|
|
| -Genomic Data for Dnmt3a |
Links |
- Protein
|
- UniPROBE Accession Number
- UP01360
|
- Species
- Mus musculus
|
- Domain
- PWWP
|
- Swiss-Prot
- O88508
|
- Name and Synonyms
- Name: DNA MTase MmuIIIA.
Synonyms:AU015806, DNA (cytosine-5)-methyltransferase 3A, DNA methyltransferase MmuIIIA, DNA MTase MmuIIIA, M.MmuIIIA, W91664
|
- IHOP
- 120611
|
- NCBI RefSeq
- NP_031898
|
- Description
- This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
|
- JASPAR
-
None Available
|
| -PBM Motif Data for Dnmt3a |
- PBM-Derived DNA Binding Site Motif
(Seed-And-Wobble)
-
|
- PWM
-
Save
|
- Top Kmer
-
AATTAATT E.S. 0.495
AATTAATT E.S. 0.495
|
- Downloads
-
Download the
zip
of all Dnmt3a PBM files
or view the downloads directory for individual files.
Please note that the files which include probe sequence data are protected by an academic research use license,
which can be viewed here.
|
| -Dnmt3a Datasets |
| Gene |
Clone Type |
Last Modified |
Save |
View |
|
Dnmt3a |
DNA binding domain only |
2017-05-12 |
|
|
- Dnmt3a Insert Sequence
-
1 ATKAADDEPE YEDGRGFGIG ELVWGKLRGF SWWPGRIVSW WMTGRSRAAE
51 GTRWVMWFGD GKFSVVCVEK LMPLSSFCSA FHQATYNKQP MYRKAIYEVL
101 QVAS
|
- References
-
Data are analyzed by array designs with AMADID #s 016060, 015681 in Mariani et al., Cell Systems 2017
|
|