-Genomic Data for Cebpb Links
Protein
UniPROBE Accession Number
UP01357
Species
Mus musculus
Domain
BRLZ,bZIP_1,bZIP_2
Name and Synonyms
Name: CCAT/enhancer binding protein (C/EBP) beta.
Synonyms:AGP/EBP, C/EBPbeta, C/EBP beta, C/EBP BETA, CCAAT/enhancer-binding protein beta, CRP2, IL-6DBP, Interleukin-6-dependent-binding protein, LAP, LIP, Liver-enriched activator transcriptional, Nfil6, NF-IL6, NF-M
Description
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:16585579, PubMed:17911624, PubMed:18486321, PubMed:20111005). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis (PubMed:9727068, PubMed:10635333, PubMed:17301242, PubMed:17601773, PubMed:19478079, PubMed:24061474, PubMed:24216764). The consensus recognition site is 5'- T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA (PubMed:15509779). Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage (PubMed:9727068, PubMed:10635333, PubMed:16585579). Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (PubMed:17911624). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:15985551, PubMed:17301242, PubMed:17601773, PubMed:20194620). Essential for female reproduction because of a critical role in ovarian follicle development (PubMed:9303532). Restricts osteoclastogenesis (PubMed:19440205).
-PBM Motif Data for Cebpb
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
ATTGCG.AA
PWM
Save
Top Kmer
ATTGCG.AA E.S. 0.498
TT.CGCAAT E.S. 0.498
Downloads
Download the zip of all Cebpb PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-Cebpb Datasets
Gene Clone Type Last Modified Save View
Cebpb DNA binding domain only 2017-05-12 search save
Cebpb Insert Sequence
1   PPAAPAKAKA KKTVDKLSDE YKMRRERNNI AVRKSRDKAK MRNLETQHKV
51  LELTAENERL QKKVEQLSRE LSTLRNLFKQ LPEPLLASAG HC



References
Data are analyzed by array designs with AMADID #s 016060, 015681 in Mariani et al., Cell Systems 2017


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