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| -Genomic Data for Cebpb |
Links |
- Protein
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- UniPROBE Accession Number
- UP01357
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- Species
- Mus musculus
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- Domain
- BRLZ,bZIP_1,bZIP_2
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- Swiss-Prot
- P28033
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- Name and Synonyms
- Name: CCAT/enhancer binding protein (C/EBP) beta.
Synonyms:AGP/EBP, C/EBPbeta, C/EBP beta, C/EBP BETA, CCAAT/enhancer-binding protein beta, CRP2, IL-6DBP, Interleukin-6-dependent-binding protein, LAP, LIP, Liver-enriched activator transcriptional, Nfil6, NF-IL6, NF-M
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- IHOP
- 120016
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- NCBI RefSeq
- NP_034013
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- Description
- Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16585579, PubMed:17911624, PubMed:18486321, PubMed:20111005). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:9727068, PubMed:10635333, PubMed:17301242, PubMed:17601773, PubMed:19478079, PubMed:24061474, PubMed:24216764). The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA (PubMed:15509779). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:9727068, PubMed:10635333, PubMed:16585579). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (PubMed:17911624). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:15985551, PubMed:17301242, PubMed:17601773, PubMed:20194620). Essential for female reproduction because of a critical role in ovarian follicle development (PubMed:9303532). Restricts osteoclastogenesis (PubMed:19440205).
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- JASPAR
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None Available
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| -PBM Motif Data for Cebpb |
- PBM-Derived DNA Binding Site Motif
(Seed-And-Wobble)
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- PWM
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Save
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- Top Kmer
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ATTGCG.AA E.S. 0.498
TT.CGCAAT E.S. 0.498
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- Downloads
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Download the
zip
of all Cebpb PBM files
or view the downloads directory for individual files.
Please note that the files which include probe sequence data are protected by an academic research use license,
which can be viewed here.
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| -Cebpb Datasets |
| Gene |
Clone Type |
Last Modified |
Save |
View |
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Cebpb |
DNA binding domain only |
2017-05-12 |
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- Cebpb Insert Sequence
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1 PPAAPAKAKA KKTVDKLSDE YKMRRERNNI AVRKSRDKAK MRNLETQHKV
51 LELTAENERL QKKVEQLSRE LSTLRNLFKQ LPEPLLASAG HC
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- References
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Data are analyzed by array designs with AMADID #s 016060, 015681 in Mariani et al., Cell Systems 2017
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