Danio rerio AT-rich interactive domain Mariani et al., Cell Systems 2017 Save View Details
Aro80 UP00329 Zn2Cys6 Saccharomyces cerevisiae Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids Zhu et al., Genome Res 2009 Save View Details
Arx UP00152 Homeobox Mus musculus aristaless related homeobox gene (Drosophila) Berger et al., Cell 2008 Save View Details
ARX UP00584 Homeobox Homo sapiens homeobox protein ARX: Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate. Barrera et al., Science 2016 Save View Details
Ascl2 UP00099 HLH Mus musculus achaete-scute complex homolog-like 2 (Drosophila) Badis et al., Science 2009 Save View Details
Asg1 UP00350 Zn2Cys6 Saccharomyces cerevisiae Proposed transcriptional activator, member of the Gal4p family of zinc cluster proteins Zhu et al., Genome Res 2009 Save View Details
ATAF1 UP00573 NAC Arabidopsis thaliana putative transcriptional activator with NAC domain Lindemose et al, Nucleic Acids Res. 2014 Save View Details
Atf1 UP00020 BRLZ, BZIP_1, BZIP_2 Mus musculus activating transcription factor 1: Mus musculus activating transcription factor 1 (Atf1), mRNA Badis et al., Science 2009 Save View Details
Atf3 UP01354 BRLZ,bZIP_1,bZIP_2 Mus musculus cAMP-dependent transcription factor ATF-3: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Bap UP00504 Homeobox Drosophila melanogaster Bagpipe: Bagpipe is expressed in a segmented pattern in visceral muscle and in a subset of cardiac muscles. It’s Loss of activity results in segmental gaps in midgut visceral muscle. Busser et al., Development 2012 Save View Details
Bapx1 UP00228 Homeobox Mus musculus bagpipe homeobox gene 1 homolog (Drosophila) Berger et al., Cell 2008 Save View Details
Barhl1 UP00166 Homeobox Mus musculus BarH-like 1 (Drosophila) Berger et al., Cell 2008 Save View Details
Barhl2 UP00145 Homeobox Mus musculus BarH-like 2 (Drosophila) Berger et al., Cell 2008 Save View Details
Barx1 UP00181 Homeobox Mus musculus BarH-like homeobox 1 Berger et al., Cell 2008 Save View Details
Barx2 UP00151 Homeobox Mus musculus BarH-like homeobox 2 Berger et al., Cell 2008 Save View Details
Bas1 UP00355 Myb Saccharomyces cerevisiae Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes Zhu et al., Genome Res 2009 Save View Details
Bbx UP00012 HMG_box Mus musculus bobby sox homolog (Drosophila) Badis et al., Science 2009 Save View Details
BCL11A UP01464 zf-C2H2, zf-H2C2_2 Homo sapiens B cell CLL/lymphoma 11A: Repressor of fetal hemoglobin (HbF) level. Involved in brain development. Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. Liu et al., Cell 2018 Save View Details
BCL11B UP01465 zf-C2H2, zf-H2C2_2 Homo sapiens B cell CLL/lymphoma 11B: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus. Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes. Liu et al., Cell 2018 Save View Details
BCL6 UP00585 zf-C2H2 Homo sapiens B-cell lymphoma 6 protein: Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation. Barrera et al., Science 2016 Save View Details
Bcl6b UP00043 zf-C2H2 Mus musculus B-cell CLL/lymphoma 6, member B: Mus musculus B-cell CLL/lymphoma 6, member B, mRNA Badis et al., Science 2009 Save View Details
Bhlhb2 UP00050 HLH Mus musculus basic helix-loop-helix domain containing, class B2: Mus musculus basic helix-loop-helix domain containing, class B2 Badis et al., Science 2009 Save View Details
Bsx UP00138 Homeobox Mus musculus brain specific homeobox Berger et al., Cell 2008 Save View Details
Cad1 UP00453 bZIP_1 Saccharomyces cerevisiae CADmium resistance : AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA Gordan et al., Gen. Bio. 2011 Save View Details
Cart1 UP00209 Homeobox Mus musculus cartilage homeo protein 1 Berger et al., Cell 2008 Save View Details
Cbf1 UP00309 HLH Saccharomyces cerevisiae Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA Zhu et al., Genome Res 2009 Save View Details
Cbf1 UP00397 HLH Saccharomyces cerevisiae Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA Berger et al., Nat Biotech 2006 Save View Details
Cdx1 UP00240 Homeobox Mus musculus caudal type homeo box 1 Berger et al., Cell 2008 Save View Details
Cdx2 UP00133 Homeobox Mus musculus caudal type homeo box 2 Berger et al., Cell 2008 Save View Details
Cebpa UP01356 BRLZ,bZIP_1,bZIP_2 Mus musculus CCAT/enhancer binding protein (C/EBP), alpha: This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. The use of alternative in-frame non-AUG (CUG) and AUG start codons results in several protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the CUG and the first AUG start codons. [provided by RefSeq, Sep 2014] Mariani et al., Cell Systems 2017 Save View Details
Cebpb UP01357 BRLZ,bZIP_1,bZIP_2 Mus musculus CCAT/enhancer binding protein (C/EBP) beta: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16585579, PubMed:17911624, PubMed:18486321, PubMed:20111005). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:9727068, PubMed:10635333, PubMed:17301242, PubMed:17601773, PubMed:19478079, PubMed:24061474, PubMed:24216764). The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA (PubMed:15509779). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:9727068, PubMed:10635333, PubMed:16585579). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (PubMed:17911624). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:15985551, PubMed:17301242, PubMed:17601773, PubMed:20194620). Essential for female reproduction because of a critical role in ovarian follicle development (PubMed:9303532). Restricts osteoclastogenesis (PubMed:19440205). Mariani et al., Cell Systems 2017 Save View Details
CEH-22 UP00396 Homeobox Caenorhabditis elegans Homeobox protein ceh-22: C.Elegans Homeobox Berger et al., Nat Biotech 2006 Save View Details
Cep3 UP00278 Zn2Cys6 Saccharomyces cerevisiae Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and ... Zhu et al., Genome Res 2009 Save View Details
Cgd2_3490 UP00395 AP2 Cryptosporidium parvum putative transcription factor Cryptosporidium parvum,single AP2 domain, orthologous to PF14_0633 in Plasmodium falciparum De Silva et al., PNAS 2008 Save View Details
Cha4 UP00300 Zn2Cys6 Saccharomyces cerevisiae DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear clu... Zhu et al., Genome Res 2009 Save View Details
CHES-1-like UP00520 Fork_head Drosophila melanogaster Nakagawa et al., PNAS 2013 Save View Details
Cin5 UP00454 bZIP_1 Saccharomyces cerevisiae Chromosome INstability : Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions Gordan et al., Gen. Bio. 2011 Save View Details
CLAMP UP00534 zf-H2C2_2 Drosophila melanogaster Chromatin-linked adaptor for MSL proteins Soruco et al., Genes Dev 2013 Save View Details
CND-1 UP00359 bHLH Caenorhabditis elegans C. elegans Neuro D homolog: cnd-1 encodes a basic helix-loop-helix protein that is most closely related to the vertebrate NeuroD transcription factors; during development, CND-1 is predicted to function as a transcriptional regulator whose activity is required for several aspects of motor neuron fate specification, including cell division patterns, proper spatiotemporal expression of fate-specific markers, and normal axonal morphology and pathfinding; CND-1::GFP expression begins in early embryogenesis (<20 cells) in four AB descendants and then continues in mitotically active AB-derived neuronal precursors, unidentified nuclei during gastrulation and enclosure, and postmitotic neurons in the head and ventral cord; at hatching CND-1::GFP expression is visible in ventral cord neurons, but this expression disappears completely by the end of the first larval stage; CND-1::GFP does not appear to be expressed in any non-neuronal ectodermal cells, as its expression does not overlap with that of LIN-26. Grove et al., Cell 2009 N/A View Details
Cphx UP00198 Homeobox Mus musculus cytoplasmic polyadenylated homeobox Berger et al., Cell 2008 Save View Details
Cramp1l UP01358 zf-C2H2 Mus musculus cramped chromatin regulator homolog 1 Mariani et al., Cell Systems 2017 Save View Details
Crx UP00176 Homeobox Mus musculus cone-rod homeobox containing gene Berger et al., Cell 2008 Save View Details
CRX UP00586 Homeobox Homo sapiens cone-rod homeobox protein: Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. Barrera et al., Science 2016 Save View Details
CSL UP00484 LAG1-DNAbind Homo sapiens recombination signal binding protein for immunoglobulin kappa J region: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate. determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some Notch protein, it acts as a transcriptional activator that activates transcriptio Del Bianco et al., PLoS ONE 2010 N/A View Details
Cst6 UP00455 bZIP_1 Saccharomyces cerevisiae Chromosome STability : Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability Gordan et al., Gen. Bio. 2011 Save View Details
Cup9 UP00308 Homeobox Saccharomyces cerevisiae Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p an... Zhu et al., Genome Res 2009 Save View Details
Cutl1 UP00219 Homeobox Mus musculus cut-like 1 (Drosophila) Berger et al., Cell 2008 Save View Details
Dbp UP01359 BRLZ,bZIP_2 Mus musculus albumin D box-binding protein: The protein encoded by this gene is a member of the Par bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, Cyp2a4, and Cyp2a5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. [provided by RefSeq, Feb 2014] Mariani et al., Cell Systems 2017 Save View Details
Dbx1 UP00255 Homeobox Mus musculus developing brain homeobox 1 Berger et al., Cell 2008 Save View Details
Dbx2 UP00218 Homeobox Mus musculus developing brain homeobox 2 Berger et al., Cell 2008 Save View Details
DDF1 UP00555 AP2 Arabidopsis lyrata DWARF AND DELAYED FLOWERING1: Orthologous to Arabidopsis thaliana DDF1 Lehti-Shiu et al., PP 2015 Save View Details
DDF2 UP00557 AP2 Arabidopsis lyrata DWARF AND DELAYED FLOWERING2: Orthologous to Arabidopsis thaliana DDF2 Lehti-Shiu et al., PP 2015 Save View Details
Dlx1 UP00202 Homeobox Mus musculus distal-less homeobox 1 Berger et al., Cell 2008 Save View Details
Dlx2 UP00126 Homeobox Mus musculus distal-less homeobox 2 Berger et al., Cell 2008 Save View Details
Dlx3 UP00154 Homeobox Mus musculus distal-less homeobox 3 Berger et al., Cell 2008 Save View Details
Dlx4 UP00110 Homeobox Mus musculus distal-less homeobox 4 Berger et al., Cell 2008 Save View Details
Dlx5 UP00230 Homeobox Mus musculus distal-less homeobox 5 Berger et al., Cell 2008 Save View Details
Dmbx1 UP00111 Homeobox Mus musculus diencephalon/mesencephalon homeobox 1 Berger et al., Cell 2008 Save View Details
DNAjc21 UP01348 zf-C2H2 Mus musculus DnaJ (Hsp40) homolog, subfamily C, member 21 Mariani et al., Cell Systems 2017 Save View Details
Dnmt3a UP01360 PWWP Mus musculus DNA MTase MmuIIIA: This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Mariani et al., Cell Systems 2017 Save View Details
Dobox4 UP00232 Homeobox Mus musculus EST CN720839: E0811A05-5 NIA Mouse four-cell-Embryo cDNA library (Long) Mus musculus cDNA clone NIA:E0811A05 IMAGE:30906628 5-, mRNA sequence Berger et al., Cell 2008 Save View Details
Dobox5 UP00143 Homeobox Mus musculus Formerly named ENSMUST00000057964.5 Berger et al., Cell 2008 Save View Details
Duxl UP00227 Homeobox Mus musculus RIKEN cDNA 1110051B16 gene Berger et al., Cell 2008 Save View Details
E2F2 UP00001 E2F_TDP Mus musculus E2F transcription factor 2 Badis et al., Science 2009 Save View Details
E2F3 UP00003 E2F_TDP Mus musculus E2F transcription factor 3 Badis et al., Science 2009 Save View Details
E2f4 UP01362 E2F_TDP Mus musculus transcription factor E2F4: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. Mariani et al., Cell Systems 2017 Save View Details
E4f1 UP01361 zf-C2H2 Mus musculus putative E3 ubiquitin-protein ligase E4F1: This gene encodes a member of the GLI-Kruppel zinc finger family. The encoded protein is likely to be multi-functional, with both adenovirus E1A-regulated transcription factor and ubiquitin E3 ligase activities, including roles in cell cycle regulation and the ubiquitination of p53. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] Mariani et al., Cell Systems 2017 Save View Details
Ecm22 UP00305 Zn2Cys6 Saccharomyces cerevisiae Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription Zhu et al., Genome Res 2009 Save View Details
Ecm22 UP00495 Zn2Cys6 Saccharomyces cerevisiae Sterol regulatory element binding protein, regulates transcription of the sterol biosynthetic genes ERG2 and ERG3; member of the fungus-specific Zn[2]-Cys[6] binuclear cluster family of transcription Gordan et al., Gen. Bio. 2011 Save View Details
Egr1 UP00007 zf-C2H2 Mus musculus early growth response 1 Badis et al., Science 2009 Save View Details
EGR2 UP00587 zf-C2H2 Homo sapiens E3 SUMO-protein ligase EGR2: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Barrera et al., Science 2016 Save View Details
Ehf UP00015 ETS Mus musculus ets homologous factor: Mus musculus EHF (Ehf) mRNA, complete cds Badis et al., Science 2009 Save View Details
Ehf UP00403 ETS Mus musculus ets homologous factor: Mus musculus EHF (Ehf) mRNA, complete cds Wei et al., EMBO J 2010 Save View Details
Elf1 UP01363 Ets Mus musculus ETS-related transcription factor Elf-1 Mariani et al., Cell Systems 2017 Save View Details
Elf2 UP00404 ETS Mus musculus ETS-related transcription factor Elf-2: Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter Wei et al., EMBO J 2010 Save View Details
Elf3 UP00090 AT_hook, ETS Mus musculus E74-like factor 3: ETS-related transcription factor Elf-3 isoform 1 Badis et al., Science 2009 Save View Details
Elf3 UP00407 AT_hook, ETS Mus musculus E74-like factor 3: ETS-related transcription factor Elf-3 isoform 1 Wei et al., EMBO J 2010 Save View Details
Elf4 UP00413 ETS Mus musculus E74-like factor 4 (ets domain transcription factor) : ETS-related transcription factor Elf-4 Wei et al., EMBO J 2010 Save View Details
Elf5 UP00409 ETS Mus musculus E74-like factor 5: ETS-related transcription factor Elf-5 Wei et al., EMBO J 2010 Save View Details
Elk1 UP00410 ETS Mus musculus ELK1, member of ETS oncogene family : ETS domain-containing protein Elk-1 Wei et al., EMBO J 2010 Save View Details
Elk3 UP00420 ETS Mus musculus ELK3, member of ETS oncogene family: ETS domain-containing protein Elk-3 Wei et al., EMBO J 2010 Save View Details
Elk4 UP00415 ETS Mus musculus ELK4, member of ETS oncogene family: ETS domain-containing protein Elk-4 Wei et al., EMBO J 2010 Save View Details
Emx2 UP00201 Homeobox Mus musculus empty spiracles homolog 2 (Drosophila) Berger et al., Cell 2008 Save View Details
En1 UP00167 Homeobox Mus musculus engrailed 1 Berger et al., Cell 2008 Save View Details
En2 UP00163 Homeobox Mus musculus engrailed 2 Berger et al., Cell 2008 Save View Details
Eomes UP00068 TBOX Mus musculus Eomesodermin homolog (Xenopus laevis): Mus musculus similar to Eomesodermin homolog (LOC235673), mRNA Badis et al., Science 2009 Save View Details
Erg UP00411 ETS Mus musculus avian erythroblastosis virus E-26 (v-ets) oncogene related: transcriptional regulator ERG Wei et al., EMBO J 2010 Save View Details
Esrra UP00079 ZnF_C4 Mus musculus estrogen related receptor, alpha: Mus musculus estrogen related receptor, alpha (Esrra), mRNA. Badis et al., Science 2009 Save View Details
Esrrb UP01364 zf-C4 Mus musculus steroid hormone receptor ERR2: Nuclear receptor, may regulate ESR1 transcriptional activity. Induces the expression of PERM1 in the skeletal muscle (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Esx1 UP00251 Homeobox Mus musculus extraembryonic, spermatogenesis, homeobox 1 Berger et al., Cell 2008 Save View Details
ESX1 UP00588 Homeobox Homo sapiens homeobox protein ESX1: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover. Barrera et al., Science 2016 Save View Details
Ets1 UP00414 ETS Mus musculus E26 avian leukemia oncogene 1, 5\' domain: protein C-ets-1 isoform 1 Wei et al., EMBO J 2010 Save View Details
Etv1 UP00421 ETS Mus musculus ets variant gene 1: ETS translocation variant 1 Wei et al., EMBO J 2010 Save View Details
Etv3 UP00422 ETS Mus musculus ets variant gene 3: ETS translocation variant 3 Wei et al., EMBO J 2010 Save View Details
Etv4 UP00417 ETS Mus musculus ets variant gene 4 (E1A enhancer binding protein, E1AF): ETS translocation variant 4 Wei et al., EMBO J 2010 Save View Details
Etv5 UP00412 ETS Mus musculus ets variant gene 5: ETS translocation variant 5 Wei et al., EMBO J 2010 Save View Details
Etv6 UP00418 ETS Mus musculus ets variant gene 6 (TEL oncogene): transcription factor ETV6 Wei et al., EMBO J 2010 Save View Details
Eve UP00505 Homeobox Drosophila melanogaster Even skipped: Even skipped may play a role in determining neuronal identity. It may be directly involved in specifying identity of individual neurons and is required for segmentation; involved in transforming the broad, spatial, aperiodic expression patterns of the gap genes into a system of precise periodic expression patterns of the pair-rule and segmentary polarity genes. Busser et al., Development 2012 Save View Details
Evx1 UP00162 Homeobox Mus musculus even skipped homeotic gene 1 homolog Berger et al., Cell 2008 Save View Details
Evx2 UP00132 Homeobox Mus musculus even skipped homeotic gene 2 homolog Berger et al., Cell 2008 Save View Details
Fhl1 UP00303 Fork_head Saccharomyces cerevisiae Putative transcriptional regulator with similarity to DNA-binding domain of Drosophila forkhead; required for rRNA processing Zhu et al., Genome Res 2009 Save View Details
Fkh1 UP00353 Fork_head Saccharomyces cerevisiae Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth; also involved in chromatin silencing at HML and HMR Zhu et al., Genome Res 2009 Save View Details
Fkh2 UP00312 Fork_head Saccharomyces cerevisiae Transcription factor of the forkhead family that regulates the cell cycle and pseudohyphal growth; also involved in chromatin silencing at HML and HMR; potential Cdc28p substrate Zhu et al., Genome Res 2009 Save View Details
Fli1 UP00416 ETS Mus musculus Friend leukemia integration 1: Friend leukemia integration 1 transcription factor Wei et al., EMBO J 2010 Save View Details
Fos UP00425 bZIP Homo sapiens FBJ murine osteosarcoma viral oncogene homolog: Proto-oncogene protein c-fos (Cellular oncogene fos)(G0/G1 switch regulatory protein 7) Alibes et al., NAR 2010 N/A View Details
Fox3_Mgra UP00529 Fork_head Mycosphaerella graminicola Nakagawa et al., PNAS 2013 Save View Details
Fox3_Tmel UP00533 Fork_head Tuber melanosporum Nakagawa et al., PNAS 2013 Save View Details
Foxa2 UP00073 Fork_head Mus musculus forkhead box A2: Mus musculus forkhead box A2 (Foxa2) Badis et al., Science 2009 Save View Details
Foxa3 UP01365 Forkhead Mus musculus Hepatocyte nuclear factor 3-gamma: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates GLUT2 transcription. Involved in regulation of neuronal-specific transcription. Involved in regulation of spermatogenesis; required for the maintenance of the testicular germ cell population and male fertility. Mariani et al., Cell Systems 2017 Save View Details
Foxb1 UP01366 Forkhead Mus musculus forkhead box protein B1 Mariani et al., Cell Systems 2017 Save View Details
FOXC1 UP00589 Forkhead Homo sapiens forkhead box protein C1: Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. Barrera et al., Science 2016 Save View Details
Foxc1 UP01346 Forkhead Mus musculus FREAC-3: Transcriptional regulator. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Foxc2 UP01367 Forkhead Mus musculus forkhead box protein C2: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. Mariani et al., Cell Systems 2017 Save View Details
Foxg1 UP01368 Forkhead Mus musculus forkhead box protein G1: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Mariani et al., Cell Systems 2017 Save View Details
Foxj1 UP00041 Fork_head Mus musculus forkhead box J1: forkhead box J1 [Mus musculus] Badis et al., Science 2009 Save View Details
Foxj2 UP01369 Forkhead Mus musculus Forkhead box protein J2: Transcriptional activator. Able to bind to two different type of DNA binding sites. Mariani et al., Cell Systems 2017 Save View Details
Foxj3 UP00039 Fork_head Mus musculus forkhead box J3: Mus musculus similar to Putative forkhead box protein KIAA1041 (LOC230700), mRNA Badis et al., Science 2009 Save View Details
Foxk1 UP00025 Fork_head Mus musculus forkhead box K1: Mus musculus forkhead box K1 (Foxk1), transcript variant 1, mRNA. Badis et al., Science 2009 Save View Details
Foxl1 UP00061 Fork_head Mus musculus forkhead box L1: M.musculus fkh-6 gene Badis et al., Science 2009 Save View Details
Foxm1 UP00528 Fork_head Mus musculus Nakagawa et al., PNAS 2013 Save View Details
Foxm1 UP01370 Fork_head Mus musculus Mariani et al., Cell Systems 2017 Save View Details
FoxM_Spur UP00531 Fork_head Strongylocentrotus purpuratus Nakagawa et al., PNAS 2013 Save View Details
Foxn1 UP00526 Fork_head Mus musculus Nakagawa et al., PNAS 2013 Save View Details
FoxN1-4_Mbre UP00525 Fork_head Monosiga brevicollis Nakagawa et al., PNAS 2013 Save View Details
FOXN2 UP00521 Fork_head Homo sapiens Nakagawa et al., PNAS 2013 Save View Details
FoxN2-3_Nvec UP00530 Fork_head Nematostella vectensis Nakagawa et al., PNAS 2013 Save View Details
FoxN2-3_Tadh UP00532 Fork_head Trichoplax adhaerens Nakagawa et al., PNAS 2013 Save View Details
FOXN4 UP00522 Fork_head Homo sapiens Nakagawa et al., PNAS 2013 Save View Details
Foxo3 UP01371 Forkhead Mus musculus forkhead box protein : Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. Mariani et al., Cell Systems 2017 Save View Details
FOXR1 UP00523 Fork_head Homo sapiens Nakagawa et al., PNAS 2013 Save View Details
Gabpa UP00013 ETS Mus musculus GA repeat binding protein, alpha: Mus musculus GA repeat binding protein, alpha Badis et al., Science 2009 Save View Details
Gabpa UP00408 ETS Mus musculus GA repeat binding protein, alpha: Mus musculus GA repeat binding protein, alpha Wei et al., EMBO J 2010 Save View Details
Gal4 UP00322 Zn2Cys6 Saccharomyces cerevisiae DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p Zhu et al., Genome Res 2009 Save View Details
Gat1 UP00287 GATA Saccharomyces cerevisiae Transcriptional activator of genes involved in nitrogen catabolite repression, member of the GATA family of DNA binding proteins; activity and localization regulated by nitrogen limitation and Ure2p Zhu et al., Genome Res 2009 Save View Details
Gat3 UP00319 GATA Saccharomyces cerevisiae Protein containing GATA family zinc finger motifs Zhu et al., Genome Res 2009 Save View Details
Gat4 UP00336 GATA Saccharomyces cerevisiae Protein containing GATA family zinc finger motifs Zhu et al., Genome Res 2009 Save View Details
Gata3 UP00032 GATA Mus musculus GATA binding protein 3: Mus musculus GATA binding protein 3 (Gata3), mRNA. Badis et al., Science 2009 Save View Details
Gata4 UP01372 GATA Mus musculus GATA-binding factor 4 Mariani et al., Cell Systems 2017 Save View Details
Gata5 UP00080 GATA Mus musculus GATA binding protein 5 Badis et al., Science 2009 Save View Details
Gata6 UP00100 GATA Mus musculus GATA binding protein 6 Badis et al., Science 2009 Save View Details
Gbx1 UP00204 Homeobox Mus musculus gastrulation brain homeobox 1 Berger et al., Cell 2008 Save View Details
Gbx2 UP00131 Homeobox Mus musculus gastrulation brain homeobox 2 Berger et al., Cell 2008 Save View Details
Gcm1 UP00070 GCM Mus musculus glial cells missing homolog 1 (Drosophila) Badis et al., Science 2009 Save View Details
Gcn4 UP00285 bZIP Saccharomyces cerevisiae Gcn4p: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Zhu et al., Genome Res 2009 Save View Details
Gcn4 UP00428 bZIP Saccharomyces cerevisiae Gcn4p: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Alibes et al., NAR 2010 Save View Details
Gcr1 UP00456 GCR1_C Saccharomyces cerevisiae GlyColysis Regulation : Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p Gordan et al., Gen. Bio. 2011 Save View Details
GFI1 UP00591 zf-C2H2 Homo sapiens zinc finger protein Gfi-1: Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes. Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development. Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling. Regulates the endotoxin- mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA. Cooperates with CBFA2T2 to regulate ITGB1- dependent neurite growth. Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters. Required for the maintenance of inner ear hair cells. Barrera et al., Science 2016 Save View Details
GFI1B UP00592 zf-C2H2 Homo sapiens zinc finger protein Gfi-1b: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down- regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma- satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. Barrera et al., Science 2016 Save View Details
Gli1 UP00538 zf-H2C2_2 Mus musculus GLI-Kruppel family member GLI1: Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation. Peterson et al., Genes Dev 2012 Save View Details
Gli2 UP00539 zf-H2C2_2 Mus musculus GLI-Kruppel family member GLI2 Peterson et al., Genes Dev 2012 Save View Details
Gli3 UP00540 zf-H2C2_2 Mus musculus GLI-Kruppel family member GLI3: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repres Peterson et al., Genes Dev 2012 Save View Details
Glis2 UP00024 zf-C2H2 Mus musculus GLIS family zinc finger 2: GLIS family zinc finger 2 (Glis2), mRNA Badis et al., Science 2009 Save View Details
Gln3 UP00318 GATA Saccharomyces cerevisiae Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source Zhu et al., Genome Res 2009 Save View Details
Gm397 UP00042 zf-C2H2 Mus musculus gene model 397, (NCBI): Mus musculus similar to Zinc finger protein 58 (Zfp-58) (Zinc finger protein Mfg-1) (LOC212386), mRNA Badis et al., Science 2009 Save View Details
Gm4881 UP00424 ETS Mus musculus predicted gene 4881: Ensembl Gene ID:ENSMUSG00000042789,Transcript ID:ENSMUST00000061154.4,Protein ID:ENSMUSP00000056357 Wei et al., EMBO J 2010 Save View Details
Gm5454 UP00423 ETS Mus musculus Predicted gene 5454: Ensembl Gene ID: ENSMUSG00000047643, Transcript ID: ENSMUST00000052030, Protein ID: ENSMUSP00000055525 Wei et al., EMBO J 2010 Save View Details
Gmeb1 UP00084 SAND Mus musculus glucocorticoid modulatory element binding protein 1: transcription termination factor 1, mRNA (cDNA clone MGC:69635 IMAGE:6847867), complete cds Badis et al., Science 2009 Save View Details
Gsc UP00112 Homeobox Mus musculus goosecoid Berger et al., Cell 2008 Save View Details
Gsh2 UP00127 Homeobox Mus musculus genomic screened homeo box 2 Berger et al., Cell 2008 Save View Details
Gsm1 UP00301 Zn2Cys6 Saccharomyces cerevisiae Putative zinc cluster protein of unknown function; computationally predicted involvement in oxidative phosphorylation, based on patterns of expression and sequence analysis Zhu et al., Genome Res 2009 Save View Details
Gzf3 UP00347 GATA Saccharomyces cerevisiae GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source;... Zhu et al., Genome Res 2009 Save View Details
Hac1 UP00457 bZIP_2 Saccharomyces cerevisiae Homologous to Atf/Creb1 : Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis Gordan et al., Gen. Bio. 2011 Save View Details
Hal9 UP00315 Zn2Cys6 Saccharomyces cerevisiae Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decrease... Zhu et al., Genome Res 2009 Save View Details
Hap1 UP00458 Zn_clus Saccharomyces cerevisiae Heme Activator Protein : Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus Gordan et al., Gen. Bio. 2011 Save View Details
Hbp1 UP00055 HMG_box Mus musculus high mobility group box transcription factor 1 Badis et al., Science 2009 Save View Details
Hdx UP00148 Homeobox Mus musculus Highly divergent homeobox Berger et al., Cell 2008 Save View Details
HESX1 UP00594 Homeobox Homo sapiens homeobox expressed in ES cells 1: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation (By similarity). Barrera et al., Science 2016 Save View Details
Hic1 UP00035 zf-C2H2 Mus musculus hypermethylated in cancer 1: Mus musculus hypermethylated in cancer 1 (Hic1) Badis et al., Science 2009 Save View Details
HLH-1 UP00387 bHLH Caenorhabditis elegans Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals exhibit weak and disorganized muscle contractions; however, ectopic expression of HLH-1 in the embryo is sufficient to convert nearly all embryonic cell types to a bodywall muscle-like fate; in regulating bodywall myogenesis, genetic studies indicate that HLH-1 acts together with the UNC-120/SRF and HND-1/HAND transcription factors, both of which can also induce muscle-like fates when overexpressed in embryos; in addition, in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in bodywall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development. Grove et al., Cell 2009 N/A View Details
HLH-1 UP00548 bHLH Caenorhabditis elegans Helix Loop Helix Protein 1: hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals exhibit weak and disorganized muscle contractions; however, ectopic expression of HLH-1 in the embryo is sufficient to convert nearly all embryonic cell types to a bodywall muscle-like fate; in regulating bodywall myogenesis, genetic studies indicate that HLH-1 acts together with the UNC-120/SRF and HND-1/HAND transcription factors, both of which can also induce muscle-like fates when overexpressed in embryos; in addition, in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in bodywall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development. De Masi et al., NAR 2011 Save View Details
HLH-10 UP00358 bHLH Caenorhabditis elegans Helix Loop Helix Protein 10: none available Grove et al., Cell 2009 N/A View Details
HLH-11 UP00357 bHLH Caenorhabditis elegans Helix Loop Helix Protein 11: none available Grove et al., Cell 2009 N/A View Details
HLH-14 UP00363 bHLH Caenorhabditis elegans Helix Loop Helix Protein 14: hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa. Grove et al., Cell 2009 N/A View Details
HLH-15 UP00361 bHLH Caenorhabditis elegans Helix Loop Helix Protein 15 : none available Grove et al., Cell 2009 N/A View Details
HLH-19 UP00378 bHLH Caenorhabditis elegans Helix Loop Helix Protein 19 : none available Grove et al., Cell 2009 N/A View Details
HLH-2 UP00384 bHLH Caenorhabditis elegans Helix Loop Helix Protein 2: hlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates. Grove et al., Cell 2009 N/A View Details
HLH-25 UP00386 bHLH Caenorhabditis elegans Helix Loop Helix Protein 25: hlh-25 encodes a REF-1-like protein with two bHLH domains that partially represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with HLH-27); lag-2 repression by HLH-25 may require UNC-37; HLH-25's paralogs include HLH-26 through HLH-29 and (more distantly) REF-1; hlh-25 is transcribed in the early MS lineage, has clustered binding sites for MED-1/2 in its promoter region, can be activated by ectopic MED-1, and loses activity in MED-1/2-deficient genetic backgrounds; HLH-25 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-25 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage; ectopic HLH-25 can induce body muscle development in skn-1(RNAi);pal-1(RNAi) embryos that would otherwise lack muscle; HLH-25 is required for embryonic viability in mass RNAi assays. Grove et al., Cell 2009 N/A View Details
HLH-26 UP00370 bHLH Caenorhabditis elegans Helix Loop Helix Protein 26: hlh-26 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-27, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-26 may require UNC-37; HLH-26's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; HLH-26 is not visibly expressed in EMS descendants, and has no obvious function in mass RNAi assays. Grove et al., Cell 2009 N/A View Details
HLH-27 UP00364 bHLH Caenorhabditis elegans Helix Loop Helix Protein 27: hlh-27 encodes a REF-1-like protein with two bHLH domains, that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-25, HLH-26, HLH-29, and perhaps HLH-28) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-29, and perhaps HLH-28); lag-2 repression by HLH-27 may require UNC-37; HLH-27's paralogs include HLH-25 through HLH-29 and (more distantly) REF-1; hlh-27 is transcribed in the early MS lineage, probably due to MED-1/2 binding of clustered sites in the hlh-27 promoter region; HLH-27 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-27 is also expressed in four EMS granddaughters (MSaa, MSap, MSpa, MSpp) beginning at the 24-cell stage, in a SKN-1-dependent manner; HLH-27 is required for embryonic viability in mass RNAi assays. Grove et al., Cell 2009 N/A View Details
HLH-29 UP00368 bHLH Caenorhabditis elegans Helix Loop Helix Protein 29: hlh-29 encodes a REF-1-like protein with two bHLH domains that represses lag-2 transcription in ABa descendants (in response to a Notch signal, redundantly with REF-1, HLH-26, and HLH-27) and tbx-37 transcription in EMS descendants (independently of Notch, redundantly with REF-1, HLH-26, HLH-27, and perhaps HLH-28); HLH-29 is identical to residues 24-262 of HLH-28, shares near-identical promoter regions in a inverted duplex, and is likely to be highly redundant with HLH-28; HLH-29 (with HLH-28) is also required for late embryonic viability, and for normal fat metabolism, yolk protein transport, gonadal and vulval development, bordering behavior, and chemosensory responses, and repression of tax-4 and osm-9 transcription; lag-2 repression by HLH-29 may require UNC-37; HLH-29's paralogs include HLH-25 through HLH-28 and (more distantly) REF-1; hlh-29 is transcribed in the early MS and E lineages, probably due to MED-1/2 binding of clustered sites in the hlh-28/hlh-29 shared promoter region; HLH-29 is expressed in ABp granddaughters ~25 minutes after ABp first contacts an APX-1-expressing cell, and in ABa descendants after a second Notch interaction; HLH-29 is also expressed in all EMS granddaughters beginning at the 24-cell stage, in a SKN-1-dependent manner; furthermore, HLH-29 is expressed in amphid and phasmid neurons, ALA and PVT neurons, chemosensory and mechanosensory neurons, ASI, ASK, PHA, PQR, and neurons of the anterior pharynx, as well as in vulva, somatic gonad, rectal glands, intestine, and larval pharyngeal muscle PM1, ventral posterior coelomocytes, spermatheca, and vulval muscles; hlh-28/29 mRNA is present throughout development, but varies roughly 30-fold in quantity, with 3.5-fold more mRNA in L1 larvae than in adults; ectopic HLH-29 can rescue the intestinal defect of ref-1(RNAi) embryos; hlh-28/29 transcription is inhibited by LIN-12 and MED-1. Grove et al., Cell 2009 N/A View Details
HLH-3 UP00379 bHLH Caenorhabditis elegans Helix Loop Helix Protein 3: hlh-3 encodes a basic helix-loop-helix transcription factor homologous to Drosophila Achaete-scute; in vitro, HLH-3 can heterodimerize, and bind an E-box-containing probe, with HLH-2, the C. elegans E/daughterless ortholog with which it is coexpressed in the nuclei of embryonic neuronal precursors. Grove et al., Cell 2009 N/A View Details
HLH-30 UP00365 bHLH Caenorhabditis elegans Helix Loop Helix Protein 30: W02C12.3 is orthologous to the human gene TRANSCRIPTION FACTOR BINDING TO IGHM ENHANCER 3 (TFE3; OMIM:314310), which when mutated leads to disease. Grove et al., Cell 2009 N/A View Details
HLH-4 UP00369 bHLH Caenorhabditis elegans Helix Loop Helix Protein 4: none available Grove et al., Cell 2009 N/A View Details
HLH-8 UP00371 bHLH Caenorhabditis elegans Helix Loop Helix Protein 8: The hlh-8 gene encodes a helix-loop-helix protein required for normal muscle development, and hence for normal defecation and egg-laying. Grove et al., Cell 2009 N/A View Details
Hlx1 UP00225 Homeobox Mus musculus H2.0-like homeo box 1 (Drosophila) Berger et al., Cell 2008 Save View Details
Hlxb9 UP00123 Homeobox Mus musculus homeobox gene HB9 Berger et al., Cell 2008 Save View Details
Hmbox1 UP00161 Homeobox Mus musculus homeobox containing 1 Berger et al., Cell 2008 Save View Details
Hmgb3 UP01373 HMG_box Mus musculus High mobility group protein B3 Mariani et al., Cell Systems 2017 Save View Details
Hmlalpha2 UP00459 Homeobox Saccharomyces cerevisiae Hidden Mat Left ALPHA : Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression Gordan et al., Gen. Bio. 2011 Save View Details
Hmx1 UP00104 Homeobox Mus musculus H6 homeo box 1 Berger et al., Cell 2008 Save View Details
Hmx2 UP00155 Homeobox Mus musculus H6 homeo box 2 Berger et al., Cell 2008 Save View Details
Hmx3 UP00157 Homeobox Mus musculus H6 homeo box 3 Berger et al., Cell 2008 Save View Details
Hnf4a UP00066 ZnF_C4 Mus musculus hepatic nuclear factor 4, alpha: Mus musculus hepatic nuclear factor 4, alpha (Hnf4a), mRNA Badis et al., Science 2009 Save View Details
Homez UP00114 Homeobox Mus musculus homeodomain leucine zipper-encoding gene Berger et al., Cell 2008 Save View Details
Hoxa1 UP00264 Homeobox Mus musculus homeo box A1 Berger et al., Cell 2008 Save View Details
Hoxa10 UP00217 Homeobox Mus musculus homeo box A10 Berger et al., Cell 2008 Save View Details
Hoxa11 UP00246 Homeobox Mus musculus homeo box A11 Berger et al., Cell 2008 Save View Details
Hoxa13 UP00183 Homeobox Mus musculus homeo box A13 Berger et al., Cell 2008 Save View Details
Hoxa2 UP00174 Homeobox Mus musculus homeo box A2 Berger et al., Cell 2008 Save View Details
Hoxa3 UP00391 Homeobox Mus musculus homeo box A3: Mus musculus homeo box A3 (Hoxa3) Berger et al., Cell 2008 Save View Details
Hoxa3 UP00063 Homeobox Mus musculus homeo box A3: Mus musculus homeo box A3 (Hoxa3) Badis et al., Science 2009 Save View Details
Hoxa4 UP00196 Homeobox Mus musculus homeo box A4 Berger et al., Cell 2008 Save View Details
Hoxa5 UP00189 Homeobox Mus musculus homeo box A5 Berger et al., Cell 2008 Save View Details
Hoxa6 UP00182 Homeobox Mus musculus homeo box A6 Berger et al., Cell 2008 Save View Details
Hoxa7 UP00164 Homeobox Mus musculus homeo box A7 Berger et al., Cell 2008 Save View Details
Hoxa9 UP00213 Homeobox Mus musculus homeo box A9 Berger et al., Cell 2008 Save View Details
Hoxb13 UP00134 Homeobox Mus musculus homeo box B13 Berger et al., Cell 2008 Save View Details
Hoxb3 UP00137 Homeobox Mus musculus homeo box B3 Berger et al., Cell 2008 Save View Details
Hoxb4 UP00144 Homeobox Mus musculus homeo box B4 Berger et al., Cell 2008 Save View Details
Hoxb5 UP00214 Homeobox Mus musculus homeo box B5 Berger et al., Cell 2008 Save View Details
Hoxb6 UP00259 Homeobox Mus musculus homeo box B6 Berger et al., Cell 2008 Save View Details
Hoxb7 UP00206 Homeobox Mus musculus homeo box B7 Berger et al., Cell 2008 Save View Details
HOXB7 UP00595 Homeobox Homo sapiens homeobox protein Hox-B7: This gene is a member of the Antp homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of melanoma and ovarian carcinoma. Barrera et al., Science 2016 Save View Details
Hoxb8 UP00263 Homeobox Mus musculus homeo box B8 Berger et al., Cell 2008 Save View Details
Hoxb9 UP00207 Homeobox Mus musculus homeo box B9 Berger et al., Cell 2008 Save View Details
Hoxc10 UP00245 Homeobox Mus musculus homeo box C10 Berger et al., Cell 2008 Save View Details
Hoxc11 UP00235 Homeobox Mus musculus homeo box C11 Berger et al., Cell 2008 Save View Details
Hoxc12 UP00135 Homeobox Mus musculus homeo box C12 Berger et al., Cell 2008 Save View Details
Hoxc13 UP00173 Homeobox Mus musculus homeo box C13 Berger et al., Cell 2008 Save View Details
Hoxc4 UP00113 Homeobox Mus musculus homeo box C4 Berger et al., Cell 2008 Save View Details
HOXC4 UP00596 Homeobox Homo sapiens homeobox protein Hox-C4: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC4, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants that encode the same protein have been described for HOXC4. Transcript variant one includes the shared exon, and transcript variant two includes only gene-specific exons. Barrera et al., Science 2016 Save View Details
Hoxc5 UP00252 Homeobox Mus musculus homeo box C5 Berger et al., Cell 2008 Save View Details
Hoxc6 UP00260 Homeobox Mus musculus homeo box C6 Berger et al., Cell 2008 Save View Details
Hoxc8 UP00242 Homeobox Mus musculus homeo box C8 Berger et al., Cell 2008 Save View Details
Hoxc9 UP00197 Homeobox Mus musculus homeo box C9 Berger et al., Cell 2008 Save View Details
Hoxd1 UP00140 Homeobox Mus musculus homeo box D1 Berger et al., Cell 2008 Save View Details
Hoxd10 UP00121 Homeobox Mus musculus homeo box D10 Berger et al., Cell 2008 Save View Details
Hoxd11 UP00117 Homeobox Mus musculus homeo box D11 Berger et al., Cell 2008 Save View Details
Hoxd12 UP00177 Homeobox Mus musculus homeo box D12 Berger et al., Cell 2008 Save View Details
Hoxd13 UP00180 Homeobox Mus musculus homeo box D13 Berger et al., Cell 2008 Save View Details
HOXD13 UP00597 Homeobox Homo sapiens homeobox protein Hox-D13: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. Barrera et al., Science 2016 Save View Details
Hoxd3 UP00241 Homeobox Mus musculus homeo box D3: M.musculus Hoxd-3 mRNA Berger et al., Cell 2008 Save View Details
Hoxd8 UP00168 Homeobox Mus musculus homeo box D8 Berger et al., Cell 2008 Save View Details
Ipf1 UP00124 Homeobox Mus musculus insulin promoter factor 1, homeodomain transcription factor Berger et al., Cell 2008 Save View Details
IRC900814 UP00072 SAND Mus musculus Arhgef12 Badis et al., Science 2009 Save View Details
Irf2 UP01405 IRF Mus musculus interferon regulatory factor 2: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. Mariani et al., Cell Systems 2017 Save View Details
Irf3 UP00086 IRF Mus musculus interferon regulatory factor 3 Badis et al., Science 2009 Save View Details
Irf4 UP00018 IRF Mus musculus interferon regulatory factor 4 Badis et al., Science 2009 Save View Details
Irf5 UP00040 IRF Mus musculus interferon regulatory factor 5 Badis et al., Science 2009 Save View Details
Irf6 UP00011 IRF Mus musculus interferon regulatory factor 6 Badis et al., Science 2009 Save View Details
Irx2 UP00236 Homeobox Mus musculus Iroquois related homeobox 2 (Drosophila) Berger et al., Cell 2008 Save View Details
Irx3 UP00223 Homeobox Mus musculus Iroquois related homeobox 3 (Drosophila) Berger et al., Cell 2008 Save View Details
Irx4 UP00194 Homeobox Mus musculus Iroquois related homeobox 4 (Drosophila) Berger et al., Cell 2008 Save View Details
Irx5 UP00250 Homeobox Mus musculus Iroquois related homeobox 5 (Drosophila) Berger et al., Cell 2008 Save View Details
Irx6 UP00150 Homeobox Mus musculus Iroquois related homeobox 6 (Drosophila) Berger et al., Cell 2008 Save View Details
Isgf3g UP00074 IRF Mus musculus interferon dependent positive acting transcription factor 3 gamma: Mus musculus interferon dependent positive acting transcription factor 3 gamma (Isgf3g), mRNA Badis et al., Science 2009 Save View Details
Isl2 UP00170 Homeobox Mus musculus insulin related protein 2 (islet 2) Berger et al., Cell 2008 Save View Details
Isx UP00243 Homeobox Mus musculus intestine-specific homeobox Berger et al., Cell 2008 Save View Details
ISX UP00598 Homeobox Homo sapiens intestine-specific homeobox: Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine. Barrera et al., Science 2016 Save View Details
Jumeau UP00519 Fork_head Drosophila melanogaster Nakagawa et al., PNAS 2013 Save View Details
Jun UP00426 bZIP Homo sapiens Transcription factor AP-1: Transcription factor that recognizes and binds to the enhancer heptamer motif 5\'-TGA[CG]TCA-3\' Alibes et al., NAR 2010 N/A View Details
Jundm2 UP00103 BRLZ, BZIP_1, BZIP_2 Mus musculus Jun dimerization protein 2: Mus musculus Jun dimerization protein 2 (Jundp2-pending), mRNA Badis et al., Science 2009 Save View Details
KLF1 UP00599 zf-C2H2 Homo sapiens Krueppel-like factor 1: Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. Barrera et al., Science 2016 Save View Details
Klf1 UP01347 zf-C2H2 Mus musculus erythroid krueppel-like transcription factor Mariani et al., Cell Systems 2017 Save View Details
KLF11 UP00600 zf-C2H2 Homo sapiens Krueppel-like factor 11: Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. Barrera et al., Science 2016 Save View Details
Klf12 UP01374 zf-C2H2 Mus musculus Krueppel-like factor 12: Confers strong transcriptional repression to the AP-2- alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter. Mariani et al., Cell Systems 2017 Save View Details
Klf7 UP00093 zf-C2H2 Mus musculus Kruppel-like factor 7 (ubiquitous): Mus musculus Kruppel-like factor 7 (ubiquitous) (Klf7), mRNA Badis et al., Science 2009 Save View Details
KLLA0F08206p UP00524 Fork_head Kluyveromyces lactis Nakagawa et al., PNAS 2013 Save View Details
Lbl UP00506 Homeobox Drosophila melanogaster Ladybird late Busser et al., Development 2012 Save View Details
Lbx2 UP00120 Homeobox Mus musculus ladybird homeobox homolog 2 (Drosophila) Berger et al., Cell 2008 Save View Details
Lef1 UP00067 HMG_box Mus musculus lymphoid enhancer binding factor 1 Badis et al., Science 2009 Save View Details
Leu3 UP00277 Zn2Cys6 Saccharomyces cerevisiae Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in ... Zhu et al., Genome Res 2009 Save View Details
Lhx1 UP00262 Homeobox Mus musculus LIM homeobox protein 1 Berger et al., Cell 2008 Save View Details
Lhx2 UP00115 Homeobox Mus musculus LIM homeobox protein 2 Berger et al., Cell 2008 Save View Details
Lhx3 UP00130 Homeobox Mus musculus LIM homeobox protein 3 Berger et al., Cell 2008 Save View Details
Lhx4 UP00261 Homeobox Mus musculus LIM homeobox protein 4 Berger et al., Cell 2008 Save View Details
Lhx5 UP00212 Homeobox Mus musculus LIM homeobox protein 5 Berger et al., Cell 2008 Save View Details
Lhx6 UP00256 Homeobox Mus musculus LIM homeobox protein 6 Berger et al., Cell 2008 Save View Details
Lhx8 UP00184 Homeobox Mus musculus LIM homeobox protein 8 Berger et al., Cell 2008 Save View Details
Lhx9 UP00175 Homeobox Mus musculus LIM homeobox protein 9 Berger et al., Cell 2008 Save View Details
LIN-32 UP00381 bHLH Caenorhabditis elegans abnormal cell LINeage: lin-32 encodes a basic helix-loop-helix transcription factor that is required for development of several types of neurons, including the touch receptor neurons and the male sensory ray neurons. Grove et al., Cell 2009 N/A View Details
Lmd UP00537 Zinc Finger C2H2 Drosophila melanogaster Lame duck: Lame duck( Lmd ), a member of the Gli superfamily of transcription factors, is essential for the specification and differentiation of fusion- competent myoblasts. Busser et al., PNAS 2012 Save View Details
Lmx1a UP00188 Homeobox Mus musculus LIM homeobox transcription factor 1 alpha Berger et al., Cell 2008 Save View Details
Lmx1b UP00169 Homeobox Mus musculus LIM homeobox transcription factor 1 beta Berger et al., Cell 2008 Save View Details
LOC100168299 UP01408 ARID Acyrthosiphon pisum AT-rich interactive domain Mariani et al., Cell Systems 2017 Save View Details
LUX UP00552 Arabidopsis thaliana Transcription factor LUX: Transcription factor that is essential for the generation of the circadian clock oscillation. Is necessary for activation of CCA1 and LHY expression. Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter. Directly regulates the expression of PRR9, a major component of the morning transcr Helfer et al., Curr Biol 2011 Save View Details
LuxR UP00392 HTH Vibrio harveyi HTH-type transcriptional regulator luxR: Regulatory protein of bacterial bioluminescence. It probably binds the autoinducer molecule and potentiates the transcription of the bioluminescence operon. (UniProt, 08/18/08) Pompeani et al., Mol Microbiol 2008 Save View Details
Lys14 UP00282 Zn2Cys6 Saccharomyces cerevisiae Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer Zhu et al., Genome Res 2009 Save View Details
Mafb UP00045 BRLZ Mus musculus v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian): Mus musculus v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) (Mafb), mRNA Badis et al., Science 2009 Save View Details
Mafg UP01375 BRLZ Mus musculus Transcription factor MafG: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Mafk UP00044 BRLZ Mus musculus v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Badis et al., Science 2009 Save View Details
MAL8P1.153 UP00429 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
MAML1 UP00485 Homo sapiens mastermind-like 1 (Drosophila): Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation Del Bianco et al., PLoS ONE 2010 N/A View Details
Matalpha2 UP00307 Homeobox Saccharomyces cerevisiae Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATal... Zhu et al., Genome Res 2009 Save View Details
Max UP00060 HLH Mus musculus Max protein Badis et al., Science 2009 Save View Details
Mbp1 UP00271 HTH APSES-type Saccharomyces cerevisiae Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis Zhu et al., Genome Res 2009 Save View Details
Mcm1 UP00326 MADS Saccharomyces cerevisiae Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes Zhu et al., Genome Res 2009 Save View Details
MDL-1 UP00382 bHLH Caenorhabditis elegans MAD-Like: mdl-1 encodes a basic helix-loop-helix (bHLH) protein similar to the vertebrate MAD transcriptional regulators; in vitro, MDL-1 can heterodimerize, and bind an E-box DNA sequence, with MXL-1, a C. elegans MAX-like bHLH protein; when expressed in rat embryonic fibroblasts, MDL-1 is able to suppress c-MYC/RAS-induced cell transformation, in a manner dependent upon an intact, predicted SIN3 interaction domain; mdl-1::gfp promoter fusions are expressed in a number of different tissues, including the posterior intestine, anterior and ventral cord neurons, pharyngeal and body wall muscles, somatic gonad precursors, and hypodermal cells; yeast one-hybrid and ChIP experiments indicate that DAF-3/Smad can bind the mdl-1 promoter; in addition, mdl-1 pharyngeal expression is specifically increased in daf-3(RNAi) animals, suggesting that DAF-3 directly negatively regulates mdl-1 transcription in pharyngeal tissue during dauer formation. Grove et al., Cell 2009 N/A View Details
Meis1 UP00186 Homeobox Mus musculus myeloid ecotropic viral integration site 1 Berger et al., Cell 2008 Save View Details
Meox1 UP00233 Homeobox Mus musculus mesenchyme homeobox 1 Berger et al., Cell 2008 Save View Details
Met32 UP00345 zf-C2H2 Saccharomyces cerevisiae Zinc-finger DNA-binding protein, involved in regulating expression of the methionine biosynthetic genes, similar to Met31p Zhu et al., Genome Res 2009 Save View Details
Mga1 UP00339 HSF_DNA-bind Saccharomyces cerevisiae Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants Zhu et al., Genome Res 2009 Save View Details
Mig1 UP00291 zf-C2H2 Saccharomyces cerevisiae Transcription factor involved in glucose repression; C2H2 zinc finger protein similar to mammalian Egr and Wilms tumor proteins Zhu et al., Genome Res 2009 Save View Details
Mig2 UP00349 zf-C2H2 Saccharomyces cerevisiae Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter Zhu et al., Genome Res 2009 Save View Details
Mig3 UP00317 zf-C2H2 Saccharomyces cerevisiae Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, a... Zhu et al., Genome Res 2009 Save View Details
Mlx UP01376 HLH Mus musculus Max-like protein X Mariani et al., Cell Systems 2017 Save View Details
Mot3 UP00460 zf-C2H2 Saccharomyces cerevisiae Modifier of Transcription : Transcriptional repressor and activator with two C2-H2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of the Tup1p-Cyc8p general repressor to promoters; involved in positive transcr Gordan et al., Gen. Bio. 2011 Save View Details
Mrg1 UP00226 Homeobox Mus musculus myeloid ecotropic viral integration site-related gene 1 Berger et al., Cell 2008 Save View Details
Mrg2 UP00210 Homeobox Mus musculus myeloid ecotropic viral integration site-related gene 2 Berger et al., Cell 2008 Save View Details
Msh UP00507 Homeobox Drosophila melanogaster Muscle segmentation homeobox: Msh plays a key role in the specification of proneural and promuscular cluster formation. It is required for the specification of dorsal and lateral muscle progenitor cells. Busser et al., Development 2012 Save View Details
Msn1 UP00461 GCR1_C Saccharomyces cerevisiae Multicopy suppressor of SNF1 mutation : Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus Gordan et al., Gen. Bio. 2011 Save View Details
Msx1 UP00234 Homeobox Mus musculus homeo box, msh-like 1 Berger et al., Cell 2008 Save View Details
Msx2 UP00156 Homeobox Mus musculus homeo box, msh-like 2 Berger et al., Cell 2008 Save View Details
MSX2 UP00603 Homeobox Homo sapiens homeobox protein MSX-2: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. Barrera et al., Science 2016 Save View Details
Msx3 UP00171 Homeobox Mus musculus homeo box, msh-like 3 Berger et al., Cell 2008 Save View Details
Msx3 UP01377 Homeobox Mus musculus homeo box, msh-like 3 Mariani et al., Cell Systems 2017 Save View Details
Mtf1 UP00097 zf-C2H2 Mus musculus metal response element binding transcription factor 1: Metal response element binding transcription factor 1 Badis et al., Science 2009 Save View Details
MTF2 UP01425 Mtf2_C Homo sapiens Metal response element binding transcription factor 2: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). Li et al., Nature 2017 Save View Details
MXL-1 UP00373 bHLH Caenorhabditis elegans MaX-Like: mxl-1 encodes a basic helix-loop-helix protein similar to the vertebrate MAX transcriptional regulators; in vitro, MXL-1 can heterodimerize, and bind an E-box DNA sequence, with MDL-1, a C. elegans MAD-like bHLH protein; mxl-1::gfp reporter fusions are expressed in the posterior intestine and in head and tail neurons. Grove et al., Cell 2009 N/A View Details
MXL-3 UP00367 bHLH Caenorhabditis elegans MaX-Like: none available Grove et al., Cell 2009 N/A View Details
Myb UP00092 SANT Mus musculus myeloblastosis oncogene: Mus musculus myeloblastosis oncogene (Myb) Badis et al., Science 2009 Save View Details
Mybl1 UP00081 SANT Mus musculus myeloblastosis oncogene-like 1: myeloblastosis oncogene-like 1 (Mybl1), mRNA Badis et al., Science 2009 Save View Details
Mybl2 UP01378 Myb_DNA-binding Mus musculus myb-like protein 2: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Myf6 UP00036 BASIC, HLH Mus musculus myogenic factor 6 Badis et al., Science 2009 Save View Details
NAP UP00574 NAC Arabidopsis thaliana NAC transcription factor protein family: Transcription factor of the NAC family involved in senescence. May function in the transition between active cell division and cell expansion. Lindemose et al, Nucleic Acids Res. 2014 Save View Details
Ndt80 UP00346 NDT80_PhoG Saccharomyces cerevisiae Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containin... Zhu et al., Genome Res 2009 Save View Details
Nhp6a UP00352 HMG_box Saccharomyces cerevisiae High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to ce... Zhu et al., Genome Res 2009 Save View Details
Nhp6b UP00325 HMG_box Saccharomyces cerevisiae High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Ap; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to ce... Zhu et al., Genome Res 2009 Save View Details
Nkx1-1 UP00220 Homeobox Mus musculus NK1 transcription factor related, locus 1 (Drosophila) Berger et al., Cell 2008 Save View Details
Nkx1-2 UP00139 Homeobox Mus musculus NK1 transcription factor related, locus 2 (Drosophila) Berger et al., Cell 2008 Save View Details
Nkx2-2 UP00231 Homeobox Mus musculus NK2 transcription factor related, locus 2 (Drosophila) Berger et al., Cell 2008 Save View Details
Nkx2-3 UP00190 Homeobox Mus musculus NK2 transcription factor related, locus 3 (Drosophila) Berger et al., Cell 2008 Save View Details
Nkx2-4 UP00107 Homeobox Mus musculus NK2 transcription factor related, locus 4 (Drosophila) Berger et al., Cell 2008 Save View Details
Nkx2-5 UP00249 Homeobox Mus musculus NK2 transcription factor related, locus 5 (Drosophila) Berger et al., Cell 2008 Save View Details
NKX2-5 UP00604 Homeobox Homo sapiens homeobox protein Nkx-2.5: This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. Barrera et al., Science 2016 Save View Details
Nkx2-6 UP00147 Homeobox Mus musculus NK2 transcription factor related, locus 6 (Drosophila) Berger et al., Cell 2008 Save View Details
NKX2-8 UP00605 Homeobox Homo sapiens homeobox protein Nkx-2.8 Barrera et al., Science 2016 Save View Details
Nkx2-9 UP00119 Homeobox Mus musculus NK2 transcription factor related, locus 9 (Drosophila) Berger et al., Cell 2008 Save View Details
Nkx3-1 UP00389 Homeobox Mus musculus NK-3 transcription factor, locus 1 (Drosophila): Mus musculus homeobox-containing protein Nkx-3.1 mRNA Berger et al., Cell 2008 Save View Details
Nkx3-1 UP00017 Homeobox Mus musculus NK-3 transcription factor, locus 1 (Drosophila): Mus musculus homeobox-containing protein Nkx-3.1 mRNA Badis et al., Science 2009 Save View Details
Nkx6-1 UP00200 Homeobox Mus musculus NK6 transcription factor related, locus 1 (Drosophila) Berger et al., Cell 2008 Save View Details
Nkx6-3 UP00238 Homeobox Mus musculus NK6 transcription factor related, locus 3 (Drosophila) Berger et al., Cell 2008 Save View Details
NOTCH1 UP00480 Homo sapiens notch 1: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot Del Bianco et al., PLoS ONE 2010 N/A View Details
NOTCH2 UP00481 Homo sapiens notch 2: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot Del Bianco et al., PLoS ONE 2010 N/A View Details
NOTCH3 UP00482 Homo sapiens notch 3: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot Del Bianco et al., PLoS ONE 2010 N/A View Details
NOTCH4 UP00483 Homo sapiens notch 4: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptot Del Bianco et al., PLoS ONE 2010 N/A View Details
NR1H4 UP00606 zf-C4 Homo sapiens bile acid receptor: This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. Barrera et al., Science 2016 Save View Details
Nr2e1 UP01379 zf-C4 Mus musculus Nuclear receptor subfamily 2 group E member 1 Mariani et al., Cell Systems 2017 Save View Details
NR2E3 UP00607 zf-C4 Homo sapiens photoreceptor-specific nuclear receptor: This protein is part of a large family of nuclear receptor transcription factors involved in signaling pathways. Nuclear receptors have been shown to regulate pathways involved in embryonic development, as well as in maintenance of proper cell function in adults. Members of this family are characterized by discrete domains that function in DNA and ligand binding. This gene encodes a retinal nuclear receptor that is a ligand-dependent transcription factor. Defects in this gene are a cause of enhanced S cone syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. Barrera et al., Science 2016 Save View Details
Nr2f1 UP01380 zf-C4 Mus musculus COUP transcription factor I: Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Nr2f2 UP00009 ZnF_C4 Mus musculus nuclear receptor subfamily 2, group F, member 2: Mus musculus nuclear receptor subfamily 2, group F, member 2 (Nr2f2), transcript variant 1, mRNA. Badis et al., Science 2009 Save View Details
Nr2f6 UP01381 zf-C4 Mus musculus Nuclear receptor subfamily 2 group F member 6: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Mariani et al., Cell Systems 2017 Save View Details
Nr5a1 UP01351 NR,zf-C4 Mus musculus adrenal 4-binding protein: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Mariani et al., Cell Systems 2017 Save View Details
Nrg1 UP00270 zf-C2H2 Saccharomyces cerevisiae Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline p... Zhu et al., Genome Res 2009 Save View Details
Nrg2 UP00462 zf-C2H2 Saccharomyces cerevisiae Negative Regulator of Glucose-controlled genes : Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p Gordan et al., Gen. Bio. 2011 Save View Details
NST2 UP00575 NAC Arabidopsis thaliana NAC transcription factor NST2: Transcription activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening of the anther endocethium, which is necessary for anther dehiscence. May also regulates the secondary cell wall lignification of other tissues such as tracheary elements Lindemose et al, Nucleic Acids Res. 2014 Save View Details
NSY-7 UP00402 Distant similarity to homeodomain Caenorhabditis elegans NSY-7: Putative uncharacterized protein Lesch et al., Genes Dev 2009 Save View Details
NTL6 UP00576 NAC Arabidopsis thaliana transcription factor NTL6: Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) (PubMed:20156199, PubMed:19947982). Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene promoters and enhances plant Lindemose et al, Nucleic Acids Res. 2014 Save View Details
NTL8 UP00577 NAC Arabidopsis thaliana protein NTM1-like 8: Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP), probably via metalloprotease activity. Regulates gibberellic acid-mediated salt-responsive repression of seed germination and flowering via FT, thus delaying seed germination under high salinity conditions. Lindemose et al, Nucleic Acids Res. 2014 Save View Details
Oaf1 UP00298 Zn2Cys6 Saccharomyces cerevisiae Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis Zhu et al., Genome Res 2009 Save View Details
Obox1 UP00216 Homeobox Mus musculus oocyte specific homeobox 1 Berger et al., Cell 2008 Save View Details
Obox2 UP00239 Homeobox Mus musculus oocyte specific homeobox 2 Berger et al., Cell 2008 Save View Details
Obox3 UP00160 Homeobox Mus musculus oocyte specific homeobox 3 Berger et al., Cell 2008 Save View Details
Obox5 UP00208 Homeobox Mus musculus oocyte specific homeobox 5 Berger et al., Cell 2008 Save View Details
Obox6 UP00109 Homeobox Mus musculus oocyte specific homeobox 6 Berger et al., Cell 2008 Save View Details
Oct-1 UP00399 POU Homo sapiens "POU domain, class 2, transcription factor 1": "POU domain, class 2, transcription factor 1" Berger et al., Nat Biotech 2006 Save View Details
Og2x UP00178 Homeobox Mus musculus OG2 homeobox gene Berger et al., Cell 2008 Save View Details
Osr1 UP00027 zf-C2H2 Mus musculus odd-skipped related 1 (Drosophila): Mus musculus HCM5520 gene, VIRTUAL TRANSCRIPT, partial sequence, genomic survey sequence Badis et al., Science 2009 Save View Details
Osr2 UP00052 zf-C2H2 Mus musculus odd-skipped related 2 (Drosophila): odd-skipped related 2 (Drosophila) (Osr2), mRNA Badis et al., Science 2009 Save View Details
Otp UP00237 Homeobox Mus musculus orthopedia homolog (Drosophila) Berger et al., Cell 2008 Save View Details
Otx1 UP00229 Homeobox Mus musculus orthodenticle homolog 1 (Drosophila) Berger et al., Cell 2008 Save View Details
Otx2 UP00267 Homeobox Mus musculus orthodenticle homolog 2 (Drosophila) Berger et al., Cell 2008 Save View Details
OVOL2 UP00608 zf-C2H2 Homo sapiens transcription factor Ovo-like 2: Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Barrera et al., Science 2016 Save View Details
PAX3 UP00609 PAX Homo sapiens paired box protein Pax-3: This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. Barrera et al., Science 2016 Save View Details
Pax4 UP00247 Homeobox, PAX Mus musculus paired box gene 4 Berger et al., Cell 2008 Save View Details
PAX4 UP00610 PAX Homo sapiens paired box protein Pax-4: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. Barrera et al., Science 2016 Save View Details
Pax6 UP00224 Homeobox, PAX Mus musculus paired box gene 6 Berger et al., Cell 2008 Save View Details
PAX6 UP00611 PAX Homo sapiens paired box protein Pax-6: This gene encodes paired box gene 6, one of many human homologs of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause ocular disorders such as aniridia and Peter's anomaly. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Barrera et al., Science 2016 Save View Details
Pax7 UP00248 Homeobox, PAX Mus musculus paired box gene 7 Berger et al., Cell 2008 Save View Details
PAX7 UP00612 PAX Homo sapiens paired box protein Pax-7: This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Three transcript variants encoding different isoforms have been found for this gene. Barrera et al., Science 2016 Save View Details
Pbf1 UP00328 Myb Saccharomyces cerevisiae Myb domain-containing protein YBL054W Zhu et al., Genome Res 2009 Save View Details
Pbf2 UP00280 Myb Saccharomyces cerevisiae Protein of unknown function, involved in telomeric gene silencing and filamentation Zhu et al., Genome Res 2009 Save View Details
Pbx1 UP00185 Homeobox Mus musculus pre B-cell leukemia transcription factor 1 Berger et al., Cell 2008 Save View Details
PBX4 UP00613 Homeobox Homo sapiens pre-B-cell leukemia transcription factor 4: This gene encodes a member of the pre-B cell leukemia transcription factor family. These proteins are homeobox proteins that play critical roles in embryonic development and cellular differentiation both as Hox cofactors and through Hox-independent pathways. The encoded protein contains a homeobox DNA-binding domain, but specific functions of the protein have not been determined. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011] Barrera et al., Science 2016 Save View Details
Pdr1 UP00290 Zn2Cys6 Saccharomyces cerevisiae Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance ... Zhu et al., Genome Res 2009 Save View Details
Pdr3 UP00463 Zn_clus Saccharomyces cerevisiae Pleiotropic Drug Resistance : Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome Gordan et al., Gen. Bio. 2011 Save View Details
PF07_0126 UP00430 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF10_0075 UP00443 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF11_0091 UP00431 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF11_0404 UP00432 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF11_0442 UP00433 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF13_0026 UP00434 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF13_0097 UP00435 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF13_0235 UP00436 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF13_0267 UP00437 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF14_0079 UP00438 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF14_0533 UP00439 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PF14_0633 UP00394 AP2 Plasmodium falciparum putative Plasmodium falciparum transcription factor, single AP2 domain De Silva et al., PNAS 2008 Save View Details
PFD0985w UP00446 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PFE0840c UP00440 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PFF0200c UP00393 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, tandem double AP2 domain De Silva et al., PNAS 2008 Save View Details
PFF0200c UP00478 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, tandem double AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PFF0670w UP00448 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PFL1075w UP00441 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PFL1085w UP00442 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
PFL1900w UP00450 AP2 Plasmodium falciparum transcription factor with AP2 domain(s), putative: putative Plasmodium falciparum transcription factor, AP2 domain Campbell et al., PLoS Pathog 2010 Save View Details
Pgr UP01385 zf-C4 Mus musculus Progesterone receptor Mariani et al., Cell Systems 2017 Save View Details
Phd1 UP00351 HTH APSES-type Saccharomyces cerevisiae Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental re.. Zhu et al., Genome Res 2009 Save View Details
PHF1 UP01424 Mtf2_C Homo sapiens PHD finger protein 1: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci. According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. Li et al., Nature 2017 Save View Details
Pho2 UP00268 Homeobox Saccharomyces cerevisiae Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction Zhu et al., Genome Res 2009 Save View Details
Pho4 UP00332 HLH Saccharomyces cerevisiae Basic helix-loop-helix (bHLH) transcription factor; binds cooperatively with Pho2p to the PHO5 promoter; function is regulated by phosphorylation at multiple sites and by phosphate availability Zhu et al., Genome Res 2009 Save View Details
Phox2a UP00221 Homeobox Mus musculus paired-like homeobox 2a Berger et al., Cell 2008 Save View Details
Phox2b UP00149 Homeobox Mus musculus paired-like homeobox 2b Berger et al., Cell 2008 Save View Details
PHOX2B UP00614 Homeobox Homo sapiens paired mesoderm homeobox protein 2B: The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Barrera et al., Science 2016 Save View Details
Pitx1 UP00153 Homeobox Mus musculus paired-like homeodomain transcription factor 1 Berger et al., Cell 2008 Save View Details
Pitx2 UP00125 Homeobox Mus musculus paired-like homeodomain transcription factor 2 Berger et al., Cell 2008 Save View Details
PITX2 UP00615 Homeobox Homo sapiens pituitary homeobox 2: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] Barrera et al., Science 2016 Save View Details
Pitx3 UP00265 Homeobox Mus musculus paired-like homeodomain transcription factor 3 Berger et al., Cell 2008 Save View Details
Pknox1 UP00203 Homeobox Mus musculus Pbx/knotted 1 homeobox Berger et al., Cell 2008 Save View Details
Pknox2 UP00205 Homeobox Mus musculus Pbx/knotted 1 homeobox 2 Berger et al., Cell 2008 Save View Details
Plagl1 UP00088 zf-C2H2 Mus musculus Pleiomorphic adenoma gene-like 1: Mus musculus similar to zinc finger protein regulator of apoptosis and cell cycle arrest (Zac1), mRNA Badis et al., Science 2009 Save View Details
PmTbr UP00501 T-box Patiria miniata P. miniata Tbrain (T-box transcription factor) Cheatle Jarvela et al., Mol Biol Evol 2014 Save View Details
Pou1f1 UP00158 Homeobox, POU Mus musculus pituitary specific transcription factor 1 Berger et al., Cell 2008 Save View Details
Pou2f1 UP00254 Homeobox, POU Mus musculus POU domain, class 2, transcription factor 1 Berger et al., Cell 2008 Save View Details
Pou2f2 UP00191 Homeobox, POU Mus musculus POU domain, class 2, transcription factor 2 Berger et al., Cell 2008 Save View Details
Pou2f3 UP00179 Homeobox, POU Mus musculus POU domain, class 2, transcription factor 3 Berger et al., Cell 2008 Save View Details
Pou3f1 UP00129 Homeobox, POU Mus musculus POU domain, class 3, transcription factor 1 Berger et al., Cell 2008 Save View Details
Pou3f2 UP00128 Homeobox, POU Mus musculus POU domain, class 3, transcription factor 2 Berger et al., Cell 2008 Save View Details
Pou3f2 UP01387 Homeobox, POU Mus musculus POU domain, class 3, transcription factor 2 Mariani et al., Cell Systems 2017 Save View Details
Pou3f3 UP00211 Homeobox, POU Mus musculus POU domain, class 3, transcription factor 3 Berger et al., Cell 2008 Save View Details
Pou3f4 UP00105 Homeobox, POU Mus musculus POU domain, class 3, transcription factor 4 Berger et al., Cell 2008 Save View Details
POU3F4 UP00616 POU Homo sapiens POU domain, class 3, transcription factor 4: This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012] Barrera et al., Science 2016 Save View Details
Pou4f1 UP01355 POU Mus musculus POU domain, class 4, transcription factor 1: Probable transcription factor which may play a role in the regulation of specific gene expression within a subset of neuronal lineages. May play a role in determining or maintaining the identities of a small subset of visual system neurons. Mariani et al., Cell Systems 2017 Save View Details
Pou4f3 UP00118 Homeobox, POU Mus musculus POU domain, class 4, transcription factor 3 Berger et al., Cell 2008 Save View Details
POU4F3 UP00617 POU Homo sapiens POU domain, class 4, transcription factor 3: This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009] Barrera et al., Science 2016 Save View Details
Pou6f1 UP00146 Homeobox, POU Mus musculus POU domain, class 6, transcription factor 1 Berger et al., Cell 2008 Save View Details
POU6F2 UP00618 POU Homo sapiens POU domain, class 6, transcription factor 2: This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009] Barrera et al., Science 2016 Save View Details
Pparg UP01350 NR,zf-C4 Mus musculus nuclear receptor subfamily 1 group C member 3: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (PubMed:19041764). Mariani et al., Cell Systems 2017 Save View Details
Prop1 UP00172 Homeobox Mus musculus paired like homeodomain factor 1 Berger et al., Cell 2008 Save View Details
PROP1 UP00619 Homeobox Homo sapiens homeobox protein prophet of Pit-1: This gene encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone. [provided by RefSeq, Sep 2011] Barrera et al., Science 2016 Save View Details
Prrx1 UP00266 Homeobox Mus musculus paired related homeobox 1 Berger et al., Cell 2008 Save View Details
Prrx2 UP00136 Homeobox Mus musculus paired related homeobox 2 Berger et al., Cell 2008 Save View Details
Ptx1 UP00508 Homeobox Drosophila melanogaster Paired-type homeobox 1 Busser et al., Development 2012 Save View Details
Put3 UP00335 Zn2Cys6 Saccharomyces cerevisiae "Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences and undergoes a conformational change to form the active state; has a Zn(2)-Cys(6) binu..." Zhu et al., Genome Res 2009 Save View Details
Rap1 UP00321 Myb Saccharomyces cerevisiae "DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (sil..." Zhu et al., Genome Res 2009 Save View Details
Rap1 UP00398 Myb Saccharomyces cerevisiae "DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (sil..." Berger et al., Nat Biotech 2006 Save View Details
Rara UP00048 ZnF_C4 Mus musculus retinoic acid receptor, alpha Badis et al., Science 2009 Save View Details
Rarb UP01388 zf-C4 Mus musculus Retinoic acid receptor beta Mariani et al., Cell Systems 2017 Save View Details
Rarg UP01389 zf-C4 Mus musculus Retinoic acid receptor gamma: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, acts mainly as an activator of gene expression due to weak binding to corepressors (By similarity). Required for limb bud development. In concert with RARA or RARB, required for skeletal growth, matrix homeostasis and growth plate function. Mariani et al., Cell Systems 2017 Save View Details
Rax UP00253 Homeobox Mus musculus retina and anterior neural fold homeobox Berger et al., Cell 2008 Save View Details
Rdr1 UP00269 Zn2Cys6 Saccharomyces cerevisiae Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins Zhu et al., Genome Res 2009 Save View Details
Rds1 UP00296 Zn2Cys6 Saccharomyces cerevisiae Zinc cluster protein involved in conferring resistance to cycloheximide Zhu et al., Genome Res 2009 Save View Details
Rds2 UP00302 Zn2Cys6 Saccharomyces cerevisiae Zinc cluster protein involved in conferring resistance to ketoconazole Zhu et al., Genome Res 2009 Save View Details
REF-1 UP00383 bHLH Caenorhabditis elegans REgulator of Fusion: ref-1 encodes a protein with two basic helix-loop-helix (bHLH) domains that is distantly related to the hairy/Enhancer of split subfamily of bHLH transcription factors; REF-1 is required in hermaphrodites during early larval development for regulating the pattern of posterior Pn.p hypodermal cell fusions, primarily through regulation of MAB-5 homeodomain protein activity; REF-1 is also required for head morphogenesis and specification of the V6 lateral seam cell fate; in males, ref-1 is a target of MAB-3 transcriptional repression which in turn, promotes expression of LIN-32, a proneural bHLH transcription factor. Grove et al., Cell 2009 N/A View Details
Retn UP01410 ARID Drosophila melanogaster AT-rich interactive domain Mariani et al., Cell Systems 2017 Save View Details
Rfx1 UP01390 RFX_DNA_binding Mus musculus regulatory factor X 1: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Rfx3 UP00098 RFX Mus musculus regulatory factor X, 3 (influences HLA class II expression) Badis et al., Science 2009 Save View Details
Rfx4 UP00056 RFX Mus musculus regulatory factor X, 4 (influences HLA class II expression) Badis et al., Science 2009 Save View Details
Rfxdc2 UP00076 RFX Mus musculus regulatory factor X domain containing 2 homolog (human): AK138890 Badis et al., Science 2009 Save View Details
Rgt1 UP00288 Zn2Cys6 Saccharomyces cerevisiae Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator ... Zhu et al., Genome Res 2009 Save View Details
Rhox11 UP00193 Homeobox Mus musculus reproductive homeobox 11 Berger et al., Cell 2008 Save View Details
Rhox6 UP00116 Homeobox Mus musculus reproductive homeobox 6 Berger et al., Cell 2008 Save View Details
Rph1 UP00348 zf-C2H2 Saccharomyces cerevisiae Transcriptional repressor of PHR1, which is a photolyase induced by DNA damage; binds to AG(4) (C(4)T) sequence upstream of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC... Zhu et al., Genome Res 2009 Save View Details
Rpn4 UP00272 zf-C2H2 Saccharomyces cerevisiae Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally reg... Zhu et al., Genome Res 2009 Save View Details
Rsc3 UP00286 Zn2Cys6 Saccharomyces cerevisiae One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Zhu et al., Genome Res 2009 Save View Details
Rsc30 UP00279 Zn2Cys6 Saccharomyces cerevisiae One of 15 subunits of the 'Remodel the Structure of Chromatin' (RSC) complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar... Zhu et al., Genome Res 2009 Save View Details
Rtg3 UP00356 HLH Saccharomyces cerevisiae Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways Zhu et al., Genome Res 2009 Save View Details
Rxra UP00053 ZnF_C4 Mus musculus retinoid X receptor alpha: retinoid X receptor alpha (Rxra), mRNA Badis et al., Science 2009 Save View Details
Rxrb UP01391 zf-C4 Mus musculus Retinoic acid receptor RXR-beta Mariani et al., Cell Systems 2017 Save View Details
Rxrg UP01392 zf-C4 Mus musculus Retinoic acid receptor RXR-gamma: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Setbp1 UP01406 AT_hook Mus musculus SET binding protein 1 Mariani et al., Cell Systems 2017 Save View Details
Sfl1 UP00320 HSF_DNA-bind Saccharomyces cerevisiae Transcription repressor involved in regulation of flocculation-related genes, inhibits transcription by recruiting general corepressor Cyc8p-Tup1p to different promoters; negatively regulated by cA... Zhu et al., Genome Res 2009 Save View Details
Sfp1 UP00342 zf-C2H2 Saccharomyces cerevisiae Transcription factor that controls expression of many ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, in... Zhu et al., Genome Res 2009 Save View Details
Sfpi1 UP00085 ETS Mus musculus SFFV proviral integration 1: Mus musculus SFFV proviral integration 1 (Sfpi1), mRNA Badis et al., Science 2009 Save View Details
Sfpi1 UP00405 ETS Mus musculus SFFV proviral integration 1: Mus musculus SFFV proviral integration 1 (Sfpi1), mRNA Wei et al., EMBO J 2010 Save View Details
Shox2 UP00257 Homeobox Mus musculus short stature homeobox 2 Berger et al., Cell 2008 Save View Details
Sip4 UP00273 Zn2Cys6 Saccharomyces cerevisiae C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1... Zhu et al., Genome Res 2009 Save View Details
Six1 UP00192 Homeobox Mus musculus sine oculis-related homeobox 1 homolog (Drosophila) Berger et al., Cell 2008 Save View Details
Six2 UP00159 Homeobox Mus musculus sine oculis-related homeobox 2 homolog (Drosophila) Berger et al., Cell 2008 Save View Details
Six3 UP00195 Homeobox Mus musculus sine oculis-related homeobox 3 homolog (Drosophila): Mus musculus sine oculis-related homeobox 3 homolog (Drosophila) (Six3), mRNA. Berger et al., Cell 2008 Save View Details
Six4 UP00199 Homeobox Mus musculus sine oculis-related homeobox 4 homolog (Drosophila) Berger et al., Cell 2008 Save View Details
Six4 UP00509 Homeobox Drosophila melanogaster Six4 Busser et al., Development 2012 Save View Details
Six6 UP00388 Homeobox Mus musculus sine oculis-related homeobox 6 homolog (Drosophila) Berger et al., Cell 2008 Save View Details
Six6 UP00008 Homeobox Mus musculus sine oculis-related homeobox 6 homolog (Drosophila) Badis et al., Science 2009 Save View Details
SIX6 UP00620 Homeobox Homo sapiens homeobox protein SIX6: The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008] Barrera et al., Science 2016 Save View Details
Skn7 UP00313 HSF_DNA-bind Saccharomyces cerevisiae Nuclear response regulator and transcription factor, part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response to oxidative stress; Zhu et al., Genome Res 2009 Save View Details
Sko1 UP00464 bZIP_1 Saccharomyces cerevisiae Suppressor of Kinase Overexpression : Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses Gordan et al., Gen. Bio. 2011 Save View Details
Slou UP00510 Homeobox Drosophila melanogaster Slouch: Slou may play a role in specifying the identity of particular somatic muscles and neurons of the CNS. Busser et al., Development 2012 Save View Details
Smad3 UP00000 DWA Mus musculus MAD homolog 3 (Drosophila) Badis et al., Science 2009 Save View Details
Smp1 UP00294 MADS Saccharomyces cerevisiae Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors Zhu et al., Genome Res 2009 Save View Details
SNAI2 UP00621 zf-C2H2 Homo sapiens zinc finger protein SNAI2: Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. Barrera et al., Science 2016 Save View Details
SND1 UP00578 NAC Arabidopsis thaliana NAC Domain transcription factor SND1: Transcriptional activator of genes involved in biosynthesis of secondary walls. Together with NST1, required for the secondary cell wall thickening and lignification of sclerenchymatous fibers and secondary xylem vessels (tracheary elements). Seems to repress the secondary cell wall thickening of xylary fibers. May also regulates the secondary cell wall lignification of other t Lindemose et al, Nucleic Acids Res. 2014 Save View Details
Sox1 UP00069 HMG_box Mus musculus SRY-box containing gene 1 Badis et al., Science 2009 Save View Details
Sox11 UP00030 HMG_box Mus musculus SRY-box containing gene 11 Badis et al., Science 2009 Save View Details
Sox12 UP00101 HMG_box Mus musculus SRY-box containing gene 12 Badis et al., Science 2009 Save View Details
Sox13 UP00096 HMG_box Mus musculus SRY-box containing gene 13: nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100, mRNA (cDNA clone MGC:35934 IMAGE:3672913), complete cds Badis et al., Science 2009 Save View Details
Sox14 UP00004 HMG_box Mus musculus SRY-box containing gene 14: Mus musculus SRY-box containing gene 14, mRNA Badis et al., Science 2009 Save View Details
Sox15 UP00075 HMG_box Mus musculus SRY-box containing gene 15 Badis et al., Science 2009 Save View Details
Sox17 UP00014 HMG_box Mus musculus SRY-box containing gene 17 Badis et al., Science 2009 Save View Details
Sox18 UP00064 HMG_box Mus musculus SRY-box containing gene 18 Badis et al., Science 2009 Save View Details
Sox21 UP00071 HMG_box Mus musculus SRY-box containing gene 21 Badis et al., Science 2009 Save View Details
Sox3 UP01349 SOXp,HMG_box Mus musculus SRY-box containing gene 3 Mariani et al., Cell Systems 2017 Save View Details
Sox30 UP00023 HMG_box Mus musculus SRY-box containing gene 30: Mus musculus SRY-box containing gene 30 (Sox30) Badis et al., Science 2009 Save View Details
Sox4 UP00062 HMG_box Mus musculus SRY-box containing gene 4: Mus musculus BAC Clone 262c6 RPCI-23, complete sequence Badis et al., Science 2009 Save View Details
Sox4 UP00401 HMG_box Homo sapiens SRY (sex determining region Y)-box 4 : This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function Scharer et al., Cancer Res 2009 Save View Details
Sox5 UP00091 HMG_box Mus musculus SRY-box containing gene 5 Badis et al., Science 2009 Save View Details
Sox7 UP00034 HMG_box Mus musculus SRY-box containing gene 7 Badis et al., Science 2009 Save View Details
Sox8 UP00051 HMG_box Mus musculus SRY-box containing gene 8: SRY-box containing gene 8, mRNA (cDNA clone MGC:78314 IMAGE:6306276), complete cds Badis et al., Science 2009 Save View Details
Sp100 UP00049 SAND Mus musculus nuclear antigen Sp100: PREDICTED: Mus musculus nuclear antigen Sp100 (Sp100) Badis et al., Science 2009 Save View Details
Sp4 UP00002 zf-C2H2 Mus musculus trans-acting transcription factor 4: Mus musculus similar to trans-acting transcription factor 4 (LOC211769), mRNA Badis et al., Science 2009 Save View Details
Spdef UP00038 ETS Mus musculus SAM pointed domain containing ets transcription factor: Mus musculus prostate specific ets transcription factor (Pse-pending), mRNA Badis et al., Science 2009 Save View Details
Spdef UP00406 ETS Mus musculus SAM pointed domain containing ets transcription factor: Mus musculus prostate specific ets transcription factor (Pse-pending), mRNA Wei et al., EMBO J 2010 Save View Details
Spic UP00419 ETS Mus musculus Spi-C transcription factor (Spi-1/PU.1 related): transcription factor Spi-C Wei et al., EMBO J 2010 Save View Details
Spt15 UP00337 TBP Saccharomyces cerevisiae TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability Zhu et al., Genome Res 2009 Save View Details
SpTbr UP00502 T-box Strongylocentrotus purpuratus S. purpuratus Tbrain (T-box transcription factor) Cheatle Jarvela et al., Mol Biol Evol 2014 Save View Details
Srd1 UP00304 GATA Saccharomyces cerevisiae Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation Zhu et al., Genome Res 2009 Save View Details
Srebf1 UP01393 HLH Mus musculus Sterol regulatory element-binding protein 1: Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE- 1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC- 3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. Mariani et al., Cell Systems 2017 Save View Details
Srf UP00077 MADS Mus musculus serum response factor Badis et al., Science 2009 Save View Details
Sry UP00016 HMG_box Mus musculus sex determining region of Chr Y Badis et al., Science 2009 Save View Details
Stb3 UP00275 Stb3 Saccharomyces cerevisiae Protein that binds Sin3p in a two-hybrid assay Zhu et al., Genome Res 2009 Save View Details
Stb4 UP00465 Zn_clus Saccharomyces cerevisiae Sin Three Binding protein : Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay Gordan et al., Gen. Bio. 2011 Save View Details
Stb5 UP00466 Zn_clus Saccharomyces cerevisiae Sin Three Binding protein : Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro Gordan et al., Gen. Bio. 2011 Save View Details
Ste12 UP00467 STE Saccharomyces cerevisiae STErile: Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth Gordan et al., Gen. Bio. 2011 Save View Details
Stp1 UP00468 zf-C2H2 Saccharomyces cerevisiae Species-specific tRNA Processing : Transcription factor, undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing Gordan et al., Gen. Bio. 2011 Save View Details
Stp2 UP00338 zf-C2H2 Saccharomyces cerevisiae Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes Zhu et al., Genome Res 2009 Save View Details
Stp4 UP00354 zf-C2H2 Saccharomyces cerevisiae Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p Zhu et al., Genome Res 2009 Save View Details
Sum1 UP00341 AT_hook Saccharomyces cerevisiae Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; involved in telomere maintenance, regulated by the pachytene checkpoint Zhu et al., Genome Res 2009 Save View Details
Sut1 UP00469 Zn_clus Saccharomyces cerevisiae Sterol UpTake : Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression Gordan et al., Gen. Bio. 2011 Save View Details
Sut2 UP00297 Zn2Cys6 Saccharomyces cerevisiae Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p Zhu et al., Genome Res 2009 Save View Details
Tbf1 UP00299 Myb Saccharomyces cerevisiae Telobox-containing general regulatory factor; binds to TTAGGG repeats within subtelomeric anti-silencing regions (STARs) and possibly throughout the genome and mediates their insulating capacity by... Zhu et al., Genome Res 2009 Save View Details
TBP UP00029 TBP Homo sapiens TATA-box-binding protein: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. Badis et al., Science 2009 Save View Details
Tbr1 UP01394 T-box Mus musculus T-brain-1: Probable transcriptional regulator involved in developmental processes. Required for normal brain development. -!- SUBUNIT: Part of a complex containing CASK, TBR1 and TSPYL2; may modulate gene expression in response to neuronal synaptic activity. Mariani et al., Cell Systems 2017 Save View Details
Tbs1 UP00306 Zn2Cys6 Saccharomyces cerevisiae Probable Zn-finger protein Zhu et al., Genome Res 2009 Save View Details
Tbx2 UP01396 T-box Mus musculus T-box protein 2: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation (By similarity). Mariani et al., Cell Systems 2017 Save View Details
Tbx20 UP01395 T-box Mus musculus T-box protein 20: Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart. Mariani et al., Cell Systems 2017 Save View Details
Tbx4 UP01397 T-box Mus musculus T-box protein 4 Mariani et al., Cell Systems 2017 Save View Details
Tbx5 UP01398 T-box Mus musculus T-box protein 5 Mariani et al., Cell Systems 2017 Save View Details
Tcf1 UP00390 Homeobox Mus musculus transcription factor 1: Mus musculus transcription factor 1 (Tcf1), mRNA. Berger et al., Cell 2008 Save View Details
Tcf1 UP00089 Homeobox Mus musculus transcription factor 1: Mus musculus transcription factor 1 (Tcf1), mRNA. Badis et al., Science 2009 Save View Details
Tcf2 UP00222 Homeobox Mus musculus transcription factor 2: TCF2 gene, VIRTUAL TRANSCRIPT, partial sequence, genomic survey sequence Berger et al., Cell 2008 Save View Details
Tcf3 UP00058 HMG_box Mus musculus transcription factor 3 Badis et al., Science 2009 Save View Details
Tcf7 UP00054 HMG_box Mus musculus Transcription factor 7, T-cell specific Badis et al., Science 2009 Save View Details
Tcf7l2 UP00083 HMG_box Mus musculus transcription factor 7-like 2, T-cell specific, HMG-box Badis et al., Science 2009 Save View Details
Tcfap2a UP00005 AP-2 Mus musculus transcription factor AP-2, alpha: Mus musculus transcription factor AP-2, alpha, mRNA Badis et al., Science 2009 Save View Details
Tcfap2b UP00010 AP-2 Mus musculus transcription factor AP-2 beta Badis et al., Science 2009 Save View Details
Tcfap2c UP00087 AP-2 Mus musculus transcription factor AP-2, gamma: Mus musculus transcription factor AP-2, gamma, mRNA (cDNA clone MGC:5992 IMAGE:3592762), complete cds Badis et al., Science 2009 Save View Details
Tcfap2e UP00028 AP-2 Mus musculus transcription factor AP-2, epsilon Badis et al., Science 2009 Save View Details
Tcfe2a UP00046 HLH Mus musculus transcription factor E2a Badis et al., Science 2009 Save View Details
Tcfec UP01400 HLH Mus musculus Transcription factor EC: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form. Mariani et al., Cell Systems 2017 Save View Details
Tea1 UP00333 Zn2Cys6 Saccharomyces cerevisiae Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein Zhu et al., Genome Res 2009 Save View Details
Tec1 UP00340 TEA Saccharomyces cerevisiae Transcription factor required for full Ty1 epxression, Ty1-mediated gene activation, and haploid invasive and diploid pseudohyphal growth; TEA/ATTS DNA-binding domain family member Zhu et al., Genome Res 2009 Save View Details
Tef UP01402 BRLZ,bZIP_1,bZIP_2 Mus musculus Thyrotroph embryonic factor: Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal binding-DNA sequence 5'- [TC][AG][AG]TTA[TC][AG]-3' (By similarity). Also activates the telokin promoter in smooth muscle-specific and calcium-dependent manner. Mariani et al., Cell Systems 2017 Save View Details
TEF-1 UP01401 TEA Mus musculus transcriptional enhancer factor TEF-1 Mariani et al., Cell Systems 2017 Save View Details
Tfap2a UP01399 AP2 Mus musculus Transcription factor AP-2-alpha Mariani et al., Cell Systems 2017 Save View Details
Tgif1 UP00122 Homeobox Mus musculus TGFB-induced factor 2 Berger et al., Cell 2008 Save View Details
Tgif2 UP00258 Homeobox Mus musculus TGFB-induced factor 2 Berger et al., Cell 2008 Save View Details
TGME49_306620 UP00583 AP2 Toxoplasma gondii TGME49_306620 AP2IX-9: AP2 domain transcription factor AP2IX-9. Domain 1 of 1. Amino acids 862-914. Radke et al., PNAS 2013 Save View Details
Tin UP00511 Homeobox Drosophila melanogaster Tinman: Tinman is required for the development of heart and visceral muscle and for the formation of somatic muscles and has crucial function in the early mesodermal subdivisions. Busser et al., Development 2012 Save View Details
Titf1 UP00165 Homeobox Mus musculus thyroid transcription factor 1 Berger et al., Cell 2008 Save View Details
Tlx2 UP00244 Homeobox Mus musculus T-cell leukemia, homeobox 2 Berger et al., Cell 2008 Save View Details
Tye7 UP00324 HLH Saccharomyces cerevisiae Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator Zhu et al., Genome Res 2009 Save View Details
Ubx UP00512 Homeobox Drosophila melanogaster Ultrabithorax: Ubx is a sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. This homeotic protein controls development of the cells in the posterior thoracic and first abdominal segments. It activates the synthesis of the decapentaplegic (DPP) growth factor. Busser et al., Development 2012 Save View Details
Ume6 UP00334 Zn2Cys6 Saccharomyces cerevisiae Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms comp... Zhu et al., Genome Res 2009 Save View Details
Uncx4.1 UP00142 Homeobox Mus musculus Unc4.1 homeobox (C. elegans) Berger et al., Cell 2008 Save View Details
Upc2 UP00470 Zn_clus Saccharomyces cerevisiae UPtake Control : Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion Gordan et al., Gen. Bio. 2011 Save View Details
Usv1 UP00343 zf-C2H2 Saccharomyces cerevisiae Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in protein folding, ATP binding, and cell wall biosynthesis Zhu et al., Genome Res 2009 Save View Details
Vax1 UP00215 Homeobox Mus musculus ventral anterior homeobox containing gene 1 Berger et al., Cell 2008 Save View Details
Vax2 UP00106 Homeobox Mus musculus ventral anterior homeobox containing gene 2 Berger et al., Cell 2008 Save View Details
VAX2 UP00623 Homeobox Homo sapiens ventral anterior homeobox 2: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. Barrera et al., Science 2016 Save View Details
VENTX UP00624 Homeobox Homo sapiens homeobox protein VENTX: This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008] Barrera et al., Science 2016 Save View Details
Vhr1 UP00471 Vhr1 Saccharomyces cerevisiae VHt1 Regulator : Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations Gordan et al., Gen. Bio. 2011 Save View Details
Vhr2 UP00472 Vhr1 Saccharomyces cerevisiae VHt1 Regulator : Non-essential nuclear protein; null mutation has global effects on transcription Gordan et al., Gen. Bio. 2011 Save View Details
VND3 UP00579 NAC Arabidopsis thaliana NAC domain containing protein: Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (By similarity). Involved in xylem formation by promoting the expression of secondary wall-associated transcription factors and of genes involved in secondary wall biosynthesis and programmed cell death, ge Lindemose et al, Nucleic Acids Res. 2014 Save View Details
VND7 UP00580 NAC Arabidopsis thaliana vascular related NAC-domain protein 7: Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating pro Lindemose et al, Nucleic Acids Res. 2014 Save View Details
VOZ2 UP00581 NAC Arabidopsis thaliana vascular plant one zinc finger protein 2: Transcriptional activator acting positively in the phytochrome B signaling pathway. Functions redundantly with VOZ1 to promote flowering downstream of phytochrome B (phyB). Down-regulates 'FLOWERING LOCUS C' (FLC) and up-regulates 'FLOWERING LOCUS T' (FT). Binds to the 38-bp cis-acting region of the AVP1 gene. Binds as a dimer to the palindromic sequence 5'-GCGTNNNNNNNACGC Lindemose et al, Nucleic Acids Res. 2014 Save View Details
Vsx1 UP00141 Homeobox Mus musculus visual system homeobox 1 homolog (zebrafish) Berger et al., Cell 2008 Save View Details
VSX1 UP00625 Homeobox Homo sapiens visual system homeobox 1: The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] Barrera et al., Science 2016 Save View Details
VSX2 UP00626 Homeobox Homo sapiens visual system homeobox 2: This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities. Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity). Barrera et al., Science 2016 Save View Details
WRKY1 UP00582 WRKY Arabidopsis thaliana WRKY transcription factor 1: Transcription factor. Binds to a 5'-CGTTGACCGAG-3' consensus core sequence which contains a W box, a frequently occurring elicitor-responsive cis-acting element. Lindemose et al, Nucleic Acids Res. 2014 Save View Details
WT1 UP00627 zf-C2H2 Homo sapiens Wilms tumor protein: This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015] Barrera et al., Science 2016 Save View Details
Xbp1 UP00330 HTH APSES-type Saccharomyces cerevisiae Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4... Zhu et al., Genome Res 2009 Save View Details
Xbp1 UP01403 BRLZ,bZIP_1,bZIP_2 Mus musculus X-box-binding protein 1: Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland (PubMed:10425189, PubMed:10652269, PubMed:16362047, PubMed:17612490). Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions (PubMed:23529610). Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (PubMed:15486293). Mariani et al., Cell Systems 2017 Save View Details
Yap1 UP00327 bZIP Saccharomyces cerevisiae Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; mediates pleiotropic drug and metal resistance; localized to the nucleus in response to the presence of oxi... Zhu et al., Genome Res 2009 Save View Details
Yap3 UP00473 bZIP_1 Saccharomyces cerevisiae Yeast AP-1: Basic leucine zipper (bZIP) transcription factor Gordan et al., Gen. Bio. 2011 Save View Details
Yap6 UP00316 bZIP Saccharomyces cerevisiae Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance Zhu et al., Genome Res 2009 Save View Details
Ybr033w UP00474 Zn_clus Saccharomyces cerevisiae Expression Dependent on Slt2 : Putative zinc cluster protein, predicted to be a transcription factor; YBR033W is not an essential gene Gordan et al., Gen. Bio. 2011 Save View Details
Ybr239c UP00331 Zn2Cys6 Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR239C is not an essential gene Zhu et al., Genome Res 2009 Save View Details
Ydr520c UP00323 Zn2Cys6 Saccharomyces cerevisiae Putative transcription factor; contains the (Zn(II)2Cys6 motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and sensitive to caffeine Zhu et al., Genome Res 2009 Save View Details
Yer130c UP00284 zf-C2H2 Saccharomyces cerevisiae Hypothetical protein Zhu et al., Genome Res 2009 Save View Details
Yer184c UP00475 Zn_clus Saccharomyces cerevisiae Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source Gordan et al., Gen. Bio. 2011 Save View Details
Ygr067c UP00293 zf-C2H2 Saccharomyces cerevisiae Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p Zhu et al., Genome Res 2009 Save View Details
Ykl222c UP00281 Zn2Cys6 Saccharomyces cerevisiae Putative protein of unknown function; similar to transcriptional regulators from the zinc cluster (binuclear cluster) protein family; null mutant is sensitive to caffeine Zhu et al., Genome Res 2009 Save View Details
Yll054c UP00283 Zn2Cys6 Saccharomyces cerevisiae Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene Zhu et al., Genome Res 2009 Save View Details
Ylr278c UP00476 Zn_clus Saccharomyces cerevisiae Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene Gordan et al., Gen. Bio. 2011 Save View Details
Yml081w UP00289 zf-C2H2 Saccharomyces cerevisiae Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YML081w is not an essential gene Zhu et al., Genome Res 2009 Save View Details
Ynr063w UP00292 Zn2Cys6 Saccharomyces cerevisiae Putative zinc-cluster protein of unknown function Zhu et al., Genome Res 2009 Save View Details
Yox1 UP00274 Homeobox Saccharomyces cerevisiae Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycl... Zhu et al., Genome Res 2009 Save View Details
Ypr013c UP00311 zf-C2H2 Saccharomyces cerevisiae Putative zinc finger protein; YPR013C is not an essential gene Zhu et al., Genome Res 2009 Save View Details
Ypr015c UP00276 zf-C2H2 Saccharomyces cerevisiae Hypothetical protein Zhu et al., Genome Res 2009 Save View Details
Ypr196w UP00314 Zn2Cys6 Saccharomyces cerevisiae nuclear protein (putative) Zhu et al., Genome Res 2009 Save View Details
Yrm1 UP00295 Zn2Cys6 Saccharomyces cerevisiae Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes Zhu et al., Genome Res 2009 Save View Details
Yrr1 UP00310 Zn2Cys6 Saccharomyces cerevisiae Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes Zhu et al., Genome Res 2009 Save View Details
Zap1 UP00477 zf-C2H2 Saccharomyces cerevisiae Zinc-responsive Activator Protein : Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains Gordan et al., Gen. Bio. 2011 Save View Details
Zbtb12 UP00019 zf-C2H2 Mus musculus zinc finger and BTB domain containing 12: Mus musculus zinc finger and BTB domain containing 12 Badis et al., Science 2009 Save View Details
Zbtb3 UP00031 zf-C2H2 Mus musculus zinc finger and BTB domain containing 3: Mus musculus RIKEN cDNA 4930563M09 gene (4930563M09Rik), mRNA Badis et al., Science 2009 Save View Details
Zbtb7b UP00047 zf-C2H2 Mus musculus Vzinc finger and BTB domain containing 7B: Mus musculus hypothetical gene supported by NM_009565 Badis et al., Science 2009 Save View Details
Zfp105 UP00037 zf-C2H2 Mus musculus zinc finger protein 105: Mus musculus zinc finger protein 105 (Zfp105) Badis et al., Science 2009 Save View Details
Zfp128 UP00094 zf-C2H2 Mus musculus zinc finger protein 128: Zinc finger protein 128 [Mus musculus] Badis et al., Science 2009 Save View Details
Zfp161 UP00065 zf-C2H2 Mus musculus zinc finger protein 161: Mus musculus zinc finger protein 161 Badis et al., Science 2009 Save View Details
Zfp187 UP00082 zf-C2H2 Mus musculus zinc finger protein 187: Mus musculus zinc finger protein 187 Badis et al., Science 2009 Save View Details
Zfp281 UP00021 zf-C2H2 Mus musculus Zinc finger protein 281: Mus musculus zinc finger protein 281, mRNA Badis et al., Science 2009 Save View Details
Zfp410 UP00033 zf-C2H2 Mus musculus zinc finger protein 410: Mus musculus HCM3688 gene, VIRTUAL TRANSCRIPT, partial sequence, genomic survey sequence Badis et al., Science 2009 Save View Details
Zfp691 UP00095 zf-C2H2 Mus musculus Zinc finger protein 691: Mus musculus similar to hypothetical protein LOC51058 (LOC242652), mRNA Badis et al., Science 2009 Save View Details
Zfp740 UP00022 zf-C2H2 Mus musculus Zinc finger protein 740 Badis et al., Science 2009 Save View Details
Zfp959 UP01407 zf-C2H2 Mus musculus zinc finger protein 959 Mariani et al., Cell Systems 2017 Save View Details
Zic1 UP00102 zf-C2H2 Mus musculus Zinc finger protein of the cerebellum 1: Mus musculus similar to zic protein member 1 (Zic1), mRNA Badis et al., Science 2009 Save View Details
Zic2 UP00057 zf-C2H2 Mus musculus Zic finger protein of the cerebellum 2: Mus musculus Zic finger protein of the cerebellum 2 (Zic2) Badis et al., Science 2009 Save View Details
Zic3 UP00006 zf-C2H2 Mus musculus zinc finger protein of the cerebellum 3: Mus musculus zinc finger protein of the cerebellum 3, mRNA (cDNA clone IMAGE:30112694), partial cds Badis et al., Science 2009 Save View Details
Zif268 UP00400 zf-C2H2 Mus musculus Transcription factor Zif268 Berger et al., Nat Biotech 2006 Save View Details
ZNF200 UP00629 zf-C2H2 Homo sapiens zinc finger protein 200: Could have a role in spermatogenesis. Barrera et al., Science 2016 Save View Details
ZNF655 UP00630 zf-C2H2 Homo sapiens zinc finger protein 655: This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] Barrera et al., Science 2016 Save View Details
Zscan10 UP01404 zf-C2H2 Mus musculus Zinc finger and SCAN domain-containing protein 10: Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4. Mariani et al., Cell Systems 2017 Save View Details
Zscan4 UP00026 zf-C2H2 Mus musculus zinc finger and SCAN domain containing 4: Mus musculus BAC clone RP23-35L23 from chromosome 7, complete sequence. Badis et al., Science 2009 Save View Details

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