-Genomic Data for FOXC1 Links
Protein
FOXC1
UniPROBE Accession Number
UP00589
Species
Homo sapiens
Domain
Forkhead
Swiss-Prot
Q12948
Name and Synonyms
Name: forkhead box protein C1.
Synonyms:ARA, FKHL7, Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC3, FREAC-3, IGDA, IHG1, IRID1, RIEG3
IHOP
88240
NCBI RefSeq
NP_001444
Description
Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye.
JASPAR
MA0032.1
-PBM Motif Data for FOXC1_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
T..GTAAACA E.S. 0.494
TGTTTAC..A E.S. 0.494
Downloads
Download the zip of all FOXC1_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for FOXC1_F112S_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
TA..TAAACA E.S. 0.464
TGTTTA..TA E.S. 0.464
Downloads
Download the zip of all FOXC1_F112S PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for FOXC1_I126M_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
TA..TAAACA E.S. 0.475
TGTTTA..TA E.S. 0.475
Downloads
Download the zip of all FOXC1_I126M PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for FOXC1_L130F_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
AT.TAATA.A E.S. 0.424
T.TATTA.AT E.S. 0.424
Downloads
Download the zip of all FOXC1_L130F PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for FOXC1_P79L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CT.T.CGTAA E.S. 0.416
TTACG.A.AG E.S. 0.416
Downloads
Download the zip of all FOXC1_P79L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for FOXC1_S131L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
C.AA.AAAAA E.S. 0.407
TTTTT.TT.G E.S. 0.407
Downloads
Download the zip of all FOXC1_S131L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for FOXC1_S82T_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
T..GTAAACA E.S. 0.497
TGTTTAC..A E.S. 0.497
Downloads
Download the zip of all FOXC1_S82T PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for FOXC1 (all alleles)
Downloads
Download the zip of all FOXC1 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-FOXC1 Datasets
Clone Clone Type Last Modified Save View
FOXC1_REF DNA binding domain only search save
FOXC1_REF Insert Sequence
1    YGPYTPQPQP KDMVKPPYSY IALITMAIQN APDKKITLNG IYQFIMDRFP
51   FYRDNKQGWQ NSIRHNLSLN ECFVKVPRDD KKPGKGSYWT LDPDSYNMFE
101  NGSFLRRRRR FKKKDAVKDK EEKDR


FOXC1_F112S DNA binding domain only search save
FOXC1_F112S Insert Sequence
1    YGPYTPQPQP KDMVKPPYSY IALITMAIQN APDKKITLNG IYQFIMDRSP
51   FYRDNKQGWQ NSIRHNLSLN ECFVKVPRDD KKPGKGSYWT LDPDSYNMFE
101  NGSFLRRRRR FKKKDAVKDK EEKDR


FOXC1_I126M DNA binding domain only search save
FOXC1_I126M Insert Sequence
1    YGPYTPQPQP KDMVKPPYSY IALITMAIQN APDKKITLNG IYQFIMDRFP
51   FYRDNKQGWQ NSMRHNLSLN ECFVKVPRDD KKPGKGSYWT LDPDSYNMFE
101  NGSFLRRRRR FKKKDAVKDK EEKDR


FOXC1_L130F DNA binding domain only search save
FOXC1_L130F Insert Sequence
1    YGPYTPQPQP KDMVKPPYSY IALITMAIQN APDKKITLNG IYQFIMDRFP
51   FYRDNKQGWQ NSIRHNFSLN ECFVKVPRDD KKPGKGSYWT LDPDSYNMFE
101  NGSFLRRRRR FKKKDAVKDK EEKDR


FOXC1_P79L DNA binding domain only search save
FOXC1_P79L Insert Sequence
1    YGPYTPQPQP KDMVKLPYSY IALITMAIQN APDKKITLNG IYQFIMDRFP
51   FYRDNKQGWQ NSIRHNLSLN ECFVKVPRDD KKPGKGSYWT LDPDSYNMFE
101  NGSFLRRRRR FKKKDAVKDK EEKDR


FOXC1_S131L DNA binding domain only search save
FOXC1_S131L Insert Sequence
1    YGPYTPQPQP KDMVKPPYSY IALITMAIQN APDKKITLNG IYQFIMDRFP
51   FYRDNKQGWQ NSIRHNLLLN ECFVKVPRDD KKPGKGSYWT LDPDSYNMFE
101  NGSFLRRRRR FKKKDAVKDK EEKDR


FOXC1_S82T DNA binding domain only search save
FOXC1_S82T Insert Sequence
1    YGPYTPQPQP KDMVKPPYTY IALITMAIQN APDKKITLNG IYQFIMDRFP
51   FYRDNKQGWQ NSIRHNLSLN ECFVKVPRDD KKPGKGSYWT LDPDSYNMFE
101  NGSFLRRRRR FKKKDAVKDK EEKDR


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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